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Fusion gene ID: 27152 |
FusionGeneSummary for PIGS_PPP1R27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIGS_PPP1R27 | Fusion gene ID: 27152 | Hgene | Tgene | Gene symbol | PIGS | PPP1R27 | Gene ID | 94005 | 116729 |
| Gene name | phosphatidylinositol glycan anchor biosynthesis class S | protein phosphatase 1 regulatory subunit 27 | |
| Synonyms | - | DYSFIP1 | |
| Cytomap | 17q11.2 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GPI transamidase component PIG-SGPI transamidase subunitphosphatidylinositol glycan, class Sphosphatidylinositol-glycan biosynthesis class S protein | protein phosphatase 1 regulatory subunit 27dysferlin interacting protein 1dysferlin-interacting protein 1 (toonin)toonin | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q96S52 | Q86WC6 | |
| Ensembl transtripts involved in fusion gene | ENST00000395346, ENST00000308360, ENST00000543734, ENST00000465444, | ENST00000330261, ENST00000573182, ENST00000570394, | |
| Fusion gene scores | * DoF score | 3 X 4 X 4=48 | 3 X 1 X 3=9 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PIGS [Title/Abstract] AND PPP1R27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPP1R27 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-D7-A748-01A | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000395346 | ENST00000330261 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| 5CDS-intron | ENST00000395346 | ENST00000573182 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| 5CDS-intron | ENST00000395346 | ENST00000570394 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| In-frame | ENST00000308360 | ENST00000330261 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| 5CDS-intron | ENST00000308360 | ENST00000573182 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| 5CDS-intron | ENST00000308360 | ENST00000570394 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| Frame-shift | ENST00000543734 | ENST00000330261 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| 5CDS-intron | ENST00000543734 | ENST00000573182 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| 5CDS-intron | ENST00000543734 | ENST00000570394 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| intron-3CDS | ENST00000465444 | ENST00000330261 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| intron-intron | ENST00000465444 | ENST00000573182 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
| intron-intron | ENST00000465444 | ENST00000570394 | PIGS | chr17 | 26881869 | - | PPP1R27 | chr17 | 79792709 | - |
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FusionProtFeatures for PIGS_PPP1R27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIGS | PPP1R27 |
| Component of the GPI transamidase complex. Essential fortransfer of GPI to proteins, particularly for formation ofcarbonyl intermediates. {ECO:0000269|PubMed:11483512}. | Inhibits phosphatase activity of protein phosphatase 1(PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PIGS | chr17:26881869 | chr17:79792709 | ENST00000308360 | - | 11 | 12 | 2_18 | 464 | 556 | Topological domain | Cytoplasmic |
| Hgene | PIGS | chr17:26881869 | chr17:79792709 | ENST00000395346 | - | 10 | 11 | 2_18 | 456 | 548 | Topological domain | Cytoplasmic |
| Hgene | PIGS | chr17:26881869 | chr17:79792709 | ENST00000308360 | - | 11 | 12 | 19_39 | 464 | 556 | Transmembrane | Helical |
| Hgene | PIGS | chr17:26881869 | chr17:79792709 | ENST00000395346 | - | 10 | 11 | 19_39 | 456 | 548 | Transmembrane | Helical |
| Tgene | >PPP1R27 | chr17:26881869 | chr17:79792709 | ENST00000330261 | - | 0 | 3 | 14_19 | -27 | 155 | Compositional bias | Note=Poly-Arg |
| Tgene | >PPP1R27 | chr17:26881869 | chr17:79792709 | ENST00000330261 | - | 0 | 3 | 63_92 | -27 | 155 | Repeat | Note=ANK 1 |
| Tgene | >PPP1R27 | chr17:26881869 | chr17:79792709 | ENST00000330261 | - | 0 | 3 | 96_125 | -27 | 155 | Repeat | Note=ANK 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PIGS | chr17:26881869 | chr17:79792709 | ENST00000308360 | - | 11 | 12 | 40_520 | 464 | 556 | Topological domain | Lumenal |
| Hgene | >PIGS | chr17:26881869 | chr17:79792709 | ENST00000308360 | - | 11 | 12 | 542_555 | 464 | 556 | Topological domain | Cytoplasmic |
| Hgene | >PIGS | chr17:26881869 | chr17:79792709 | ENST00000395346 | - | 10 | 11 | 40_520 | 456 | 548 | Topological domain | Lumenal |
| Hgene | >PIGS | chr17:26881869 | chr17:79792709 | ENST00000395346 | - | 10 | 11 | 542_555 | 456 | 548 | Topological domain | Cytoplasmic |
| Hgene | >PIGS | chr17:26881869 | chr17:79792709 | ENST00000308360 | - | 11 | 12 | 521_541 | 464 | 556 | Transmembrane | Helical |
| Hgene | >PIGS | chr17:26881869 | chr17:79792709 | ENST00000395346 | - | 10 | 11 | 521_541 | 456 | 548 | Transmembrane | Helical |
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FusionGeneSequence for PIGS_PPP1R27 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIGS_ENST00000395346_chr17_26881869_-_PPP1R27_ENST00000330261_chr17_79792709_-_456aa MPSEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTRESVPLDDQEKLPFTVVHEREIPLKYKM KIKCRFQKAYRRALDHEEEALSSGSVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFNIIGRRIVQ VAQAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYA MLGVNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKT YNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIK >In-frame_PIGS_ENST00000308360_chr17_26881869_-_PPP1R27_ENST00000330261_chr17_79792709_-_464aa MAAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTRESVPLDDQEKLPFTVVHER EIPLKYKMKIKCRFQKAYRRALDHEEEALSSGSVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFN IIGRRIVQVAQAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSV DSQILYYAMLGVNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIM VYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLAQLLG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIGS_ENST00000395346_chr17_26881869_-_PPP1R27_ENST00000330261_chr17_79792709_-_1368nt ATGCCCTCAGAGGTGGCCCGGGGCAAGCGCGCCGCCCTCTTCTTCGCTGCGGTGGCCATCGTGCTGGGGCTACCGCTCTGGTGGAAGACC ACGGAGACCTACCGGGCCTCGTTGCCTTACTCCCAGATCAGTGGCCTGAATGCCCTTCAGCTCCGCCTCATGGTGCCTGTCACTGTCGTG TTTACGCGGGAGTCAGTGCCCCTGGACGACCAGGAGAAGCTGCCCTTCACCGTTGTGCATGAAAGAGAGATTCCTCTGAAATACAAAATG AAAATCAAATGCCGTTTCCAGAAGGCCTATCGGAGGGCTTTGGACCATGAGGAGGAGGCCCTGTCATCGGGCAGTGTGCAAGAGGCAGAA GCCATGTTAGATGAGCCTCAGGAACAAGCGGAGGGCTCCCTGACTGTGTACGTGATATCTGAACACTCCTCACTTCTTCCCCAGGACATG ATGAGCTACATTGGGCCCAAGAGGACAGCAGTGGTGCGGGGGATAATGCACCGGGAGGCCTTTAACATCATTGGCCGCCGCATAGTCCAG GTGGCCCAGGCCATGTCTTTGACTGAGGATGTGCTTGCTGCTGCTCTGGCTGACCACCTTCCAGAGGACAAGTGGAGCGCTGAGAAGAGG CGGCCTCTCAAGTCCAGCTTGGGCTATGAGATCACCTTCAGTTTACTCAACCCAGACCCCAAGTCCCATGATGTCTACTGGGACATTGAG GGGGCTGTCCGGCGCTATGTGCAACCTTTCCTGAATGCCCTCGGTGCCGCTGGCAACTTCTCTGTGGACTCTCAGATTCTTTACTATGCA ATGTTGGGGGTGAATCCCCGCTTTGACTCAGCTTCCTCCAGCTACTATTTGGACATGCACAGCCTCCCCCATGTCATCAACCCAGTGGAG TCCCGGCTGGGATCCAGTGCTGCCTCCTTGTACCCTGTGCTCAACTTTCTACTCTACGTGCCTGAGCTTGCACACTCACCGCTGTACATT CAGGACAAGGATGGCGCTCCAGTGGCCACCAATGCCTTCCATAGTCCCCGCTGGGGTGGCATTATGGTATATAATGTTGACTCCAAAACC TATAATGCCTCAGTGCTGCCAGTGAGAGTCGAGGTGGACATGGTGCGAGTGATGGAGGTGTTCCTGGCACAGTTGCGGTTGCTCTTTGGG ATTGCTCAGCCCCAGCTGCCTCCAAAATGCCTGCTTTCAGGGCCTACGAGTGAAGGGCTAATGACCTGGGAGCTAGACCGGCTGCTCTGG GCTCGGTCAGTGGAGAACCTGGCCACAGCCACCACCACCCTTACCTCCCTGGCGCAGCTTCTGGGCAAGATCAGCAACATTGTCATTAAG >In-frame_PIGS_ENST00000308360_chr17_26881869_-_PPP1R27_ENST00000330261_chr17_79792709_-_1392nt ATGGCGGCCGCCGGGGCTGCGGCTACACACCTAGAGGTGGCCCGGGGCAAGCGCGCCGCCCTCTTCTTCGCTGCGGTGGCCATCGTGCTG GGGCTACCGCTCTGGTGGAAGACCACGGAGACCTACCGGGCCTCGTTGCCTTACTCCCAGATCAGTGGCCTGAATGCCCTTCAGCTCCGC CTCATGGTGCCTGTCACTGTCGTGTTTACGCGGGAGTCAGTGCCCCTGGACGACCAGGAGAAGCTGCCCTTCACCGTTGTGCATGAAAGA GAGATTCCTCTGAAATACAAAATGAAAATCAAATGCCGTTTCCAGAAGGCCTATCGGAGGGCTTTGGACCATGAGGAGGAGGCCCTGTCA TCGGGCAGTGTGCAAGAGGCAGAAGCCATGTTAGATGAGCCTCAGGAACAAGCGGAGGGCTCCCTGACTGTGTACGTGATATCTGAACAC TCCTCACTTCTTCCCCAGGACATGATGAGCTACATTGGGCCCAAGAGGACAGCAGTGGTGCGGGGGATAATGCACCGGGAGGCCTTTAAC ATCATTGGCCGCCGCATAGTCCAGGTGGCCCAGGCCATGTCTTTGACTGAGGATGTGCTTGCTGCTGCTCTGGCTGACCACCTTCCAGAG GACAAGTGGAGCGCTGAGAAGAGGCGGCCTCTCAAGTCCAGCTTGGGCTATGAGATCACCTTCAGTTTACTCAACCCAGACCCCAAGTCC CATGATGTCTACTGGGACATTGAGGGGGCTGTCCGGCGCTATGTGCAACCTTTCCTGAATGCCCTCGGTGCCGCTGGCAACTTCTCTGTG GACTCTCAGATTCTTTACTATGCAATGTTGGGGGTGAATCCCCGCTTTGACTCAGCTTCCTCCAGCTACTATTTGGACATGCACAGCCTC CCCCATGTCATCAACCCAGTGGAGTCCCGGCTGGGATCCAGTGCTGCCTCCTTGTACCCTGTGCTCAACTTTCTACTCTACGTGCCTGAG CTTGCACACTCACCGCTGTACATTCAGGACAAGGATGGCGCTCCAGTGGCCACCAATGCCTTCCATAGTCCCCGCTGGGGTGGCATTATG GTATATAATGTTGACTCCAAAACCTATAATGCCTCAGTGCTGCCAGTGAGAGTCGAGGTGGACATGGTGCGAGTGATGGAGGTGTTCCTG GCACAGTTGCGGTTGCTCTTTGGGATTGCTCAGCCCCAGCTGCCTCCAAAATGCCTGCTTTCAGGGCCTACGAGTGAAGGGCTAATGACC TGGGAGCTAGACCGGCTGCTCTGGGCTCGGTCAGTGGAGAACCTGGCCACAGCCACCACCACCCTTACCTCCCTGGCGCAGCTTCTGGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIGS_ENST00000395346_chr17_26881869_-_PPP1R27_ENST00000330261_chr17_79792709_-_5077nt AGCTCTGCCCCCACGGTGGCCGGAGCAGCCGGAAGCTAGCATGGCGGCCGCCGGGGCTGCGGCTACACACCTAGGTGCGGTGGGCTTCGG GTGGGGGGCCTGCAGCTAGCTGATGGCAAGGGAGGAATAGCAGGGGTGGGGATTGTGGTGTGCGAGAGGTCCCGCGGACGGGGGGCTCGG GGGTCTCTTCAGACGAGATTCCCTTCAGGCTTGGGCCGGGTCCCTTCGCACGGAGATCCCAATGAACGCGGGCCCCTGGAGGCCGGTGGT TGGGGCTTCTCCGCGTCGGGGATGGGGCCGGTACCCTAGCCCGTTTCCAGCGCCTCAGTCGGTTCCCCATGCCCTCAGAGGTGGCCCGGG GCAAGCGCGCCGCCCTCTTCTTCGCTGCGGTGGCCATCGTGCTGGGGCTACCGCTCTGGTGGAAGACCACGGAGACCTACCGGGCCTCGT TGCCTTACTCCCAGATCAGTGGCCTGAATGCCCTTCAGCTCCGCCTCATGGTGCCTGTCACTGTCGTGTTTACGCGGGAGTCAGTGCCCC TGGACGACCAGGAGAAGCTGCCCTTCACCGTTGTGCATGAAAGAGAGATTCCTCTGAAATACAAAATGAAAATCAAATGCCGTTTCCAGA AGGCCTATCGGAGGGCTTTGGACCATGAGGAGGAGGCCCTGTCATCGGGCAGTGTGCAAGAGGCAGAAGCCATGTTAGATGAGCCTCAGG AACAAGCGGAGGGCTCCCTGACTGTGTACGTGATATCTGAACACTCCTCACTTCTTCCCCAGGACATGATGAGCTACATTGGGCCCAAGA GGACAGCAGTGGTGCGGGGGATAATGCACCGGGAGGCCTTTAACATCATTGGCCGCCGCATAGTCCAGGTGGCCCAGGCCATGTCTTTGA CTGAGGATGTGCTTGCTGCTGCTCTGGCTGACCACCTTCCAGAGGACAAGTGGAGCGCTGAGAAGAGGCGGCCTCTCAAGTCCAGCTTGG GCTATGAGATCACCTTCAGTTTACTCAACCCAGACCCCAAGTCCCATGATGTCTACTGGGACATTGAGGGGGCTGTCCGGCGCTATGTGC AACCTTTCCTGAATGCCCTCGGTGCCGCTGGCAACTTCTCTGTGGACTCTCAGATTCTTTACTATGCAATGTTGGGGGTGAATCCCCGCT TTGACTCAGCTTCCTCCAGCTACTATTTGGACATGCACAGCCTCCCCCATGTCATCAACCCAGTGGAGTCCCGGCTGGGATCCAGTGCTG CCTCCTTGTACCCTGTGCTCAACTTTCTACTCTACGTGCCTGAGCTTGCACACTCACCGCTGTACATTCAGGACAAGGATGGCGCTCCAG TGGCCACCAATGCCTTCCATAGTCCCCGCTGGGGTGGCATTATGGTATATAATGTTGACTCCAAAACCTATAATGCCTCAGTGCTGCCAG TGAGAGTCGAGGTGGACATGGTGCGAGTGATGGAGGTGTTCCTGGCACAGTTGCGGTTGCTCTTTGGGATTGCTCAGCCCCAGCTGCCTC CAAAATGCCTGCTTTCAGGGCCTACGAGTGAAGGGCTAATGACCTGGGAGCTAGACCGGCTGCTCTGGGCTCGGTCAGTGGAGAACCTGG CCACAGCCACCACCACCCTTACCTCCCTGGCGCAGCTTCTGGGCAAGATCAGCAACATTGTCATTAAGGACGACGTGGCATCTGAGCTGA TCTGGTCGGGACCGGATACATTATTAACCCCAGTGCAGTAGGGTCCCCAGGGGCAACCTGCCCCACAGCGCCCAAGATGCCTAGCAGAAC TGCCCGCTATGCCCGCTACAGCCCACGGCAGCGGCGGCGGCGGATGCTGGCTGATCGCAGCGTGCGTTTCCCTAATGATGTCCTGTTCTT GGACCACATCCGGCAGGGTGACCTGGAGCAGGTGGGGCGCTTCATCCGGACTCGGAAAGTCTCCCTGGCCACCATCCACCCCTCAGGCCT GGCCGCCTTGCATGAAGCCGTGCTCTCTGGAAACCTGGAATGCGTGAAGCTGCTGGTCAAATACGGGGCTGACATTCACCAGCGAGATGA GGCGGGCTGGACACCCCTGCACATTGCCTGCAGCGATGGGTACCCTGACATAGCCAGCTGGGGCCACAACTTTGGTGAAGAAGGATATAT TCGGATGGCAAGAAATAAAGGAAATCATTGTGGGATTGCTAGCTTTCCCTCTTACCCAGAAATCTAGAGGATCTCTCCTTTTTATAACAA ATCAAGAAATATGAAGCACTTTCTCTTAACTTAATTTTTCCTGCTGTATCCAGAAGAAATAATTGTGTCATGATTAATGTGTATTTACTG TACTAATTAGAAAATATAGTTTGAGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGTACTTGGGAGGCCAAGGCAGGCATATCAACTT GAGGCCAGGAGTTAAAGAGCAGCCTGGCTAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCGAGCACGGTGGTGCAT GCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCACGAGATTCCTTGAACCCAAGAGGTTGAGGCTATGTTGAGCTGAGATCACACCACTG TACTCCAGCCTGGATGACAGAGTGGAGACTCTGTTTCAAAAAAACAGAAAAGAAAATATAGTTTGATTCTTCATTTTTTTAAATTTGCAA ATCTCAGGATAAAGTTTGCTAAGTAAATTAGTAATGTACTATAGATATAACTGTACAAAAATTGTTCAACCTAAAACAATCTGTAATTGC TTATTGTTTTATTGTATACTCTTTGTCTTTTTAAGACCCCTAATAGCCTTTTGTAACTTGATGGCTTAAAAATACTTAATAAATCTGCCA TTTCAAATTTCTATCATTGCCACATACCATTCTTATTCCTAGGCAACTATTAATAATCTATCCTGAGAATATTAATTGTGGTATTCTGGT GATGGGGTTTAGCAACTTTGATGGAAGAAAATATTAGGCTATAAATGTCCTAAGGACTCAGATTGTATCTTTGTACAGAAGAGGATTCAA AACGCCACGTGTAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCTGAAGTAGGAGGATCGTCTTGAGCCCAGGAGTTCAAGACCA GCCTGGACAACATAGTGAGACCTTGTCTCCACAAAAATAAAAAAGAAACTATCCAGGAGTGGTGGTGTGTGCCTGTGGTCCCTGCTATGC AGATGTCTAAGACAGGAGGATCACAAGAGCCCAGGAGGTTGAGAATGCAGTGAGCTTGTAATTGCACCACTGCACTCCAGCCTGGGTGAC AGAGCAAGACCCTGTCTTAAAAAAAGAGGATTCAACACATATTTTTATATTATGTTAAAGTAAAGAAATGCATAAAAGACAAGCACTTTG GAAGAATTATTTTAATGATCAACAATTTAATGTATTAGTCCAAATTATTTTTACGTAGTCATCAACAATTTGACCAGGGCCTTTATTTGG CAAATAACTGAGCCAACCAGAATAAAATAACCAATACTCCACTGCTCATATTTTTATCTAATTCAGATGGATCTTCCTTACAACTGCTCT AGATTAGTAGATGCATCTAAGCAGGCAGCAGGAACTTTAAATTTTTTAAGTTCATGTCTATGACATGAACAATGTGTGGGATAATGTCAT TAATATATCCTAAATTAACCTAAACGTATTTCACTAACTCTGGCTCCTTCTCCATAAAGCACATTTTAAGGAACAAGAATTGCTAAATAT AAAAACATAAATAATACCATAATACATGGCTATCATCAAAAGTGTATAGAATATTATAGTTTAAAAGTATTTAGTTGATTACTTTTCAGT TTTGTTTTGTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCTCAGTTCACTGCAACTTCTGCCTCCC GAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTATAGGCGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTAGT AAAGACAGGGTTTTGCCACATTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCCCAGCCTCCCAAAGTGCTAAGAT TACAGGCGTGAGCCACTGAGCCCAGCCTACTTTTCAGTTTTTAACATAATTTTTGTTTTATCCACAACTTTTCAAGTATTGAAAGTAGAA TAAAAACATGGGTTCTTAGTCTTTAGCTATCTGTTAAAGCCTATGAATGCCTTCTTAAAATCATGTTTTTAAATGCATAAAATATATAGG ATTACAAAGGAATCTAATTATATCGAAATACAGTTATTAAAATGTTAAAAGATAAGTTTGTTATATATTAATATGCATGCTTCTTTATAA ATGCATTAAATAAGAGTTAATAGCTATCCTAAATTTGAAATAGTGATAAGCATAATGAAAATAGATGCAAAAAACTAATGTGATATGAAA ATATCTGGGTTTTTCTTTTGATGATGAAGTATTGCTAATATTACCGTGGTTTATGAACTATGTTCAGAATTGAAGAAAATCCTAACTTTC AGTTAGAGGTTAGTGACGGGGTTCAGGACACCCTACACAAAATACAGCACTTTGACATATTGAATATTTTAAGCTGAAGGCATTTGAGGA AATTGCAGAAGCAGGAAGGTGACTCTGACCTTCTGCCTGCTGTTCTCCCCAGAAGCAGCCATAAAACCTGGGAAGGATTTTCTGACCTTC CCCTGAAGTAGATCATAAGACTGTCATGTAAGAGGTGCTCTCCTGGCACCCAGAGAAAAGGAGCATCCTTACCTCCAAAAGCACAGGGAC ACAAAGAGGAATCTAAACAAACAGGCCTCTCAGTTTCCCCCAGTTTATTACATTTAGCTTGTTCACACTTTGCCCTATGACATTTCTACA TCACTGGCTGCTCTTCATCAAACCTACTATAAAAAACATTCAAGTTCAACTGTTTCTTTGGGCCTTTATTTCCTTATGGAGCCCCTCGTG >In-frame_PIGS_ENST00000308360_chr17_26881869_-_PPP1R27_ENST00000330261_chr17_79792709_-_5139nt TCCATTTTCAGATGAGCCTCGGAGCTGCCTGTAGTTGCCCAGCTAGTATTTAAGGACTGCAGAGGTTGCGCTCTTGATTGCGGGGCTAGA AGTGTGTTCTACAGGGAAGCGGGGAACTTCGTTCCAGCAGCGCCGAAACCCGCACGGCCCCTAGGCTGTCCCTCCGCGCCCGGGTGACTT CCTTTCAGATCCCCAGCGAAGCTCCCAGCGGAGCCCTCCCACCCCTCGCCCGCTTGCTCCCGTCTGCGGGTCTGGAGTAGCGCTCGCGAT TGGCCCCGATCACCGCCGCGGTCCTGCCCCCTCGTTGCAGAGATTCCGATTGGGTGAGGCTCACGAAGCTCTGCCCCCACGGTGGCCGGA GCAGCCGGAAGCTAGCATGGCGGCCGCCGGGGCTGCGGCTACACACCTAGAGGTGGCCCGGGGCAAGCGCGCCGCCCTCTTCTTCGCTGC GGTGGCCATCGTGCTGGGGCTACCGCTCTGGTGGAAGACCACGGAGACCTACCGGGCCTCGTTGCCTTACTCCCAGATCAGTGGCCTGAA TGCCCTTCAGCTCCGCCTCATGGTGCCTGTCACTGTCGTGTTTACGCGGGAGTCAGTGCCCCTGGACGACCAGGAGAAGCTGCCCTTCAC CGTTGTGCATGAAAGAGAGATTCCTCTGAAATACAAAATGAAAATCAAATGCCGTTTCCAGAAGGCCTATCGGAGGGCTTTGGACCATGA GGAGGAGGCCCTGTCATCGGGCAGTGTGCAAGAGGCAGAAGCCATGTTAGATGAGCCTCAGGAACAAGCGGAGGGCTCCCTGACTGTGTA CGTGATATCTGAACACTCCTCACTTCTTCCCCAGGACATGATGAGCTACATTGGGCCCAAGAGGACAGCAGTGGTGCGGGGGATAATGCA CCGGGAGGCCTTTAACATCATTGGCCGCCGCATAGTCCAGGTGGCCCAGGCCATGTCTTTGACTGAGGATGTGCTTGCTGCTGCTCTGGC TGACCACCTTCCAGAGGACAAGTGGAGCGCTGAGAAGAGGCGGCCTCTCAAGTCCAGCTTGGGCTATGAGATCACCTTCAGTTTACTCAA CCCAGACCCCAAGTCCCATGATGTCTACTGGGACATTGAGGGGGCTGTCCGGCGCTATGTGCAACCTTTCCTGAATGCCCTCGGTGCCGC TGGCAACTTCTCTGTGGACTCTCAGATTCTTTACTATGCAATGTTGGGGGTGAATCCCCGCTTTGACTCAGCTTCCTCCAGCTACTATTT GGACATGCACAGCCTCCCCCATGTCATCAACCCAGTGGAGTCCCGGCTGGGATCCAGTGCTGCCTCCTTGTACCCTGTGCTCAACTTTCT ACTCTACGTGCCTGAGCTTGCACACTCACCGCTGTACATTCAGGACAAGGATGGCGCTCCAGTGGCCACCAATGCCTTCCATAGTCCCCG CTGGGGTGGCATTATGGTATATAATGTTGACTCCAAAACCTATAATGCCTCAGTGCTGCCAGTGAGAGTCGAGGTGGACATGGTGCGAGT GATGGAGGTGTTCCTGGCACAGTTGCGGTTGCTCTTTGGGATTGCTCAGCCCCAGCTGCCTCCAAAATGCCTGCTTTCAGGGCCTACGAG TGAAGGGCTAATGACCTGGGAGCTAGACCGGCTGCTCTGGGCTCGGTCAGTGGAGAACCTGGCCACAGCCACCACCACCCTTACCTCCCT GGCGCAGCTTCTGGGCAAGATCAGCAACATTGTCATTAAGGACGACGTGGCATCTGAGCTGATCTGGTCGGGACCGGATACATTATTAAC CCCAGTGCAGTAGGGTCCCCAGGGGCAACCTGCCCCACAGCGCCCAAGATGCCTAGCAGAACTGCCCGCTATGCCCGCTACAGCCCACGG CAGCGGCGGCGGCGGATGCTGGCTGATCGCAGCGTGCGTTTCCCTAATGATGTCCTGTTCTTGGACCACATCCGGCAGGGTGACCTGGAG CAGGTGGGGCGCTTCATCCGGACTCGGAAAGTCTCCCTGGCCACCATCCACCCCTCAGGCCTGGCCGCCTTGCATGAAGCCGTGCTCTCT GGAAACCTGGAATGCGTGAAGCTGCTGGTCAAATACGGGGCTGACATTCACCAGCGAGATGAGGCGGGCTGGACACCCCTGCACATTGCC TGCAGCGATGGGTACCCTGACATAGCCAGCTGGGGCCACAACTTTGGTGAAGAAGGATATATTCGGATGGCAAGAAATAAAGGAAATCAT TGTGGGATTGCTAGCTTTCCCTCTTACCCAGAAATCTAGAGGATCTCTCCTTTTTATAACAAATCAAGAAATATGAAGCACTTTCTCTTA ACTTAATTTTTCCTGCTGTATCCAGAAGAAATAATTGTGTCATGATTAATGTGTATTTACTGTACTAATTAGAAAATATAGTTTGAGGCC GGGCACGGTGGCTCACGCCTGTAATCCCAGTACTTGGGAGGCCAAGGCAGGCATATCAACTTGAGGCCAGGAGTTAAAGAGCAGCCTGGC TAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCGAGCACGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCT GAGGCACGAGATTCCTTGAACCCAAGAGGTTGAGGCTATGTTGAGCTGAGATCACACCACTGTACTCCAGCCTGGATGACAGAGTGGAGA CTCTGTTTCAAAAAAACAGAAAAGAAAATATAGTTTGATTCTTCATTTTTTTAAATTTGCAAATCTCAGGATAAAGTTTGCTAAGTAAAT TAGTAATGTACTATAGATATAACTGTACAAAAATTGTTCAACCTAAAACAATCTGTAATTGCTTATTGTTTTATTGTATACTCTTTGTCT TTTTAAGACCCCTAATAGCCTTTTGTAACTTGATGGCTTAAAAATACTTAATAAATCTGCCATTTCAAATTTCTATCATTGCCACATACC ATTCTTATTCCTAGGCAACTATTAATAATCTATCCTGAGAATATTAATTGTGGTATTCTGGTGATGGGGTTTAGCAACTTTGATGGAAGA AAATATTAGGCTATAAATGTCCTAAGGACTCAGATTGTATCTTTGTACAGAAGAGGATTCAAAACGCCACGTGTAGTGGCTCATGCCTGT AATCCCAACACTTTGGGAGGCTGAAGTAGGAGGATCGTCTTGAGCCCAGGAGTTCAAGACCAGCCTGGACAACATAGTGAGACCTTGTCT CCACAAAAATAAAAAAGAAACTATCCAGGAGTGGTGGTGTGTGCCTGTGGTCCCTGCTATGCAGATGTCTAAGACAGGAGGATCACAAGA GCCCAGGAGGTTGAGAATGCAGTGAGCTTGTAATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTTAAAAAAAGAG GATTCAACACATATTTTTATATTATGTTAAAGTAAAGAAATGCATAAAAGACAAGCACTTTGGAAGAATTATTTTAATGATCAACAATTT AATGTATTAGTCCAAATTATTTTTACGTAGTCATCAACAATTTGACCAGGGCCTTTATTTGGCAAATAACTGAGCCAACCAGAATAAAAT AACCAATACTCCACTGCTCATATTTTTATCTAATTCAGATGGATCTTCCTTACAACTGCTCTAGATTAGTAGATGCATCTAAGCAGGCAG CAGGAACTTTAAATTTTTTAAGTTCATGTCTATGACATGAACAATGTGTGGGATAATGTCATTAATATATCCTAAATTAACCTAAACGTA TTTCACTAACTCTGGCTCCTTCTCCATAAAGCACATTTTAAGGAACAAGAATTGCTAAATATAAAAACATAAATAATACCATAATACATG GCTATCATCAAAAGTGTATAGAATATTATAGTTTAAAAGTATTTAGTTGATTACTTTTCAGTTTTGTTTTGTTTTTTGAGACGGAGTCTC ACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCTCAGTTCACTGCAACTTCTGCCTCCCGAGTTCAAGCGATTCTCCTGCCTCAGCC TCCCGAGTAGCTGGAATTATAGGCGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAAAGACAGGGTTTTGCCACATTAGCCAG GCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCCCAGCCTCCCAAAGTGCTAAGATTACAGGCGTGAGCCACTGAGCCCAGCCT ACTTTTCAGTTTTTAACATAATTTTTGTTTTATCCACAACTTTTCAAGTATTGAAAGTAGAATAAAAACATGGGTTCTTAGTCTTTAGCT ATCTGTTAAAGCCTATGAATGCCTTCTTAAAATCATGTTTTTAAATGCATAAAATATATAGGATTACAAAGGAATCTAATTATATCGAAA TACAGTTATTAAAATGTTAAAAGATAAGTTTGTTATATATTAATATGCATGCTTCTTTATAAATGCATTAAATAAGAGTTAATAGCTATC CTAAATTTGAAATAGTGATAAGCATAATGAAAATAGATGCAAAAAACTAATGTGATATGAAAATATCTGGGTTTTTCTTTTGATGATGAA GTATTGCTAATATTACCGTGGTTTATGAACTATGTTCAGAATTGAAGAAAATCCTAACTTTCAGTTAGAGGTTAGTGACGGGGTTCAGGA CACCCTACACAAAATACAGCACTTTGACATATTGAATATTTTAAGCTGAAGGCATTTGAGGAAATTGCAGAAGCAGGAAGGTGACTCTGA CCTTCTGCCTGCTGTTCTCCCCAGAAGCAGCCATAAAACCTGGGAAGGATTTTCTGACCTTCCCCTGAAGTAGATCATAAGACTGTCATG TAAGAGGTGCTCTCCTGGCACCCAGAGAAAAGGAGCATCCTTACCTCCAAAAGCACAGGGACACAAAGAGGAATCTAAACAAACAGGCCT CTCAGTTTCCCCCAGTTTATTACATTTAGCTTGTTCACACTTTGCCCTATGACATTTCTACATCACTGGCTGCTCTTCATCAAACCTACT ATAAAAAACATTCAAGTTCAACTGTTTCTTTGGGCCTTTATTTCCTTATGGAGCCCCTCGTGTCGTGTAAAACTTATATTAAATAAATGT |
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FusionGenePPI for PIGS_PPP1R27 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIGS | GPAA1, FBXO6, PIGU, PIGK, PIGT, ATP6V1B1, LMAN1, HSPA1L, SDHB, MMS19, KRT40, KRTAP10-8, KRTAP10-3, NOTCH2NL, KIRREL2, LYPD3, PRSS50, ENPP6, EGFR, TCTN2, TCTN3, FANCD2, PPM1A, SF3A2, DNAJA2, DNAJC8, SF3B1, TMEM131, MICALL2, YIPF5, USMG5, MYH6, CNTROB, VNN2, GPR89B, SOAT1, NDUFS1, ACAP2, NDUFA9 | PPP1R27 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIGS_PPP1R27 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIGS_PPP1R27 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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