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Fusion gene ID: 27137 |
FusionGeneSummary for PIGL_TBC1D26 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIGL_TBC1D26 | Fusion gene ID: 27137 | Hgene | Tgene | Gene symbol | PIGL | TBC1D26 | Gene ID | 9487 | 353149 |
| Gene name | phosphatidylinositol glycan anchor biosynthesis class L | TBC1 domain family member 26 | |
| Synonyms | CHIME | - | |
| Cytomap | 17p11.2 | 17p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseN-acetylglucosaminylphosphatidylinositol deacetylasePIG-Lphosphatidylinositol glycan, class Lphosphatidylinositol-glycan biosynthesis class L protein | TBC1 domain family member 26 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9Y2B2 | Q86UD7 | |
| Ensembl transtripts involved in fusion gene | ENST00000581006, ENST00000498772, ENST00000225609, ENST00000395844, ENST00000463810, | ENST00000437605, ENST00000579428, ENST00000583620, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PIGL [Title/Abstract] AND TBC1D26 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A14P-01A | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000581006 | ENST00000437605 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000581006 | ENST00000579428 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| 5CDS-intron | ENST00000581006 | ENST00000583620 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000498772 | ENST00000437605 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000498772 | ENST00000579428 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| 5CDS-intron | ENST00000498772 | ENST00000583620 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000225609 | ENST00000437605 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000225609 | ENST00000579428 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| 5CDS-intron | ENST00000225609 | ENST00000583620 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000395844 | ENST00000437605 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| In-frame | ENST00000395844 | ENST00000579428 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| 5CDS-intron | ENST00000395844 | ENST00000583620 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| intron-3CDS | ENST00000463810 | ENST00000437605 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| intron-3CDS | ENST00000463810 | ENST00000579428 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
| intron-intron | ENST00000463810 | ENST00000583620 | PIGL | chr17 | 16137384 | + | TBC1D26 | chr17 | 15643414 | + |
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FusionProtFeatures for PIGL_TBC1D26 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIGL | TBC1D26 |
| Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. | May act as a GTPase-activating protein for Rab familyprotein(s). {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PIGL | chr17:16137384 | chr17:15643414 | ENST00000225609 | + | 2 | 7 | 2_22 | 111 | 253 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PIGL | chr17:16137384 | chr17:15643414 | ENST00000225609 | + | 2 | 7 | 23_252 | 111 | 253 | Topological domain | Cytoplasmic |
| Tgene | TBC1D26 | chr17:16137384 | chr17:15643414 | ENST00000437605 | + | 7 | 15 | 101_250 | 165 | 400 | Domain | Rab-GAP TBC |
| Tgene | TBC1D26 | chr17:16137384 | chr17:15643414 | ENST00000579428 | + | 7 | 9 | 101_250 | 165 | 211 | Domain | Rab-GAP TBC |
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FusionGeneSequence for PIGL_TBC1D26 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIGL_ENST00000581006_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_197aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK ELLQSCDVLGIPLSSVMIIDNRQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEEDAFWALTQLLAGERHSLWYSTAQILPGSRG >In-frame_PIGL_ENST00000581006_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_157aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK >In-frame_PIGL_ENST00000498772_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_197aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK ELLQSCDVLGIPLSSVMIIDNRQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEEDAFWALTQLLAGERHSLWYSTAQILPGSRG >In-frame_PIGL_ENST00000498772_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_157aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK >In-frame_PIGL_ENST00000225609_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_197aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK ELLQSCDVLGIPLSSVMIIDNRQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEEDAFWALTQLLAGERHSLWYSTAQILPGSRG >In-frame_PIGL_ENST00000225609_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_157aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK >In-frame_PIGL_ENST00000395844_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_197aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK ELLQSCDVLGIPLSSVMIIDNRQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEEDAFWALTQLLAGERHSLWYSTAQILPGSRG >In-frame_PIGL_ENST00000395844_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_157aa MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIGL_ENST00000581006_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_591nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCCTGTGTCTGCCAGAGGAA GATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATACTGCCTGGCTCGAGAGGC >In-frame_PIGL_ENST00000581006_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_471nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCACAGGCATGGGTGTCTCTT >In-frame_PIGL_ENST00000498772_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_591nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCCTGTGTCTGCCAGAGGAA GATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATACTGCCTGGCTCGAGAGGC >In-frame_PIGL_ENST00000498772_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_471nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCACAGGCATGGGTGTCTCTT >In-frame_PIGL_ENST00000225609_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_591nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCCTGTGTCTGCCAGAGGAA GATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATACTGCCTGGCTCGAGAGGC >In-frame_PIGL_ENST00000225609_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_471nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCACAGGCATGGGTGTCTCTT >In-frame_PIGL_ENST00000395844_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_591nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCCTGTGTCTGCCAGAGGAA GATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATACTGCCTGGCTCGAGAGGC >In-frame_PIGL_ENST00000395844_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_471nt ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCTCAGAACGAATGAAGAGT CGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAGGAGAGACTCGTAAGAAA GAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGGAATTATGTGACATCCTC GTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCACAGGCATGGGTGTCTCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIGL_ENST00000581006_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_1472nt CAGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCC TCAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCC ATGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAA GGAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAG GAATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTC CTGTGTCTGCCAGAGGAAGATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATA CTGCCTGGCTCGAGAGGCTCCTATCGCACCAGGAGCAGGTGCTGCACAAGTCCTTCCCAAAGATCATGAGACACCTGGGCAAGGAAGGGC TGTGCATTGAGGGTTCCATGCTGACGAGGCTCCTCCGGTGTTTCCTTGATGGGAAATCCTTCGGGCTCACCCTGAGACTGTGGGATGTGT TCATCTTGGAGGGCGCGCGGGTACTGACAGCCATGGTGCATGCATCATTCAAAATACACAGGAAGCACCTCATGAAGCTTTCCTGGAGCA CTGTCTGGGAGTTTCAGGAGCGACTCTCTCAGAGCTGGGCCCTGGAGGACAACGCGGTCCTCAGGAACCTTCAAACCTCTATGAAGGAAC TCACAAAAAAACACTGGGACCTGCCACCCCCAGGGAGCTTGCTACAAAATGCACATTGCTATACCATAGCCTGGGGCTTGCAATCCAAGG CTGGCAAGGATTCCTGCACGTCAAGGGCCTCAGGTGACTTTCATGCACACCCAAGTCAGAAGGCTCTCCTGAATCCTGGATGTCACCTTC CTGCCCAAAAAAGGAGGAACGAGGGTCAACCAGCAGCAGACCAGTCACAAAAAGAGATGAAATGTGAGTGCATGGCCTTCCTGACACCCA GACAAAACTTTGGGCACAAAGCCAGGCTGCAGCTCTGGCCACTGACTTGGACCAGGGATGCCCCCATGCAGGCCGGTGTGCCCTGGCTGC TCTTGACACCCTCTGGCTCCTGACACCCTCTCTTCGGCTGCCTGCGTTAGGAAGGGAGAACCTGCCAGTTTTCAGAAGAAAATGTAGCTT TATTATAACATAGGAAAGACTGCAAGTTATTACGGGAGGAGGAGGAGGCCTGAAACAGCTCCTGAAAATGAGAGGGAAAAGGAAGGTGTA >In-frame_PIGL_ENST00000581006_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_1195nt CAGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCC TCAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCC ATGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAA GGAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAG GAATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCA CAGGCATGGGTGTCTCTTGGGGGTGTTGCAACTTCTTGAAAATTCAGTGTTTGTCCACCAGGACGTAGTAGGCAGGACTTCAGCTCGCTG CTGGCAGAAAAGGGCTGAAGCCCAGACTCCTGGTGTCACATGGACCCAATCACCACGTCTCAGATGAAGAAACGACCTTCCCCTCCTGGT GTTGCCCCAAAGCCTAGGAGCTTGGCAGGGTCCCACACAGGATGGTCCTTGTAGGAGACAGGTTTGACAAGTTGCTGAGGTGCCTGATGG GCCAGGCACTTGTCATGAAATGAGTTTGCATCCTGGGGGAGCCTCTTCTTCACTGGAAACCTGGCAAGGATCCAATTTCCCCTTTGCCTG AACCCCATAGGAGCATAGCAGATAGGGAGGGGGGTCACCCAGGTGGCTGTTCCTGCTTGGCCCCCACTTTCCAGACCATTCCAGGCAGGG AGAGCTGCTGAGCTGACTGCATGAGCTGCCCACATGGAGGACCCAGCCACCCCTTATGTCCGGCAGGCAGCCCTTGGGCTGTTGCAGGAC CTTTTGTGTGGTGGTCAGCGCCCCGCTGCCTGCCCTCGTGGCAGGTGCAGTTCACAGGTGCTGCCCCAGGCCTGGCACAGTGGCCTCCCC AGCCTGGCCCAGGGGAGGGAGCATGAACAATCCCTGACTGTGCCCTTTCGGGCCATGTGAGCTTGGACACTTGCTGCAGGAGTCCCCCCA >In-frame_PIGL_ENST00000498772_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_1471nt AGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCT CAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCA TGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAG GAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGG AATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCC TGTGTCTGCCAGAGGAAGATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATAC TGCCTGGCTCGAGAGGCTCCTATCGCACCAGGAGCAGGTGCTGCACAAGTCCTTCCCAAAGATCATGAGACACCTGGGCAAGGAAGGGCT GTGCATTGAGGGTTCCATGCTGACGAGGCTCCTCCGGTGTTTCCTTGATGGGAAATCCTTCGGGCTCACCCTGAGACTGTGGGATGTGTT CATCTTGGAGGGCGCGCGGGTACTGACAGCCATGGTGCATGCATCATTCAAAATACACAGGAAGCACCTCATGAAGCTTTCCTGGAGCAC TGTCTGGGAGTTTCAGGAGCGACTCTCTCAGAGCTGGGCCCTGGAGGACAACGCGGTCCTCAGGAACCTTCAAACCTCTATGAAGGAACT CACAAAAAAACACTGGGACCTGCCACCCCCAGGGAGCTTGCTACAAAATGCACATTGCTATACCATAGCCTGGGGCTTGCAATCCAAGGC TGGCAAGGATTCCTGCACGTCAAGGGCCTCAGGTGACTTTCATGCACACCCAAGTCAGAAGGCTCTCCTGAATCCTGGATGTCACCTTCC TGCCCAAAAAAGGAGGAACGAGGGTCAACCAGCAGCAGACCAGTCACAAAAAGAGATGAAATGTGAGTGCATGGCCTTCCTGACACCCAG ACAAAACTTTGGGCACAAAGCCAGGCTGCAGCTCTGGCCACTGACTTGGACCAGGGATGCCCCCATGCAGGCCGGTGTGCCCTGGCTGCT CTTGACACCCTCTGGCTCCTGACACCCTCTCTTCGGCTGCCTGCGTTAGGAAGGGAGAACCTGCCAGTTTTCAGAAGAAAATGTAGCTTT ATTATAACATAGGAAAGACTGCAAGTTATTACGGGAGGAGGAGGAGGCCTGAAACAGCTCCTGAAAATGAGAGGGAAAAGGAAGGTGTAA >In-frame_PIGL_ENST00000498772_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_1194nt AGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCT CAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCA TGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAG GAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGG AATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCAC AGGCATGGGTGTCTCTTGGGGGTGTTGCAACTTCTTGAAAATTCAGTGTTTGTCCACCAGGACGTAGTAGGCAGGACTTCAGCTCGCTGC TGGCAGAAAAGGGCTGAAGCCCAGACTCCTGGTGTCACATGGACCCAATCACCACGTCTCAGATGAAGAAACGACCTTCCCCTCCTGGTG TTGCCCCAAAGCCTAGGAGCTTGGCAGGGTCCCACACAGGATGGTCCTTGTAGGAGACAGGTTTGACAAGTTGCTGAGGTGCCTGATGGG CCAGGCACTTGTCATGAAATGAGTTTGCATCCTGGGGGAGCCTCTTCTTCACTGGAAACCTGGCAAGGATCCAATTTCCCCTTTGCCTGA ACCCCATAGGAGCATAGCAGATAGGGAGGGGGGTCACCCAGGTGGCTGTTCCTGCTTGGCCCCCACTTTCCAGACCATTCCAGGCAGGGA GAGCTGCTGAGCTGACTGCATGAGCTGCCCACATGGAGGACCCAGCCACCCCTTATGTCCGGCAGGCAGCCCTTGGGCTGTTGCAGGACC TTTTGTGTGGTGGTCAGCGCCCCGCTGCCTGCCCTCGTGGCAGGTGCAGTTCACAGGTGCTGCCCCAGGCCTGGCACAGTGGCCTCCCCA GCCTGGCCCAGGGGAGGGAGCATGAACAATCCCTGACTGTGCCCTTTCGGGCCATGTGAGCTTGGACACTTGCTGCAGGAGTCCCCCCAT >In-frame_PIGL_ENST00000225609_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_1471nt AGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCT CAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCA TGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAG GAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGG AATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCC TGTGTCTGCCAGAGGAAGATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATAC TGCCTGGCTCGAGAGGCTCCTATCGCACCAGGAGCAGGTGCTGCACAAGTCCTTCCCAAAGATCATGAGACACCTGGGCAAGGAAGGGCT GTGCATTGAGGGTTCCATGCTGACGAGGCTCCTCCGGTGTTTCCTTGATGGGAAATCCTTCGGGCTCACCCTGAGACTGTGGGATGTGTT CATCTTGGAGGGCGCGCGGGTACTGACAGCCATGGTGCATGCATCATTCAAAATACACAGGAAGCACCTCATGAAGCTTTCCTGGAGCAC TGTCTGGGAGTTTCAGGAGCGACTCTCTCAGAGCTGGGCCCTGGAGGACAACGCGGTCCTCAGGAACCTTCAAACCTCTATGAAGGAACT CACAAAAAAACACTGGGACCTGCCACCCCCAGGGAGCTTGCTACAAAATGCACATTGCTATACCATAGCCTGGGGCTTGCAATCCAAGGC TGGCAAGGATTCCTGCACGTCAAGGGCCTCAGGTGACTTTCATGCACACCCAAGTCAGAAGGCTCTCCTGAATCCTGGATGTCACCTTCC TGCCCAAAAAAGGAGGAACGAGGGTCAACCAGCAGCAGACCAGTCACAAAAAGAGATGAAATGTGAGTGCATGGCCTTCCTGACACCCAG ACAAAACTTTGGGCACAAAGCCAGGCTGCAGCTCTGGCCACTGACTTGGACCAGGGATGCCCCCATGCAGGCCGGTGTGCCCTGGCTGCT CTTGACACCCTCTGGCTCCTGACACCCTCTCTTCGGCTGCCTGCGTTAGGAAGGGAGAACCTGCCAGTTTTCAGAAGAAAATGTAGCTTT ATTATAACATAGGAAAGACTGCAAGTTATTACGGGAGGAGGAGGAGGCCTGAAACAGCTCCTGAAAATGAGAGGGAAAAGGAAGGTGTAA >In-frame_PIGL_ENST00000225609_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_1194nt AGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCT CAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCA TGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAG GAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGG AATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCAC AGGCATGGGTGTCTCTTGGGGGTGTTGCAACTTCTTGAAAATTCAGTGTTTGTCCACCAGGACGTAGTAGGCAGGACTTCAGCTCGCTGC TGGCAGAAAAGGGCTGAAGCCCAGACTCCTGGTGTCACATGGACCCAATCACCACGTCTCAGATGAAGAAACGACCTTCCCCTCCTGGTG TTGCCCCAAAGCCTAGGAGCTTGGCAGGGTCCCACACAGGATGGTCCTTGTAGGAGACAGGTTTGACAAGTTGCTGAGGTGCCTGATGGG CCAGGCACTTGTCATGAAATGAGTTTGCATCCTGGGGGAGCCTCTTCTTCACTGGAAACCTGGCAAGGATCCAATTTCCCCTTTGCCTGA ACCCCATAGGAGCATAGCAGATAGGGAGGGGGGTCACCCAGGTGGCTGTTCCTGCTTGGCCCCCACTTTCCAGACCATTCCAGGCAGGGA GAGCTGCTGAGCTGACTGCATGAGCTGCCCACATGGAGGACCCAGCCACCCCTTATGTCCGGCAGGCAGCCCTTGGGCTGTTGCAGGACC TTTTGTGTGGTGGTCAGCGCCCCGCTGCCTGCCCTCGTGGCAGGTGCAGTTCACAGGTGCTGCCCCAGGCCTGGCACAGTGGCCTCCCCA GCCTGGCCCAGGGGAGGGAGCATGAACAATCCCTGACTGTGCCCTTTCGGGCCATGTGAGCTTGGACACTTGCTGCAGGAGTCCCCCCAT >In-frame_PIGL_ENST00000395844_chr17_16137384_+_TBC1D26_ENST00000437605_chr17_15643414_+_1471nt AGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCT CAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCA TGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAG GAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGG AATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGAGGTGGGCTACCACAGGGACCTGAGCCGCATCACTGCCATCCTCCTCC TGTGTCTGCCAGAGGAAGATGCTTTCTGGGCGCTTACCCAGTTGCTCGCTGGTGAGAGGCACTCCCTGTGGTATTCTACAGCCCAAATAC TGCCTGGCTCGAGAGGCTCCTATCGCACCAGGAGCAGGTGCTGCACAAGTCCTTCCCAAAGATCATGAGACACCTGGGCAAGGAAGGGCT GTGCATTGAGGGTTCCATGCTGACGAGGCTCCTCCGGTGTTTCCTTGATGGGAAATCCTTCGGGCTCACCCTGAGACTGTGGGATGTGTT CATCTTGGAGGGCGCGCGGGTACTGACAGCCATGGTGCATGCATCATTCAAAATACACAGGAAGCACCTCATGAAGCTTTCCTGGAGCAC TGTCTGGGAGTTTCAGGAGCGACTCTCTCAGAGCTGGGCCCTGGAGGACAACGCGGTCCTCAGGAACCTTCAAACCTCTATGAAGGAACT CACAAAAAAACACTGGGACCTGCCACCCCCAGGGAGCTTGCTACAAAATGCACATTGCTATACCATAGCCTGGGGCTTGCAATCCAAGGC TGGCAAGGATTCCTGCACGTCAAGGGCCTCAGGTGACTTTCATGCACACCCAAGTCAGAAGGCTCTCCTGAATCCTGGATGTCACCTTCC TGCCCAAAAAAGGAGGAACGAGGGTCAACCAGCAGCAGACCAGTCACAAAAAGAGATGAAATGTGAGTGCATGGCCTTCCTGACACCCAG ACAAAACTTTGGGCACAAAGCCAGGCTGCAGCTCTGGCCACTGACTTGGACCAGGGATGCCCCCATGCAGGCCGGTGTGCCCTGGCTGCT CTTGACACCCTCTGGCTCCTGACACCCTCTCTTCGGCTGCCTGCGTTAGGAAGGGAGAACCTGCCAGTTTTCAGAAGAAAATGTAGCTTT ATTATAACATAGGAAAGACTGCAAGTTATTACGGGAGGAGGAGGAGGCCTGAAACAGCTCCTGAAAATGAGAGGGAAAAGGAAGGTGTAA >In-frame_PIGL_ENST00000395844_chr17_16137384_+_TBC1D26_ENST00000579428_chr17_15643414_+_1194nt AGTGCTGCTTACCCATCATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGGGTTTGGGACTCCT CAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAAAGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCA TGTTTTTTGCTCCCACAGTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAATTACTACAATCAAG GAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGGATTCCACTCTCCAGTGTAATGATTATTGACAACAGGCAGCAGG AATTATGTGACATCCTCGTGGCCTATTCTGCATATAACCCTGTGAGTATTCCCGGGCAGCGATATTCCTGGGACATGTGCCCATATTCAC AGGCATGGGTGTCTCTTGGGGGTGTTGCAACTTCTTGAAAATTCAGTGTTTGTCCACCAGGACGTAGTAGGCAGGACTTCAGCTCGCTGC TGGCAGAAAAGGGCTGAAGCCCAGACTCCTGGTGTCACATGGACCCAATCACCACGTCTCAGATGAAGAAACGACCTTCCCCTCCTGGTG TTGCCCCAAAGCCTAGGAGCTTGGCAGGGTCCCACACAGGATGGTCCTTGTAGGAGACAGGTTTGACAAGTTGCTGAGGTGCCTGATGGG CCAGGCACTTGTCATGAAATGAGTTTGCATCCTGGGGGAGCCTCTTCTTCACTGGAAACCTGGCAAGGATCCAATTTCCCCTTTGCCTGA ACCCCATAGGAGCATAGCAGATAGGGAGGGGGGTCACCCAGGTGGCTGTTCCTGCTTGGCCCCCACTTTCCAGACCATTCCAGGCAGGGA GAGCTGCTGAGCTGACTGCATGAGCTGCCCACATGGAGGACCCAGCCACCCCTTATGTCCGGCAGGCAGCCCTTGGGCTGTTGCAGGACC TTTTGTGTGGTGGTCAGCGCCCCGCTGCCTGCCCTCGTGGCAGGTGCAGTTCACAGGTGCTGCCCCAGGCCTGGCACAGTGGCCTCCCCA GCCTGGCCCAGGGGAGGGAGCATGAACAATCCCTGACTGTGCCCTTTCGGGCCATGTGAGCTTGGACACTTGCTGCAGGAGTCCCCCCAT 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FusionGenePPI for PIGL_TBC1D26 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIGL | MEIS2 | TBC1D26 | APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIGL_TBC1D26 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIGL_TBC1D26 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PIGL | C1848392 | Zunich neuroectodermal syndrome | 1 | ORPHANET;UNIPROT |
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