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Fusion gene ID: 27131 |
FusionGeneSummary for PIGG_SPINK2 |
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Fusion gene information | Fusion gene name: PIGG_SPINK2 | Fusion gene ID: 27131 | Hgene | Tgene | Gene symbol | PIGG | SPINK2 | Gene ID | 54872 | 6691 |
Gene name | phosphatidylinositol glycan anchor biosynthesis class G | serine peptidase inhibitor, Kazal type 2 | |
Synonyms | GPI7|LAS21|MRT53|PRO4405|RLGS1930 | HUSI-II | |
Cytomap | 4p16.3 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | GPI ethanolamine phosphate transferase 2phosphatidylinositol-glycan biosynthesis class G protein | serine protease inhibitor Kazal-type 2epididymis tissue protein Li 172serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5H8A4 | P20155 | |
Ensembl transtripts involved in fusion gene | ENST00000296306, ENST00000310340, ENST00000453061, ENST00000504346, ENST00000383028, ENST00000536264, ENST00000502311, ENST00000503111, ENST00000509768, | ENST00000248701, ENST00000506738, ENST00000504762, | |
Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 5 X 3 X 5=75 |
# samples | 3 | 5 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PIGG [Title/Abstract] AND SPINK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PIGG | GO:0006506 | GPI anchor biosynthetic process | 15632136 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | GBM | TCGA-27-1830-01A | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000296306 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000296306 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000296306 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000310340 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000310340 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000310340 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000453061 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000453061 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000453061 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000504346 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000504346 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000504346 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000383028 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000383028 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000383028 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000536264 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000536264 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000536264 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
intron-3CDS | ENST00000502311 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
intron-3CDS | ENST00000502311 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
intron-3CDS | ENST00000502311 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000503111 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000503111 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000503111 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000509768 | ENST00000248701 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000509768 | ENST00000506738 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
Frame-shift | ENST00000509768 | ENST00000504762 | PIGG | chr4 | 502759 | + | SPINK2 | chr4 | 57676350 | - |
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FusionProtFeatures for PIGG_SPINK2 |
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Hgene | Tgene |
PIGG | SPINK2 |
Strong inhibitor of acrosin in male and/or femalegenital tract. Also inhibits trypsin.{ECO:0000269|PubMed:19422058}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIGG_SPINK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PIGG_SPINK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PIGG | APP, GLP1R, LGR4, CD97, NCR3LG1, HTR3A, ATP6V0E1 | SPINK2 | KRTAP5-9, ADAMTSL4, KRTAP10-3, NOTCH2NL, MAPK8IP2, GCHFR, ATP5S, NUDT8, MIPEP, DCAF15, CTTNBP2NL, PRTFDC1, UBR2, PDP2, IDE, PMPCB, RSPRY1, PMPCA, MOB4, STRIP1, IKBIP, STRN, UBR1, STRN3, STRN4, ATP6V1D |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIGG_SPINK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIGG_SPINK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |