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Fusion gene ID: 27077 |
FusionGeneSummary for PIAS1_ZNF609 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIAS1_ZNF609 | Fusion gene ID: 27077 | Hgene | Tgene | Gene symbol | PIAS1 | ZNF609 | Gene ID | 8554 | 23060 |
| Gene name | protein inhibitor of activated STAT 1 | zinc finger protein 609 | |
| Synonyms | DDXBP1|GBP|GU/RH-II|ZMIZ3 | - | |
| Cytomap | 15q23 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT pr | zinc finger protein 609 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O75925 | O15014 | |
| Ensembl transtripts involved in fusion gene | ENST00000249636, ENST00000545237, ENST00000567417, | ENST00000326648, ENST00000416172, ENST00000559364, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 7 X 9 X 3=189 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/189*10)=-0.918386234446348 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PIAS1 [Title/Abstract] AND ZNF609 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIAS1 | GO:0016925 | protein sumoylation | 18579533 |
| Hgene | PIAS1 | GO:0033235 | positive regulation of protein sumoylation | 17696781|21965678 |
| Tgene | ZNF609 | GO:2000291 | regulation of myoblast proliferation | 28344082 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J9-A8CL-01A | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000249636 | ENST00000326648 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| 5CDS-intron | ENST00000249636 | ENST00000416172 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| 5CDS-intron | ENST00000249636 | ENST00000559364 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| intron-3CDS | ENST00000545237 | ENST00000326648 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| intron-intron | ENST00000545237 | ENST00000416172 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| intron-intron | ENST00000545237 | ENST00000559364 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| intron-3CDS | ENST00000567417 | ENST00000326648 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| intron-intron | ENST00000567417 | ENST00000416172 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
| intron-intron | ENST00000567417 | ENST00000559364 | PIAS1 | chr15 | 68346688 | + | ZNF609 | chr15 | 64970315 | + |
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FusionProtFeatures for PIAS1_ZNF609 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIAS1 | ZNF609 |
| Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway, the p53 pathway and the steroidhormone signaling pathway. In vitro, binds A/T-rich DNA. Theeffects of this transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.Together with PRMT1, may repress STAT1 transcriptional activity,in the late phase of interferon gamma (IFN-gamma) signaling.Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotestheir ubiquitin-mediated degradation. PIAS1-mediated sumoylationof PML promotes its interaction with CSNK2A1/CK2 which in turnpromotes PML phosphorylation and degradation (By similarity).Enhances the sumoylation of MTA1 and may participate in itsparalog-selective sumoylation. Plays a dynamic role inadipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity). {ECO:0000250|UniProtKB:O88907,ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:19136629,ECO:0000269|PubMed:21965678}. | Transcription factor, which activates RAG1, and possiblyRAG2, transcription. Through the regulation of RAG1/2 expression,may regulate thymocyte maturation. Along with NIPBL and themultiprotein complex Integrator, promotes cortical neuronmigration during brain development by regulating the transcriptionof crucial genes in this process. Preferentially binds promoterscontaining paused RNA polymerase II. Up-regulates the expressionof SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.{ECO:0000250|UniProtKB:Q8BZ47}. Isoform 2: Involved in the regulation of myoblastproliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ZNF609 | chr15:68346688 | chr15:64970315 | ENST00000326648 | + | 3 | 9 | 1333_1336 | 1134 | 2578 | Compositional bias | Note=Poly-Gly |
| Tgene | >ZNF609 | chr15:68346688 | chr15:64970315 | ENST00000326648 | + | 3 | 9 | 1366_1371 | 1134 | 2578 | Compositional bias | Note=Poly-His |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 577_634 | 8 | 652 | Compositional bias | Note=Ser-rich |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 11_45 | 8 | 652 | Domain | SAP |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 124_288 | 8 | 652 | Domain | PINIT |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 19_23 | 8 | 652 | Motif | Note=LXXLL motif |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 368_380 | 8 | 652 | Motif | Nuclear localization signal |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 56_64 | 8 | 652 | Motif | Nuclear localization signal |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 462_473 | 8 | 652 | Region | SUMO1-binding |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 520_615 | 8 | 652 | Region | Note=4 X 4 AA repeats of N-T-S-L |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 520_523 | 8 | 652 | Repeat | Note=1 |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 557_560 | 8 | 652 | Repeat | Note=2 |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 598_601 | 8 | 652 | Repeat | Note=3%3B approximate |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 612_615 | 8 | 652 | Repeat | Note=4%3B approximate |
| Hgene | >PIAS1 | chr15:68346688 | chr15:64970315 | ENST00000249636 | + | 1 | 14 | 320_397 | 8 | 652 | Zinc finger | SP-RING-type |
| Tgene | ZNF609 | chr15:68346688 | chr15:64970315 | ENST00000326648 | + | 3 | 9 | 725_735 | 1134 | 2578 | Compositional bias | Note=Poly-Lys |
| Tgene | ZNF609 | chr15:68346688 | chr15:64970315 | ENST00000326648 | + | 3 | 9 | 952_955 | 1134 | 2578 | Compositional bias | Note=Poly-Ser |
| Tgene | ZNF609 | chr15:68346688 | chr15:64970315 | ENST00000326648 | + | 3 | 9 | 495_520 | 1134 | 2578 | Zinc finger | C2H2-type |
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FusionGeneSequence for PIAS1_ZNF609 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIAS1_ENST00000249636_chr15_68346688_+_ZNF609_ENST00000326648_chr15_64970315_+_286aa MADSAELKEAEPRMWTYVYPAKYSDIKSEDERWKEERDRKLKEERSRSKDSVPKEDGKESTSSDCKLPTSEESRLGSKEPRPSVHVPVSS PLTQHQSYIPYMHGYSYSQSYDPNHPSYRSMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVTCKSSSESKALDILQQHA SHYKSKSPTISDKTSQERDRGGCGVVGGGGSCSSVGGASGGERSVDRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIAS1_ENST00000249636_chr15_68346688_+_ZNF609_ENST00000326648_chr15_64970315_+_858nt ATGGCGGACAGTGCGGAACTAAAGGAGGCAGAGCCCCGGATGTGGACATATGTTTATCCTGCCAAGTACTCAGACATCAAGTCAGAGGAT GAGCGGTGGAAGGAGGAGCGGGACCGCAAATTGAAGGAGGAAAGGAGTCGGAGTAAGGACTCTGTCCCCAAGGAAGATGGGAAGGAAAGC ACAAGTAGTGACTGCAAGCTGCCCACGTCAGAGGAGTCTCGCCTTGGGAGCAAGGAGCCCCGGCCAAGTGTCCATGTGCCTGTGTCCTCC CCACTTACCCAGCACCAGTCCTACATCCCCTACATGCACGGCTATTCCTACAGTCAGTCCTACGACCCCAACCACCCCAGCTACCGGAGC ATGCCTGCTGTGATGATGCAGAACTACCCAGGTTCCTACCTGCCTTCCAGCTACTCTTTTTCCCCATATGGCAGCAAGGTCTCAGGTGGT GAAGATGCTGACAAGGCACGAGCCAGCCCCAGTGTGACTTGTAAATCCAGCTCAGAGTCCAAAGCCCTGGACATCTTGCAGCAGCATGCC AGTCACTACAAGAGCAAGTCTCCCACGATAAGTGATAAAACTTCTCAGGAGAGAGATCGAGGAGGCTGTGGGGTGGTTGGGGGTGGTGGC AGCTGTAGCAGCGTCGGGGGAGCAAGTGGGGGTGAACGGAGTGTTGACCGGCCCCGCACCTCTCCTTCCCAGCGCCTGATGTCCACACAC CACCACCACCACCACTTGGGGTACTCATTGCTCCCAGCACAGTACAACTTACCCTATGCAGCAGGGCTTTCTTCTACAGCCATTGTTGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIAS1_ENST00000249636_chr15_68346688_+_ZNF609_ENST00000326648_chr15_64970315_+_5385nt GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGGAGGCAGA GCCCCGGATGTGGACATATGTTTATCCTGCCAAGTACTCAGACATCAAGTCAGAGGATGAGCGGTGGAAGGAGGAGCGGGACCGCAAATT GAAGGAGGAAAGGAGTCGGAGTAAGGACTCTGTCCCCAAGGAAGATGGGAAGGAAAGCACAAGTAGTGACTGCAAGCTGCCCACGTCAGA GGAGTCTCGCCTTGGGAGCAAGGAGCCCCGGCCAAGTGTCCATGTGCCTGTGTCCTCCCCACTTACCCAGCACCAGTCCTACATCCCCTA CATGCACGGCTATTCCTACAGTCAGTCCTACGACCCCAACCACCCCAGCTACCGGAGCATGCCTGCTGTGATGATGCAGAACTACCCAGG TTCCTACCTGCCTTCCAGCTACTCTTTTTCCCCATATGGCAGCAAGGTCTCAGGTGGTGAAGATGCTGACAAGGCACGAGCCAGCCCCAG TGTGACTTGTAAATCCAGCTCAGAGTCCAAAGCCCTGGACATCTTGCAGCAGCATGCCAGTCACTACAAGAGCAAGTCTCCCACGATAAG TGATAAAACTTCTCAGGAGAGAGATCGAGGAGGCTGTGGGGTGGTTGGGGGTGGTGGCAGCTGTAGCAGCGTCGGGGGAGCAAGTGGGGG TGAACGGAGTGTTGACCGGCCCCGCACCTCTCCTTCCCAGCGCCTGATGTCCACACACCACCACCACCACCACTTGGGGTACTCATTGCT CCCAGCACAGTACAACTTACCCTATGCAGCAGGGCTTTCTTCTACAGCCATTGTTGCCAGCCAACAAGGCTCAACTCCCTCACTCTACCC ACCCCCCAGGAGGTGAGAATGACACCAAGTGCCCGGATAAAGTCAGCTTCACGGGCCCGGACTGGCTTACCCAAGGAGGTGCTGAAGGTG CCGTTTAGACATCAGTTAAATGGTGTTGATCATCCTGTTTGCCGTTTCCACCATGACTGAAGGCAGACCCTTGGCTATCTCACCTCCACC AGACCTCCGGACTACCTGACCCTACCTCTTCCTCAGGAGCTGGAGAGCTGGTACTTAGCAAAAATATTTATTCTCTCAGCCACAGTTATG ACTATTGTGGCCTCTGTGGAGATGAAGGCACGGGAAGCAACCAGGGGAACATGGCCTCAGCCCAGAGAAGCCACTGCTCTGTTCCCCAAG CCCTTGGTCTGCTGCTGGAGCAGTACCAGCCCCCCCGCCCACCAGGGAGGGACCCCCACCCCCAAGCACTGGGTAAGGTCTGAAGACAGC ACAGCAGCCATACCCCTCACCATCATTACCACCATCACCAGATTCTGCATCTCCCTAGTGCTTTGCACCCTGGGAATTGGCAGCATGTGG AGGAACTAGAATCTCAGGAAAGAAATTGGGGGTTGTTTTCTACATAATTGTGAAAACAAGGTCTTCAAATGTGGAGACTTCTCCCCATTT ACATGAGCACATATAAACGCTCACAACCTAGCCTGGAAAGGAAGACCAAGGCATCTGCCCCAACATGGCCTTGAGCTGCCTGTGAGGCAG GGGGCAGGGGTTCCAACACCAGCACAGGGCTCCCCAGGGACACTGGGAGCAAGCTGGTGCTGGAGCATGAATGACGTCTGTGAAGTAGAA CCTGCGTCCCCACTAAGTCCTGCTGCTTCTTATTCCCCAACTCCTTGCCCTTTTCCCTTCCCTCCTAACCCCTTGGTGCCTTTCCCAGGG GGATCCCCACACTGGTCTTGCCTCTTCTTTTCCACTGCTTGGCTCTTAAGCCTCAGGCAGATAAACTAGTATTCCCCCCAGCTTGGGGAA CCTTGGAGTCTGCCAGGTCACCTTAGGGCAAGGCCCAGAAGGCAGCCCCTGGGAGCACCCAGCAGTTCTTGGAGATGTCCTGTCATCTAG CCATCTGATATCTTCCTCATTTGAGGCCACAGATATATACAGCCCAATTCCTCTGTCTACAAGTACATGATTTTATATAGCTCAGTCTAT AACCTCCATGTGGGCCAATATAAGCTGTGTTTCTTGGTAACACATATTTTGTTTGAGGGGCCACTGGCCATGGGAGGTTATTTGTTCCTT AGACCCTGGAATAACACATCCAAGCCATTACTTATTAGAGTCTCAGAATGTACTCAGTGGAGCTGTGCTTTGAGGCAGCCAACATTTCTC TGCTCTCCTTAGAAATGCAGTCTCCCAATGGAAGCTTTATACTCTTTGTACTGGGAAAGTGAGGATGATTTGGTAGCTTTATTGGGGTCA TGTCTTCCCCAAGGTGTGGGGAGCTTAGCTTACTTGGCTTTTGAGGTATCATCCCTCTGTTCTCCCCTCCTATCTTTCCATGACCCTCTG GATTGAGAGAGAGAGATAAAGACTGACAGACACCAGTGTAGGCTGGAAAAGGGAGTGTGTGACCAGAGTGCCAAAAGTGACTAGGAGCAG GAACTTGGCTCCGACTCAGTTTGGAAAATGGGAAATAGGGGACAGTAAGCACAATGCCCAGTAGTAGTTGATTTCCAAGGACCCTGGAAC CCTACACTTGAGAGGCTTAGGGTCACCATCTGCTCAAGAGGATCCCCTCTGATCTACAGGCCTTTTCCCTAGGTTTCTGCCTCCTCGTTT TTGTTCAAGTTGGGTTCTGAGTCCTCCCCAAAAACCATTGTTTTAGACCTCTTGGCAGGGCCCCAAAACAGCCTCCCTCATACCCATCAT TCCCTCTGCCTTCTGCTGCCCTCATGGGCAGTGCTCTGAGCAGTGACCTCCCTTTCCTCCGTGGAAGTAGCTAGTGCAGACACCGTCATC CCACCCCACCTGAGTCACCCCAACCAAGAGGGTGACTGAATTTCAGCCTGATTATGCCCTCCTGGGGCTCCTGTGAGGTGGAGCCAAGGT TCCCTCTCTGTTCCTGTTTGTTTTTAAATATTGTTGTGTGTTTTGTATCTGTGGCACTGGCCTGCAGCATACTCTGTATATATTGTAAAG AAACCGTTAGGAGTAATTTTCTTTTGCATTGGGCAGGCATGGCCCTGCATTCCTGCCCTTTCCACTCATTCTGTAACACAGAGGACGAAC TTCTGTATTAGCTGGGCAGCCTTGGGTTCTCCAGAAGAGAACAGGTTTTTCTTTTCCTTTTTAATTTTTCTTCTTAAACATTTGGCTCTT TGATCCTCATATCCAAGTCTCCCCTGAAGAGTAGGAGCTGCTCAGAAGAGCAGGTGAAAGCCACCATGGCAGATCCTGATGCCTGCCGGG CCTAGTCTTCCCTCTGAAATAACATGAAGCAGCAGCTGTGGAGATTCTTGACAAGTGCTGAGTGAAAGATTTGCTGCCCACCTCTACATG GGGAGGAGAAACACAGGTGGGAGCTACCTGTGGCATCCATGACCTAGTCAGAGGGATGAGATGCTCAGCAGGGGTCCCCATCCTATCCCA CCCCACAAACAAAGGCTGGAAAAATTTGCTACCAAGGGCCAAGACCACCAGACCAAGCCTGTTTATGAGCCACCCCTGCCCAGGCCCTCA CAGACATTGCTCACGGGGCTTCCCATAGAGGAGAAGCTAAAGAGGGAGGGGGCCTCATCCCCAGATAGATCAGGCAAGGCTTGGAGAGCT GCTCTTTAGGATCCACATCAACTACTTCCTCATTTTAAGGTATGGCAGTTCCCTTCATCCCCTTTTCCTGCCTTGTACATGTACATGTAT GAAATTTCCTTCTCTTACCGAACTCTCTCCACACATCACAAGGTCAAAGAACCACACGCTTAGAAGGGTAAGAGGGCACCCTATGAAATG AAATGGTGATTTCTTGAGTCTCTTTTTTCCACGTTTAAGGGGCCATGGCAGGACTTAGAGTTGCGAGTTAAGACTGCAGAGGGCTAGAGA ATTATTTCATACAGGCTTTGAGGCCACCCATGTCACTTATCCCGTATACCCTCTCACCATCCCCTTGTCTACTCTGATGCCCCCAAGATG CAACTGGGCAGCTAGTTGGCCCCATAATTCTGGGCCTTTGTTGTTTGTTTTAATTACTTGGGCATCCCAGGAAGCTTTCCAGTGATCTCC TACCATGGGCCCCCCTCCTGGGATCAAGCCCCTCCCAGGCCCTGTCCCCAGCCCCTCCTGCCCCAGCCCACCCGCTTGCCTTGGTGCTCA GCCCTCCCATTGGGAGCAGGTTGGGGCGAGCTGGAGGCCCGGGCTGGAGGGGCAGTGTTGCTGTTCATAGATTTTGTTCCATTGGCGTTG CTCTGTTGAATTTAATTTCAGTCTTCCTGATTCTTCCCTTCTGTAAAGTGTACATTACCAAGTTCCTTGTTTTTTTATATATATATATAA ATATATATATATACAAACTGTACTCTTTTTGCCTTTGTACATTCAGGCAAGAAGAGAAAATAAATCTTTTTAAGAGACAATCACAAATCT GTGAGGGCTGCTGGTTATTTCTCCTGGAGTTTGCTGCTGAGCTGCCTCTTCCTTCCTCCCAATTTTCCTGTTCTCCCTCAGCTCTCCTGA TCTTCCTGGCCCTGCTCCATATGCATCCTCAGCTTCACTTTCCCTGGCTGATGGCAAGCTGTTGAATCCAGTGTCCAGACTACCTGCCTT GTAACCCTTTTCTGCCCAGCATTGTTTTCTGGCTTGGCCACTGGCTTAGCCCAGGAGCTTTACTCTGTGCCCTGGCCTCCCCTCTCTTCA CCTTTAGATTTCCATTCACCGAAGTGGCTTTGGACCCCTGGGTACTCTGGGACCTGTTTCCTGGAGGCCCTGGCTTGGGACACTCACCTG TGAAACTATGCAGCTGGGAGCTCTCTGCCTAAGAGTTTGCACTATTTAAACCTGCCTGGGAGTTAGGACGGATGGTTTTAGGAATGACCG GAAAACTACCCCTAAAACTCCCCCGACATTCCAGCCTCTAGAATGCTCTGATCCAGAGCTCAGTGGATGATTCCCAGCTGGTGGACTCCT GTGGCTACCCCATCAGAACAAGGGCTAAGGGTTTATGGGTCAAGAGTATTTGATCAGAATTTTAAAGGGTGGTATACTCTGAAACACAGC CCAACCAAACCATTGTTTGGCCGCTTTCTCTTTTCCTCTACCTTCCTCATCCCCACTTTTTTCCCTTTCTCTCTACTTCCTCTTCTTAAT |
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FusionGenePPI for PIAS1_ZNF609 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIAS1 | STAT1, DNMT3A, STAB2, UBE2I, SUMO1, SP3, TP53, CSRP2, AR, MX1, SUMO2, SIAH1, SIAH2, AKT1, ZMIZ2, BRCA1, MBD1, CREB1, SREBF2, GLUL, MITF, NCOR1, PPARG, TRIM27, ZNF76, JUN, HIC1, DDX5, SATB1, MAML1, DCLRE1A, DNMT3B, RBBP6, SAFB, ESR1, PPP1CA, MDC1, PRDM1, MDM2, CHUK, DNM1, PML, ATXN7, SRSF1, NFATC1, CEBPE, CEBPA, FLI1, CSNK2A1, CASP8AP2, MYB, SERBP1, ZMYND11, RAD54L2, PLAG1, NR1H3, NR1H2, PPARGC1B, PPARGC1A, BARD1, PAXIP1, PPP1CC, HTT, ATXN1, SMAD7, PRPF40A, SKIL, SMAD4, SMAD1, SOX2, SGTA, YWHAZ, SPOP, SUMO3, SHFM1, CBS, L3MBTL2, CEP250, TRIM63, TRIM55, ZNF451, PIAS1, FOXA1, HIF1A, ID1, KLC1, FRAT1, ERP44, POLK, VPS16, PIAS2, PTK2, TERF2, TRIM5, HECTD2, GSK3B, NCOA3, PSME3, TRIM35, GTF2IRD1, NR0B2, EP300 | ZNF609 | ATXN1, SOX2, HDAC1, AUTS2, NTRK1, PRKCI, USP7, DYNLL1, ATL3, VWA9, NANOG, EYA2, FLCN, SBSPON, THSD4, PIGT, RCCD1, EXOC5, CYLD, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIAS1_ZNF609 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIAS1_ZNF609 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PIAS1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | PIAS1 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
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