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Fusion gene ID: 27075 |
FusionGeneSummary for PIAS1_MEF2A |
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Fusion gene information | Fusion gene name: PIAS1_MEF2A | Fusion gene ID: 27075 | Hgene | Tgene | Gene symbol | PIAS1 | MEF2A | Gene ID | 8554 | 4205 |
Gene name | protein inhibitor of activated STAT 1 | myocyte enhancer factor 2A | |
Synonyms | DDXBP1|GBP|GU/RH-II|ZMIZ3 | ADCAD1|RSRFC4|RSRFC9|mef2 | |
Cytomap | 15q23 | 15q26.3 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT pr | myocyte-specific enhancer factor 2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)serum response factor-like protein 1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O75925 | Q02078 | |
Ensembl transtripts involved in fusion gene | ENST00000249636, ENST00000545237, ENST00000567417, | ENST00000453228, ENST00000354410, ENST00000558856, ENST00000558812, ENST00000338042, ENST00000557785, ENST00000449277, ENST00000557942, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 5 X 4 X 4=80 |
# samples | 5 | 5 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PIAS1 [Title/Abstract] AND MEF2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PIAS1 | GO:0016925 | protein sumoylation | 18579533 |
Hgene | PIAS1 | GO:0033235 | positive regulation of protein sumoylation | 17696781|21965678 |
Tgene | MEF2A | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16484498 |
Tgene | MEF2A | GO:0000165 | MAPK cascade | 9858528 |
Tgene | MEF2A | GO:0006351 | transcription, DNA-templated | 16043483 |
Tgene | MEF2A | GO:0010613 | positive regulation of cardiac muscle hypertrophy | 24161931 |
Tgene | MEF2A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7760790|9858528|10748098|15466416|20590529|21468593 |
Tgene | MEF2A | GO:0071277 | cellular response to calcium ion | 16484498 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A1KY-01A | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000249636 | ENST00000453228 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000354410 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000558856 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000558812 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000338042 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000557785 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000449277 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
5CDS-intron | ENST00000249636 | ENST00000557942 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-3CDS | ENST00000545237 | ENST00000453228 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000354410 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000558856 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000558812 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000338042 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000557785 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000449277 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000545237 | ENST00000557942 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-3CDS | ENST00000567417 | ENST00000453228 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000354410 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000558856 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000558812 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000338042 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000557785 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000449277 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
intron-intron | ENST00000567417 | ENST00000557942 | PIAS1 | chr15 | 68346688 | + | MEF2A | chr15 | 100211528 | + |
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FusionProtFeatures for PIAS1_MEF2A |
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Hgene | Tgene |
PIAS1 | MEF2A |
Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway, the p53 pathway and the steroidhormone signaling pathway. In vitro, binds A/T-rich DNA. Theeffects of this transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.Together with PRMT1, may repress STAT1 transcriptional activity,in the late phase of interferon gamma (IFN-gamma) signaling.Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotestheir ubiquitin-mediated degradation. PIAS1-mediated sumoylationof PML promotes its interaction with CSNK2A1/CK2 which in turnpromotes PML phosphorylation and degradation (By similarity).Enhances the sumoylation of MTA1 and may participate in itsparalog-selective sumoylation. Plays a dynamic role inadipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity). {ECO:0000250|UniProtKB:O88907,ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:19136629,ECO:0000269|PubMed:21965678}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000354410 | + | 0 | 11 | 141_186 | -210 | 500 | Compositional bias | Note=Ser/Thr-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000354410 | + | 0 | 11 | 420_446 | -210 | 500 | Compositional bias | Note=Gln/Pro-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000354410 | + | 0 | 11 | 4_31 | -210 | 500 | Compositional bias | Note=Lys-rich (basic) |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000449277 | + | 1 | 9 | 141_186 | 18 | 430 | Compositional bias | Note=Ser/Thr-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000449277 | + | 1 | 9 | 420_446 | 18 | 430 | Compositional bias | Note=Gln/Pro-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000453228 | + | 2 | 10 | 141_186 | 86 | 498 | Compositional bias | Note=Ser/Thr-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000453228 | + | 2 | 10 | 420_446 | 86 | 498 | Compositional bias | Note=Gln/Pro-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557785 | + | 3 | 11 | 141_186 | 86 | 498 | Compositional bias | Note=Ser/Thr-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557785 | + | 3 | 11 | 420_446 | 86 | 498 | Compositional bias | Note=Gln/Pro-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557942 | + | 3 | 12 | 141_186 | 86 | 506 | Compositional bias | Note=Ser/Thr-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557942 | + | 3 | 12 | 420_446 | 86 | 506 | Compositional bias | Note=Gln/Pro-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000558812 | + | 1 | 10 | 141_186 | 18 | 438 | Compositional bias | Note=Ser/Thr-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000558812 | + | 1 | 10 | 420_446 | 18 | 438 | Compositional bias | Note=Gln/Pro-rich |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000354410 | + | 0 | 11 | 58_86 | -210 | 500 | DNA binding | Mef2-type |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000449277 | + | 1 | 9 | 58_86 | 18 | 430 | DNA binding | Mef2-type |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000558812 | + | 1 | 10 | 58_86 | 18 | 438 | DNA binding | Mef2-type |
Tgene | >MEF2A | chr15:68346688 | chr15:100211528 | ENST00000354410 | + | 0 | 11 | 3_57 | -210 | 500 | Domain | MADS-box |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 577_634 | 8 | 652 | Compositional bias | Note=Ser-rich |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 11_45 | 8 | 652 | Domain | SAP |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 124_288 | 8 | 652 | Domain | PINIT |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 19_23 | 8 | 652 | Motif | Note=LXXLL motif |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 368_380 | 8 | 652 | Motif | Nuclear localization signal |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 56_64 | 8 | 652 | Motif | Nuclear localization signal |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 462_473 | 8 | 652 | Region | SUMO1-binding |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 520_615 | 8 | 652 | Region | Note=4 X 4 AA repeats of N-T-S-L |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 520_523 | 8 | 652 | Repeat | Note=1 |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 557_560 | 8 | 652 | Repeat | Note=2 |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 598_601 | 8 | 652 | Repeat | Note=3%3B approximate |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 612_615 | 8 | 652 | Repeat | Note=4%3B approximate |
Hgene | >PIAS1 | chr15:68346688 | chr15:100211528 | ENST00000249636 | + | 1 | 14 | 320_397 | 8 | 652 | Zinc finger | SP-RING-type |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000449277 | + | 1 | 9 | 4_31 | 18 | 430 | Compositional bias | Note=Lys-rich (basic) |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000453228 | + | 2 | 10 | 4_31 | 86 | 498 | Compositional bias | Note=Lys-rich (basic) |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557785 | + | 3 | 11 | 4_31 | 86 | 498 | Compositional bias | Note=Lys-rich (basic) |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557942 | + | 3 | 12 | 4_31 | 86 | 506 | Compositional bias | Note=Lys-rich (basic) |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000558812 | + | 1 | 10 | 4_31 | 18 | 438 | Compositional bias | Note=Lys-rich (basic) |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000453228 | + | 2 | 10 | 58_86 | 86 | 498 | DNA binding | Mef2-type |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557785 | + | 3 | 11 | 58_86 | 86 | 498 | DNA binding | Mef2-type |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557942 | + | 3 | 12 | 58_86 | 86 | 506 | DNA binding | Mef2-type |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000449277 | + | 1 | 9 | 3_57 | 18 | 430 | Domain | MADS-box |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000453228 | + | 2 | 10 | 3_57 | 86 | 498 | Domain | MADS-box |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557785 | + | 3 | 11 | 3_57 | 86 | 498 | Domain | MADS-box |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000557942 | + | 3 | 12 | 3_57 | 86 | 506 | Domain | MADS-box |
Tgene | MEF2A | chr15:68346688 | chr15:100211528 | ENST00000558812 | + | 1 | 10 | 3_57 | 18 | 438 | Domain | MADS-box |
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FusionGeneSequence for PIAS1_MEF2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PIAS1_ENST00000249636_chr15_68346688_+_MEF2A_ENST00000453228_chr15_100211528_+_420aa MADSAELKTLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAA SSTLTDSSMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSPPPPG GGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGM LSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQ |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PIAS1_ENST00000249636_chr15_68346688_+_MEF2A_ENST00000453228_chr15_100211528_+_1260nt ATGGCGGACAGTGCGGAACTAAAGACTTTAAGAAAGAAAGGCCTTAATGGTTGTGAGAGCCCTGATGCTGACGATTACTTTGAGCACAGT CCACTCTCGGAGGACAGATTCAGCAAACTAAATGAAGATAGTGATTTTATTTTCAAACGAGGCCCTCCTGGTCTGCCACCTCAGAACTTT TCAATGTCTGTCACAGTTCCAGTGACCAGCCCCAATGCTTTGTCCTACACTAACCCAGGGAGTTCACTGGTGTCCCCATCTTTGGCAGCC AGCTCAACGTTAACAGATTCAAGCATGCTCTCTCCACCTCAAACCACATTACATAGAAATGTGTCTCCTGGAGCTCCTCAGAGACCACCA AGTACTGGCAATGCAGGTGGGATGTTGAGCACTACAGACCTCACAGTGCCAAATGGAGCTGGAAGCAGTCCAGTGGGGAATGGATTTGTA AACTCAAGAGCTTCTCCAAATTTGATTGGAGCTACTGGTGCAAATAGCTTAGGCAAAGTCATGCCTACAAAGTCTCCCCCTCCACCAGGT GGTGGTAATCTTGGAATGAACAGTAGGAAACCAGATCTTCGAGTTGTCATCCCCCCTTCAAGCAAGGGCATGATGCCTCCACTAAATACC CAGAGGATCAGTAGTTCTCAAGCCACTCAACCTCTTGCTACCCCAGTCGTGTCTGTGACAACCCCAAGCTTGCCTCCGCAAGGACTTGTG TACTCAGCAATGCCGACTGCCTACAACACTGATTATTCACTGACCAGCGCTGACCTGTCAGCCCTTCAAGGCTTCAACTCGCCAGGAATG CTGTCGCTGGGACAGGTGTCGGCCTGGCAGCAGCACCACCTAGGACAAGCAGCCCTCAGCTCTCTTGTTGCTGGAGGGCAGTTATCTCAG GGTTCCAATTTATCCATTAATACCAACCAAAACATCAGCATCAAGTCCGAACCGATTTCACCTCCTCGGGATCGTATGACCCCATCGGGC TTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCCGCCGCCACCACCGCAGCCCCAGCCACAACCCCCGCAGCCCCAGCCCCGACAG GAAATGGGGCGCTCCCCTGTGGACAGTCTGAGCAGCTCTAGTAGCTCCTATGATGGCAGTGATCGGGAGGATCCACGGGGCGACTTCCAT TCTCCAATTGTGCTTGGCCGACCCCCAAACACTGAGGACAGAGAAAGCCCTTCTGTAAAGCGAATGAGGATGGACGCGTGGGTGACCTAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PIAS1_ENST00000249636_chr15_68346688_+_MEF2A_ENST00000453228_chr15_100211528_+_5059nt GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGACTTTAAG AAAGAAAGGCCTTAATGGTTGTGAGAGCCCTGATGCTGACGATTACTTTGAGCACAGTCCACTCTCGGAGGACAGATTCAGCAAACTAAA TGAAGATAGTGATTTTATTTTCAAACGAGGCCCTCCTGGTCTGCCACCTCAGAACTTTTCAATGTCTGTCACAGTTCCAGTGACCAGCCC CAATGCTTTGTCCTACACTAACCCAGGGAGTTCACTGGTGTCCCCATCTTTGGCAGCCAGCTCAACGTTAACAGATTCAAGCATGCTCTC TCCACCTCAAACCACATTACATAGAAATGTGTCTCCTGGAGCTCCTCAGAGACCACCAAGTACTGGCAATGCAGGTGGGATGTTGAGCAC TACAGACCTCACAGTGCCAAATGGAGCTGGAAGCAGTCCAGTGGGGAATGGATTTGTAAACTCAAGAGCTTCTCCAAATTTGATTGGAGC TACTGGTGCAAATAGCTTAGGCAAAGTCATGCCTACAAAGTCTCCCCCTCCACCAGGTGGTGGTAATCTTGGAATGAACAGTAGGAAACC AGATCTTCGAGTTGTCATCCCCCCTTCAAGCAAGGGCATGATGCCTCCACTAAATACCCAGAGGATCAGTAGTTCTCAAGCCACTCAACC TCTTGCTACCCCAGTCGTGTCTGTGACAACCCCAAGCTTGCCTCCGCAAGGACTTGTGTACTCAGCAATGCCGACTGCCTACAACACTGA TTATTCACTGACCAGCGCTGACCTGTCAGCCCTTCAAGGCTTCAACTCGCCAGGAATGCTGTCGCTGGGACAGGTGTCGGCCTGGCAGCA GCACCACCTAGGACAAGCAGCCCTCAGCTCTCTTGTTGCTGGAGGGCAGTTATCTCAGGGTTCCAATTTATCCATTAATACCAACCAAAA CATCAGCATCAAGTCCGAACCGATTTCACCTCCTCGGGATCGTATGACCCCATCGGGCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCA GCAGCCGCCGCCACCACCGCAGCCCCAGCCACAACCCCCGCAGCCCCAGCCCCGACAGGAAATGGGGCGCTCCCCTGTGGACAGTCTGAG CAGCTCTAGTAGCTCCTATGATGGCAGTGATCGGGAGGATCCACGGGGCGACTTCCATTCTCCAATTGTGCTTGGCCGACCCCCAAACAC TGAGGACAGAGAAAGCCCTTCTGTAAAGCGAATGAGGATGGACGCGTGGGTGACCTAAGGCTTCCAAGCTGATGTTTGTACTTTTGTGTT ACTGCAGTGACCTGCCCTACATATCTAAATCGGTAAATAAGGACATGAGTTAAATATATTTATATGTACATACATATATATATCCCTTTA CATATATATGTATGTGGGTGTGAGTGTGTATGTGTGGGTGTGTGTTACATACACAGAATCAGGCACTTACCTGCAAACTCCTTGTAGGTC TGCAGATGTGTGTCCCATGGCAGACAAAGCACCCTGTAGGCACAGACAAGTCTGGCACTTCCTTGGACTACTTGTTTCGTAAAGATAACC AGTTTTTGCAGAGAAACGTGTACCCATATATAATTCTCCCACACTAGCTTGCAGAAACCTAGAGGGCCCCCTACTTGTTTTATTTAACTG TGCAGTGACTGTAGTTACTTAAGAGAAAATGCTTTGTAGAACAGAGCAGTAGAAAAGCAGGAACCAAGAAAGCAATACTGTACATAAAAT GTCATTTATATTTTCCAACCTGGCATGGGTGTCTGTTGCAAAGGGGTGCATGGGAAAGGGCTGTTGATATTAAAAACAAACAAAACAAAA AAGCCCCACACATAACTGTTTTGCACGTGCAAAAATGTATTGGGTCAAGAAGTGATCTTTAGCTAATAAAGAAAGAGAATAGAAAACACG CATGAGATATTCAGAAAATACTAGCCTAGAAATATAGAGCATTAACAAAGTAAAATTAATATATTAAGTTATAATTGGAATATGTCAGAA GTTTCTTTTTACATTCATATCTTAAAAATTAAAGAAACTGATTTTAGCTCATGTATATTTTATATGAAAGAAAACACCCTTATGAATTGA TGACTATATATAAAATTATATTCACTACTTTTGAACACATTCTGCTATGAATTATTTATATAAGCCAAAGCTATATGTTGTAACTTTTTT TTAGAGAATAGCTTTATCTTGGTTTAACTCTTTAGTTTTATTTTAAGAGGGGAAAACAAAAATATCTTGCAAGCAGAACCTTGGAAAAAA AAAGCCATGAACACTTATTCTAAATGTAAATTAAAAGTTGAGCCAAACTCTTTGTGTATATAGCATCTTAAATATATTATCACCTTTGAT GTAAGTACCTATGTATTGTATGGTCACCAGATTAAAAAGTATATTTTTGTGGATTGCCGCCAATCTGGGGGGAAAAGGCGAGGTCCTTTA TTAAGTATTCACTGTTTAATATTTACTATTTTGTTAAATATACTGTACTTTGGATTTTAATTATTAGCCCAGTTTTTTCAGAGGATTGTA TAAAGGGGTTTCTCCCCTCACTGGTGGTGAATGTGTGATGTTACATTGTAATCTTTGTGCTGTATGGGTTGAGCATCATTATATATTTTG TATGTGTACATAAATAGCAAAGTGGCAAAAAAAATTGGTGTTAAGTTCATCCTGCATAAGTATAAAATGTGTTGTAACAGATTTTGTAAG GCATTATTTAAAACTTGCCTTTTGTGAGGAAAAAATGTAGTAGAAAAAGCTGACCTAATTTAATTAATATTAGAGAAAATGGCAAAATAG TAGATGAGCACAAAGGTTTTATAAGTGGTAAATGATTAGGGGAAAATAATCATGGGGAAAGGGATCTTTTTTCCTTGACCCTCTGAAAAC AGAACGATGCAGCTGGTTACAAAATCCTACCGTTATCAGCTCTTCTGCACATTGCAGTGATGCTTTGGTATGCGGGGAGAAACACTCTTA GGGTGCTGGTCCTTGGCATGACTCTTGCCATTCTAATTGGAATTAGTGCCACCCTCAGCTTGGATTTTGAACAAGGCCTTATTCTTTCAG GAAGACAACTAATGGATGATAGCAAGTTCATCCACTTACTGGGCTTGTGCCATGAGCAAAATTCAAAGTCCTGTATATCTTTCATTGTAG ATTTTTAAATACTCCTTTTCCTAAAAAACTCAAGGGTTTAAAAATTGCTATTTTATATTTTAAATGATATTGAGCAGCTACCTACAATTT CTATGTACATTTTGTTCCCCCCCCCCCACCCCCCCCCCAAATTACGTTCCTTTTGACATTTTCCTCATCTGCTGTTTGTGACAAGTCATC AGCCAGATTTCCTGACTGACACATAGGTATGATCAGTGCAGGAGAGACCTGCGCACCACAGGCTGCAAACTGGAGGTTCTGTTCTCATGG CAGTTTGGGCAGTAACTTTTGAGAGAGGCCAAAAAAAGGAGGATGACATGCTGTCTCCTCTCTTCAGTATAGACATTAGGCTCTTATTCA GAAAGGATTTTTCTTTAAAAATGTACTTACTTTACTGAACTACTTACAGGCACATTTCTTCATAAGGCCACACCTAATCCAAACAAGACA GTCTCCCAACACTGAAGTTCCAAAATAATCCTTACCACTTTGTAAACCATTTATAGCTTTGAAAGTGTTAAGTGATTCCTTCGTTATTAT TTATGCATGTTCATGAACTTCTGCTGTACATTGGAATAGGAGTTAACACATTCACATTTACTGTCTATTTTCTTGTGTGCCTTATGAGAT GGCTTTTCTGACTGTATCTCAATAGTCTTTCTTTCTATGCAGGTTTATAATCAGTACAACTACTGTTTTCTAAAATACTACTACTCAAGG CTCGGAGTTTGTATTTAAATTACACTGACCAAGTAACAATGTATTCCATTTCAGGAACTGAATATTTGACTGTTAACCTTTTTCCCATAC GTCCAGTGTGGCATGGAGCATATGGACTTGACAGACATCTCTCACCCAGACGCCCACGTGTGAACACACCCACATCCACATCTCTGGGTG GAAACCAGCCTAGAGAGGGGACGACGCTAATGGTGTTGCTTTAGAACCGTCTTTTCTTACCCTTTTAGACTCGTGTTTTGTATGAGACAC CATTGCAAGAAAATTTTATCCCTCCAGAAGTATTTTATTACTAAAGAACAAAAGCAAAAAAAGCTTAAATTGCACTGGTTAAAGTACAGT TTCCAACAGCTGTCCTTCCTCAGTACTCTAATGGCCACTCCACCGCGAGTGGAAGTCACTGTTGTGTGTACACAGGTGGTCCCAATCAAA ACTCCATCTTTTGAGCCCAATTATGTCCATTTTGTTATAGACTAAATCAGGGGTTTGTTCTACAAGAACAATACATGTTTTACCCTTTCC TTTAACTAGAAGGATAACTAGTAATGCATCAACATAATTTCTGTATTAACCATCATGCGCACAAGAAATACATAGTAAATAAGGAAGCTG AAAACTCCTGGCATTGGATCTTAAGCTAGATGATTAGAATGTGAAAAAGATTTTACAAATGTAAAACTTCTATTTCTCTGTAGAAACTTT CTTCACTTTGCTGTGCAAGAAGACACTGCTTTGCTATATTTAAAATGGCTTTTTTAAAAGAGATTTATGTATTTGGTAAATGTTTGTAGT CAACAGTTCACACAAGAAGCTGTACACGGTTTGATCATGTAAAACCGTTTGGCGGCACAAGCTGGACTTTGTTGCCATCCTTGAGATGAA CCTTTTAAGAAAAATAAGTTAATCTCAATTTTTCCCTGAATGTGTTGTTTTTCTTCATTATACAATAAATATAATAGTGAACTTTTTATC |
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FusionGenePPI for PIAS1_MEF2A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PIAS1 | STAT1, DNMT3A, STAB2, UBE2I, SUMO1, SP3, TP53, CSRP2, AR, MX1, SUMO2, SIAH1, SIAH2, AKT1, ZMIZ2, BRCA1, MBD1, CREB1, SREBF2, GLUL, MITF, NCOR1, PPARG, TRIM27, ZNF76, JUN, HIC1, DDX5, SATB1, MAML1, DCLRE1A, DNMT3B, RBBP6, SAFB, ESR1, PPP1CA, MDC1, PRDM1, MDM2, CHUK, DNM1, PML, ATXN7, SRSF1, NFATC1, CEBPE, CEBPA, FLI1, CSNK2A1, CASP8AP2, MYB, SERBP1, ZMYND11, RAD54L2, PLAG1, NR1H3, NR1H2, PPARGC1B, PPARGC1A, BARD1, PAXIP1, PPP1CC, HTT, ATXN1, SMAD7, PRPF40A, SKIL, SMAD4, SMAD1, SOX2, SGTA, YWHAZ, SPOP, SUMO3, SHFM1, CBS, L3MBTL2, CEP250, TRIM63, TRIM55, ZNF451, PIAS1, FOXA1, HIF1A, ID1, KLC1, FRAT1, ERP44, POLK, VPS16, PIAS2, PTK2, TERF2, TRIM5, HECTD2, GSK3B, NCOA3, PSME3, TRIM35, GTF2IRD1, NR0B2, EP300 | MEF2A | VGLL4, HDAC4, HDAC9, THRA, EP300, HDAC5, SMAD2, MAPK14, ASCL1, MYOG, MAPK7, MEF2D, ACTN4, HDAC7, HDAC1, HNRNPA1, UBE2I, PHB2, ERBB2IP, DDB1, NDUFB9, GNB2, GNG12, TBP, TAF8, HDAC3, HAND1, XPO1, KLC4, JUN, ATF3, ATF7, CABIN1, HIST1H2BA, MEF2C, HIRA, REV3L, SH2B1, HIST1H2BC, HIST3H3, JUND, CCDC15, MAPKAPK3, SETX, TTLL7, ZCWPW1, ITGB1, MEF2B, XYLT1, DNMT3L, TSR3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIAS1_MEF2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIAS1_MEF2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PIAS1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | PIAS1 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | MEF2A | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | MEF2A | C0349204 | Nonorganic psychosis | 1 | PSYGENET |