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Fusion gene ID: 27074

FusionGeneSummary for PIAS1_MAP2K5

Fusion gene summary

Fusion gene information	Fusion gene name: PIAS1_MAP2K5
	Fusion gene ID: 27074
		Hgene	Tgene
	Gene symbol	PIAS1	MAP2K5
	Gene ID	8554	5607
	Gene name	protein inhibitor of activated STAT 1	mitogen-activated protein kinase kinase 5
	Synonyms	DDXBP1\|GBP\|GU/RH-II\|ZMIZ3	HsT17454\|MAPKK5\|MEK5\|PRKMK5
	Cytomap	15q23	15q23
	Type of gene	protein-coding	protein-coding
	Description	E3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT pr	dual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5
	Modification date	20180522	20180523
	UniProtAcc	O75925	Q13163
	Ensembl transtripts involved in fusion gene	ENST00000249636, ENST00000545237, ENST00000567417,	ENST00000178640, ENST00000560591, ENST00000395476, ENST00000354498, ENST00000340972,
Fusion gene scores	* DoF score	5 X 3 X 4=60	8 X 7 X 9=504
	# samples	5	13
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/504*10)=-1.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PIAS1 [Title/Abstract] AND MAP2K5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PIAS1	GO:0016925	protein sumoylation	18579533
Hgene	PIAS1	GO:0033235	positive regulation of protein sumoylation	17696781\|21965678

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	CESC	TCGA-RA-A741-01A	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000249636	ENST00000178640	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000249636	ENST00000560591	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000249636	ENST00000395476	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000249636	ENST00000354498	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000249636	ENST00000340972	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
In-frame	ENST00000545237	ENST00000178640	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000545237	ENST00000560591	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000545237	ENST00000395476	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000545237	ENST00000354498	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000545237	ENST00000340972	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
intron-3CDS	ENST00000567417	ENST00000178640	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000567417	ENST00000560591	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000567417	ENST00000395476	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000567417	ENST00000354498	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000567417	ENST00000340972	PIAS1	chr15	68379088	+	MAP2K5	chr15	67984817	+

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FusionProtFeatures for PIAS1_MAP2K5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PIAS1 O75925	MAP2K5 Q13163
Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway, the p53 pathway and the steroidhormone signaling pathway. In vitro, binds A/T-rich DNA. Theeffects of this transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.Together with PRMT1, may repress STAT1 transcriptional activity,in the late phase of interferon gamma (IFN-gamma) signaling.Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotestheir ubiquitin-mediated degradation. PIAS1-mediated sumoylationof PML promotes its interaction with CSNK2A1/CK2 which in turnpromotes PML phosphorylation and degradation (By similarity).Enhances the sumoylation of MTA1 and may participate in itsparalog-selective sumoylation. Plays a dynamic role inadipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity). {ECO:0000250\|UniProtKB:O88907,ECO:0000269\|PubMed:14500712, ECO:0000269\|PubMed:19136629,ECO:0000269\|PubMed:21965678}.	Acts as a scaffold for the formation of a ternaryMAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of thispathway appears to play a critical role in protecting cells fromstress-induced apoptosis, neuronal survival and cardiacdevelopment and angiogenesis. {ECO:0000269\|PubMed:7759517,ECO:0000269\|PubMed:9384584}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

11_45

156

652

Domain

SAP

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

19_23

156

652

Motif

Note=LXXLL motif

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

56_64

156

652

Motif

Nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

577_634

156

652

Compositional bias

Note=Ser-rich

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

124_288

156

652

Domain

PINIT

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

368_380

156

652

Motif

Nuclear localization signal

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

462_473

156

652

Region

SUMO1-binding

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

520_615

156

652

Region

Note=4 X 4 AA repeats of N-T-S-L

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

520_523

156

652

Repeat

Note=1

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

557_560

156

652

Repeat

Note=2

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

598_601

156

652

Repeat

Note=3%3B approximate

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

612_615

156

652

Repeat

Note=4%3B approximate

Hgene

PIAS1

chr15:68379088

chr15:67984817

ENST00000249636

320_397

156

652

Zinc finger

SP-RING-type

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000178640

166_409

282

449

Domain

Protein kinase

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000178640

18_109

282

449

Domain

PB1

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000354498

166_409

246

413

Domain

Protein kinase

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000354498

18_109

246

413

Domain

PB1

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000395476

166_409

282

439

Domain

Protein kinase

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000395476

18_109

282

439

Domain

PB1

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000178640

172_180

282

449

Nucleotide binding

ATP

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000354498

172_180

246

413

Nucleotide binding

ATP

Tgene

MAP2K5

chr15:68379088

chr15:67984817

ENST00000395476

172_180

282

439

Nucleotide binding

ATP

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FusionGeneSequence for PIAS1_MAP2K5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_PIAS1_ENST00000249636_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_323aa
MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLS
PSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLDVKPSNMLVNTRGQVKLCDFGVST
QLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFI

>In-frame_PIAS1_ENST00000545237_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_325aa
MFTLQDSYVKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPAT
LSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLDVKPSNMLVNTRGQVKLCDFGV
STQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVH

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_PIAS1_ENST00000249636_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_969nt
ATGGCGGACAGTGCGGAACTAAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAG
CACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTC
TATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCT
CCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTG
GAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTG
ATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACT
CAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCAT
TCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGATCTTTA
ATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATC
ACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAAT

>In-frame_PIAS1_ENST00000545237_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_975nt
ATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGA
AACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAG
GAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACT
TTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACAT
GAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGAT
GAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTT
AGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGA
ATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGA
TCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACAT
TTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGAT

* Fusion transcript sequences (Full-length transcript).

>In-frame_PIAS1_ENST00000249636_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_1490nt
GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG
GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGCAAATGGT
TATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGC
CCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGAC
GCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGG
TCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCC
AGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTC
CAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGT
TGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTAT
GGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGA
TGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAG
GCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGC
GCTGGAGGAGAGGCGGAGCCAGCAGGGGCCCCCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCA
CCCGTCGCCCTTCTCCGTATGCTGCCTGCGCCAGAAGAGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGT
GGCCTTGCCTGGGGAGCCCCATGTGTGGCCCACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGT
AAAGGGTGGGGCATTGAGAATGGAGGCTCCCAGGGTCCCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTC

>In-frame_PIAS1_ENST00000545237_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_2089nt
TTGTTGTGGGCGCCTCTGGCGGGGGTGGCGGGGGAAGAGATAGGGAGTCCGGAGGTAGGGGCTGCAGCTGTCTCATGGGCTCGGCTTTTT
CACCTTCCAGTTAGCCTCCCTGCCCCCCATGGGGAGCTGGGGCTGGGGGCAGGGTGCTCTCGTAGGGGGGATTGGGAAAGCTCCCCGTGG
CCGCTTCCTCTTCCTCCTTTGCAGTCCCGGGCTCCTGTCAGGCGCTCTTCTCAGACCCCCGGGAACTTGGCTTCGGCCGCCCCGCCCCTC
CGTGGATCCCAGTAGCCCCCGCCCCGGACTCGGCTTTCCCCGGCTGCTCGCTTGTCAGGAAGCGCCTGGGGTGCCCCGCTTGTGGGAAGC
GCGATCCCGGGGCGATAGGGTGGGGATCTGGGGGAGAAGCTCTGGTAAAGTTTAGCGAGCCCCGGGCCGGCGTTGGGGTTCGGCTGAGAG
GTAGTGAGCGGGACGTTACTCTTTCTCTCTGATTCCGGGCAGCCGAGGGGAGAAACCCCCTCGAAGAGTGTGTCTTTGGAAGCAGTGTTG
GGAGGGGGGGATGCAGCTACCTCTCTCCCTTCTTTTGCCTTAGCTGGTGTGGAGGGTGAGAGGAGCCTTTGGGGGTCTCTGCACACACCA
TGATGGCGATGCTGTAGCTGATGGAGAACAACCAAATGCCAGATTTGATTCTGTAGAGTTTTTCCTGTGGAATATCCTCACCGAAAGAGC
TTTTCTCCTAATAACTTCACAATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTA
CTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCT
GCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACAT
TCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTT
TCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTA
CCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTT
AAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGG
ATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCT
CAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAG
TTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCG
TTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGCGCTGGAGGAGAGGCGGAGCCAGCAGGGGCCC
CCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCACCCGTCGCCCTTCTCCGTATGCTGCCTGCGC
CAGAAGAGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGTGGCCTTGCCTGGGGAGCCCCATGTGTGGCCC
ACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGTAAAGGGTGGGGCATTGAGAATGGAGGCTCCC
AGGGTCCCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTCAGCATCACTGATGGGAATAAAAGTATTAATG

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FusionGenePPI for PIAS1_MAP2K5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
PIAS1	STAT1, DNMT3A, STAB2, UBE2I, SUMO1, SP3, TP53, CSRP2, AR, MX1, SUMO2, SIAH1, SIAH2, AKT1, ZMIZ2, BRCA1, MBD1, CREB1, SREBF2, GLUL, MITF, NCOR1, PPARG, TRIM27, ZNF76, JUN, HIC1, DDX5, SATB1, MAML1, DCLRE1A, DNMT3B, RBBP6, SAFB, ESR1, PPP1CA, MDC1, PRDM1, MDM2, CHUK, DNM1, PML, ATXN7, SRSF1, NFATC1, CEBPE, CEBPA, FLI1, CSNK2A1, CASP8AP2, MYB, SERBP1, ZMYND11, RAD54L2, PLAG1, NR1H3, NR1H2, PPARGC1B, PPARGC1A, BARD1, PAXIP1, PPP1CC, HTT, ATXN1, SMAD7, PRPF40A, SKIL, SMAD4, SMAD1, SOX2, SGTA, YWHAZ, SPOP, SUMO3, SHFM1, CBS, L3MBTL2, CEP250, TRIM63, TRIM55, ZNF451, PIAS1, FOXA1, HIF1A, ID1, KLC1, FRAT1, ERP44, POLK, VPS16, PIAS2, PTK2, TERF2, TRIM5, HECTD2, GSK3B, NCOA3, PSME3, TRIM35, GTF2IRD1, NR0B2, EP300	MAP2K5	MAP3K3, MAP3K2, PRKCZ, MAPK7, MAP2K5, YWHAZ, CDC42BPB, ENO1, SQSTM1, ASRGL1, STAMBP, PRKCI, PARD6A, HSP90AA1, GCH1, XRCC6, ESRRA, RPL28, NXF1, LNX2, TRAF7, C10orf88, CDC37

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000178640	+	12	22	64_68	282	449	MAP3K2/MAP3K3
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000354498	+	12	22	64_68	246	413	MAP3K2/MAP3K3
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000395476	+	12	21	64_68	282	439	MAP3K2/MAP3K3
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000178640	+	12	22	117_131	282	449	MAPK7
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000178640	+	12	22	18_25	282	449	MAPK7
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000354498	+	12	22	117_131	246	413	MAPK7
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000354498	+	12	22	18_25	246	413	MAPK7
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000395476	+	12	21	117_131	282	439	MAPK7
Tgene	MAP2K5	chr15:68379088	chr15:67984817	ENST00000395476	+	12	21	18_25	282	439	MAPK7

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for PIAS1_MAP2K5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PIAS1_MAP2K5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PIAS1	C0037274	Dermatologic disorders	1	CTD_human
Hgene	PIAS1	C0311375	Arsenic Poisoning	1	CTD_human
Tgene	MAP2K5	C0005910	Body Weight	1	CTD_human
Tgene	MAP2K5	C0011581	Depressive disorder	1	PSYGENET
Tgene	MAP2K5	C0236733	Amphetamine-Related Disorders	1	CTD_human

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Fusion gene ID: 27074

FusionGeneSummary for PIAS1_MAP2K5

FusionProtFeatures for PIAS1_MAP2K5

FusionGeneSequence for PIAS1_MAP2K5

FusionGenePPI for PIAS1_MAP2K5

RelatedDrugs for PIAS1_MAP2K5

RelatedDiseases for PIAS1_MAP2K5