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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27074

FusionGeneSummary for PIAS1_MAP2K5

check button Fusion gene summary
Fusion gene informationFusion gene name: PIAS1_MAP2K5
Fusion gene ID: 27074
HgeneTgene
Gene symbol

PIAS1

MAP2K5

Gene ID

8554

5607

Gene nameprotein inhibitor of activated STAT 1mitogen-activated protein kinase kinase 5
SynonymsDDXBP1|GBP|GU/RH-II|ZMIZ3HsT17454|MAPKK5|MEK5|PRKMK5
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT prdual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5
Modification date2018052220180523
UniProtAcc

O75925

Q13163

Ensembl transtripts involved in fusion geneENST00000249636, ENST00000545237, 
ENST00000567417, 
ENST00000178640, 
ENST00000560591, ENST00000395476, 
ENST00000354498, ENST00000340972, 
Fusion gene scores* DoF score5 X 3 X 4=608 X 7 X 9=504
# samples 513
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIAS1 [Title/Abstract] AND MAP2K5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePIAS1

GO:0016925

protein sumoylation

18579533

HgenePIAS1

GO:0033235

positive regulation of protein sumoylation

17696781|21965678


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-RA-A741-01APIAS1chr15

68379088

+MAP2K5chr15

67984817

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000249636ENST00000178640PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000560591PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000395476PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000354498PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000249636ENST00000340972PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
In-frameENST00000545237ENST00000178640PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000560591PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000395476PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000354498PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
5CDS-intronENST00000545237ENST00000340972PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
intron-3CDSENST00000567417ENST00000178640PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000560591PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000395476PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000354498PIAS1chr15

68379088

+MAP2K5chr15

67984817

+
intron-intronENST00000567417ENST00000340972PIAS1chr15

68379088

+MAP2K5chr15

67984817

+

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FusionProtFeatures for PIAS1_MAP2K5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIAS1

O75925

MAP2K5

Q13163

Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway, the p53 pathway and the steroidhormone signaling pathway. In vitro, binds A/T-rich DNA. Theeffects of this transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.Together with PRMT1, may repress STAT1 transcriptional activity,in the late phase of interferon gamma (IFN-gamma) signaling.Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotestheir ubiquitin-mediated degradation. PIAS1-mediated sumoylationof PML promotes its interaction with CSNK2A1/CK2 which in turnpromotes PML phosphorylation and degradation (By similarity).Enhances the sumoylation of MTA1 and may participate in itsparalog-selective sumoylation. Plays a dynamic role inadipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity). {ECO:0000250|UniProtKB:O88907,ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:19136629,ECO:0000269|PubMed:21965678}. Acts as a scaffold for the formation of a ternaryMAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of thispathway appears to play a critical role in protecting cells fromstress-induced apoptosis, neuronal survival and cardiacdevelopment and angiogenesis. {ECO:0000269|PubMed:7759517,ECO:0000269|PubMed:9384584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+21411_45156652DomainSAP
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+21419_23156652MotifNote=LXXLL motif
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+21456_64156652MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214577_634156652Compositional biasNote=Ser-rich
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214124_288156652DomainPINIT
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214368_380156652MotifNuclear localization signal
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214462_473156652RegionSUMO1-binding
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214520_615156652RegionNote=4 X 4 AA repeats of N-T-S-L
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214520_523156652RepeatNote=1
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214557_560156652RepeatNote=2
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214598_601156652RepeatNote=3%3B approximate
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214612_615156652RepeatNote=4%3B approximate
HgenePIAS1chr15:68379088chr15:67984817ENST00000249636+214320_397156652Zinc fingerSP-RING-type
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640+1222166_409282449DomainProtein kinase
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640+122218_109282449DomainPB1
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498+1222166_409246413DomainProtein kinase
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498+122218_109246413DomainPB1
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476+1221166_409282439DomainProtein kinase
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476+122118_109282439DomainPB1
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640+1222172_180282449Nucleotide bindingATP
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498+1222172_180246413Nucleotide bindingATP
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476+1221172_180282439Nucleotide bindingATP


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FusionGeneSequence for PIAS1_MAP2K5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PIAS1_ENST00000249636_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_323aa
MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELTRRRFPQKIMTPADLSIPNVHSSPMPATLS
PSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFTDLLDELIKPTSLDVKPSNMLVNTRGQVKLCDFGVST
QLVNSIAKTTVGTNATMAPERISGEQTGIHSDVWSLGISFMELALGRFPTPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFI

>In-frame_PIAS1_ENST00000545237_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_325aa
MFTLQDSTVKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELTRRRFPQKIMTPADLSIPNVHSSPMPAT
LSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFTDLLDELIKPTSLDVKPSNMLVNTRGQVKLCDFGV
STQLVNSIAKTTVGTNATMAPERISGEQTGIHSDVWSLGISFMELALGRFPTPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PIAS1_ENST00000249636_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_969nt
ATGGCGGACAGTGCGGAACTAAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAG
CACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTC
TATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCT
CCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTG
GAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTG
ATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACT
CAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCAT
TCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGATCTTTA
ATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATC
ACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAAT

>In-frame_PIAS1_ENST00000545237_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_975nt
ATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGA
AACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAG
GAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACT
TTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACAT
GAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGAT
GAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTT
AGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGA
ATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGA
TCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACAT
TTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PIAS1_ENST00000249636_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_1490nt
GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG
GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGCAAATGGT
TATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGC
CCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGAC
GCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGG
TCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCC
AGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTC
CAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGT
TGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTAT
GGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGA
TGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAG
GCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGC
GCTGGAGGAGAGGCGGAGCCAGCAGGGGCCCCCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCA
CCCGTCGCCCTTCTCCGTATGCTGCCTGCGCCAGAAGAGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGT
GGCCTTGCCTGGGGAGCCCCATGTGTGGCCCACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGT
AAAGGGTGGGGCATTGAGAATGGAGGCTCCCAGGGTCCCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTC

>In-frame_PIAS1_ENST00000545237_chr15_68379088_+_MAP2K5_ENST00000178640_chr15_67984817_+_2089nt
TTGTTGTGGGCGCCTCTGGCGGGGGTGGCGGGGGAAGAGATAGGGAGTCCGGAGGTAGGGGCTGCAGCTGTCTCATGGGCTCGGCTTTTT
CACCTTCCAGTTAGCCTCCCTGCCCCCCATGGGGAGCTGGGGCTGGGGGCAGGGTGCTCTCGTAGGGGGGATTGGGAAAGCTCCCCGTGG
CCGCTTCCTCTTCCTCCTTTGCAGTCCCGGGCTCCTGTCAGGCGCTCTTCTCAGACCCCCGGGAACTTGGCTTCGGCCGCCCCGCCCCTC
CGTGGATCCCAGTAGCCCCCGCCCCGGACTCGGCTTTCCCCGGCTGCTCGCTTGTCAGGAAGCGCCTGGGGTGCCCCGCTTGTGGGAAGC
GCGATCCCGGGGCGATAGGGTGGGGATCTGGGGGAGAAGCTCTGGTAAAGTTTAGCGAGCCCCGGGCCGGCGTTGGGGTTCGGCTGAGAG
GTAGTGAGCGGGACGTTACTCTTTCTCTCTGATTCCGGGCAGCCGAGGGGAGAAACCCCCTCGAAGAGTGTGTCTTTGGAAGCAGTGTTG
GGAGGGGGGGATGCAGCTACCTCTCTCCCTTCTTTTGCCTTAGCTGGTGTGGAGGGTGAGAGGAGCCTTTGGGGGTCTCTGCACACACCA
TGATGGCGATGCTGTAGCTGATGGAGAACAACCAAATGCCAGATTTGATTCTGTAGAGTTTTTCCTGTGGAATATCCTCACCGAAAGAGC
TTTTCTCCTAATAACTTCACAATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTA
CTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCT
GCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACAT
TCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTT
TCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTA
CCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTT
AAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGG
ATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCT
CAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCCGTCCTTCCAGTTGGAGAG
TTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCG
TTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGCGCTGGAGGAGAGGCGGAGCCAGCAGGGGCCC
CCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACCAAGGAGAACAACCCACCCGTCGCCCTTCTCCGTATGCTGCCTGCGC
CAGAAGAGCTTTGCTGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGTGGCCTTGCCTGGGGAGCCCCATGTGTGGCCC
ACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGACACTGGCAGAGAGGTAAAGGGTGGGGCATTGAGAATGGAGGCTCCC
AGGGTCCCTGCCCACTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTCAGCATCACTGATGGGAATAAAAGTATTAATG


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FusionGenePPI for PIAS1_MAP2K5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIAS1STAT1, DNMT3A, STAB2, UBE2I, SUMO1, SP3, TP53, CSRP2, AR, MX1, SUMO2, SIAH1, SIAH2, AKT1, ZMIZ2, BRCA1, MBD1, CREB1, SREBF2, GLUL, MITF, NCOR1, PPARG, TRIM27, ZNF76, JUN, HIC1, DDX5, SATB1, MAML1, DCLRE1A, DNMT3B, RBBP6, SAFB, ESR1, PPP1CA, MDC1, PRDM1, MDM2, CHUK, DNM1, PML, ATXN7, SRSF1, NFATC1, CEBPE, CEBPA, FLI1, CSNK2A1, CASP8AP2, MYB, SERBP1, ZMYND11, RAD54L2, PLAG1, NR1H3, NR1H2, PPARGC1B, PPARGC1A, BARD1, PAXIP1, PPP1CC, HTT, ATXN1, SMAD7, PRPF40A, SKIL, SMAD4, SMAD1, SOX2, SGTA, YWHAZ, SPOP, SUMO3, SHFM1, CBS, L3MBTL2, CEP250, TRIM63, TRIM55, ZNF451, PIAS1, FOXA1, HIF1A, ID1, KLC1, FRAT1, ERP44, POLK, VPS16, PIAS2, PTK2, TERF2, TRIM5, HECTD2, GSK3B, NCOA3, PSME3, TRIM35, GTF2IRD1, NR0B2, EP300MAP2K5MAP3K3, MAP3K2, PRKCZ, MAPK7, MAP2K5, YWHAZ, CDC42BPB, ENO1, SQSTM1, ASRGL1, STAMBP, PRKCI, PARD6A, HSP90AA1, GCH1, XRCC6, ESRRA, RPL28, NXF1, LNX2, TRAF7, C10orf88, CDC37


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640+122264_68282449MAP3K2/MAP3K3
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498+122264_68246413MAP3K2/MAP3K3
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476+122164_68282439MAP3K2/MAP3K3
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640+1222117_131282449MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000178640+122218_25282449MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498+1222117_131246413MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000354498+122218_25246413MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476+1221117_131282439MAPK7
TgeneMAP2K5chr15:68379088chr15:67984817ENST00000395476+122118_25282439MAPK7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIAS1_MAP2K5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIAS1_MAP2K5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIAS1C0037274Dermatologic disorders1CTD_human
HgenePIAS1C0311375Arsenic Poisoning1CTD_human
TgeneMAP2K5C0005910Body Weight1CTD_human
TgeneMAP2K5C0011581Depressive disorder1PSYGENET
TgeneMAP2K5C0236733Amphetamine-Related Disorders1CTD_human