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Fusion gene ID: 27073 |
FusionGeneSummary for PIAS1_HMCN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIAS1_HMCN2 | Fusion gene ID: 27073 | Hgene | Tgene | Gene symbol | PIAS1 | HMCN2 | Gene ID | 8554 | 256158 |
| Gene name | protein inhibitor of activated STAT 1 | hemicentin 2 | |
| Synonyms | DDXBP1|GBP|GU/RH-II|ZMIZ3 | - | |
| Cytomap | 15q23 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 SUMO-protein ligase PIAS1AR interacting proteinDEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1DEAD/H box-binding protein 1E3 SUMO-protein transferase PIAS1RNA helicase II-binding proteingu-binding proteinprotein inhibitor of activated STAT pr | hemicentin-2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O75925 | Q8NDA2 | |
| Ensembl transtripts involved in fusion gene | ENST00000249636, ENST00000545237, ENST00000567417, | ENST00000428715, ENST00000487727, ENST00000302481, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PIAS1 [Title/Abstract] AND HMCN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIAS1 | GO:0016925 | protein sumoylation | 18579533 |
| Hgene | PIAS1 | GO:0033235 | positive regulation of protein sumoylation | 17696781|21965678 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A7B1-01A | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000249636 | ENST00000428715 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| 5CDS-intron | ENST00000249636 | ENST00000487727 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| 5CDS-intron | ENST00000249636 | ENST00000302481 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| In-frame | ENST00000545237 | ENST00000428715 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| 5CDS-intron | ENST00000545237 | ENST00000487727 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| 5CDS-intron | ENST00000545237 | ENST00000302481 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| intron-3CDS | ENST00000567417 | ENST00000428715 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| intron-intron | ENST00000567417 | ENST00000487727 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
| intron-intron | ENST00000567417 | ENST00000302481 | PIAS1 | chr15 | 68379088 | + | HMCN2 | chr9 | 133297964 | + |
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FusionProtFeatures for PIAS1_HMCN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIAS1 | HMCN2 |
| Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway, the p53 pathway and the steroidhormone signaling pathway. In vitro, binds A/T-rich DNA. Theeffects of this transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.Together with PRMT1, may repress STAT1 transcriptional activity,in the late phase of interferon gamma (IFN-gamma) signaling.Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotestheir ubiquitin-mediated degradation. PIAS1-mediated sumoylationof PML promotes its interaction with CSNK2A1/CK2 which in turnpromotes PML phosphorylation and degradation (By similarity).Enhances the sumoylation of MTA1 and may participate in itsparalog-selective sumoylation. Plays a dynamic role inadipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity). {ECO:0000250|UniProtKB:O88907,ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:19136629,ECO:0000269|PubMed:21965678}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 11_45 | 156 | 652 | Domain | SAP |
| Hgene | PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 19_23 | 156 | 652 | Motif | Note=LXXLL motif |
| Hgene | PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 56_64 | 156 | 652 | Motif | Nuclear localization signal |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1066_1159 | -85 | 221 | Domain | Ig-like C2-type 7 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1164_1244 | -85 | 221 | Domain | Ig-like C2-type 8 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1265_1338 | -85 | 221 | Domain | Ig-like C2-type 9 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1343_1429 | -85 | 221 | Domain | Ig-like C2-type 10 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1436_1525 | -85 | 221 | Domain | Ig-like C2-type 11 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1530_1618 | -85 | 221 | Domain | Ig-like C2-type 12 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1623_1714 | -85 | 221 | Domain | Ig-like C2-type 13 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1717_1805 | -85 | 221 | Domain | Ig-like C2-type 14 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1810_1887 | -85 | 221 | Domain | Ig-like C2-type 15 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1894_1982 | -85 | 221 | Domain | Ig-like C2-type 16 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 1985_2074 | -85 | 221 | Domain | Ig-like C2-type 17 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2079_2165 | -85 | 221 | Domain | Ig-like C2-type 18 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2170_2261 | -85 | 221 | Domain | Ig-like C2-type 19 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2264_2353 | -85 | 221 | Domain | Ig-like C2-type 20 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2358_2447 | -85 | 221 | Domain | Ig-like C2-type 21 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2452_2540 | -85 | 221 | Domain | Ig-like C2-type 22 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2545_2636 | -85 | 221 | Domain | Ig-like C2-type 23 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2641_2732 | -85 | 221 | Domain | Ig-like C2-type 24 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2739_2833 | -85 | 221 | Domain | Ig-like C2-type 25 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2849_2938 | -85 | 221 | Domain | Ig-like C2-type 26 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 2945_3032 | -85 | 221 | Domain | Ig-like C2-type 27 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3037_3127 | -85 | 221 | Domain | Ig-like C2-type 28 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3131_3219 | -85 | 221 | Domain | Ig-like C2-type 29 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3224_3314 | -85 | 221 | Domain | Ig-like C2-type 30 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3319_3406 | -85 | 221 | Domain | Ig-like C2-type 31 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3412_3497 | -85 | 221 | Domain | Ig-like C2-type 32 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3502_3588 | -85 | 221 | Domain | Ig-like C2-type 33 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3593_3681 | -85 | 221 | Domain | Ig-like C2-type 34 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3686_3772 | -85 | 221 | Domain | Ig-like C2-type 35 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3777_3848 | -85 | 221 | Domain | Ig-like C2-type 36 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3851_3937 | -85 | 221 | Domain | Ig-like C2-type 37 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 38_205 | -85 | 221 | Domain | Note=VWFA |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 3942_4027 | -85 | 221 | Domain | Ig-like C2-type 38 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4031_4118 | -85 | 221 | Domain | Ig-like C2-type 39 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4123_4204 | -85 | 221 | Domain | Ig-like C2-type 40 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4212_4295 | -85 | 221 | Domain | Ig-like C2-type 41 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4303_4388 | -85 | 221 | Domain | Ig-like C2-type 42 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4392_4614 | -85 | 221 | Domain | Nidogen G2 beta-barrel |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4628_4668 | -85 | 221 | Domain | EGF-like 1%3B calcium-binding |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4669_4712 | -85 | 221 | Domain | EGF-like 2%3B calcium-binding |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4713_4751 | -85 | 221 | Domain | EGF-like 3%3B calcium-binding |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4756_4796 | -85 | 221 | Domain | EGF-like 4%3B calcium-binding |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 4863_4902 | -85 | 221 | Domain | EGF-like 5%3B calcium-binding |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 517_602 | -85 | 221 | Domain | Ig-like C2-type 1 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 607_690 | -85 | 221 | Domain | Ig-like C2-type 2 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 697_780 | -85 | 221 | Domain | Ig-like C2-type 3 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 785_879 | -85 | 221 | Domain | Ig-like C2-type 4 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 884_970 | -85 | 221 | Domain | Ig-like C2-type 5 |
| Tgene | >HMCN2 | chr15:68379088 | chr9:133297964 | ENST00000302481 | + | 0 | 4 | 975_1061 | -85 | 221 | Domain | Ig-like C2-type 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 577_634 | 156 | 652 | Compositional bias | Note=Ser-rich |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 124_288 | 156 | 652 | Domain | PINIT |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 368_380 | 156 | 652 | Motif | Nuclear localization signal |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 462_473 | 156 | 652 | Region | SUMO1-binding |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 520_615 | 156 | 652 | Region | Note=4 X 4 AA repeats of N-T-S-L |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 520_523 | 156 | 652 | Repeat | Note=1 |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 557_560 | 156 | 652 | Repeat | Note=2 |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 598_601 | 156 | 652 | Repeat | Note=3%3B approximate |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 612_615 | 156 | 652 | Repeat | Note=4%3B approximate |
| Hgene | >PIAS1 | chr15:68379088 | chr9:133297964 | ENST00000249636 | + | 2 | 14 | 320_397 | 156 | 652 | Zinc finger | SP-RING-type |
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FusionGeneSequence for PIAS1_HMCN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIAS1_ENST00000249636_chr15_68379088_+_HMCN2_ENST00000428715_chr9_133297964_+_826aa MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELTRRRFPQKIMTPADLSIPNVHSSPMPATLS PSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFTDLLDELIKPTSLGEPQGSWGSMTGVINGRKFGVATL NTSVMQEAHSGVSSIHSSIRHVPANVGPLMRVLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFATGELLTMTQVARGLDPDGL LLLDVVVNGVVPESLADADLQVQDFEEHYVQTGPGQLFVGSTQRFFQGGLPSFLRCNHSIQYNAARGPQPQLVQHLRASAISSAFDPEAE ALRFQLATALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQ RCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNL QGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDL DECRVRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQD CGTGGPSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPANRTELSMLEPDPRSPFALRPLRAGLGAVYTRRALTRAGLYRLTVRAAAPRH >In-frame_PIAS1_ENST00000545237_chr15_68379088_+_HMCN2_ENST00000428715_chr9_133297964_+_828aa MFTLQDSTVKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELTRRRFPQKIMTPADLSIPNVHSSPMPAT LSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFTDLLDELIKPTSLGEPQGSWGSMTGVINGRKFGVA TLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMRVLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFATGELLTMTQVARGLDPD GLLLLDVVVNGVVPESLADADLQVQDFEEHYVQTGPGQLFVGSTQRFFQGGLPSFLRCNHSIQYNAARGPQPQLVQHLRASAISSAFDPE AEALRFQLATALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCRE GQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCH NLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCT DLDECRVRNLCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCS QDCGTGGPSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPANRTELSMLEPDPRSPFALRPLRAGLGAVYTRRALTRAGLYRLTVRAAAP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIAS1_ENST00000249636_chr15_68379088_+_HMCN2_ENST00000428715_chr9_133297964_+_2478nt ATGGCGGACAGTGCGGAACTAAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAG CACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTC TATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCT CCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTG GAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTG ATAAAACCCACCAGTCTAGGGGAGCCCCAGGGGAGCTGGGGCAGCATGACTGGGGTGATAAATGGCCGGAAATTTGGCGTGGCCACACTC AACACCAGCGTGATGCAGGAGGCACACTCCGGGGTCAGCAGCATCCACAGCAGCATCCGCCATGTCCCAGCAAACGTGGGGCCTCTGATG CGGGTGCTCGTGGTCACCATCGCCCCCATCTACTGGGCCCTGGCCAGAGAGAGTGGGGAAGCCCTGAATGGCCACTCTCTGACTGGGGGC AGGTTCCGGCAGGAGTCACACGTGGAGTTTGCTACAGGGGAGCTGCTCACGATGACCCAGGTGGCCCGGGGTCTGGATCCCGATGGCCTC CTGCTCCTCGACGTGGTGGTCAATGGCGTTGTCCCCGAGAGCCTGGCTGACGCAGATCTTCAAGTGCAGGACTTTGAGGAGCACTACGTG CAAACAGGGCCTGGCCAGCTGTTCGTGGGCTCCACACAGCGCTTCTTCCAGGGCGGCCTCCCCTCGTTCCTACGCTGCAACCACAGCATC CAGTACAACGCGGCCCGGGGCCCCCAGCCCCAGCTGGTGCAGCACCTGCGGGCCTCAGCTATCAGCTCGGCCTTTGATCCAGAGGCCGAG GCCCTGCGCTTCCAGCTCGCTACAGCCCTGCAGGCGGAGGAGAACGAGGTCGGCTGCCCCGAGGGCTTTGAGCTGGACTCCCAGGGAGCG TTTTGTGTGGACAGGGACGAGTGCTCAGGAGGCCCTAGCCCCTGCTCCCATGCCTGCCTTAATGCACCCGGCCGCTTCTCCTGCACCTGC CCCACTGGCTTCGCCCTGGCCTGGGATGACAGGAACTGCAGAGATGTGGACGAGTGTGCGTGGGATGCTCACCTCTGCCGAGAGGGACAG CGCTGTGTGAACCTGCTCGGGTCCTACCGCTGCCTCCCCGACTGTGGGCCTGGCTTCCGGGTGGCTGATGGGGCCGGCTGTGAAGATGTG GACGAATGCCTGGAGGGGTTGGACGACTGTCACTACAACCAGCTCTGCGAGAACACCCCAGGCGGTCACCGCTGCAGCTGCCCCAGGGGT TACCGGATGCAGGGCCCCAGCCTGCCCTGCCTAGATGTCAATGAGTGCCTGCAGCTGCCCAAGGCCTGCGCCTACCAGTGCCACAACCTC CAGGGCAGCTACCGCTGCCTGTGCCCCCCAGGCCAGACCCTCCTTCGCGACGGCAAGGCCTGCACCTCACTGGAGCGGAATGGACAAAAT GTGACCACCGTCAGCCACCGAGGCCCTCTATTGCCCTGGCTGCGGCCCTGGGCCTCGATCCCCGGTACCTCCTACCACGCCTGGGTCTCT CTCCGTCCGGGTCCCATGGCCCTGAGCAGTGTGGGCCGGGCCTGGTGCCCTCCTGGTTTCATCAGGCAGAACGGAGTCTGCACAGACCTT GACGAGTGCCGCGTGAGGAACCTGTGTCAGCACGCCTGCCGCAACACTGAGGGCAGCTACCAGTGCCTGTGCCCCGCCGGCTACCGTCTG CTCCCCAGCGGGAAGAACTGCCAGGACATCAACGAGTGCGAGGAGGAGAGCATCGAGTGTGGACCCGGCCAGATGTGCTTCAACACCCGT GGCAGCTACCAGTGTGTGGACACACCCTGTCCTGCCACCTACCGGCAGGGCCCCAGCCCTGGGACGTGCTTCCGGCGCTGCTCGCAGGAC TGCGGCACGGGCGGCCCCTCTACGCTGCAGTACCGGCTGCTGCCGCTGCCCCTGGGCGTGCGCGCCCACCACGACGTGGCCCGCCTCACC GCCTTCTCCGAGGTCGGCGTCCCCGCCAACCGCACCGAGCTCAGCATGCTGGAGCCCGACCCCCGCAGCCCCTTCGCGCTGCGTCCGCTG CGCGCGGGCCTTGGCGCGGTCTACACCCGTCGCGCGCTCACCCGCGCCGGCCTCTACCGGCTCACCGTGCGTGCTGCGGCACCGCGCCAC >In-frame_PIAS1_ENST00000545237_chr15_68379088_+_HMCN2_ENST00000428715_chr9_133297964_+_2484nt ATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGA AACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAG GAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACT TTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACAT GAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGAT GAACTGATAAAACCCACCAGTCTAGGGGAGCCCCAGGGGAGCTGGGGCAGCATGACTGGGGTGATAAATGGCCGGAAATTTGGCGTGGCC ACACTCAACACCAGCGTGATGCAGGAGGCACACTCCGGGGTCAGCAGCATCCACAGCAGCATCCGCCATGTCCCAGCAAACGTGGGGCCT CTGATGCGGGTGCTCGTGGTCACCATCGCCCCCATCTACTGGGCCCTGGCCAGAGAGAGTGGGGAAGCCCTGAATGGCCACTCTCTGACT GGGGGCAGGTTCCGGCAGGAGTCACACGTGGAGTTTGCTACAGGGGAGCTGCTCACGATGACCCAGGTGGCCCGGGGTCTGGATCCCGAT GGCCTCCTGCTCCTCGACGTGGTGGTCAATGGCGTTGTCCCCGAGAGCCTGGCTGACGCAGATCTTCAAGTGCAGGACTTTGAGGAGCAC TACGTGCAAACAGGGCCTGGCCAGCTGTTCGTGGGCTCCACACAGCGCTTCTTCCAGGGCGGCCTCCCCTCGTTCCTACGCTGCAACCAC AGCATCCAGTACAACGCGGCCCGGGGCCCCCAGCCCCAGCTGGTGCAGCACCTGCGGGCCTCAGCTATCAGCTCGGCCTTTGATCCAGAG GCCGAGGCCCTGCGCTTCCAGCTCGCTACAGCCCTGCAGGCGGAGGAGAACGAGGTCGGCTGCCCCGAGGGCTTTGAGCTGGACTCCCAG GGAGCGTTTTGTGTGGACAGGGACGAGTGCTCAGGAGGCCCTAGCCCCTGCTCCCATGCCTGCCTTAATGCACCCGGCCGCTTCTCCTGC ACCTGCCCCACTGGCTTCGCCCTGGCCTGGGATGACAGGAACTGCAGAGATGTGGACGAGTGTGCGTGGGATGCTCACCTCTGCCGAGAG GGACAGCGCTGTGTGAACCTGCTCGGGTCCTACCGCTGCCTCCCCGACTGTGGGCCTGGCTTCCGGGTGGCTGATGGGGCCGGCTGTGAA GATGTGGACGAATGCCTGGAGGGGTTGGACGACTGTCACTACAACCAGCTCTGCGAGAACACCCCAGGCGGTCACCGCTGCAGCTGCCCC AGGGGTTACCGGATGCAGGGCCCCAGCCTGCCCTGCCTAGATGTCAATGAGTGCCTGCAGCTGCCCAAGGCCTGCGCCTACCAGTGCCAC AACCTCCAGGGCAGCTACCGCTGCCTGTGCCCCCCAGGCCAGACCCTCCTTCGCGACGGCAAGGCCTGCACCTCACTGGAGCGGAATGGA CAAAATGTGACCACCGTCAGCCACCGAGGCCCTCTATTGCCCTGGCTGCGGCCCTGGGCCTCGATCCCCGGTACCTCCTACCACGCCTGG GTCTCTCTCCGTCCGGGTCCCATGGCCCTGAGCAGTGTGGGCCGGGCCTGGTGCCCTCCTGGTTTCATCAGGCAGAACGGAGTCTGCACA GACCTTGACGAGTGCCGCGTGAGGAACCTGTGTCAGCACGCCTGCCGCAACACTGAGGGCAGCTACCAGTGCCTGTGCCCCGCCGGCTAC CGTCTGCTCCCCAGCGGGAAGAACTGCCAGGACATCAACGAGTGCGAGGAGGAGAGCATCGAGTGTGGACCCGGCCAGATGTGCTTCAAC ACCCGTGGCAGCTACCAGTGTGTGGACACACCCTGTCCTGCCACCTACCGGCAGGGCCCCAGCCCTGGGACGTGCTTCCGGCGCTGCTCG CAGGACTGCGGCACGGGCGGCCCCTCTACGCTGCAGTACCGGCTGCTGCCGCTGCCCCTGGGCGTGCGCGCCCACCACGACGTGGCCCGC CTCACCGCCTTCTCCGAGGTCGGCGTCCCCGCCAACCGCACCGAGCTCAGCATGCTGGAGCCCGACCCCCGCAGCCCCTTCGCGCTGCGT CCGCTGCGCGCGGGCCTTGGCGCGGTCTACACCCGTCGCGCGCTCACCCGCGCCGGCCTCTACCGGCTCACCGTGCGTGCTGCGGCACCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIAS1_ENST00000249636_chr15_68379088_+_HMCN2_ENST00000428715_chr9_133297964_+_3056nt GGGGCTTCGAGCGCCCTGAGCGGGGCGGAGGCTAGAGGCGGGCTGGGAAGGTGGAGGGGCGGGCCGGGGCGGGGCCAGGCCGGCTAGAGG GGCGGGTCTAGCGGCGGCCCCCGGCGAAGTTCACTGCGCTTGCGCTGACAGACGCAAGATGGCGGACAGTGCGGAACTAAAGCAAATGGT TATGAGCCTTAGAGTTTCTGAACTCCAAGTACTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGC CCTGCATTTGCTAAAGGCTGGCTGTAGTCCTGCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGAC GCCTGCAGACTTGTCCATCCCCAACGTACATTCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGG TCACCCTGCATCATCGCCATTACTCCCTGTTTCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCC AGTCCATCCGGATATAAAACTTCAAAAATTACCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGGGGAGCCCCAGGG GAGCTGGGGCAGCATGACTGGGGTGATAAATGGCCGGAAATTTGGCGTGGCCACACTCAACACCAGCGTGATGCAGGAGGCACACTCCGG GGTCAGCAGCATCCACAGCAGCATCCGCCATGTCCCAGCAAACGTGGGGCCTCTGATGCGGGTGCTCGTGGTCACCATCGCCCCCATCTA CTGGGCCCTGGCCAGAGAGAGTGGGGAAGCCCTGAATGGCCACTCTCTGACTGGGGGCAGGTTCCGGCAGGAGTCACACGTGGAGTTTGC TACAGGGGAGCTGCTCACGATGACCCAGGTGGCCCGGGGTCTGGATCCCGATGGCCTCCTGCTCCTCGACGTGGTGGTCAATGGCGTTGT CCCCGAGAGCCTGGCTGACGCAGATCTTCAAGTGCAGGACTTTGAGGAGCACTACGTGCAAACAGGGCCTGGCCAGCTGTTCGTGGGCTC CACACAGCGCTTCTTCCAGGGCGGCCTCCCCTCGTTCCTACGCTGCAACCACAGCATCCAGTACAACGCGGCCCGGGGCCCCCAGCCCCA GCTGGTGCAGCACCTGCGGGCCTCAGCTATCAGCTCGGCCTTTGATCCAGAGGCCGAGGCCCTGCGCTTCCAGCTCGCTACAGCCCTGCA GGCGGAGGAGAACGAGGTCGGCTGCCCCGAGGGCTTTGAGCTGGACTCCCAGGGAGCGTTTTGTGTGGACAGGGACGAGTGCTCAGGAGG CCCTAGCCCCTGCTCCCATGCCTGCCTTAATGCACCCGGCCGCTTCTCCTGCACCTGCCCCACTGGCTTCGCCCTGGCCTGGGATGACAG GAACTGCAGAGATGTGGACGAGTGTGCGTGGGATGCTCACCTCTGCCGAGAGGGACAGCGCTGTGTGAACCTGCTCGGGTCCTACCGCTG CCTCCCCGACTGTGGGCCTGGCTTCCGGGTGGCTGATGGGGCCGGCTGTGAAGATGTGGACGAATGCCTGGAGGGGTTGGACGACTGTCA CTACAACCAGCTCTGCGAGAACACCCCAGGCGGTCACCGCTGCAGCTGCCCCAGGGGTTACCGGATGCAGGGCCCCAGCCTGCCCTGCCT AGATGTCAATGAGTGCCTGCAGCTGCCCAAGGCCTGCGCCTACCAGTGCCACAACCTCCAGGGCAGCTACCGCTGCCTGTGCCCCCCAGG CCAGACCCTCCTTCGCGACGGCAAGGCCTGCACCTCACTGGAGCGGAATGGACAAAATGTGACCACCGTCAGCCACCGAGGCCCTCTATT GCCCTGGCTGCGGCCCTGGGCCTCGATCCCCGGTACCTCCTACCACGCCTGGGTCTCTCTCCGTCCGGGTCCCATGGCCCTGAGCAGTGT GGGCCGGGCCTGGTGCCCTCCTGGTTTCATCAGGCAGAACGGAGTCTGCACAGACCTTGACGAGTGCCGCGTGAGGAACCTGTGTCAGCA CGCCTGCCGCAACACTGAGGGCAGCTACCAGTGCCTGTGCCCCGCCGGCTACCGTCTGCTCCCCAGCGGGAAGAACTGCCAGGACATCAA CGAGTGCGAGGAGGAGAGCATCGAGTGTGGACCCGGCCAGATGTGCTTCAACACCCGTGGCAGCTACCAGTGTGTGGACACACCCTGTCC TGCCACCTACCGGCAGGGCCCCAGCCCTGGGACGTGCTTCCGGCGCTGCTCGCAGGACTGCGGCACGGGCGGCCCCTCTACGCTGCAGTA CCGGCTGCTGCCGCTGCCCCTGGGCGTGCGCGCCCACCACGACGTGGCCCGCCTCACCGCCTTCTCCGAGGTCGGCGTCCCCGCCAACCG CACCGAGCTCAGCATGCTGGAGCCCGACCCCCGCAGCCCCTTCGCGCTGCGTCCGCTGCGCGCGGGCCTTGGCGCGGTCTACACCCGTCG CGCGCTCACCCGCGCCGGCCTCTACCGGCTCACCGTGCGTGCTGCGGCACCGCGCCACCAAAGCGTCTTCGTCTTGCTCATCGCCGTGTC CCCCTACCCCTACTAAACGGGAGAGGGCATTGGCGGCCGCCCTGGCGTGACCCCCGAGGAAGGGGTCGAGGAGAAGCTTGGTCCACGCCA CCTGCTGTGGCAAGCGGAGCGTCATCGTCTCCCGCCCCGTGCGTCAGCGAGACCTTGGGTCAACACGACCCTGCGCACAGCCTTGACCCC CGACAGCGAGGACCTGACCTCACAGAGGGAGGCGTCCAGGGCGGCCCTTGGGTGGCCAGTCCCGCAGGCAGGGCCCGGGGAAGCCCGGAT CAGACCTCCAGGTCTGATCCGCCCCTCAGTGGGAGCGGGACAGGGACACAGGGCACCTGGACGCGCGGGAGAGGGGGCAGACCCCGCGTT >In-frame_PIAS1_ENST00000545237_chr15_68379088_+_HMCN2_ENST00000428715_chr9_133297964_+_3655nt TTGTTGTGGGCGCCTCTGGCGGGGGTGGCGGGGGAAGAGATAGGGAGTCCGGAGGTAGGGGCTGCAGCTGTCTCATGGGCTCGGCTTTTT CACCTTCCAGTTAGCCTCCCTGCCCCCCATGGGGAGCTGGGGCTGGGGGCAGGGTGCTCTCGTAGGGGGGATTGGGAAAGCTCCCCGTGG CCGCTTCCTCTTCCTCCTTTGCAGTCCCGGGCTCCTGTCAGGCGCTCTTCTCAGACCCCCGGGAACTTGGCTTCGGCCGCCCCGCCCCTC CGTGGATCCCAGTAGCCCCCGCCCCGGACTCGGCTTTCCCCGGCTGCTCGCTTGTCAGGAAGCGCCTGGGGTGCCCCGCTTGTGGGAAGC GCGATCCCGGGGCGATAGGGTGGGGATCTGGGGGAGAAGCTCTGGTAAAGTTTAGCGAGCCCCGGGCCGGCGTTGGGGTTCGGCTGAGAG GTAGTGAGCGGGACGTTACTCTTTCTCTCTGATTCCGGGCAGCCGAGGGGAGAAACCCCCTCGAAGAGTGTGTCTTTGGAAGCAGTGTTG GGAGGGGGGGATGCAGCTACCTCTCTCCCTTCTTTTGCCTTAGCTGGTGTGGAGGGTGAGAGGAGCCTTTGGGGGTCTCTGCACACACCA TGATGGCGATGCTGTAGCTGATGGAGAACAACCAAATGCCAGATTTGATTCTGTAGAGTTTTTCCTGTGGAATATCCTCACCGAAAGAGC TTTTCTCCTAATAACTTCACAATGTTTACACTCCAAGATTCGTATGTTAAGCAAATGGTTATGAGCCTTAGAGTTTCTGAACTCCAAGTA CTGTTGGGCTACGCCGGGAGAAACAAGCACGGACGCAAACACGAACTTCTCACAAAAGCCCTGCATTTGCTAAAGGCTGGCTGTAGTCCT GCTGTGCAAATGAAAATTAAGGAACTCTATAGGCGGCGGTTCCCACAGAAAATCATGACGCCTGCAGACTTGTCCATCCCCAACGTACAT TCAAGTCCTATGCCAGCAACTTTGTCTCCATCTACCATTCCACAACTCACTTACGATGGTCACCCTGCATCATCGCCATTACTCCCTGTT TCTCTTCTGGGACCTAAACATGAACTGGAACTCCCACATCTTACATCAGCTCTTCACCCAGTCCATCCGGATATAAAACTTCAAAAATTA CCATTTTATGATTTACTGGATGAACTGATAAAACCCACCAGTCTAGGGGAGCCCCAGGGGAGCTGGGGCAGCATGACTGGGGTGATAAAT GGCCGGAAATTTGGCGTGGCCACACTCAACACCAGCGTGATGCAGGAGGCACACTCCGGGGTCAGCAGCATCCACAGCAGCATCCGCCAT GTCCCAGCAAACGTGGGGCCTCTGATGCGGGTGCTCGTGGTCACCATCGCCCCCATCTACTGGGCCCTGGCCAGAGAGAGTGGGGAAGCC CTGAATGGCCACTCTCTGACTGGGGGCAGGTTCCGGCAGGAGTCACACGTGGAGTTTGCTACAGGGGAGCTGCTCACGATGACCCAGGTG GCCCGGGGTCTGGATCCCGATGGCCTCCTGCTCCTCGACGTGGTGGTCAATGGCGTTGTCCCCGAGAGCCTGGCTGACGCAGATCTTCAA GTGCAGGACTTTGAGGAGCACTACGTGCAAACAGGGCCTGGCCAGCTGTTCGTGGGCTCCACACAGCGCTTCTTCCAGGGCGGCCTCCCC TCGTTCCTACGCTGCAACCACAGCATCCAGTACAACGCGGCCCGGGGCCCCCAGCCCCAGCTGGTGCAGCACCTGCGGGCCTCAGCTATC AGCTCGGCCTTTGATCCAGAGGCCGAGGCCCTGCGCTTCCAGCTCGCTACAGCCCTGCAGGCGGAGGAGAACGAGGTCGGCTGCCCCGAG GGCTTTGAGCTGGACTCCCAGGGAGCGTTTTGTGTGGACAGGGACGAGTGCTCAGGAGGCCCTAGCCCCTGCTCCCATGCCTGCCTTAAT GCACCCGGCCGCTTCTCCTGCACCTGCCCCACTGGCTTCGCCCTGGCCTGGGATGACAGGAACTGCAGAGATGTGGACGAGTGTGCGTGG GATGCTCACCTCTGCCGAGAGGGACAGCGCTGTGTGAACCTGCTCGGGTCCTACCGCTGCCTCCCCGACTGTGGGCCTGGCTTCCGGGTG GCTGATGGGGCCGGCTGTGAAGATGTGGACGAATGCCTGGAGGGGTTGGACGACTGTCACTACAACCAGCTCTGCGAGAACACCCCAGGC GGTCACCGCTGCAGCTGCCCCAGGGGTTACCGGATGCAGGGCCCCAGCCTGCCCTGCCTAGATGTCAATGAGTGCCTGCAGCTGCCCAAG GCCTGCGCCTACCAGTGCCACAACCTCCAGGGCAGCTACCGCTGCCTGTGCCCCCCAGGCCAGACCCTCCTTCGCGACGGCAAGGCCTGC ACCTCACTGGAGCGGAATGGACAAAATGTGACCACCGTCAGCCACCGAGGCCCTCTATTGCCCTGGCTGCGGCCCTGGGCCTCGATCCCC GGTACCTCCTACCACGCCTGGGTCTCTCTCCGTCCGGGTCCCATGGCCCTGAGCAGTGTGGGCCGGGCCTGGTGCCCTCCTGGTTTCATC AGGCAGAACGGAGTCTGCACAGACCTTGACGAGTGCCGCGTGAGGAACCTGTGTCAGCACGCCTGCCGCAACACTGAGGGCAGCTACCAG TGCCTGTGCCCCGCCGGCTACCGTCTGCTCCCCAGCGGGAAGAACTGCCAGGACATCAACGAGTGCGAGGAGGAGAGCATCGAGTGTGGA CCCGGCCAGATGTGCTTCAACACCCGTGGCAGCTACCAGTGTGTGGACACACCCTGTCCTGCCACCTACCGGCAGGGCCCCAGCCCTGGG ACGTGCTTCCGGCGCTGCTCGCAGGACTGCGGCACGGGCGGCCCCTCTACGCTGCAGTACCGGCTGCTGCCGCTGCCCCTGGGCGTGCGC GCCCACCACGACGTGGCCCGCCTCACCGCCTTCTCCGAGGTCGGCGTCCCCGCCAACCGCACCGAGCTCAGCATGCTGGAGCCCGACCCC CGCAGCCCCTTCGCGCTGCGTCCGCTGCGCGCGGGCCTTGGCGCGGTCTACACCCGTCGCGCGCTCACCCGCGCCGGCCTCTACCGGCTC ACCGTGCGTGCTGCGGCACCGCGCCACCAAAGCGTCTTCGTCTTGCTCATCGCCGTGTCCCCCTACCCCTACTAAACGGGAGAGGGCATT GGCGGCCGCCCTGGCGTGACCCCCGAGGAAGGGGTCGAGGAGAAGCTTGGTCCACGCCACCTGCTGTGGCAAGCGGAGCGTCATCGTCTC CCGCCCCGTGCGTCAGCGAGACCTTGGGTCAACACGACCCTGCGCACAGCCTTGACCCCCGACAGCGAGGACCTGACCTCACAGAGGGAG GCGTCCAGGGCGGCCCTTGGGTGGCCAGTCCCGCAGGCAGGGCCCGGGGAAGCCCGGATCAGACCTCCAGGTCTGATCCGCCCCTCAGTG GGAGCGGGACAGGGACACAGGGCACCTGGACGCGCGGGAGAGGGGGCAGACCCCGCGTTAGGGGTGGCAGCAGCTGTCGCCCGGCCACAC 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FusionGenePPI for PIAS1_HMCN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIAS1 | STAT1, DNMT3A, STAB2, UBE2I, SUMO1, SP3, TP53, CSRP2, AR, MX1, SUMO2, SIAH1, SIAH2, AKT1, ZMIZ2, BRCA1, MBD1, CREB1, SREBF2, GLUL, MITF, NCOR1, PPARG, TRIM27, ZNF76, JUN, HIC1, DDX5, SATB1, MAML1, DCLRE1A, DNMT3B, RBBP6, SAFB, ESR1, PPP1CA, MDC1, PRDM1, MDM2, CHUK, DNM1, PML, ATXN7, SRSF1, NFATC1, CEBPE, CEBPA, FLI1, CSNK2A1, CASP8AP2, MYB, SERBP1, ZMYND11, RAD54L2, PLAG1, NR1H3, NR1H2, PPARGC1B, PPARGC1A, BARD1, PAXIP1, PPP1CC, HTT, ATXN1, SMAD7, PRPF40A, SKIL, SMAD4, SMAD1, SOX2, SGTA, YWHAZ, SPOP, SUMO3, SHFM1, CBS, L3MBTL2, CEP250, TRIM63, TRIM55, ZNF451, PIAS1, FOXA1, HIF1A, ID1, KLC1, FRAT1, ERP44, POLK, VPS16, PIAS2, PTK2, TERF2, TRIM5, HECTD2, GSK3B, NCOA3, PSME3, TRIM35, GTF2IRD1, NR0B2, EP300 | HMCN2 | SRPK2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIAS1_HMCN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIAS1_HMCN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PIAS1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | PIAS1 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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