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Fusion gene ID: 27072 |
FusionGeneSummary for PI4KB_SYT11 |
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Fusion gene information | Fusion gene name: PI4KB_SYT11 | Fusion gene ID: 27072 | Hgene | Tgene | Gene symbol | PI4KB | SYT11 | Gene ID | 5298 | 91683 |
Gene name | phosphatidylinositol 4-kinase beta | synaptotagmin 12 | |
Synonyms | NPIK|PI4K-BETA|PI4K92|PI4KBETA|PI4KIIIBETA|PIK4CB | SYT11|sytXII | |
Cytomap | 1q21.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol 4-kinase betaPtdIns 4-kinase betaphosphatidylinositol 4-kinase, catalytic, betaphosphatidylinositol 4-kinase, wortmannin-sensitivetype III phosphatidylinositol 4-kinase beta | synaptotagmin-12synaptotagmin-XII | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UBF8 | Q9BT88 | |
Ensembl transtripts involved in fusion gene | ENST00000368874, ENST00000271657, ENST00000368875, ENST00000368873, ENST00000529142, ENST00000368872, | ENST00000368324, ENST00000539162, | |
Fusion gene scores | * DoF score | 3 X 5 X 5=75 | 4 X 1 X 4=16 |
# samples | 5 | 4 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PI4KB [Title/Abstract] AND SYT11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-86-A4P7-01A | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000368874 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-5UTR | ENST00000368874 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
intron-3CDS | ENST00000271657 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
intron-5UTR | ENST00000271657 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-3CDS | ENST00000368875 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-5UTR | ENST00000368875 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-3CDS | ENST00000368873 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-5UTR | ENST00000368873 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-3CDS | ENST00000529142 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-5UTR | ENST00000529142 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-3CDS | ENST00000368872 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
5UTR-5UTR | ENST00000368872 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
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FusionProtFeatures for PI4KB_SYT11 |
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Hgene | Tgene |
PI4KB | SYT11 |
Phosphorylates phosphatidylinositol (PI) in the firstcommitted step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgidisintegration/reorganization during mitosis, possibly via itsphosphorylation. Involved in Golgi-to-plasma membrane trafficking(By similarity). {ECO:0000250, ECO:0000269|PubMed:10559940,ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:9405935}. | May be involved in Ca(2+)-dependent exocytosis ofsecretory vesicles through Ca(2+) and phospholipid binding to theC2 domain or may serve as Ca(2+) sensors in the process ofvesicular trafficking and exocytosis. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PI4KB_SYT11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PI4KB_SYT11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PI4KB | YWHAG, YWHAB, YWHAQ, SFN, NCS1, KBTBD7, MYC, RDM1, CASP1, CDK7, XPO1, UTRN, PTAR1, C10orf76, DNAJC10, RAB3IP, CBY1 | SYT11 | APPBP2, PARK2, ATP13A2, SGTA, TTC1, UBE2O, PDLIM7, PRKAR1B, PDLIM5, NTRK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PI4KB_SYT11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PI4KB_SYT11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SYT11 | C0036341 | Schizophrenia | 1 | PSYGENET |