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Fusion gene ID: 27058 |
FusionGeneSummary for PI4KA_FAM175A |
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Fusion gene information | Fusion gene name: PI4KA_FAM175A | Fusion gene ID: 27058 | Hgene | Tgene | Gene symbol | PI4KA | FAM175A | Gene ID | 5297 |
Gene name | phosphatidylinositol 4-kinase alpha | ||
Synonyms | PI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230 | ||
Cytomap | 22q11.21 | ||
Type of gene | protein-coding | ||
Description | phosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, a | ||
Modification date | 20180523 | ||
UniProtAcc | P42356 | ||
Ensembl transtripts involved in fusion gene | ENST00000255882, ENST00000572273, ENST00000414196, ENST00000466162, | ENST00000505489, ENST00000321945, ENST00000506553, ENST00000515303, | |
Fusion gene scores | * DoF score | 15 X 8 X 10=1200 | 2 X 1 X 2=4 |
# samples | 21 | 2 | |
** MAII score | log2(21/1200*10)=-2.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PI4KA [Title/Abstract] AND FAM175A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PI4KA | GO:0016310 | phosphorylation | 25327288 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-VP-A87J-01A | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000255882 | ENST00000505489 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000255882 | ENST00000321945 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000255882 | ENST00000506553 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000255882 | ENST00000515303 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000572273 | ENST00000505489 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000572273 | ENST00000321945 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000572273 | ENST00000506553 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5CDS-5UTR | ENST00000572273 | ENST00000515303 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
intron-5UTR | ENST00000414196 | ENST00000505489 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
intron-5UTR | ENST00000414196 | ENST00000321945 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
intron-5UTR | ENST00000414196 | ENST00000506553 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
intron-5UTR | ENST00000414196 | ENST00000515303 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5UTR-5UTR | ENST00000466162 | ENST00000505489 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5UTR-5UTR | ENST00000466162 | ENST00000321945 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5UTR-5UTR | ENST00000466162 | ENST00000506553 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
5UTR-5UTR | ENST00000466162 | ENST00000515303 | PI4KA | chr22 | 21147481 | - | FAM175A | chr4 | 84403397 | - |
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FusionProtFeatures for PI4KA_FAM175A |
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Hgene | Tgene |
PI4KA | FAM175A |
Acts on phosphatidylinositol (PtdIns) in the firstcommitted step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268,ECO:0000269|PubMed:23229899}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PI4KA_FAM175A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PI4KA_FAM175A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PI4KA | STRN4, LCK, MRPL44, TNNT1, C8orf33, HARS, FN1, VCAM1, ITGA4, CCDC8, CD274, CA14, HLA-B, HLA-C, CD244, TGOLN2, NTRK1, MED4, MED20, SORT1, SYNCRIP, MRPL1, BAG6, FOXL1, NDUFA4, C17orf89, CDH1, PPP3CB, PPP3CC, PI4KAP1, PLBD1, SERPINB7, SERPINB2, KLK5, KLK7, POF1B, A2ML1, CRYAB, SDR9C7, ECM1, JUP, ADH7, TYMP, IVL, HAL, FLG, CDSN, UBR4, OPRM1, RGS20, SERPINA12, RNASE7, SBSN, NEFH, CHRM3, C5AR2, FAM174A, S100A9, CALML3, NPY2R, SDC2, NCCRP1, DSG1, TGM1, SERPINB13, CD83, DSC2, EVPL, DUSP14, LOR, CD79B, MTNR1B, TRIM25 | FAM175A | BRCC3, BRE, BABAM1, UIMC1, UBC, BRCA1, BARD1, HSPA4, SUMO2, MDC1, PAXIP1, FANCG, LAMC1, WTAP, RABGGTB, TEKT4, PARP1, PSMC5, ALDH6A1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PI4KA_FAM175A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PI4KA_FAM175A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PI4KA | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | PI4KA | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | PI4KA | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | PI4KA | C4225295 | POLYMICROGYRIA, PERISYLVIAN, WITH CEREBELLAR HYPOPLASIA AND ARTHROGRYPOSIS | 1 | UNIPROT |