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Fusion gene ID: 27052 |
FusionGeneSummary for PI4K2B_PI4K2B |
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Fusion gene information | Fusion gene name: PI4K2B_PI4K2B | Fusion gene ID: 27052 | Hgene | Tgene | Gene symbol | PI4K2B | PI4K2B | Gene ID | 55300 | 55300 |
Gene name | phosphatidylinositol 4-kinase type 2 beta | phosphatidylinositol 4-kinase type 2 beta | |
Synonyms | PI4KIIB|PIK42B | PI4KIIB|PIK42B | |
Cytomap | 4p15.2 | 4p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol 4-kinase type 2-betaPI4KII-BETAphosphatidylinositol 4-kinase type-II beta | phosphatidylinositol 4-kinase type 2-betaPI4KII-BETAphosphatidylinositol 4-kinase type-II beta | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TCG2 | Q8TCG2 | |
Ensembl transtripts involved in fusion gene | ENST00000512921, ENST00000507794, ENST00000264864, | ENST00000512921, ENST00000507794, ENST00000264864, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PI4K2B [Title/Abstract] AND PI4K2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW936523 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000512921 | ENST00000512921 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000512921 | ENST00000507794 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000512921 | ENST00000264864 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000507794 | ENST00000512921 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000507794 | ENST00000507794 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000507794 | ENST00000264864 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000264864 | ENST00000512921 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000264864 | ENST00000507794 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
intron-intron | ENST00000264864 | ENST00000264864 | PI4K2B | chr4 | 25255306 | + | PI4K2B | chr4 | 25238182 | + |
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FusionProtFeatures for PI4K2B_PI4K2B |
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Hgene | Tgene |
PI4K2B | PI4K2B |
Together with PI4K2A and the type III PI4Ks (PIK4CA andPIK4CB) it contributes to the overall PI4-kinase activity of thecell. This contribution may be especially significant in plasmamembrane, endosomal and Golgi compartments. The phosphorylation ofphosphatidylinositol (PI) to PI4P is the first committed step inthe generation of phosphatidylinositol 4,5-bisphosphate (PIP2), aprecursor of the second messenger inositol 1,4,5-trisphosphate(InsP3). Contributes to the production of InsP3 in stimulatedcells and is likely to be involved in the regulation of vesiculartrafficking. {ECO:0000269|PubMed:11923287}. | Together with PI4K2A and the type III PI4Ks (PIK4CA andPIK4CB) it contributes to the overall PI4-kinase activity of thecell. This contribution may be especially significant in plasmamembrane, endosomal and Golgi compartments. The phosphorylation ofphosphatidylinositol (PI) to PI4P is the first committed step inthe generation of phosphatidylinositol 4,5-bisphosphate (PIP2), aprecursor of the second messenger inositol 1,4,5-trisphosphate(InsP3). Contributes to the production of InsP3 in stimulatedcells and is likely to be involved in the regulation of vesiculartrafficking. {ECO:0000269|PubMed:11923287}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PI4K2B_PI4K2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PI4K2B_PI4K2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PI4K2B_PI4K2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PI4K2B_PI4K2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PI4K2B | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PI4K2B | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PI4K2B | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | PI4K2B | C0036341 | Schizophrenia | 1 | PSYGENET |