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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27052

FusionGeneSummary for PI4K2B_PI4K2B

check button Fusion gene summary
Fusion gene informationFusion gene name: PI4K2B_PI4K2B
Fusion gene ID: 27052
HgeneTgene
Gene symbol

PI4K2B

PI4K2B

Gene ID

55300

55300

Gene namephosphatidylinositol 4-kinase type 2 betaphosphatidylinositol 4-kinase type 2 beta
SynonymsPI4KIIB|PIK42BPI4KIIB|PIK42B
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4-kinase type 2-betaPI4KII-BETAphosphatidylinositol 4-kinase type-II betaphosphatidylinositol 4-kinase type 2-betaPI4KII-BETAphosphatidylinositol 4-kinase type-II beta
Modification date2018052320180523
UniProtAcc

Q8TCG2

Q8TCG2

Ensembl transtripts involved in fusion geneENST00000512921, ENST00000507794, 
ENST00000264864, 
ENST00000512921, 
ENST00000507794, ENST00000264864, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: PI4K2B [Title/Abstract] AND PI4K2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW936523PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000512921ENST00000512921PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000512921ENST00000507794PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000512921ENST00000264864PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000507794ENST00000512921PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000507794ENST00000507794PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000507794ENST00000264864PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000264864ENST00000512921PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000264864ENST00000507794PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+
intron-intronENST00000264864ENST00000264864PI4K2Bchr4

25255306

+PI4K2Bchr4

25238182

+

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FusionProtFeatures for PI4K2B_PI4K2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PI4K2B

Q8TCG2

PI4K2B

Q8TCG2

Together with PI4K2A and the type III PI4Ks (PIK4CA andPIK4CB) it contributes to the overall PI4-kinase activity of thecell. This contribution may be especially significant in plasmamembrane, endosomal and Golgi compartments. The phosphorylation ofphosphatidylinositol (PI) to PI4P is the first committed step inthe generation of phosphatidylinositol 4,5-bisphosphate (PIP2), aprecursor of the second messenger inositol 1,4,5-trisphosphate(InsP3). Contributes to the production of InsP3 in stimulatedcells and is likely to be involved in the regulation of vesiculartrafficking. {ECO:0000269|PubMed:11923287}. Together with PI4K2A and the type III PI4Ks (PIK4CA andPIK4CB) it contributes to the overall PI4-kinase activity of thecell. This contribution may be especially significant in plasmamembrane, endosomal and Golgi compartments. The phosphorylation ofphosphatidylinositol (PI) to PI4P is the first committed step inthe generation of phosphatidylinositol 4,5-bisphosphate (PIP2), aprecursor of the second messenger inositol 1,4,5-trisphosphate(InsP3). Contributes to the production of InsP3 in stimulatedcells and is likely to be involved in the regulation of vesiculartrafficking. {ECO:0000269|PubMed:11923287}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PI4K2B_PI4K2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PI4K2B_PI4K2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PI4K2B_PI4K2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PI4K2B_PI4K2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePI4K2BC0005586Bipolar Disorder1PSYGENET
HgenePI4K2BC0036341Schizophrenia1PSYGENET
TgenePI4K2BC0005586Bipolar Disorder1PSYGENET
TgenePI4K2BC0036341Schizophrenia1PSYGENET