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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 27051

FusionGeneSummary for PI4K2B_INSR

check button Fusion gene summary
Fusion gene informationFusion gene name: PI4K2B_INSR
Fusion gene ID: 27051
HgeneTgene
Gene symbol

PI4K2B

INSR

Gene ID

55300

3643

Gene namephosphatidylinositol 4-kinase type 2 betainsulin receptor
SynonymsPI4KIIB|PIK42BCD220|HHF5
Cytomap

4p15.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4-kinase type 2-betaPI4KII-BETAphosphatidylinositol 4-kinase type-II betainsulin receptorIR
Modification date2018052320180523
UniProtAcc

Q8TCG2

P06213

Ensembl transtripts involved in fusion geneENST00000512921, ENST00000507794, 
ENST00000264864, 
ENST00000341500, 
ENST00000302850, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 10 X 6=780
# samples 215
** MAII scorelog2(2/8*10)=1.32192809488736log2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PI4K2B [Title/Abstract] AND INSR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINSR

GO:0001934

positive regulation of protein phosphorylation

7556070

TgeneINSR

GO:0007186

G-protein coupled receptor signaling pathway

9092559

TgeneINSR

GO:0008284

positive regulation of cell proliferation

17925406

TgeneINSR

GO:0008286

insulin receptor signaling pathway

6849137|8440175|20455999

TgeneINSR

GO:0018108

peptidyl-tyrosine phosphorylation

8496180

TgeneINSR

GO:0032148

activation of protein kinase B activity

7556070

TgeneINSR

GO:0032869

cellular response to insulin stimulus

8440175

TgeneINSR

GO:0043410

positive regulation of MAPK cascade

20455999

TgeneINSR

GO:0045725

positive regulation of glycogen biosynthetic process

17925406

TgeneINSR

GO:0046326

positive regulation of glucose import

3518947

TgeneINSR

GO:0046777

protein autophosphorylation

6849137|8496180

TgeneINSR

GO:0051290

protein heterotetramerization

1898103

TgeneINSR

GO:0060267

positive regulation of respiratory burst

9092559


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KZ-01API4K2Bchr4

25236053

+INSRchr19

7267907

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000512921ENST00000341500PI4K2Bchr4

25236053

+INSRchr19

7267907

-
intron-3CDSENST00000512921ENST00000302850PI4K2Bchr4

25236053

+INSRchr19

7267907

-
intron-3CDSENST00000507794ENST00000341500PI4K2Bchr4

25236053

+INSRchr19

7267907

-
intron-3CDSENST00000507794ENST00000302850PI4K2Bchr4

25236053

+INSRchr19

7267907

-
In-frameENST00000264864ENST00000341500PI4K2Bchr4

25236053

+INSRchr19

7267907

-
In-frameENST00000264864ENST00000302850PI4K2Bchr4

25236053

+INSRchr19

7267907

-

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FusionProtFeatures for PI4K2B_INSR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PI4K2B

Q8TCG2

INSR

P06213

Together with PI4K2A and the type III PI4Ks (PIK4CA andPIK4CB) it contributes to the overall PI4-kinase activity of thecell. This contribution may be especially significant in plasmamembrane, endosomal and Golgi compartments. The phosphorylation ofphosphatidylinositol (PI) to PI4P is the first committed step inthe generation of phosphatidylinositol 4,5-bisphosphate (PIP2), aprecursor of the second messenger inositol 1,4,5-trisphosphate(InsP3). Contributes to the production of InsP3 in stimulatedcells and is likely to be involved in the regulation of vesiculartrafficking. {ECO:0000269|PubMed:11923287}. Receptor tyrosine kinase which mediates the pleiotropicactions of insulin. Binding of insulin leads to phosphorylation ofseveral intracellular substrates, including, insulin receptorsubstrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signalingintermediates. Each of these phosphorylated proteins serve asdocking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognizedifferent phosphotyrosine residues, including the p85 regulatorysubunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead tothe activation of two main signaling pathways: the PI3K-AKT/PKBpathway, which is responsible for most of the metabolic actions ofinsulin, and the Ras-MAPK pathway, which regulates expression ofsome genes and cooperates with the PI3K pathway to control cellgrowth and differentiation. Binding of the SH2 domains of PI3K tophosphotyrosines on IRS1 leads to the activation of PI3K and thegeneration of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3),a lipid second messenger, which activates several PIP3-dependentserine/threonine kinases, such as PDPK1 and subsequently AKT/PKB.The net effect of this pathway is to produce a translocation ofthe glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles tothe cell membrane to facilitate glucose transport. Moreover, uponinsulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD;regulates the expression of gluconeogenic and lipogenic enzymes bycontrolling the activity of the winged helix or forkhead (FOX)class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulatescell growth and metabolism and integrates signals from insulin.AKT mediates insulin-stimulated protein synthesis byphosphorylating TSC2 thereby activating mTORC1 pathway. TheRas/RAF/MAP2K/MAPK pathway is mainly involved in mediating cellgrowth, survival and cellular differentiation of insulin.Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers theactivation of the Ras/RAF/MAP2K/MAPK pathway. In addition tobinding insulin, the insulin receptor can bind insulin-like growthfactors (IGFI and IGFII). Isoform Short has a higher affinity forIGFII binding. When present in a hybrid receptor with IGF1R, bindsIGF1. PubMed:12138094 shows that hybrid receptors composed ofIGF1R and INSR isoform Long are activated with a high affinity byIGF1, with low affinity by IGF2 and not significantly activated byinsulin, and that hybrid receptors composed of IGF1R and INSRisoform Short are activated by IGF1, IGF2 and insulin. Incontrast, PubMed:16831875 shows that hybrid receptors composed ofIGF1R and INSR isoform Long and hybrid receptors composed of IGF1Rand INSR isoform Short have similar binding characteristics, bothbind IGF1 and have a low affinity for insulin.{ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505,ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688,ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530,ECO:0000269|PubMed:9428692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PI4K2B_INSR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PI4K2B_ENST00000264864_chr4_25236053_+_INSR_ENST00000341500_chr19_7267907_-_1427aa
MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAGDEELPLPPGDVGVSRSSSAELDRSRPAVSV
CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFE
MVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSH
CQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQY
VIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGY
LKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDI
ALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQN
HPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAE
DSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGD
VGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGP
VTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
YLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGM
VYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNP
GRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTS
SDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHS

>In-frame_PI4K2B_ENST00000264864_chr4_25236053_+_INSR_ENST00000302850_chr19_7267907_-_1439aa
MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAGDEELPLPPGDVGVSRSSSAELDRSRPAVSV
CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFE
MVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSH
CQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQY
VIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGY
LKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDI
ALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQN
HPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAE
DSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAED
PRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSART
MPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNG
SWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKIT
LLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSY
LRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMA
PESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PI4K2B_ENST00000264864_chr4_25236053_+_INSR_ENST00000341500_chr19_7267907_-_4281nt
ATGGAGGATCCCTCCGAGCCCGACCGGTTGGCGTCCGCGGACGGCGGGAGCCCGGAGGAGGAGGAGGATGGGGAGCGGGAGCCGCTGCTA
CCGCGGATCGCCTGGGCCCACCCGCGGAGAGGCGCCCCAGGCAGCGCCGTGAGGCTGCTGGACGCTGCCGGGGAGGAGGGCGAGGCCGGC
GACGAGGAGCTGCCCCTCCCGCCCGGGGACGTGGGGGTCTCCCGGAGTTCGTCCGCCGAGCTGGACCGGAGCCGCCCCGCGGTTTCAGTG
TGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTGCTCTGTCATCGAAGGACACTTGCAGATACTCTTG
ATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGATTACTTGCTGCTCTTCCGGGTCTAT
GGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGCTGGTCATCTTCGAG
ATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTGTTAC
TTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAGTGTGGAGAC
ATCTGTCCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCAC
TGCCAGAAAGTTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCT
CAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCAC
TTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTAC
GTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCC
TGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACCGTCATCAAC
GGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTAT
CTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAAATTGGGAAC
TACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACTCTTC
TTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATT
GCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTG
AGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAG
TTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAAC
CACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGG
ACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCA
TCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAA
GACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCT
CAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAG
GAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGGCGAT
GTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGG
CCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAAC
CAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCT
GTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTG
AGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTG
TCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGAC
TATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTAT
CTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTT
CCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATG
GTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGA
GAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGC
CAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCT
GGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTG
CATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAA
ACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCT
TCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTG
AAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAAC
CCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGC
GAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAG
AGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGA

>In-frame_PI4K2B_ENST00000264864_chr4_25236053_+_INSR_ENST00000302850_chr19_7267907_-_4317nt
ATGGAGGATCCCTCCGAGCCCGACCGGTTGGCGTCCGCGGACGGCGGGAGCCCGGAGGAGGAGGAGGATGGGGAGCGGGAGCCGCTGCTA
CCGCGGATCGCCTGGGCCCACCCGCGGAGAGGCGCCCCAGGCAGCGCCGTGAGGCTGCTGGACGCTGCCGGGGAGGAGGGCGAGGCCGGC
GACGAGGAGCTGCCCCTCCCGCCCGGGGACGTGGGGGTCTCCCGGAGTTCGTCCGCCGAGCTGGACCGGAGCCGCCCCGCGGTTTCAGTG
TGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTGCTCTGTCATCGAAGGACACTTGCAGATACTCTTG
ATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGATTACTTGCTGCTCTTCCGGGTCTAT
GGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGCTGGTCATCTTCGAG
ATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTGTTAC
TTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAGTGTGGAGAC
ATCTGTCCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCAC
TGCCAGAAAGTTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCT
CAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCAC
TTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTAC
GTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCC
TGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACCGTCATCAAC
GGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTAT
CTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAAATTGGGAAC
TACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACTCTTC
TTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATT
GCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTG
AGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAG
TTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAAC
CACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGG
ACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCA
TCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAA
GACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCT
CAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAG
GAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGAGGAC
CCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCC
TCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACAC
TTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACC
ATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCG
AAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCAC
TTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGC
TCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTT
GTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCT
TCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACC
CTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTG
GCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCAT
CACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTAC
CTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCT
GACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAA
ATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCA
CCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAA
CAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGA
GTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTG
CACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATG
GAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PI4K2B_ENST00000264864_chr4_25236053_+_INSR_ENST00000341500_chr19_7267907_-_9271nt
GGAGGCGCGAGGTGGGGCGCGGCCGGCGGCGAGGCGGGACAACCGCTGGGCGGGCGCCAAGCGTGCCCGTGCGCTGGTGAGGTGGCGTCC
GTTCTACCCGGTCGCTCCCGTTCCGCGCCATGCAGAGCCCAGTCTCTGGCACCTGGCTGCTCTGATCTGGTCTCAGCGCGGAGGGAGCAG
AGGGAGTCCATGGAGGATCCCTCCGAGCCCGACCGGTTGGCGTCCGCGGACGGCGGGAGCCCGGAGGAGGAGGAGGATGGGGAGCGGGAG
CCGCTGCTACCGCGGATCGCCTGGGCCCACCCGCGGAGAGGCGCCCCAGGCAGCGCCGTGAGGCTGCTGGACGCTGCCGGGGAGGAGGGC
GAGGCCGGCGACGAGGAGCTGCCCCTCCCGCCCGGGGACGTGGGGGTCTCCCGGAGTTCGTCCGCCGAGCTGGACCGGAGCCGCCCCGCG
GTTTCAGTGTGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTGCTCTGTCATCGAAGGACACTTGCAG
ATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGATTACTTGCTGCTCTTC
CGGGTCTATGGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGCTGGTC
ATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAG
CTCTGTTACTTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAG
TGTGGAGACATCTGTCCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACT
CATAGTCACTGCCAGAAAGTTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGC
AACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCG
TACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGC
CACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGC
CTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACC
GTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATT
TCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAA
ATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGG
AAACTCTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGA
AACGACATTGCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAG
ATCTTGCTGAGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAAT
GTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAA
TCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGAT
GAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTG
TCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGG
CAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCT
GAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAG
GAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCC
CTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAG
GAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAG
GCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATT
GTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTG
TATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTG
CGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTAC
GTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGA
AGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGT
GATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCC
TTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCC
AGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTG
TCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAG
AATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAG
AAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGAC
ATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTC
ACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAA
CAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGG
CAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTC
TTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCG
CACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACAC
ATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGG
GTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCG
TTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGG
CAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAG
CAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACT
TCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGC
TTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACC
AATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACG
GCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCT
CTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTC
ACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAA
GAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAAT
TTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTG
GGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGC
TAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAG
GTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTC
TTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATG
GACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCA
GTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGT
TGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACC
GTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATG
CGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGT
CATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATG
ATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAA
TTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAG
TGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATA
TATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGT
GATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGG
AACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAG
GTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCA
TCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTT
CCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAG
CACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCT
TTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTT
TTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCC
ATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACC
TGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAA
AGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGG
TTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCT
TAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCA
CATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGG
AAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCA
TAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAA
TGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGG
TCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAA
TGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACA
TGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAA
AGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTA
AGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACC
AGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGG
AGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGC
TTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAA
CTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCC
TTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAATGACCTGTTTATATTAAAATTCTGATTAAATTATCTGAGAAT

>In-frame_PI4K2B_ENST00000264864_chr4_25236053_+_INSR_ENST00000302850_chr19_7267907_-_4935nt
GGAGGCGCGAGGTGGGGCGCGGCCGGCGGCGAGGCGGGACAACCGCTGGGCGGGCGCCAAGCGTGCCCGTGCGCTGGTGAGGTGGCGTCC
GTTCTACCCGGTCGCTCCCGTTCCGCGCCATGCAGAGCCCAGTCTCTGGCACCTGGCTGCTCTGATCTGGTCTCAGCGCGGAGGGAGCAG
AGGGAGTCCATGGAGGATCCCTCCGAGCCCGACCGGTTGGCGTCCGCGGACGGCGGGAGCCCGGAGGAGGAGGAGGATGGGGAGCGGGAG
CCGCTGCTACCGCGGATCGCCTGGGCCCACCCGCGGAGAGGCGCCCCAGGCAGCGCCGTGAGGCTGCTGGACGCTGCCGGGGAGGAGGGC
GAGGCCGGCGACGAGGAGCTGCCCCTCCCGCCCGGGGACGTGGGGGTCTCCCGGAGTTCGTCCGCCGAGCTGGACCGGAGCCGCCCCGCG
GTTTCAGTGTGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTGCTCTGTCATCGAAGGACACTTGCAG
ATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGATTACTTGCTGCTCTTC
CGGGTCTATGGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGCTGGTC
ATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAG
CTCTGTTACTTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAG
TGTGGAGACATCTGTCCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACT
CATAGTCACTGCCAGAAAGTTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGC
AACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCG
TACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGC
CACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGC
CTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACC
GTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATT
TCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAA
ATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGG
AAACTCTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGA
AACGACATTGCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAG
ATCTTGCTGAGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAAT
GTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAA
TCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGAT
GAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTG
TCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGG
CAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCT
GAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAG
GAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGT
GCCGAGGACCCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCC
AACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGC
TTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGT
GCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGG
CAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCC
CGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCG
GGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCC
CTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTT
TACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAG
AAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAG
ACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTC
ACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTG
AAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCA
GAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTT
ACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGG
TGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGC
TTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGT
CCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAG
GACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTT
GAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTC
AAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCT
TCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCT
CACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAAC
TAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGG
ATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTT


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FusionGenePPI for PI4K2B_INSR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PI4K2BMAPK14, HSP90AA1, AKT1, ELAVL1, SPINT2, EFNB2, PLAUR, GMPPB, GFOD1, HAVCR2, MANSC1, TRIP13, SSSCA1, SIRT6, KBTBD4, HDAC10, PDDC1, TRIM25INSRCSK, IRS1, FRS2, SOCS3, IRS2, GRB10, MAPK1, MAPK3, AHSG, KHDRBS1, PTPN11, PTPN6, ENPP1, HRAS, CAV1, GRB2, SMAD2, PRKCD, VAV3, INSRR, SH2B1, INPPL1, SNX6, SNX1, SNX2, SNX4, RASA1, JAK2, VAV1, GRB7, SHC1, SYNCRIP, GRB14, PTPN1, SORBS1, SH2B2, HGS, SOCS1, SOCS6, PLCG1, STAT5A, STAT5B, JAK1, DOK1, IRF7, TEAD1, MOK, ARRB2, KRT31, SNX17, SNX27, SQSTM1, ATIC, PTPLAD1, PRKAA1, PRKAA2, KIF5A, PTPRK, PON2, NTRK1, TMEM17, MARCH1, PPM1A, PPM1F, PTPRR, DUSP18, MPZL2, SSH1, UNC5CL, FAM19A4, SCGB1D1, CLEC3A, FAM19A3, INSL5, DNASE1L2, DUSP19, STYX, TRIM25, INSR, ACP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PI4K2B_INSR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneINSRP06213DB00046Insulin LisproInsulin receptorbiotechapproved
TgeneINSRP06213DB00047Insulin GlargineInsulin receptorbiotechapproved
TgeneINSRP06213DB00071Insulin PorkInsulin receptorbiotechapproved
TgeneINSRP06213DB01306Insulin AspartInsulin receptorbiotechapproved
TgeneINSRP06213DB01307Insulin DetemirInsulin receptorbiotechapproved
TgeneINSRP06213DB01309Insulin GlulisineInsulin receptorbiotechapproved
TgeneINSRP06213DB09564Insulin DegludecInsulin receptorbiotechapproved
TgeneINSRP06213DB00030Insulin HumanInsulin receptorbiotechapproved|investigational
TgeneINSRP06213DB01277MecaserminInsulin receptorbiotechapproved|investigational

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RelatedDiseases for PI4K2B_INSR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePI4K2BC0005586Bipolar Disorder1PSYGENET
HgenePI4K2BC0036341Schizophrenia1PSYGENET
TgeneINSRC0342278Diabetes Mellitus, Insulin-Resistant, with Acanthosis Nigricans18CTD_human;UNIPROT
TgeneINSRC0265344Donohue Syndrome14CTD_human;ORPHANET;UNIPROT
TgeneINSRC0271695Rabson-Mendenhall Syndrome7ORPHANET;UNIPROT
TgeneINSRC0011860Diabetes Mellitus, Non-Insulin-Dependent3HPO;UNIPROT
TgeneINSRC1864952Hyperinsulinemic Hypoglycemia, Familial, 53CTD_human;ORPHANET;UNIPROT
TgeneINSRC0011853Diabetes Mellitus, Experimental2CTD_human
TgeneINSRC0020459Hyperinsulinism2CTD_human;HPO
TgeneINSRC0021655Insulin Resistance2CTD_human
TgeneINSRC0024115Lung diseases2CTD_human
TgeneINSRC0002395Alzheimer's Disease1CTD_human
TgeneINSRC0011882Diabetic Neuropathies1CTD_human
TgeneINSRC0020429Hyperalgesia1CTD_human
TgeneINSRC0020456Hyperglycemia1CTD_human;HPO
TgeneINSRC0030567Parkinson Disease1CTD_human
TgeneINSRC0235833Congenital diaphragmatic hernia1CTD_human
TgeneINSRC0236969Substance-Related Disorders1CTD_human
TgeneINSRC0271650Impaired glucose tolerance1CTD_human
TgeneINSRC0752347Lewy Body Disease1CTD_human