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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27043

FusionGeneSummary for PHYKPL_STMN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHYKPL_STMN1
Fusion gene ID: 27043
HgeneTgene
Gene symbol

PHYKPL

STMN1

Gene ID

85007

3925

Gene name5-phosphohydroxy-L-lysine phospho-lyasestathmin 1
SynonymsAGXT2L2|PHLUC1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN
Cytomap

5q35.3

1p36.11

Type of geneprotein-codingprotein-coding
Description5-phosphohydroxy-L-lysine phospho-lyase5-phosphonooxy-L-lysine phospho-lyasealanine--glyoxylate aminotransferase 2-like 2stathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215
Modification date2018052320180523
UniProtAcc

Q8IUZ5

P16949

Ensembl transtripts involved in fusion geneENST00000308158, ENST00000481811, 
ENST00000476170, 
ENST00000426559, 
ENST00000455785, ENST00000399728, 
ENST00000465604, ENST00000357865, 
ENST00000374291, 
Fusion gene scores* DoF score4 X 4 X 1=165 X 5 X 4=100
# samples 55
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHYKPL [Title/Abstract] AND STMN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTMN1

GO:0007019

microtubule depolymerization

9880330

TgeneSTMN1

GO:0007052

mitotic spindle organization

9271428


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK123488PHYKPLchr5

177653443

-STMN1chr1

26228239

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000308158ENST00000426559PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000308158ENST00000455785PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000308158ENST00000399728PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-5UTRENST00000308158ENST00000465604PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000308158ENST00000357865PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000308158ENST00000374291PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000481811ENST00000426559PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000481811ENST00000455785PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000481811ENST00000399728PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-5UTRENST00000481811ENST00000465604PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000481811ENST00000357865PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000481811ENST00000374291PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000476170ENST00000426559PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000476170ENST00000455785PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000476170ENST00000399728PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-5UTRENST00000476170ENST00000465604PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000476170ENST00000357865PHYKPLchr5

177653443

-STMN1chr1

26228239

-
intron-intronENST00000476170ENST00000374291PHYKPLchr5

177653443

-STMN1chr1

26228239

-

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FusionProtFeatures for PHYKPL_STMN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHYKPL

Q8IUZ5

STMN1

P16949

Catalyzes the pyridoxal-phosphate-dependent breakdown of5-phosphohydroxy-L-lysine, converting it to ammonia, inorganicphosphate and 2-aminoadipate semialdehyde.{ECO:0000269|PubMed:22241472}. Involved in the regulation of the microtubule (MT)filament system by destabilizing microtubules. Prevents assemblyand promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.Involved in the control of the learned and innate fear (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHYKPL_STMN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHYKPL_STMN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHYKPL_STMN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePHYKPLQ8IUZ5DB00114Pyridoxal Phosphate5-phosphohydroxy-L-lysine phospho-lyasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for PHYKPL_STMN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHYKPLC3554344PHOSPHOHYDROXYLYSINURIA1UNIPROT
TgeneSTMN1C0011570Mental Depression3PSYGENET
TgeneSTMN1C0011581Depressive disorder3PSYGENET
TgeneSTMN1C0017638Glioma1CTD_human
TgeneSTMN1C0024667Animal Mammary Neoplasms1CTD_human
TgeneSTMN1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSTMN1C0033578Prostatic Neoplasms1CTD_human
TgeneSTMN1C1458155Mammary Neoplasms1CTD_human