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Fusion gene ID: 27043 |
FusionGeneSummary for PHYKPL_STMN1 |
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Fusion gene information | Fusion gene name: PHYKPL_STMN1 | Fusion gene ID: 27043 | Hgene | Tgene | Gene symbol | PHYKPL | STMN1 | Gene ID | 85007 | 3925 |
Gene name | 5-phosphohydroxy-L-lysine phospho-lyase | stathmin 1 | |
Synonyms | AGXT2L2|PHLU | C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN | |
Cytomap | 5q35.3 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | 5-phosphohydroxy-L-lysine phospho-lyase5-phosphonooxy-L-lysine phospho-lyasealanine--glyoxylate aminotransferase 2-like 2 | stathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IUZ5 | P16949 | |
Ensembl transtripts involved in fusion gene | ENST00000308158, ENST00000481811, ENST00000476170, | ENST00000426559, ENST00000455785, ENST00000399728, ENST00000465604, ENST00000357865, ENST00000374291, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 5 X 5 X 4=100 |
# samples | 5 | 5 | |
** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PHYKPL [Title/Abstract] AND STMN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STMN1 | GO:0007019 | microtubule depolymerization | 9880330 |
Tgene | STMN1 | GO:0007052 | mitotic spindle organization | 9271428 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK123488 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000308158 | ENST00000426559 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000308158 | ENST00000455785 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000308158 | ENST00000399728 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-5UTR | ENST00000308158 | ENST00000465604 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000308158 | ENST00000357865 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000308158 | ENST00000374291 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000481811 | ENST00000426559 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000481811 | ENST00000455785 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000481811 | ENST00000399728 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-5UTR | ENST00000481811 | ENST00000465604 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000481811 | ENST00000357865 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000481811 | ENST00000374291 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000476170 | ENST00000426559 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000476170 | ENST00000455785 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000476170 | ENST00000399728 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-5UTR | ENST00000476170 | ENST00000465604 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000476170 | ENST00000357865 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
intron-intron | ENST00000476170 | ENST00000374291 | PHYKPL | chr5 | 177653443 | - | STMN1 | chr1 | 26228239 | - |
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FusionProtFeatures for PHYKPL_STMN1 |
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Hgene | Tgene |
PHYKPL | STMN1 |
Catalyzes the pyridoxal-phosphate-dependent breakdown of5-phosphohydroxy-L-lysine, converting it to ammonia, inorganicphosphate and 2-aminoadipate semialdehyde.{ECO:0000269|PubMed:22241472}. | Involved in the regulation of the microtubule (MT)filament system by destabilizing microtubules. Prevents assemblyand promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.Involved in the control of the learned and innate fear (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHYKPL_STMN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHYKPL_STMN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHYKPL_STMN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PHYKPL | Q8IUZ5 | DB00114 | Pyridoxal Phosphate | 5-phosphohydroxy-L-lysine phospho-lyase | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PHYKPL_STMN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PHYKPL | C3554344 | PHOSPHOHYDROXYLYSINURIA | 1 | UNIPROT |
Tgene | STMN1 | C0011570 | Mental Depression | 3 | PSYGENET |
Tgene | STMN1 | C0011581 | Depressive disorder | 3 | PSYGENET |
Tgene | STMN1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | STMN1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | STMN1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | STMN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | STMN1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |