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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27029

FusionGeneSummary for PHTF1_ESRRG

check button Fusion gene summary
Fusion gene informationFusion gene name: PHTF1_ESRRG
Fusion gene ID: 27029
HgeneTgene
Gene symbol

PHTF1

ESRRG

Gene ID

10745

2104

Gene nameputative homeodomain transcription factor 1estrogen related receptor gamma
SynonymsPHTFERR-gamma|ERR3|ERRg|ERRgamma|NR3B3
Cytomap

1p13.2

1q41

Type of geneprotein-codingprotein-coding
Descriptionputative homeodomain transcription factor 1estrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3
Modification date2018051920180519
UniProtAcc

Q9UMS5

P62508

Ensembl transtripts involved in fusion geneENST00000393357, ENST00000369596, 
ENST00000369598, ENST00000369600, 
ENST00000369604, ENST00000357783, 
ENST00000447664, ENST00000474926, 
ENST00000361525, ENST00000366940, 
ENST00000361395, ENST00000366938, 
ENST00000359162, ENST00000493603, 
ENST00000463665, ENST00000487276, 
ENST00000493748, ENST00000471371, 
ENST00000391890, ENST00000366937, 
ENST00000408911, ENST00000360012, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHTF1 [Title/Abstract] AND ESRRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-TS-A7P1-01APHTF1chr1

114300321

-ESRRGchr1

217113015

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000393357ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000393357ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000393357ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000393357ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000393357ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000393357ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000393357ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000393357ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369596ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369596ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369596ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369596ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369596ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369596ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369596ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369598ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369598ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369598ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369598ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369598ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369598ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369598ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369600ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369600ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369600ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369600ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369600ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369600ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369600ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369604ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369604ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000369604ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369604ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369604ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369604ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000369604ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000357783ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000357783ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000357783ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000357783ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000357783ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000357783ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000357783ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000447664ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000447664ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-5UTRENST00000447664ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000447664ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000447664ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000447664ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
5CDS-intronENST00000447664ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000361525PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000366940PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000361395PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000366938PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000359162PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000493603PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-intronENST00000474926ENST00000463665PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-intronENST00000474926ENST00000487276PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000493748PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-5UTRENST00000474926ENST00000471371PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-intronENST00000474926ENST00000391890PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-intronENST00000474926ENST00000366937PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-intronENST00000474926ENST00000408911PHTF1chr1

114300321

-ESRRGchr1

217113015

-
intron-intronENST00000474926ENST00000360012PHTF1chr1

114300321

-ESRRGchr1

217113015

-

Top

FusionProtFeatures for PHTF1_ESRRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHTF1

Q9UMS5

ESRRG

P62508

May play a role in transcription regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PHTF1_ESRRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PHTF1_ESRRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHTF1HOXB9, CAPN5, GPR156, LYPD3, TRIM25ESRRGESRRG, NCOA1, HGS, ESRRA, NRIP1, SP1, PPARGC1A, NR0B2, PARK2, NR0B1, DUT, PROX1, EBP, PNRC1, PNRC2, ARHGEF15, TLE1, APP, SRA1, SRPK1, KIFC3, MEOX2, NUP160, KIAA1598, CCDC67, SUMO1P1, PSMC5, DNMT3L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PHTF1_ESRRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneESRRGP62508DB00675TamoxifenEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB02659Cholic AcidEstrogen-related receptor gammasmall moleculeapproved
TgeneESRRGP62508DB00255DiethylstilbestrolEstrogen-related receptor gammasmall moleculeapproved|investigational
TgeneESRRGP62508DB00783EstradiolEstrogen-related receptor gammasmall moleculeapproved|investigational|vet_approved

Top

RelatedDiseases for PHTF1_ESRRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource