|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27018 |
FusionGeneSummary for PHLPP2_PHLPP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHLPP2_PHLPP2 | Fusion gene ID: 27018 | Hgene | Tgene | Gene symbol | PHLPP2 | PHLPP2 | Gene ID | 23035 | 23035 |
| Gene name | PH domain and leucine rich repeat protein phosphatase 2 | PH domain and leucine rich repeat protein phosphatase 2 | |
| Synonyms | PHLPPL|PPM3B | PHLPPL|PPM3B | |
| Cytomap | 16q22.2 | 16q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PH domain leucine-rich repeat-containing protein phosphatase 2protein phosphatase, Mg2+/Mn2+ dependent 3B | PH domain leucine-rich repeat-containing protein phosphatase 2protein phosphatase, Mg2+/Mn2+ dependent 3B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6ZVD8 | Q6ZVD8 | |
| Ensembl transtripts involved in fusion gene | ENST00000540628, ENST00000360429, ENST00000568954, ENST00000393524, ENST00000356272, ENST00000567016, | ENST00000540628, ENST00000360429, ENST00000568954, ENST00000393524, ENST00000356272, ENST00000567016, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 1=12 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PHLPP2 [Title/Abstract] AND PHLPP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW885592 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + | ||
| ChiTaRS3.1 | AW885594 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000540628 | ENST00000540628 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000540628 | ENST00000360429 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000540628 | ENST00000568954 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000540628 | ENST00000393524 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000540628 | ENST00000356272 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000540628 | ENST00000567016 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000360429 | ENST00000540628 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000360429 | ENST00000360429 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000360429 | ENST00000568954 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000360429 | ENST00000393524 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000360429 | ENST00000356272 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000360429 | ENST00000567016 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000568954 | ENST00000540628 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000568954 | ENST00000360429 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000568954 | ENST00000568954 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000568954 | ENST00000393524 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000568954 | ENST00000356272 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000568954 | ENST00000567016 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000393524 | ENST00000540628 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000393524 | ENST00000360429 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000393524 | ENST00000568954 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000393524 | ENST00000393524 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000393524 | ENST00000356272 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000393524 | ENST00000567016 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000356272 | ENST00000540628 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000356272 | ENST00000360429 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000356272 | ENST00000568954 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000356272 | ENST00000393524 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000356272 | ENST00000356272 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000356272 | ENST00000567016 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000567016 | ENST00000540628 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000567016 | ENST00000360429 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000567016 | ENST00000568954 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000567016 | ENST00000393524 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000567016 | ENST00000356272 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
| intron-intron | ENST00000567016 | ENST00000567016 | PHLPP2 | chr16 | 71718965 | + | PHLPP2 | chr16 | 71717160 | + |
Top |
FusionProtFeatures for PHLPP2_PHLPP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHLPP2 | PHLPP2 |
| Protein phosphatase involved in regulation of Akt andPKC signaling. Mediates dephosphorylation in the C-terminal domainhydrophobic motif of members of the AGC Ser/Thr protein kinasefamily; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCBisoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balancebetween cell survival and apoptosis through a cascade thatprimarily alters the function of transcription factors thatregulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation.Also controls the phosphorylation of AKT3. Dephosphorylates STK4on 'Thr-387' leading to STK4 activation and apoptosis(PubMed:20513427). Dephosphorylates RPS6KB1 and is involved inregulation of cap-dependent translation (PubMed:21986499).Inhibits cancer cell proliferation and may act as a tumorsuppressor. Dephosphorylation of PRKCA and PRKCB leads to theirdestabilization and degradation. Dephosphorylates RAF1 inhibitingits kinase activity (PubMed:24530606).{ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466,ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427,ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. | Protein phosphatase involved in regulation of Akt andPKC signaling. Mediates dephosphorylation in the C-terminal domainhydrophobic motif of members of the AGC Ser/Thr protein kinasefamily; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCBisoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balancebetween cell survival and apoptosis through a cascade thatprimarily alters the function of transcription factors thatregulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation.Also controls the phosphorylation of AKT3. Dephosphorylates STK4on 'Thr-387' leading to STK4 activation and apoptosis(PubMed:20513427). Dephosphorylates RPS6KB1 and is involved inregulation of cap-dependent translation (PubMed:21986499).Inhibits cancer cell proliferation and may act as a tumorsuppressor. Dephosphorylation of PRKCA and PRKCB leads to theirdestabilization and degradation. Dephosphorylates RAF1 inhibitingits kinase activity (PubMed:24530606).{ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466,ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427,ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PHLPP2_PHLPP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PHLPP2_PHLPP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PHLPP2_PHLPP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PHLPP2_PHLPP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|