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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27017

FusionGeneSummary for PHLPP2_KIF22

check button Fusion gene summary
Fusion gene informationFusion gene name: PHLPP2_KIF22
Fusion gene ID: 27017
HgeneTgene
Gene symbol

PHLPP2

KIF22

Gene ID

23035

3835

Gene namePH domain and leucine rich repeat protein phosphatase 2kinesin family member 22
SynonymsPHLPPL|PPM3BA-328A3.2|KID|KNSL4|OBP|OBP-1|OBP-2|SEMDJL2
Cytomap

16q22.2

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionPH domain leucine-rich repeat-containing protein phosphatase 2protein phosphatase, Mg2+/Mn2+ dependent 3Bkinesin-like protein KIF22kinesin-like DNA-binding protein pseudogenekinesin-like protein 4oriP binding proteinorigin of plasmid DNA replication-binding protein
Modification date2018052320180523
UniProtAcc

Q6ZVD8

Q14807

Ensembl transtripts involved in fusion geneENST00000540628, ENST00000360429, 
ENST00000568954, ENST00000393524, 
ENST00000356272, ENST00000567016, 
ENST00000561482, ENST00000160827, 
ENST00000400750, ENST00000400751, 
ENST00000569382, ENST00000563263, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 2=12
# samples 35
** MAII scorelog2(3/8*10)=1.90689059560852log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHLPP2 [Title/Abstract] AND KIF22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-97-A4M1-01APHLPP2chr16

71710350

-KIF22chr16

29808214

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000540628ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-intronENST00000540628ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000360429ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000568954ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000393524ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000356272ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000567016ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+

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FusionProtFeatures for PHLPP2_KIF22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHLPP2

Q6ZVD8

KIF22

Q14807

Protein phosphatase involved in regulation of Akt andPKC signaling. Mediates dephosphorylation in the C-terminal domainhydrophobic motif of members of the AGC Ser/Thr protein kinasefamily; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCBisoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balancebetween cell survival and apoptosis through a cascade thatprimarily alters the function of transcription factors thatregulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation.Also controls the phosphorylation of AKT3. Dephosphorylates STK4on 'Thr-387' leading to STK4 activation and apoptosis(PubMed:20513427). Dephosphorylates RPS6KB1 and is involved inregulation of cap-dependent translation (PubMed:21986499).Inhibits cancer cell proliferation and may act as a tumorsuppressor. Dephosphorylation of PRKCA and PRKCB leads to theirdestabilization and degradation. Dephosphorylates RAF1 inhibitingits kinase activity (PubMed:24530606).{ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466,ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427,ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. Kinesin family member that is involved in spindleformation and the movements of chromosomes during mitosis andmeiosis. Binds to microtubules and to DNA (By similarity). Plays arole in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869,ECO:0000269|PubMed:25743205}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHLPP2_KIF22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHLPP2_KIF22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHLPP2RDX, USP1, EZR, SLC9A3R2, SLC9A3R1, VAT1, USP12, USP46, PHLPP1, WDR48, SNX27, WDR20, PPP3CA, DMWD, SUGT1, LRRC6, FANCI, CUL3KIF22SIAH1, GDF9, IMMT, PJA1, SVIL, CHFR, ATXN1, MOV10, NXF1, BRCA1, OBSL1, MAPK14, HIST1H2BG, HIST1H3A, C4A, CCNB1, FUS, SP110, RPL10, RBM45, KPNA3, KPNA4, LIMS1, PSEN2, STAT6, TAF12, MPDZ, COX5A, CEP350, BCL2L11, HMGXB4, MARCH6, CEPT1, CD2BP2, CKAP2, PHF21A, SFMBT1, EPB41L4B, BIRC6, ZNF668, C2orf44, CCNL2, C18orf21, UTP23, PSRC1, CIRH1A, KNSTRN, PGM2L1, TEAD2, FOXE1, FOXL1, FOXM1, FOXQ1, CDC14B, TBC1D15, CNPY2, USP47, ZYG11B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHLPP2_KIF22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHLPP2_KIF22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKIF22C1863732Spondyloepimetaphyseal dysplasia with multiple dislocations2ORPHANET;UNIPROT