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Fusion gene ID: 27009 |
FusionGeneSummary for PHLDB2_RAB7A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHLDB2_RAB7A | Fusion gene ID: 27009 | Hgene | Tgene | Gene symbol | PHLDB2 | RAB7A | Gene ID | 90102 | 7879 |
| Gene name | pleckstrin homology like domain family B member 2 | RAB7A, member RAS oncogene family | |
| Synonyms | LL5b|LL5beta | PRO2706|RAB7 | |
| Cytomap | 3q13.2 | 3q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology-like domain family B member 2LL5 betaprotein LL5-beta | ras-related protein Rab-7aRAB7, member RAS oncogene familyRas-associated protein RAB7 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q86SQ0 | P51149 | |
| Ensembl transtripts involved in fusion gene | ENST00000393923, ENST00000412622, ENST00000431670, ENST00000393925, ENST00000481953, ENST00000495180, ENST00000478922, ENST00000477695, ENST00000470699, | ENST00000265062, ENST00000482525, ENST00000485280, | |
| Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 11 X 9 X 5=495 |
| # samples | 9 | 12 | |
| ** MAII score | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/495*10)=-2.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHLDB2 [Title/Abstract] AND RAB7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAB7A | GO:0022615 | protein to membrane docking | 24344282 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRP | TCGA-G7-6793-01A | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000393923 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000393923 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000393923 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000412622 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000412622 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000412622 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000431670 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000431670 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000431670 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000393925 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000393925 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000393925 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000481953 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000481953 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000481953 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000495180 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000495180 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| 5CDS-5UTR | ENST00000495180 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000478922 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000478922 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000478922 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000477695 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000477695 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000477695 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000470699 | ENST00000265062 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000470699 | ENST00000482525 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
| intron-5UTR | ENST00000470699 | ENST00000485280 | PHLDB2 | chr3 | 111658477 | + | RAB7A | chr3 | 128514203 | + |
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FusionProtFeatures for PHLDB2_RAB7A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHLDB2 | RAB7A |
| Seems to be involved in the assembly of the postsynapticapparatus. May play a role in acetyl-choline receptor (AChR)aggregation in the postsynaptic membrane (By similarity).{ECO:0000250, ECO:0000269|PubMed:12376540}. | Key regulator in endo-lysosomal trafficking. Governsearly-to-late endosomal maturation, microtubule minus-end as wellas plus-end directed endosomal migration and positioning, andendosome-lysosome transport through different protein-proteininteraction cascades. Plays a central role, not only in endosomaltraffic, but also in many other cellular and physiological events,such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport inthe axons of neurons and lipid metabolism. Also involved inregulation of some specialized endosomal membrane trafficking,such as maturation of melanosomes, pathogen-induced phagosomes (orvacuoles) and autophagosomes. Plays a role in the maturation andacidification of phagosomes that engulf pathogens, such asS.aureus and M.tuberculosis. Plays a role in the fusion ofphagosomes with lysosomes. Plays important roles in microbialpathogen infection and survival, as well as in participating inthe life cycle of viruses. Microbial pathogens possess survivalstrategies governed by RAB7A, sometimes by employing RAB7Afunction (e.g. Salmonella) and sometimes by excluding RAB7Afunction (e.g. Mycobacterium). In concert with RAC1, plays a rolein regulating the formation of RBs (ruffled borders) inosteoclasts. Controls the endosomal trafficking and neuriteoutgrowth signaling of NTRK1/TRKA (PubMed:11179213,PubMed:12944476, PubMed:14617358, PubMed:20028791,PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved inthe ADRB2-stimulated lipolysis through lipophagy, a cytosoliclipase-independent autophagic pathway (By similarity). Requiredfor the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413). {ECO:0000250|UniProtKB:P51150,ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476,ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791,ECO:0000269|PubMed:22660413}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHLDB2_RAB7A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHLDB2_RAB7A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PHLDB2 | FLNC, SH3KBP1, MYC, USP7, YWHAQ, LATS2, YWHAB, CEP250, CCDC8, CLK1, CEP128, CAPZA2, DVL2, FLNA, MYO1C, PDGFRA, OFD1, DYNLL1, KIF23, ATP6AP2, SYNPO, RACGAP1, MYO19, KIF7, MYO18A, C10orf2, CDH1, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, RTKN, MAST3, LIMA1, MAGI1, CGN, TESK2, DCLK1, PPM1H, ZNF638, DENND4C, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, FAM110B, USP21, MAPKAP1, ANKRD34A, FAM53C, NF1, CBY1, NADK, FAM110A, TIAM1, CDC25C, KIAA1804, RASAL2, CAMSAP2, GIGYF2, INPP5E, RAB3IP, G3BP1 | RAB7A | EIF1B, CHM, RILP, RHEB, RAB17, RAB4A, RAB4B, RAB5A, RAB5B, RAB6A, RAB22A, PSMA7, UCHL5, PPP2R1A, PPP2R1B, ZFYVE28, ELAVL1, SLC2A4, KCNN4, RNF115, ATP13A2, RAB1A, RAB11A, RAB8A, RAB11B, EEF1A1, HNRNPK, EIF4G2, HSPA5, CORO1C, VCP, FN1, ATF2, BAG3, LGALS3, RPA1, RPA2, RPA3, FUS, KRTAP10-9, KRTAP10-3, CUL7, EED, UBAC2, FAF2, SNX3, VPS26A, VPS35, VPS29, VPS11, VPS16, VPS18, VPS39, VPS41, ANXA2, ARL8B, ATP5O, HSP90B1, HSPA9, MECR, RAB2A, RAB5C, APRT, DHRS7B, GDI2, HNRNPA3, MSI2, NUTF2, PDHA1, RAB10, RAB1B, RAP1A, RAP1B, SDHB, SLC25A3, UBE2V1, TMEM189-UBE2V1, RAB8B, TCTN2, TCTN3, CNTRL, FBF1, TMEM17, TMEM216, ABCD1, RHOG, ATP2A2, ATP2B1, ATP6V1B2, ATP6V0A1, ATP6AP1, CAV1, CFL1, AP2M1, CPM, CPT1A, STOM, FLOT2, GNB2, JUP, KTN1, NDUFA7, NDUFA8, NDUFB4, NDUFB7, NDUFB8, NDUFS1, NDUFS6, NDUFV2, PC, CHMP1A, PHB, ABCD3, RPN2, SOAT1, SSFA2, TFRC, VDAC1, VDAC2, GDI1, OAZ1, ATP6AP2, LAP3, GTSE1, GPRC5A, ATP6V0D1, XPR1, ABCG2, ATP6V1G1, MLEC, PIEZO1, IST1, LRPPRC, FLOT1, ERLIN1, CKAP4, IMMT, ERLIN2, PHB2, CHMP2B, MYOF, UQCRQ, CHMP2A, STOML2, TRPM7, CHCHD3, MUC13, KIDINS220, MBOAT7, TMEM43, CYBRD1, YIPF5, TMUB1, CHCHD6, CCDC115, MCU, PRKCDBP, CHMP4B, STT3B, PTRF, C6orf120, LRRK2, PARK2, NOTCH1, U2AF2, TSG101, CHMP5, COX15, DLST, TRIM25, TP53 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHLDB2_RAB7A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHLDB2_RAB7A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RAB7A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | RAB7A | C1833219 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
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