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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26961

FusionGeneSummary for PHF3_R3HCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF3_R3HCC1
Fusion gene ID: 26961
HgeneTgene
Gene symbol

PHF3

R3HCC1

Gene ID

23469

203069

Gene namePHD finger protein 3R3H domain and coiled-coil containing 1
Synonyms--
Cytomap

6q12

8p21.3

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 3R3H and coiled-coil domain-containing protein 1
Modification date2018051920180523
UniProtAcc

Q92576

Q9Y3T6

Ensembl transtripts involved in fusion geneENST00000262043, ENST00000509330, 
ENST00000393387, ENST00000420043, 
ENST00000522012, ENST00000518454, 
ENST00000265806, ENST00000411463, 
Fusion gene scores* DoF score11 X 5 X 7=3852 X 2 X 2=8
# samples 132
** MAII scorelog2(13/385*10)=-1.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PHF3 [Title/Abstract] AND R3HCC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A8I4-01APHF3chr6

64346055

+R3HCC1chr8

23146019

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000262043ENST00000522012PHF3chr6

64346055

+R3HCC1chr8

23146019

+
5UTR-5UTRENST00000262043ENST00000518454PHF3chr6

64346055

+R3HCC1chr8

23146019

+
5UTR-5UTRENST00000262043ENST00000265806PHF3chr6

64346055

+R3HCC1chr8

23146019

+
5UTR-5UTRENST00000262043ENST00000411463PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-3UTRENST00000509330ENST00000522012PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000509330ENST00000518454PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000509330ENST00000265806PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000509330ENST00000411463PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-3UTRENST00000393387ENST00000522012PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000393387ENST00000518454PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000393387ENST00000265806PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000393387ENST00000411463PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-3UTRENST00000420043ENST00000522012PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000420043ENST00000518454PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000420043ENST00000265806PHF3chr6

64346055

+R3HCC1chr8

23146019

+
intron-5UTRENST00000420043ENST00000411463PHF3chr6

64346055

+R3HCC1chr8

23146019

+

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FusionProtFeatures for PHF3_R3HCC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHF3

Q92576

R3HCC1

Q9Y3T6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHF3_R3HCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHF3_R3HCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHF3SIRT7, MAPK3, HECW2, BMI1, CLK1, ORC1, SUPT5H, YWHAZ, USP37, TMA16, ID2, TRIM25R3HCC1NXF1, SAMD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHF3_R3HCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHF3_R3HCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHF3C0001973Alcoholic Intoxication, Chronic2PSYGENET