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Fusion gene ID: 26960 |
FusionGeneSummary for PHF3_QKI |
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Fusion gene information | Fusion gene name: PHF3_QKI | Fusion gene ID: 26960 | Hgene | Tgene | Gene symbol | PHF3 | QKI | Gene ID | 23469 | 9444 |
Gene name | PHD finger protein 3 | QKI, KH domain containing RNA binding | |
Synonyms | - | Hqk|QK|QK1|QK3|hqkI | |
Cytomap | 6q12 | 6q26 | |
Type of gene | protein-coding | protein-coding | |
Description | PHD finger protein 3 | protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q92576 | Q96PU8 | |
Ensembl transtripts involved in fusion gene | ENST00000262043, ENST00000509330, ENST00000393387, ENST00000420043, | ENST00000275262, ENST00000392127, ENST00000453779, ENST00000361752, ENST00000361195, ENST00000424802, | |
Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 13 X 14 X 6=1092 |
# samples | 13 | 18 | |
** MAII score | log2(13/385*10)=-1.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1092*10)=-2.60090404459018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PHF3 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UVM | TCGA-VD-A8KJ-01A | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000262043 | ENST00000275262 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
5UTR-3CDS | ENST00000262043 | ENST00000392127 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
5UTR-3CDS | ENST00000262043 | ENST00000453779 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
5UTR-3CDS | ENST00000262043 | ENST00000361752 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
5UTR-3CDS | ENST00000262043 | ENST00000361195 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
5UTR-3CDS | ENST00000262043 | ENST00000424802 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000509330 | ENST00000275262 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000509330 | ENST00000392127 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000509330 | ENST00000453779 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000509330 | ENST00000361752 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000509330 | ENST00000361195 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000509330 | ENST00000424802 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000393387 | ENST00000275262 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000393387 | ENST00000392127 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000393387 | ENST00000453779 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000393387 | ENST00000361752 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000393387 | ENST00000361195 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000393387 | ENST00000424802 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000420043 | ENST00000275262 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000420043 | ENST00000392127 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000420043 | ENST00000453779 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000420043 | ENST00000361752 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000420043 | ENST00000361195 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
intron-3CDS | ENST00000420043 | ENST00000424802 | PHF3 | chr6 | 64346055 | + | QKI | chr6 | 163983014 | + |
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FusionProtFeatures for PHF3_QKI |
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Hgene | Tgene |
PHF3 | QKI |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHF3_QKI |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHF3_QKI |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHF3 | SIRT7, MAPK3, HECW2, BMI1, CLK1, ORC1, SUPT5H, YWHAZ, USP37, TMA16, ID2, TRIM25 | QKI | HNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF3_QKI |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF3_QKI |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PHF3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Tgene | QKI | C0036341 | Schizophrenia | 5 | PSYGENET |
Tgene | QKI | C0017638 | Glioma | 1 | CTD_human |
Tgene | QKI | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | QKI | C1269683 | Major Depressive Disorder | 1 | PSYGENET |