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Fusion gene ID: 26958 |
FusionGeneSummary for PHF3_NUS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHF3_NUS1 | Fusion gene ID: 26958 | Hgene | Tgene | Gene symbol | PHF3 | NUS1 | Gene ID | 23469 | 116150 |
| Gene name | PHD finger protein 3 | NUS1, dehydrodolichyl diphosphate synthase subunit | |
| Synonyms | - | C6orf68|CDG1AA|MGC:7199|MRD55|NgBR|TANGO14 | |
| Cytomap | 6q12 | 6q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PHD finger protein 3 | dehydrodolichyl diphosphate synthase complex subunit NUS1Nogo-B receptordehydrodolichyl diphosphate syntase complex subunit NUS1di-trans,poly-cis-decaprenylcistransferasenuclear undecaprenyl pyrophosphate synthase 1 homologtransport and golgi organiz | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q92576 | Q96E22 | |
| Ensembl transtripts involved in fusion gene | ENST00000262043, ENST00000509330, ENST00000393387, ENST00000420043, | ENST00000368494, | |
| Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 2 X 1 X 2=4 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/385*10)=-1.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: PHF3 [Title/Abstract] AND NUS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A135-01A | PHF3 | chr6 | 64356700 | + | NUS1 | chr6 | 118014205 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262043 | ENST00000368494 | PHF3 | chr6 | 64356700 | + | NUS1 | chr6 | 118014205 | + |
| In-frame | ENST00000509330 | ENST00000368494 | PHF3 | chr6 | 64356700 | + | NUS1 | chr6 | 118014205 | + |
| In-frame | ENST00000393387 | ENST00000368494 | PHF3 | chr6 | 64356700 | + | NUS1 | chr6 | 118014205 | + |
| intron-3CDS | ENST00000420043 | ENST00000368494 | PHF3 | chr6 | 64356700 | + | NUS1 | chr6 | 118014205 | + |
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FusionProtFeatures for PHF3_NUS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHF3 | NUS1 |
| With DHDDS, forms the dehydrodolichyl diphosphatesynthase (DDS) complex, an essential component of the dolicholmonophosphate (Dol-P) biosynthetic machinery. Adds multiple copiesof isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP)to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor ofdolichol which is utilized as a sugar carrier in proteinglycosylation in the endoplasmic reticulum (ER). Regulates theglycosylation and stability of nascent NPC2, thereby promotingtrafficking of LDL-derived cholesterol. Acts as a specificreceptor for the N-terminus of Nogo-B, a neural and cardiovascularregulator. {ECO:0000269|PubMed:16835300,ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PHF3 | chr6:64356700 | chr6:118014205 | ENST00000262043 | + | 2 | 16 | 1797_1865 | 81 | 2040 | Compositional bias | Note=Pro-rich |
| Hgene | >PHF3 | chr6:64356700 | chr6:118014205 | ENST00000393387 | + | 1 | 15 | 1797_1865 | 81 | 2040 | Compositional bias | Note=Pro-rich |
| Hgene | >PHF3 | chr6:64356700 | chr6:118014205 | ENST00000262043 | + | 2 | 16 | 927_1046 | 81 | 2040 | Domain | TFIIS central |
| Hgene | >PHF3 | chr6:64356700 | chr6:118014205 | ENST00000393387 | + | 1 | 15 | 927_1046 | 81 | 2040 | Domain | TFIIS central |
| Hgene | >PHF3 | chr6:64356700 | chr6:118014205 | ENST00000262043 | + | 2 | 16 | 717_772 | 81 | 2040 | Zinc finger | PHD-type |
| Hgene | >PHF3 | chr6:64356700 | chr6:118014205 | ENST00000393387 | + | 1 | 15 | 717_772 | 81 | 2040 | Zinc finger | PHD-type |
| Tgene | NUS1 | chr6:64356700 | chr6:118014205 | ENST00000368494 | + | 0 | 5 | 117_135 | 138 | 294 | Transmembrane | Helical%3B Name%3D3 |
| Tgene | NUS1 | chr6:64356700 | chr6:118014205 | ENST00000368494 | + | 0 | 5 | 1_23 | 138 | 294 | Transmembrane | Helical%3B Name%3D1 |
| Tgene | NUS1 | chr6:64356700 | chr6:118014205 | ENST00000368494 | + | 0 | 5 | 35_56 | 138 | 294 | Transmembrane | Helical%3B Name%3D2 |
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FusionGeneSequence for PHF3_NUS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PHF3_ENST00000262043_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_237aa MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFCLPVLDSNDPNFQMPCSTGIFKRNNSR LMDEILKQQQELLGLDCSKYSPEFANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPD >In-frame_PHF3_ENST00000509330_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_237aa MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFCLPVLDSNDPNFQMPCSTGIFKRNNSR LMDEILKQQQELLGLDCSKYSPEFANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPD >In-frame_PHF3_ENST00000393387_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_237aa MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFCLPVLDSNDPNFQMPCSTGIFKRNNSR LMDEILKQQQELLGLDCSKYSPEFANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PHF3_ENST00000262043_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_711nt ATGGATATAGTTGATACATTTAATCATTTAATTCCTACTGAACACTTAGATGATGCCCTATTTCTAGGATCCAACCTGGAGAATGAAGTC TGTGAGGATTTTAGTGCAAGTCAAAATGTCTTAGAGGACTCGCTGAAGAACATGCTCAGCGATAAGGATCCTATGCTAGGATCTGCAAGT AACCAGTTCTGTTTGCCTGTTTTGGATAGCAATGATCCCAATTTCCAGATGCCTTGTTCAACAGGTATTTTCAAAAGAAATAATTCCAGA TTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAA GATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATTGTAAGAGCTGCTCAGGACTTT TGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTGTCCTGAT CCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTGACTGAGATTGTCTCTTTGCCT >In-frame_PHF3_ENST00000509330_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_711nt ATGGATATAGTTGATACATTTAATCATTTAATTCCTACTGAACACTTAGATGATGCCCTATTTCTAGGATCCAACCTGGAGAATGAAGTC TGTGAGGATTTTAGTGCAAGTCAAAATGTCTTAGAGGACTCGCTGAAGAACATGCTCAGCGATAAGGATCCTATGCTAGGATCTGCAAGT AACCAGTTCTGTTTGCCTGTTTTGGATAGCAATGATCCCAATTTCCAGATGCCTTGTTCAACAGGTATTTTCAAAAGAAATAATTCCAGA TTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAA GATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATTGTAAGAGCTGCTCAGGACTTT TGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTGTCCTGAT CCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTGACTGAGATTGTCTCTTTGCCT >In-frame_PHF3_ENST00000393387_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_711nt ATGGATATAGTTGATACATTTAATCATTTAATTCCTACTGAACACTTAGATGATGCCCTATTTCTAGGATCCAACCTGGAGAATGAAGTC TGTGAGGATTTTAGTGCAAGTCAAAATGTCTTAGAGGACTCGCTGAAGAACATGCTCAGCGATAAGGATCCTATGCTAGGATCTGCAAGT AACCAGTTCTGTTTGCCTGTTTTGGATAGCAATGATCCCAATTTCCAGATGCCTTGTTCAACAGGTATTTTCAAAAGAAATAATTCCAGA TTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAA GATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATTGTAAGAGCTGCTCAGGACTTT TGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTGTCCTGAT CCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTGACTGAGATTGTCTCTTTGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PHF3_ENST00000262043_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_4676nt CCGCGCCGCCGCCGCACGCCGATGGCTGCGGGGTCTCGCGCCGTCGCACCGTCCCCACGCGGCAAGCGACCTTCGGGCTCAGGGCGGCGG CGGCTGCAACGAGGATTAGGAGGGCGGCGCGGAAGCCAAGAATAGTGTCGTCAGCAGCAGCCATTTGGTCCCAGGAGGAAAAGAGGCTGT GGCAGCGACGCCGACGTCCTGCGCGTACCCCCTCTCCGCGGCACCCACCGGGCCCCCTCCTCCTCCTCTTCGGCGGCGGCAGCGTCCACC ATCTTCCTCTTGCTGCCAGTGGTAGCGCTCGTCTGGCGGAGCTGGGGCTGAAAGACACACAGAAGTCTTCATGGATATAGTTGATACATT TAATCATTTAATTCCTACTGAACACTTAGATGATGCCCTATTTCTAGGATCCAACCTGGAGAATGAAGTCTGTGAGGATTTTAGTGCAAG TCAAAATGTCTTAGAGGACTCGCTGAAGAACATGCTCAGCGATAAGGATCCTATGCTAGGATCTGCAAGTAACCAGTTCTGTTTGCCTGT TTTGGATAGCAATGATCCCAATTTCCAGATGCCTTGTTCAACAGGTATTTTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAA ACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAAGATGATCAAGTTTTAAATTG CCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATTGTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAA GCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTGTCCTGATCCTGATTTAGTATTGAAGTT CGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTGACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTA TGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAACAGCGTCTGGGAAAGTAGTGGTCATTGGTTGCATAATTTGATTTGAG GCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGCACCTATGAAACCCTGTACACACCTAGTTCATAATCCTCATAATTTA TCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAGTGTGTGTGTGTGCGTGTGCACGTGCACACATGTGCACGTTTGTATGTATGGAA ATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGACCTACAACTTTGAGCAAATAGCAGTGATGTTTTAGGAACTGAAATG TCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGGGGAGAAGAGGGCCTGATTAGAACTGTTCTGGTTGTGTTTGGCGGGA GGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAATTTTTAAGAATAATATATTGACTTACTGAACTGAAGCATTCTGAGT TGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGTTAAAATCTTGCTCACCTTCAGAGCAGAGGGAATACCTATCTTCAGA TATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTATTCTGGGTTCTGAAGTCTGGTATTCTG GTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTATTCTGAGAGTTGCTCTGTATTCTGGGTTCTGAAGATTATTTGAAAA ATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACATTGGATTAGGCAGTCAAAAAAACCAAGCAAGCATAAAAGGTCAATAA GTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGAAAGAAAGTTTTATTTCCTTTTTTGTTTGATGGGCAGTATGCCATAT TATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTTATTTAAAATAAACATTTGAGGGAAGTTACCAAGGCAGCTTTTTTCC TCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGCATGGTTAATACCTGAGATTTTTACTCAGTAAATCCTGATGGTTACT GTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGGAATAAAATATTACCAAAGTCTATAAAAATAAATTTTACATGTTCTC TTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGAATAATTGATTTCTTGATAGGTGTTTAATATTTCTTCCCTCACTGCT GATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTTCAGAAAACCCTTATCAACAAGTGTACAATACTTATCTAAAACTATA CATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGAAAAATAGCAAAGAAGACTGGATTTGGAAAGCATGGTCTACAATTGG TTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGGATTATGAAACCCCATTTATGATTTTTTAAATACACTTGAAATAAAA ATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGCATAATCCATTATACGTTGTACGACTTTTTTTTTTTGTTTTAATTTA TTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGAATTTCTGATTCCTTATACTGTGATTATATTATATTGAGGCATTTGT AGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAGGTATAAATGTCTTATAAACATTCTGGAGTATGTATAGCTTTAATGA ATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTTGTTAAAGTTAAGTTAGTCAAATAAATTACCTACTGGAATATAGCCC AAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTTCTCCTTCCATTCATAAGTATATACTTGAAAGTACATCTGTAGCCTA TGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAACTACTAGGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTT TATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCATTGGTTGTTCTGTAATTCCTGCCAAAAGCATCACAAGTTGTACATCA TCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAACAAAAGTATGTGTCTTTATTTGTATTGGAAAATACTGTCTTTAAAT TGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTAAACCTGTTTTATGGATGGCAGCTTGGAGCATAGCAAGAAGTTGGAG GATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAAAACTATAATAATCGGTTACTGTTATAAAGTTTAAAAGGTGGTTTTA ATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAATGCCTGTCTTTGAGAGGAAGGTGTTATAATATTAATGAACAGTGCC AAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTTACTGGATTAGCTCCCTCCTCCTGTGTGATGGTACCATGCATAGAGT CAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGTAAATAATGTGTAAAGCCAGTTTTTATGATTAAGGAATCAAATTTAT TGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAAAACCAATAAAAGAATATACTCTTTTCATTGACTATAGTATTATGTG AATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAATAAGAAATGCATATGACTAGATAGCAATAGTGTTTTTTTTAGATGG TATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAACATTTGGAATCTTATAATGTTACTTGCTTTTTGATAGATAATAGTGA AATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACAGTAATTAAAATTTGAATTTTTACCGAATATGAAATTTCCAAATTAA AAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTTGTCAAATGAGAAAATTTAAAGGTAAGAGTTATGGTTTGTCTTATGC TGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGACAATTGTTTTTTTGTGCATAGTTTTCATCTAAAATTAAGTTTACCA AAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTACTATAAAGTTCAGGACAGTTTGAAATAAAACCCAGGAAACAAGATT AATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACTATGATGCAATGGATAGGAAAAGGTAGTGCAAAAAGAATTTCTTAAG GTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGAGAAACAAAGGAATGTAACCTTATTGATTACATTTTTGGTGATCACC >In-frame_PHF3_ENST00000509330_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_4703nt GCTGAGGCGCGGGCGCGCAGGCCCGAGGCACGGCGGGCGCTGCCTGGAAGGCCCGTCTCGCAGGCCCCCGGATCCGGCCGTTGGGGCCTC TTCCTTCTCAGGGAGCCCCAGCATGGAGCTTTGGGCCTTGGTTTCGGGAAACTGGGACTGGCCCTGGCTGCTAGGCTGCTCCCTGCTGCT GCTTTTTGGAGATGAGAGTTGCTCTTCCATTTATCCTCCAGTTACCGCGCGCTTTTGTGCCCGGGACTCAAACTGTGGACTCCTTTTGCT TAGTTTGAAATGAGAAGCCTAGACTCTTGCCTTCCGATAATACATGTAATTTAATGAACCACTTGTCGATACGGCTGAAAGACACACAGA AGTCTTCATGGATATAGTTGATACATTTAATCATTTAATTCCTACTGAACACTTAGATGATGCCCTATTTCTAGGATCCAACCTGGAGAA TGAAGTCTGTGAGGATTTTAGTGCAAGTCAAAATGTCTTAGAGGACTCGCTGAAGAACATGCTCAGCGATAAGGATCCTATGCTAGGATC TGCAAGTAACCAGTTCTGTTTGCCTGTTTTGGATAGCAATGATCCCAATTTCCAGATGCCTTGTTCAACAGGTATTTTCAAAAGAAATAA TTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAA TGACAAAGATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATTGTAAGAGCTGCTCA GGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTG TCCTGATCCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTGACTGAGATTGTCTC TTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAACAGCGTCTGGGAAAGTAGTG GTCATTGGTTGCATAATTTGATTTGAGGCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGCACCTATGAAACCCTGTACA CACCTAGTTCATAATCCTCATAATTTATCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAGTGTGTGTGTGTGCGTGTGCACGTGCA CACATGTGCACGTTTGTATGTATGGAAATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGACCTACAACTTTGAGCAAAT AGCAGTGATGTTTTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGGGGAGAAGAGGGCCTGATTA GAACTGTTCTGGTTGTGTTTGGCGGGAGGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAATTTTTAAGAATAATATATT GACTTACTGAACTGAAGCATTCTGAGTTGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGTTAAAATCTTGCTCACCTTC AGAGCAGAGGGAATACCTATCTTCAGATATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTA TTCTGGGTTCTGAAGTCTGGTATTCTGGTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTATTCTGAGAGTTGCTCTGTA TTCTGGGTTCTGAAGATTATTTGAAAAATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACATTGGATTAGGCAGTCAAAAA AACCAAGCAAGCATAAAAGGTCAATAAGTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGAAAGAAAGTTTTATTTCCTT TTTTGTTTGATGGGCAGTATGCCATATTATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTTATTTAAAATAAACATTTGA GGGAAGTTACCAAGGCAGCTTTTTTCCTCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGCATGGTTAATACCTGAGATT TTTACTCAGTAAATCCTGATGGTTACTGTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGGAATAAAATATTACCAAAGT CTATAAAAATAAATTTTACATGTTCTCTTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGAATAATTGATTTCTTGATAG GTGTTTAATATTTCTTCCCTCACTGCTGATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTTCAGAAAACCCTTATCAACA AGTGTACAATACTTATCTAAAACTATACATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGAAAAATAGCAAAGAAGACTG GATTTGGAAAGCATGGTCTACAATTGGTTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGGATTATGAAACCCCATTTAT GATTTTTTAAATACACTTGAAATAAAAATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGCATAATCCATTATACGTTGT ACGACTTTTTTTTTTTGTTTTAATTTATTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGAATTTCTGATTCCTTATACT GTGATTATATTATATTGAGGCATTTGTAGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAGGTATAAATGTCTTATAAAC ATTCTGGAGTATGTATAGCTTTAATGAATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTTGTTAAAGTTAAGTTAGTCA AATAAATTACCTACTGGAATATAGCCCAAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTTCTCCTTCCATTCATAAGTA TATACTTGAAAGTACATCTGTAGCCTATGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAACTACTAGGATTCTGATTTCA GATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCATTGGTTGTTCTGTAATTCCT GCCAAAAGCATCACAAGTTGTACATCATCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAACAAAAGTATGTGTCTTTAT TTGTATTGGAAAATACTGTCTTTAAATTGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTAAACCTGTTTTATGGATGGC AGCTTGGAGCATAGCAAGAAGTTGGAGGATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAAAACTATAATAATCGGTTAC TGTTATAAAGTTTAAAAGGTGGTTTTAATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAATGCCTGTCTTTGAGAGGAA GGTGTTATAATATTAATGAACAGTGCCAAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTTACTGGATTAGCTCCCTCCT CCTGTGTGATGGTACCATGCATAGAGTCAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGTAAATAATGTGTAAAGCCAG TTTTTATGATTAAGGAATCAAATTTATTGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAAAACCAATAAAAGAATATAC TCTTTTCATTGACTATAGTATTATGTGAATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAATAAGAAATGCATATGACTA GATAGCAATAGTGTTTTTTTTAGATGGTATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAACATTTGGAATCTTATAATGT TACTTGCTTTTTGATAGATAATAGTGAAATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACAGTAATTAAAATTTGAATTT TTACCGAATATGAAATTTCCAAATTAAAAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTTGTCAAATGAGAAAATTTAA AGGTAAGAGTTATGGTTTGTCTTATGCTGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGACAATTGTTTTTTTGTGCAT AGTTTTCATCTAAAATTAAGTTTACCAAAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTACTATAAAGTTCAGGACAGT TTGAAATAAAACCCAGGAAACAAGATTAATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACTATGATGCAATGGATAGGAA AAGGTAGTGCAAAAAGAATTTCTTAAGGTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGAGAAACAAAGGAATGTAACC TTATTGATTACATTTTTGGTGATCACCGAGAATTTTTTGTACTATATTTTAAAAAATGTATTCTACTGTAACAAGTTAATAAAGAGATTT >In-frame_PHF3_ENST00000393387_chr6_64356700_+_NUS1_ENST00000368494_chr6_118014205_+_4362nt GGGCTGAAAGACACACAGAAGTCTTCATGGATATAGTTGATACATTTAATCATTTAATTCCTACTGAACACTTAGATGATGCCCTATTTC TAGGATCCAACCTGGAGAATGAAGTCTGTGAGGATTTTAGTGCAAGTCAAAATGTCTTAGAGGACTCGCTGAAGAACATGCTCAGCGATA AGGATCCTATGCTAGGATCTGCAAGTAACCAGTTCTGTTTGCCTGTTTTGGATAGCAATGATCCCAATTTCCAGATGCCTTGTTCAACAG GTATTTTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCAC CAGAATTTGCAAATAGTAATGACAAAGATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAG ATATTGTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTT TACTTAGTTCAAATGGTTGTCCTGATCCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCA GATTGACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAAC AGCGTCTGGGAAAGTAGTGGTCATTGGTTGCATAATTTGATTTGAGGCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGC ACCTATGAAACCCTGTACACACCTAGTTCATAATCCTCATAATTTATCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAGTGTGTGT GTGTGCGTGTGCACGTGCACACATGTGCACGTTTGTATGTATGGAAATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGA CCTACAACTTTGAGCAAATAGCAGTGATGTTTTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGG GGAGAAGAGGGCCTGATTAGAACTGTTCTGGTTGTGTTTGGCGGGAGGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAA TTTTTAAGAATAATATATTGACTTACTGAACTGAAGCATTCTGAGTTGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGT TAAAATCTTGCTCACCTTCAGAGCAGAGGGAATACCTATCTTCAGATATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACT TGAGAGTGTTGCTCTGGTATTCTGGGTTCTGAAGTCTGGTATTCTGGTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTA TTCTGAGAGTTGCTCTGTATTCTGGGTTCTGAAGATTATTTGAAAAATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACAT TGGATTAGGCAGTCAAAAAAACCAAGCAAGCATAAAAGGTCAATAAGTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGA AAGAAAGTTTTATTTCCTTTTTTGTTTGATGGGCAGTATGCCATATTATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTT ATTTAAAATAAACATTTGAGGGAAGTTACCAAGGCAGCTTTTTTCCTCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGC ATGGTTAATACCTGAGATTTTTACTCAGTAAATCCTGATGGTTACTGTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGG AATAAAATATTACCAAAGTCTATAAAAATAAATTTTACATGTTCTCTTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGA ATAATTGATTTCTTGATAGGTGTTTAATATTTCTTCCCTCACTGCTGATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTT CAGAAAACCCTTATCAACAAGTGTACAATACTTATCTAAAACTATACATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGA AAAATAGCAAAGAAGACTGGATTTGGAAAGCATGGTCTACAATTGGTTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGG ATTATGAAACCCCATTTATGATTTTTTAAATACACTTGAAATAAAAATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGC ATAATCCATTATACGTTGTACGACTTTTTTTTTTTGTTTTAATTTATTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGA ATTTCTGATTCCTTATACTGTGATTATATTATATTGAGGCATTTGTAGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAG GTATAAATGTCTTATAAACATTCTGGAGTATGTATAGCTTTAATGAATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTT GTTAAAGTTAAGTTAGTCAAATAAATTACCTACTGGAATATAGCCCAAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTT CTCCTTCCATTCATAAGTATATACTTGAAAGTACATCTGTAGCCTATGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAAC TACTAGGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCAT TGGTTGTTCTGTAATTCCTGCCAAAAGCATCACAAGTTGTACATCATCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAA CAAAAGTATGTGTCTTTATTTGTATTGGAAAATACTGTCTTTAAATTGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTA AACCTGTTTTATGGATGGCAGCTTGGAGCATAGCAAGAAGTTGGAGGATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAA AACTATAATAATCGGTTACTGTTATAAAGTTTAAAAGGTGGTTTTAATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAA TGCCTGTCTTTGAGAGGAAGGTGTTATAATATTAATGAACAGTGCCAAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTT ACTGGATTAGCTCCCTCCTCCTGTGTGATGGTACCATGCATAGAGTCAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGT AAATAATGTGTAAAGCCAGTTTTTATGATTAAGGAATCAAATTTATTGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAA AACCAATAAAAGAATATACTCTTTTCATTGACTATAGTATTATGTGAATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAA TAAGAAATGCATATGACTAGATAGCAATAGTGTTTTTTTTAGATGGTATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAAC ATTTGGAATCTTATAATGTTACTTGCTTTTTGATAGATAATAGTGAAATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACA GTAATTAAAATTTGAATTTTTACCGAATATGAAATTTCCAAATTAAAAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTT GTCAAATGAGAAAATTTAAAGGTAAGAGTTATGGTTTGTCTTATGCTGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGA CAATTGTTTTTTTGTGCATAGTTTTCATCTAAAATTAAGTTTACCAAAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTA CTATAAAGTTCAGGACAGTTTGAAATAAAACCCAGGAAACAAGATTAATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACT ATGATGCAATGGATAGGAAAAGGTAGTGCAAAAAGAATTTCTTAAGGTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGA GAAACAAAGGAATGTAACCTTATTGATTACATTTTTGGTGATCACCGAGAATTTTTTGTACTATATTTTAAAAAATGTATTCTACTGTAA |
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FusionGenePPI for PHF3_NUS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PHF3 | SIRT7, MAPK3, HECW2, BMI1, CLK1, ORC1, SUPT5H, YWHAZ, USP37, TMA16, ID2, TRIM25 | NUS1 | SPINT2, HLA-DPA1, DHDDS, TCTN2, TCTN3, POTEI, HSPA8, C5AR2, KCNC4, PCDHA3, ACTB, PCDHAC2, CHRNA9, EFNB2, ZNRF4, PTGER3, GPR114, LRRTM1, TMEM30B, HLA-C, APLNR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF3_NUS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF3_NUS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PHF3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Tgene | NUS1 | C0025202 | melanoma | 1 | CTD_human |
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