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Fusion gene ID: 26957 |
FusionGeneSummary for PHF3_NOMO2 |
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Fusion gene information | Fusion gene name: PHF3_NOMO2 | Fusion gene ID: 26957 | Hgene | Tgene | Gene symbol | PHF3 | NOMO2 | Gene ID | 23469 | 283820 |
Gene name | PHD finger protein 3 | NODAL modulator 2 | |
Synonyms | - | Nomo|PM5 | |
Cytomap | 6q12 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | PHD finger protein 3 | nodal modulator 2pM5 protein 2pM5 protein, centromeric copy | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q92576 | Q5JPE7 | |
Ensembl transtripts involved in fusion gene | ENST00000262043, ENST00000509330, ENST00000393387, ENST00000420043, | ENST00000330537, ENST00000381474, ENST00000543392, | |
Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 3 X 3 X 1=9 |
# samples | 13 | 3 | |
** MAII score | log2(13/385*10)=-1.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PHF3 [Title/Abstract] AND NOMO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG008491 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000262043 | ENST00000330537 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
In-frame | ENST00000262043 | ENST00000381474 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
In-frame | ENST00000262043 | ENST00000543392 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
intron-3CDS | ENST00000509330 | ENST00000330537 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
intron-3CDS | ENST00000509330 | ENST00000381474 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
intron-3CDS | ENST00000509330 | ENST00000543392 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
In-frame | ENST00000393387 | ENST00000330537 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
In-frame | ENST00000393387 | ENST00000381474 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
In-frame | ENST00000393387 | ENST00000543392 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
intron-3CDS | ENST00000420043 | ENST00000330537 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
intron-3CDS | ENST00000420043 | ENST00000381474 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
intron-3CDS | ENST00000420043 | ENST00000543392 | PHF3 | chr6 | 64422978 | + | NOMO2 | chr16 | 18518182 | - |
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FusionProtFeatures for PHF3_NOMO2 |
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Hgene | Tgene |
PHF3 | NOMO2 |
May antagonize Nodal signaling and subsequentorganization of axial structures during mesodermal patterning, viaits interaction with NCLN. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >NOMO2 | chr6:64422978 | chr16:18518182 | ENST00000330537 | - | 0 | 31 | 1177_1267 | -57 | 1223 | Topological domain | Cytoplasmic |
Tgene | >NOMO2 | chr6:64422978 | chr16:18518182 | ENST00000330537 | - | 0 | 31 | 32_1155 | -57 | 1223 | Topological domain | Lumenal |
Tgene | >NOMO2 | chr6:64422978 | chr16:18518182 | ENST00000381474 | - | 0 | 32 | 1177_1267 | -22 | 1268 | Topological domain | Cytoplasmic |
Tgene | >NOMO2 | chr6:64422978 | chr16:18518182 | ENST00000381474 | - | 0 | 32 | 32_1155 | -22 | 1268 | Topological domain | Lumenal |
Tgene | >NOMO2 | chr6:64422978 | chr16:18518182 | ENST00000330537 | - | 0 | 31 | 1156_1176 | -57 | 1223 | Transmembrane | Helical |
Tgene | >NOMO2 | chr6:64422978 | chr16:18518182 | ENST00000381474 | - | 0 | 32 | 1156_1176 | -22 | 1268 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHF3_NOMO2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000330537_chr16_18518182_-_0aa >In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000381474_chr16_18518182_-_0aa >In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000543392_chr16_18518182_-_0aa >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000330537_chr16_18518182_-_0aa >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000381474_chr16_18518182_-_0aa >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000543392_chr16_18518182_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000330537_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000381474_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000543392_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000330537_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000381474_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000543392_chr16_18518182_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000330537_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000381474_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000262043_chr6_64422978_+_NOMO2_ENST00000543392_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000330537_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000381474_chr16_18518182_-_0nt >In-frame_PHF3_ENST00000393387_chr6_64422978_+_NOMO2_ENST00000543392_chr16_18518182_-_0nt |
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FusionGenePPI for PHF3_NOMO2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF3_NOMO2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF3_NOMO2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PHF3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |