![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 26956 |
FusionGeneSummary for PHF3_FNTA |
![]() |
Fusion gene information | Fusion gene name: PHF3_FNTA | Fusion gene ID: 26956 | Hgene | Tgene | Gene symbol | PHF3 | FNTA | Gene ID | 23469 | 2339 |
Gene name | PHD finger protein 3 | farnesyltransferase, CAAX box, alpha | |
Synonyms | - | FPTA|PGGT1A|PTAR2 | |
Cytomap | 6q12 | 8p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | PHD finger protein 3 | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFTase-alphaGGTase-I-alphafarnesyl-protein transferase alpha-subunitprotein prenyltransferase alpha subunit repeat containing 2ras proteins prenyltransferase subunit alphatype | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q92576 | P49354 | |
Ensembl transtripts involved in fusion gene | ENST00000262043, ENST00000509330, ENST00000393387, ENST00000420043, | ENST00000302279, ENST00000342116, ENST00000524546, ENST00000529687, | |
Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 4 X 7 X 4=112 |
# samples | 13 | 8 | |
** MAII score | log2(13/385*10)=-1.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PHF3 [Title/Abstract] AND FNTA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FNTA | GO:0018343 | protein farnesylation | 16893176|19228685 |
Tgene | FNTA | GO:0018344 | protein geranylgeranylation | 16893176 |
Tgene | FNTA | GO:0090044 | positive regulation of tubulin deacetylation | 19228685 |
Tgene | FNTA | GO:0090045 | positive regulation of deacetylase activity | 19228685 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A1KC-01B | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000262043 | ENST00000302279 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
5CDS-intron | ENST00000262043 | ENST00000342116 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
5CDS-3UTR | ENST00000262043 | ENST00000524546 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
5CDS-5UTR | ENST00000262043 | ENST00000529687 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-3CDS | ENST00000509330 | ENST00000302279 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-intron | ENST00000509330 | ENST00000342116 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-3UTR | ENST00000509330 | ENST00000524546 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-5UTR | ENST00000509330 | ENST00000529687 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
Frame-shift | ENST00000393387 | ENST00000302279 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
5CDS-intron | ENST00000393387 | ENST00000342116 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
5CDS-3UTR | ENST00000393387 | ENST00000524546 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
5CDS-5UTR | ENST00000393387 | ENST00000529687 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-3CDS | ENST00000420043 | ENST00000302279 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-intron | ENST00000420043 | ENST00000342116 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-3UTR | ENST00000420043 | ENST00000524546 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
intron-5UTR | ENST00000420043 | ENST00000529687 | PHF3 | chr6 | 64423071 | + | FNTA | chr8 | 42919244 | + |
Top |
FusionProtFeatures for PHF3_FNTA |
![]() |
Hgene | Tgene |
PHF3 | FNTA |
Essential subunit of both the farnesyltransferase andthe geranylgeranyltransferase complex. Contributes to the transferof a farnesyl or geranylgeranyl moiety from farnesyl orgeranylgeranyl diphosphate to a cysteine at the fourth positionfrom the C-terminus of several proteins having the C-terminalsequence Cys-aliphatic-aliphatic-X. May positively regulateneuromuscular junction development downstream of MUSK via itsfunction in RAC1 prenylation and activation.{ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937,ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009,ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PHF3_FNTA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PHF3_FNTA |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHF3 | SIRT7, MAPK3, HECW2, BMI1, CLK1, ORC1, SUPT5H, YWHAZ, USP37, TMA16, ID2, TRIM25 | FNTA | ACVR1, TGFB1, PTP4A2, TGFBR1, HDAC6, VAV2, TGM2, INHBB, STAT2, SAFB2, RPL13A, DYRK1A, HK2, AMMECR1L, HEYL, NAP1L1, FNTB, DARS2, TOP1, BRCA1, BRAF, FGFR3, KDM6A, CAPN1, ARFGAP1, TSKS, RPL18, C10orf71, EPB41L5, FAM117B, ARNT2, XRCC3, ATAD5, BLM, MTOR, RPS19 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PHF3_FNTA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PHF3_FNTA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PHF3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |