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Fusion gene ID: 26953 |
FusionGeneSummary for PHF3_C6orf123 |
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Fusion gene information | Fusion gene name: PHF3_C6orf123 | Fusion gene ID: 26953 | Hgene | Tgene | Gene symbol | PHF3 | C6orf123 | Gene ID | 23469 |
Gene name | PHD finger protein 3 | ||
Synonyms | - | ||
Cytomap | 6q12 | ||
Type of gene | protein-coding | ||
Description | PHD finger protein 3 | ||
Modification date | 20180519 | ||
UniProtAcc | Q92576 | ||
Ensembl transtripts involved in fusion gene | ENST00000262043, ENST00000509330, ENST00000393387, ENST00000420043, | ENST00000366822, | |
Fusion gene scores | * DoF score | 11 X 5 X 7=385 | 1 X 1 X 1=1 |
# samples | 13 | 1 | |
** MAII score | log2(13/385*10)=-1.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PHF3 [Title/Abstract] AND C6orf123 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-EB-A82B-01A | PHF3 | chr6 | 64346055 | + | C6orf123 | chr6 | 168191773 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000262043 | ENST00000366822 | PHF3 | chr6 | 64346055 | + | C6orf123 | chr6 | 168191773 | - |
intron-5UTR | ENST00000509330 | ENST00000366822 | PHF3 | chr6 | 64346055 | + | C6orf123 | chr6 | 168191773 | - |
intron-5UTR | ENST00000393387 | ENST00000366822 | PHF3 | chr6 | 64346055 | + | C6orf123 | chr6 | 168191773 | - |
intron-5UTR | ENST00000420043 | ENST00000366822 | PHF3 | chr6 | 64346055 | + | C6orf123 | chr6 | 168191773 | - |
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FusionProtFeatures for PHF3_C6orf123 |
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Hgene | Tgene |
PHF3 | C6orf123 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHF3_C6orf123 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHF3_C6orf123 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHF3 | SIRT7, MAPK3, HECW2, BMI1, CLK1, ORC1, SUPT5H, YWHAZ, USP37, TMA16, ID2, TRIM25 | C6orf123 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF3_C6orf123 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF3_C6orf123 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PHF3 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |