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Fusion gene ID: 26949 |
FusionGeneSummary for PHF23_TOM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHF23_TOM1 | Fusion gene ID: 26949 | Hgene | Tgene | Gene symbol | PHF23 | TOM1 | Gene ID | 79142 | 10043 |
| Gene name | PHD finger protein 23 | target of myb1 membrane trafficking protein | |
| Synonyms | hJUNE-1b | - | |
| Cytomap | 17p13.1 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PHD finger protein 23PDH-containing protein JUNE-1PHD finger protein 23a | target of Myb protein 1target of myb 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9BUL5 | O60784 | |
| Ensembl transtripts involved in fusion gene | ENST00000320316, ENST00000571362, ENST00000576955, ENST00000454255, ENST00000570753, | ENST00000447733, ENST00000449058, ENST00000425375, ENST00000411850, ENST00000436462, ENST00000382034, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 5=100 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHF23 [Title/Abstract] AND TOM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-ZS-A9CD-01A | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000320316 | ENST00000447733 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000320316 | ENST00000449058 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000320316 | ENST00000425375 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000320316 | ENST00000411850 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000320316 | ENST00000436462 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5CDS-3UTR | ENST00000320316 | ENST00000382034 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000571362 | ENST00000447733 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000571362 | ENST00000449058 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000571362 | ENST00000425375 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000571362 | ENST00000411850 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| In-frame | ENST00000571362 | ENST00000436462 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5CDS-3UTR | ENST00000571362 | ENST00000382034 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5UTR-3CDS | ENST00000576955 | ENST00000447733 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5UTR-3CDS | ENST00000576955 | ENST00000449058 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5UTR-3CDS | ENST00000576955 | ENST00000425375 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5UTR-3CDS | ENST00000576955 | ENST00000411850 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5UTR-3CDS | ENST00000576955 | ENST00000436462 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| 5UTR-3UTR | ENST00000576955 | ENST00000382034 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000454255 | ENST00000447733 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000454255 | ENST00000449058 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000454255 | ENST00000425375 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000454255 | ENST00000411850 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000454255 | ENST00000436462 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3UTR | ENST00000454255 | ENST00000382034 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000570753 | ENST00000447733 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000570753 | ENST00000449058 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000570753 | ENST00000425375 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000570753 | ENST00000411850 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3CDS | ENST00000570753 | ENST00000436462 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
| intron-3UTR | ENST00000570753 | ENST00000382034 | PHF23 | chr17 | 7142565 | - | TOM1 | chr22 | 35741718 | + |
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FusionProtFeatures for PHF23_TOM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHF23 | TOM1 |
| Acts as a negative regulator of autophagy, throughpromoting ubiquitination and degradation of LRSAM1, an E3ubiquitin ligase that promotes autophagy in response to starvationor infecting bacteria. {ECO:0000269|PubMed:25484098}. | May be involved in intracellular trafficking. Probableassociation with membranes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PHF23 | chr17:7142565 | chr22:35741718 | ENST00000320316 | - | 1 | 5 | 248_261 | 11 | 404 | Compositional bias | Note=Poly-Glu |
| Hgene | >PHF23 | chr17:7142565 | chr22:35741718 | ENST00000320316 | - | 1 | 5 | 339_387 | 11 | 404 | Zinc finger | Note=PHD-type |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000411850 | + | 11 | 15 | 20_152 | 408 | 494 | Domain | VHS |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000411850 | + | 11 | 15 | 215_303 | 408 | 494 | Domain | GAT |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000425375 | + | 10 | 14 | 20_152 | 363 | 448 | Domain | VHS |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000425375 | + | 10 | 14 | 215_303 | 363 | 448 | Domain | GAT |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000447733 | + | 11 | 15 | 20_152 | 375 | 461 | Domain | VHS |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000447733 | + | 11 | 15 | 215_303 | 375 | 461 | Domain | GAT |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000449058 | + | 11 | 15 | 20_152 | 408 | 493 | Domain | VHS |
| Tgene | TOM1 | chr17:7142565 | chr22:35741718 | ENST00000449058 | + | 11 | 15 | 215_303 | 408 | 493 | Domain | GAT |
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FusionGeneSequence for PHF23_TOM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000447733_chr22_35741718_+_97aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRXIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERX >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000449058_chr22_35741718_+_96aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERXX >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000425375_chr22_35741718_+_96aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERXX >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000411850_chr22_35741718_+_97aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRXIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERX >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000436462_chr22_35741718_+_96aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERXX >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000447733_chr22_35741718_+_97aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRXIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERX >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000449058_chr22_35741718_+_96aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERXX >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000425375_chr22_35741718_+_96aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERXX >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000411850_chr22_35741718_+_97aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRXIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERX >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000436462_chr22_35741718_+_96aa MLEAMAEPSPEDPSHPGLPHGGHRAVAVHXRGXXCGRAXGGHQRRIXQIPGRTGQSRGPIAQPLQPLSXGAPGSPIWPSAPEEDPGERXX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000447733_chr22_35741718_+_292nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCG ATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGA >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000449058_chr22_35741718_+_289nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATT GCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGA >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000425375_chr22_35741718_+_289nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATT GCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGA >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000411850_chr22_35741718_+_292nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCG ATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGA >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000436462_chr22_35741718_+_289nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATT GCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGA >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000447733_chr22_35741718_+_292nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCG ATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGA >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000449058_chr22_35741718_+_289nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATT GCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGA >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000425375_chr22_35741718_+_289nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATT GCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGA >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000411850_chr22_35741718_+_292nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCG ATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGA >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000436462_chr22_35741718_+_289nt ATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGA CGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATT GCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000447733_chr22_35741718_+_1302nt AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA GGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGT CCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGC AGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCC CCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGC AGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGC TGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACAC TGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATG GCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGC GCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCA TCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTAT >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000449058_chr22_35741718_+_1294nt AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA GAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCC CCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGCAGC CCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCCCCT TTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGT GGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGG CTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGC CAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATGGCT TTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGCGCA GTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCATCC TTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTATCCC >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000425375_chr22_35741718_+_1299nt AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA GAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCC CCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGCAGC CCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCCCCT TTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGT GGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGG CTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGC CAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATGGCT TTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGCGCA GTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCATCC TTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTATCCC >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000411850_chr22_35741718_+_1302nt AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA GGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGT CCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGC AGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCC CCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGC AGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGC TGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACAC TGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATG GCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGTACGAAGCTGCAACTCTGCGC GCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCCCTCCGCTGCCTTGCCCTCCA TCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACTGGGAGAGGTGCCTTTTGTAT >In-frame_PHF23_ENST00000320316_chr17_7142565_-_TOM1_ENST00000436462_chr22_35741718_+_1005nt AGGAGGGAGCAGGCGGCCGGCGGCGCGGGGGGAGGGGGCCCGGTCCGGGAGTGCGGGAGGCAGTGGTAGAGGGAGGTGGCGGCAGCGGCT AGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAGCACTAGAGGCGGCACCGGGATCC CCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGAGCCCAGTCCCGAAGATCCCAGTC ACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAGAGCCTAAGGGGGTCACCAGCGAA GAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCTCAGCTGAGGGGCCCCCGGGTCCC CCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAGTGTGGGGTCTGGCACCCTGCAGC CCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCTTTGGGGGTGGCTTGTTACCCCCT TTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGT GGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGG CTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGC CAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCTCTGCTGCATGGGGCCCCATGGCT >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000447733_chr22_35741718_+_1235nt AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG AGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCC CCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTAT GAGTGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCT GCTTTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGA ACTGGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGA GGCCCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCC AAGGAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCT GCTCTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCA GGTACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTG CCCCTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGT >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000449058_chr22_35741718_+_1227nt AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG AGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCT CAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG TGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCT TTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACT GGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC CCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAG GAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCT CTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGT ACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCC CTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACT >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000425375_chr22_35741718_+_1232nt AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG AGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCT CAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG TGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCT TTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACT GGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC CCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAG GAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCT CTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCAGGT ACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTGCCC CTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGTACT >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000411850_chr22_35741718_+_1235nt AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG AGCCTAAGGGGGTCACCAGCGAAGGTAAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCC CCTCAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTAT GAGTGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCT GCTTTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGA ACTGGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGA GGCCCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCC AAGGAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCT GCTCTGCTGCATGGGGCCCCATGGCTTTGGCTGGCCACTGAGGGTAGGGTGTGGAGGTGTGGAGGCCCCCTGAGGAGCTGCGGCGGCCCA GGTACGAAGCTGCAACTCTGCGCGCAGTGGGCGAGATCTCATCAGCCCCAGGCTGCAGGTGAGGCTTCAGGGGATGCTGGGGCCCCACTG CCCCTCCGCTGCCTTGCCCTCCATCCTTCCTCTGTTCCTTCTGGCCGGGCACCACAGCACTGGGGCTCACCTCTTGGTTGATCCTCTTGT >In-frame_PHF23_ENST00000571362_chr17_7142565_-_TOM1_ENST00000436462_chr22_35741718_+_938nt AGAGGGAGGTGGCGGCAGCGGCTAGCGGACTCGAGTCTCAACCGGGCTGAGGCGGACACTTCTGTGGAGCGAAGCAGTGGGAGCATCGAG CACTAGAGGCGGCACCGGGATCCCCGGCTCCGGGGAGGGGGGCGCCGGACCGGGAGGAGGGGAGGGGGCGATGCTGGAAGCCATGGCGGA GCCCAGTCCCGAAGATCCCAGTCACCCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCACTGACGTGGGTAATGATGCGGAAG AGCCTAAGGGGGTCACCAGCGAAGAATTTGACAAATTCCTGGAAGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCAGCCCCT CAGCTGAGGGGCCCCCGGGTCCCCCATCTGGCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG TGTGGGGTCTGGCACCCTGCAGCCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTGTTAAGGCTGCT TTGGGGGTGGCTTGTTACCCCCTTTTCCTCCTCTTTGAAGACGGAGCTGCCCCAGCTGTGGCTGGGGGTGTGGAGGCAGTGGGATGAACT GGGGGACAGGTCTGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC CCCAGGACAGGCTGGCTGGCTGGCTGGCTGCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAG GAGCCCTTCAGAGCCCACACTGCCAGTCGAGGCCTGGCTGGAGGCTGGCCACAGTGGAAATTCTGCCGAGCCTCTTGTCCCTTCCCTGCT |
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FusionGenePPI for PHF23_TOM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PHF23 | PRSS23, HCCS, LRSAM1, ERBB2, STK11, FOXK2, SIN3A, SAP130, ARID4B, SIN3B, SAP30, SUDS3, BRMS1L | TOM1 | TOLLIP, ZFYVE16, CLTC, IL1R1, UBC, NEDD4, TSG101, RAC1, UBE2D1, APP, VCP, ZNF512B, MYO6, PARK2, RPS27, ILVBL, SSBP2, PTBP2, ME1, EXOSC4, GARS, HIST1H1E, TBCD, WDR12, YAP1, MAP3K1, NTRK1, DOHH, DDI2, XPO1, MYO19, LITAF, SMURF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF23_TOM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF23_TOM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TOM1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | TOM1 | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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