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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26945

FusionGeneSummary for PHF21B_NCOR1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF21B_NCOR1
Fusion gene ID: 26945
HgeneTgene
Gene symbol

PHF21B

NCOR1

Gene ID

112885

9611

Gene namePHD finger protein 21Bnuclear receptor corepressor 1
SynonymsBHC80L|PHF4N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR
Cytomap

22q13.31

17p12-p11.2

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 21BPHD finger protein 4nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1
Modification date2018051920180523
UniProtAcc

Q96EK2

O75376

Ensembl transtripts involved in fusion geneENST00000403565, ENST00000313237, 
ENST00000396103, ENST00000404079, 
ENST00000447824, ENST00000462631, 
ENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 
Fusion gene scores* DoF score4 X 2 X 4=323 X 3 X 2=18
# samples 43
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHF21B [Title/Abstract] AND NCOR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF961392PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000403565ENST00000268712PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000403565ENST00000395851PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000403565ENST00000395857PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000403565ENST00000395848PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000403565ENST00000583226PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000313237ENST00000268712PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000313237ENST00000395851PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000313237ENST00000395857PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000313237ENST00000395848PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000313237ENST00000583226PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000396103ENST00000268712PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000396103ENST00000395851PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000396103ENST00000395857PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000396103ENST00000395848PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000396103ENST00000583226PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000404079ENST00000268712PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000404079ENST00000395851PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000404079ENST00000395857PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000404079ENST00000395848PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000404079ENST00000583226PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000447824ENST00000268712PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000447824ENST00000395851PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000447824ENST00000395857PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000447824ENST00000395848PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000447824ENST00000583226PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000462631ENST00000268712PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000462631ENST00000395851PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000462631ENST00000395857PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000462631ENST00000395848PHF21Bchr22

45280646

-NCOR1chr17

15945890

+
intron-intronENST00000462631ENST00000583226PHF21Bchr22

45280646

-NCOR1chr17

15945890

+

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FusionProtFeatures for PHF21B_NCOR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHF21B

Q96EK2

NCOR1

O75376

Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHF21B_NCOR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHF21B_NCOR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHF21B_NCOR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHF21B_NCOR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNCOR1C0005695Bladder Neoplasm1CTD_human
TgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
TgeneNCOR1C0014175Endometriosis1CTD_human
TgeneNCOR1C0017636Glioblastoma1CTD_human
TgeneNCOR1C0023903Liver neoplasms1CTD_human
TgeneNCOR1C1458155Mammary Neoplasms1CTD_human