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Fusion gene ID: 26937 |
FusionGeneSummary for PHF21A_GLIS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHF21A_GLIS2 | Fusion gene ID: 26937 | Hgene | Tgene | Gene symbol | PHF21A | GLIS2 | Gene ID | 51317 | 84662 |
| Gene name | PHD finger protein 21A | GLIS family zinc finger 2 | |
| Synonyms | BHC80|BM-006 | NKL|NPHP7 | |
| Cytomap | 11p11.2 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa) | zinc finger protein GLIS2GLI-similar 2Kruppel-like zinc finger protein GLIS2nephrocystin-7neuronal Krueppel-like protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96BD5 | Q9BZE0 | |
| Ensembl transtripts involved in fusion gene | ENST00000257821, ENST00000323180, ENST00000418153, ENST00000527753, | ENST00000262366, ENST00000433375, | |
| Fusion gene scores | * DoF score | 15 X 7 X 13=1365 | 1 X 1 X 2=2 |
| # samples | 19 | 2 | |
| ** MAII score | log2(19/1365*10)=-2.84482962747627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/2*10)=3.32192809488736 | |
| Context | PubMed: PHF21A [Title/Abstract] AND GLIS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CN-6994-01A | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| TCGA | RV | LAML | TCGA-AB-2965-03A | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000257821 | ENST00000262366 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| In-frame | ENST00000257821 | ENST00000433375 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| intron-3CDS | ENST00000323180 | ENST00000262366 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| intron-3CDS | ENST00000323180 | ENST00000433375 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| In-frame | ENST00000418153 | ENST00000262366 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| In-frame | ENST00000418153 | ENST00000433375 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| intron-3CDS | ENST00000527753 | ENST00000262366 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
| intron-3CDS | ENST00000527753 | ENST00000433375 | PHF21A | chr11 | 45967391 | - | GLIS2 | chr16 | 4386726 | + |
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FusionProtFeatures for PHF21A_GLIS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHF21A | GLIS2 |
| Component of the BHC complex, a corepressor complex thatrepresses transcription of neuron-specific genes in non-neuronalcells. The BHC complex is recruited at RE1/NRSE sites by REST andacts by deacetylating and demethylating specific sites onhistones, thereby acting as a chromatin modifier. In the BHCcomplex, it may act as a scaffold. Inhibits KDM1A-mediateddemethylation of 'Lys-4' of histone H3 in vitro, suggesting a rolein demethylation regulation. {ECO:0000269|PubMed:16140033}. | Can act either as a transcriptional repressor or as atranscriptional activator, depending on the cell context. Acts asa repressor of the Hedgehog signaling pathway (By similarity).Represses the Hedgehog-dependent expression of Wnt4 (Bysimilarity). Necessary to maintain the differentiated epithelialphenotype in renal cells through the inhibition of SNAI1, whichitself induces the epithelial-to-mesenchymal transition (Bysimilarity). Represses transcriptional activation mediated byCTNNB1 in the Wnt signaling pathway. May act by recruiting thecorepressors CTBP1 and HDAC3. May be involved in neurondifferentiation (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PHF21A | chr11:45967391 | chr16:4386726 | ENST00000257821 | - | 14 | 18 | 4_108 | 484 | 682 | Compositional bias | Note=Gln-rich |
| Hgene | PHF21A | chr11:45967391 | chr16:4386726 | ENST00000418153 | - | 14 | 18 | 4_108 | 483 | 681 | Compositional bias | Note=Gln-rich |
| Hgene | PHF21A | chr11:45967391 | chr16:4386726 | ENST00000257821 | - | 14 | 18 | 425_437 | 484 | 682 | DNA binding | Note=A.T hook |
| Hgene | PHF21A | chr11:45967391 | chr16:4386726 | ENST00000418153 | - | 14 | 18 | 425_437 | 483 | 681 | DNA binding | Note=A.T hook |
| Tgene | >GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 363_460 | 258 | 525 | Compositional bias | Note=Gly-rich |
| Tgene | >GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 363_460 | 258 | 525 | Compositional bias | Note=Gly-rich |
| Tgene | >GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 263_287 | 258 | 525 | Zinc finger | C2H2-type 4 |
| Tgene | >GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 293_317 | 258 | 525 | Zinc finger | C2H2-type 5 |
| Tgene | >GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 263_287 | 258 | 525 | Zinc finger | C2H2-type 4 |
| Tgene | >GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 293_317 | 258 | 525 | Zinc finger | C2H2-type 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000257821 | - | 14 | 18 | 558_603 | 484 | 682 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000323180 | - | 1 | 18 | 558_603 | -123 | 635 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000418153 | - | 14 | 18 | 558_603 | 483 | 681 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000323180 | - | 1 | 18 | 4_108 | -123 | 635 | Compositional bias | Note=Gln-rich |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000323180 | - | 1 | 18 | 425_437 | -123 | 635 | DNA binding | Note=A.T hook |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000257821 | - | 14 | 18 | 486_680 | 484 | 682 | Region | Note=Required for transcriptional repression |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000323180 | - | 1 | 18 | 486_680 | -123 | 635 | Region | Note=Required for transcriptional repression |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000418153 | - | 14 | 18 | 486_680 | 483 | 681 | Region | Note=Required for transcriptional repression |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000257821 | - | 14 | 18 | 488_535 | 484 | 682 | Zinc finger | PHD-type |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000323180 | - | 1 | 18 | 488_535 | -123 | 635 | Zinc finger | PHD-type |
| Hgene | >PHF21A | chr11:45967391 | chr16:4386726 | ENST00000418153 | - | 14 | 18 | 488_535 | 483 | 681 | Zinc finger | PHD-type |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 148_171 | 258 | 525 | Region | Transcription repression |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 71_137 | 258 | 525 | Region | Transcription activation |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 148_171 | 258 | 525 | Region | Transcription repression |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 71_137 | 258 | 525 | Region | Transcription activation |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 168_193 | 258 | 525 | Zinc finger | C2H2-type 1 |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 202_229 | 258 | 525 | Zinc finger | C2H2-type 2%3B atypical |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 235_257 | 258 | 525 | Zinc finger | C2H2-type 3 |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 168_193 | 258 | 525 | Zinc finger | C2H2-type 1 |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 202_229 | 258 | 525 | Zinc finger | C2H2-type 2%3B atypical |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 235_257 | 258 | 525 | Zinc finger | C2H2-type 3 |
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FusionGeneSequence for PHF21A_GLIS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PHF21A_ENST00000257821_chr11_45967391_-_GLIS2_ENST00000262366_chr16_4386726_+_750aa MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL QTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKF TPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKR EENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQ SSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDVRSPTSAPTRAATSAIPTPVTALSTRAPTMWTSPTTARCPAATSATRTPAHCASTS RPMATLCPTSSKSSCSCAHPPSRHCPPPTAAPMSVGPRSSSPTQLPSLEALACPAYPYPWPPAPLTSVPWPVATVGAVGVGGAWALGCQA PSCLSIWPRTRCCPRPLGLADWACLWSPSLLAQLVARPRGRRGVGRCPPGPWAWRATRRPLKGRRAAAPGQAPMDSPCCQAPCWTCPRAS >In-frame_PHF21A_ENST00000257821_chr11_45967391_-_GLIS2_ENST00000433375_chr16_4386726_+_750aa MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL QTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKF TPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKR EENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQ SSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDVRSPTSAPTRAATSAIPTPVTALSTRAPTMWTSPTTARCPAATSATRTPAHCASTS RPMATLCPTSSKSSCSCAHPPSRHCPPPTAAPMSVGPRSSSPTQLPSLEALACPAYPYPWPPAPLTSVPWPVATVGAVGVGGAWALGCQA PSCLSIWPRTRCCPRPLGLADWACLWSPSLLAQLVARPRGRRGVGRCPPGPWAWRATRRPLKGRRAAAPGQAPMDSPCCQAPCWTCPRAS >In-frame_PHF21A_ENST00000418153_chr11_45967391_-_GLIS2_ENST00000262366_chr16_4386726_+_749aa MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL QTSSKVTGPGAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFT PTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKRE ENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQS SHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDVRSPTSAPTRAATSAIPTPVTALSTRAPTMWTSPTTARCPAATSATRTPAHCASTSR PMATLCPTSSKSSCSCAHPPSRHCPPPTAAPMSVGPRSSSPTQLPSLEALACPAYPYPWPPAPLTSVPWPVATVGAVGVGGAWALGCQAP SCLSIWPRTRCCPRPLGLADWACLWSPSLLAQLVARPRGRRGVGRCPPGPWAWRATRRPLKGRRAAAPGQAPMDSPCCQAPCWTCPRAST >In-frame_PHF21A_ENST00000418153_chr11_45967391_-_GLIS2_ENST00000433375_chr16_4386726_+_749aa MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQ PLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNL QTSSKVTGPGAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFT PTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKRE ENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQS SHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDVRSPTSAPTRAATSAIPTPVTALSTRAPTMWTSPTTARCPAATSATRTPAHCASTSR PMATLCPTSSKSSCSCAHPPSRHCPPPTAAPMSVGPRSSSPTQLPSLEALACPAYPYPWPPAPLTSVPWPVATVGAVGVGGAWALGCQAP SCLSIWPRTRCCPRPLGLADWACLWSPSLLAQLVARPRGRRGVGRCPPGPWAWRATRRPLKGRRAAAPGQAPMDSPCCQAPCWTCPRAST |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PHF21A_ENST00000257821_chr11_45967391_-_GLIS2_ENST00000262366_chr16_4386726_+_2252nt ATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAAT GCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAG AACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAA CCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAG AAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTG GGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTC CAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCT CCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTG GCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTC ACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCC ATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAA AAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGG GAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAG CGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGC ACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAA TCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCC ACCTCCACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGCTTTAAGCACACGC GCACCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCA AGGCCCATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCCGCCCCCGACGGCG GCCCCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGG CCCCCGGCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCTGGGCTGCCAGGCC CCGTCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTG CTGGCGCAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGCCACAAGACGCCCC TTGAAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCA ACTCAGCTGCCAGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAAACCGGCTGTGGTGAACT >In-frame_PHF21A_ENST00000257821_chr11_45967391_-_GLIS2_ENST00000433375_chr16_4386726_+_2252nt ATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAAT GCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAG AACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAA CCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAG AAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTG GGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTC CAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCT CCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTG GCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTC ACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCC ATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAA AAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGG GAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAG CGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGC ACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAA TCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCC ACCTCCACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGCTTTAAGCACACGC GCACCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCA AGGCCCATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCCGCCCCCGACGGCG GCCCCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGG CCCCCGGCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCTGGGCTGCCAGGCC CCGTCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTG CTGGCGCAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGCCACAAGACGCCCC TTGAAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCA ACTCAGCTGCCAGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAAACCGGCTGTGGTGAACT >In-frame_PHF21A_ENST00000418153_chr11_45967391_-_GLIS2_ENST00000262366_chr16_4386726_+_2249nt ATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAAT GCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAG AACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAA CCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAG AAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTG GGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTC CAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGGTTCAGGCAACACCTCCT CAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCC CAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACC CCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATG GCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAA CAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAG GAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGA AAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACA ATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCC AGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACC TCCACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGCTTTAAGCACACGCGCA CCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCAAGG CCCATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCCGCCCCCGACGGCGGCC CCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGGCCC CCGGCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCTGGGCTGCCAGGCCCCG TCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTGCTG GCGCAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGCCACAAGACGCCCCTTG AAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCAACT >In-frame_PHF21A_ENST00000418153_chr11_45967391_-_GLIS2_ENST00000433375_chr16_4386726_+_2249nt ATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAAT GCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAG AACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAA CCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAG AAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTG GGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTC CAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGGTTCAGGCAACACCTCCT CAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCC CAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACC CCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATG GCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAA CAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAG GAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGA AAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACA ATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCC AGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACC TCCACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGCTTTAAGCACACGCGCA CCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCAAGG CCCATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCCGCCCCCGACGGCGGCC CCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGGCCC CCGGCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCTGGGCTGCCAGGCCCCG TCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTGCTG GCGCAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGCCACAAGACGCCCCTTG AAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCAACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PHF21A_ENST00000257821_chr11_45967391_-_GLIS2_ENST00000262366_chr16_4386726_+_4949nt GGTGAATGGGCTGGTGGTGCTCGCTGCTGCTGCTGAGAGGAGGAGGAGGATGAAGAGTTGGGCTTGTTTGTCTCCTACAGTTTCTCTCCT GCTGCTCTGATTCCCCCCTCCCGATTCCGGCCCGGGGCCTGTGTGTGTCCCTCCTGGAGGAGGAGGAGGATCCAGTTCCTCCCCCCAACC CCCTCCTCCCCACCCCCCCTTGCCTGGGGAAGAGGAGGAAAGAAACAGCCCAGAGAGAGAGAGAGAGAGAGAGTGAGTGAGAGAGAGAGG AGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAGAGGCCCAGAGCAGC AGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCTGCTTCTCCTGCTCA GAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCAGTTTCCCCAAAATT GCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAAGGTAGAGGATGGAG TTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAATGCTGAC TTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAGAACCTG ATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTA CAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACT GTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAG AGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACG TCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAG CCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAG AATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCC ACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCC CAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAG ACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAG AACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAA AGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATG CACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGT CATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCC ACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGCTTTAAGCACACGCGCACCC ACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCAAGGCCC ATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCCGCCCCCGACGGCGGCCCCT ATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGGCCCCCG GCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCTGGGCTGCCAGGCCCCGTCC TGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTGCTGGCG CAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGCCACAAGACGCCCCTTGAAA GGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCAACTCAG CTGCCAGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAAACCGGCTGTGGTGAACTGAGCCC ATCCTGCGGACAGTTGTGGTGCCCCCCCGGCAGCTCCCGGCACTGCCCCCGACGAACGGAAACTCTTCTGTGAAATAGCAATAATGTCCT ACTGCCCGGGCAGCCCCAGCCCAGCCCGCCGGGAGCAAGGATGGTGCTAGGTCATTCATGGCTGGCCTCCCAGCCCCCGGGTGGGGACCT GGCCTGTCATGCAGGGAGAGCTGTGCTCCTGGGTGCTGAAGCCTCGCTCCTGTCTGTCCCCCACCACCTGGCCCTCAGCTTCTGAGAGGC TTTCCCCTGCCCGACCTCCTCCCGTTTCCCTCTCCCACCCTGGCACCTCCCTCACCTAGTGACCACCCATGGCAAGTTGCCCTCTCCCAG CAGAGGGGGTGGGTGGGGTGGCATCTGCCCTCCCTGCTAGCACCAGGCTCCCCCTTCCTGAGAGGAGCCCCCAGGGACCAGAGGCCTGCC CTTCCCTCCTAGGCTTACCCAGCCCCTGCCCTGGGGGCTCCTTGGACCCCTTTCCCTCTGACCCTGCCTCCAGAGGGAAAGCAAGACAGA TGCAGGCCCCTGCAAAGCCCCAGGTAGAAGCATGCCCCCCAGGACAAGGCGCCTCCCACTAGTTAGGAGGAGGCCCGCTCTGCAGCCGCC GTCCTCACCCCAGGCCAGGCCTGCAGTACCAGACGGGATAGCTGGCCACTCCACCCCTGCACCCCAGGGTCTCCTCCCTCTACCTTTTGG GGCACCCTGGGAGCGTGGGAAGCAGGTCCGAGGGCCCCTGAGCTGGCAAGGGGAGGTGCCAGGCCAGCTGTGGTGCCAAGATACTGAGTG ACCTGGGCCCTGGCTCAGGGAGCATGTGGGGCCAGGCCCAGCGCCCCGTCTTCCTCCTTCTACCCCCGCTGGGCCTGGCCTGGGCAGCGC CCCCTGCAGAGGCCTTTGGGTCCTTGGTCCTGTAACAGGAAGGGGGAGGCTGGCTGGGGACGACCGACCACAGGCTGGGACACAGCTCCT GGTCTGGGGGCTCCAAGTGACAGCATGCAGGGGAGGGGGCTCCCAGTCAGTGCTGTGTTGGGAGCTTTCTGGAGGCTGTGGACTGAAGGC CTTGAGGGAAGCAGTGGCTGGAGGAGGGTGCTGGACCCATGACACGTTGCTTCCTCTGGCTTTTCCCTGCTGGGCCGCTTTCTCAGAGGC ACTTCCCCACCCCTAACACCCAGTGGGCCCCCCCAGGTTCTGTGCCACTCAGAGGGACCCTGGCAGGGGCCAGAACCACTTAAGGGTGGT GCTGGAGGGCCTTGTGCCCCAGTCCCATCCCAGGACGCCCTGAGGGATGGACGCAGCCATGCACCCCCCATCTGGGGCCTCTCCCTGCTC CCTCTCCCACCTGGCAGCTGGGAGTTCTGGCTTCTAGGCCTGCCCTGTCACCAGGCCTCTGAGTGGCCAGGCCCTTCCACCTCCCCATCT GTAAAACGAGGCAGCTGCCCGGACAGCCTTGGGGTCCTTAGTGGCCCTGCAGGTCCTCTGGCAGCTCTGCTGACCCCACCCTCTCCCGGA CTGCCCTTCTGTCCCAGAGGGGTCACCCTGACCCGGCCCACCTTGCCACTGGGCTTTGGACTCCAGCCCTGACAGGGCCCAGCCACACTG GCTCTGCCCCTCGAAGGGGCTATGAGCAAGGTAGGAGGGAGCTGGTCTCCTTTCTTCGGGCCCCACCCAGGCCCTGAGCACCCCCCACCC CTGTGAGGGCCCCAGGCCTTAAGTCCCTGGCGGGGTCATGGGTTTGCGACTTGAGCAGAGCGGAGGAACAGGGCACTGGAAGGCCGACGA GCTCAGCATGCGACTCGGTGACGGACCAGGCTCGGCAGGGCCGGTGTACTTTTTGTGGTTGTCATTGGTGTGTTGTTGCACATTCCAGGA CGTCAGTATTTTAACAGGTTCTAAGTGCCTTTCTATCGTAGCTTATGTTTTCCTCCTCTTGGCTCCATTGCTGTTAGCATAGAGTTTTAA >In-frame_PHF21A_ENST00000257821_chr11_45967391_-_GLIS2_ENST00000433375_chr16_4386726_+_4949nt GGTGAATGGGCTGGTGGTGCTCGCTGCTGCTGCTGAGAGGAGGAGGAGGATGAAGAGTTGGGCTTGTTTGTCTCCTACAGTTTCTCTCCT GCTGCTCTGATTCCCCCCTCCCGATTCCGGCCCGGGGCCTGTGTGTGTCCCTCCTGGAGGAGGAGGAGGATCCAGTTCCTCCCCCCAACC CCCTCCTCCCCACCCCCCCTTGCCTGGGGAAGAGGAGGAAAGAAACAGCCCAGAGAGAGAGAGAGAGAGAGAGTGAGTGAGAGAGAGAGG AGAGGAGAGGAGGAGGAGGAGGAGGGAGAAGGGAACAACCTACCATCTTAACACACTAATATCTAAAAAGTGCGAGAGGCCCAGAGCAGC AGCAGAAGCAGCAGCAGCAGCTCCAGCTTCTTCCCTCCCTCCCCATGAAGAAGAGTTCCCTCCTCCTCCTCCTCCTGCTTCTCCTGCTCA GAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCTGAAGGAGAGCCAGTTTCCCCAAAATT GCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGAGAAAGTGGAGAAGGTAGAGGATGGAG TTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAATGAAGCAGGATCCACAGAATGCTGAC TTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAGTAGTTGAACAGCTACGGAAGAACCTG ATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTA CAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACT GTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAG AGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACG TCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAG CCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAG AATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCC ACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCC CAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAG ACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAG AACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAA AGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATG CACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGT CATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCC ACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGACCGCTTTAAGCACACGCGCACCC ACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCAAGGCCC ATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACTGCCCGCCCCCGACGGCGGCCCCT ATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGGCCCCCG GCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGGCCCTGGGCTGCCAGGCCCCGTCC TGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTGCTGGCG CAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGAGGGCCACAAGACGCCCCTTGAAA GGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCAACTCAG CTGCCAGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAAACCGGCTGTGGTGAACTGAGCCC ATCCTGCGGACAGTTGTGGTGCCCCCCCGGCAGCTCCCGGCACTGCCCCCGACGAACGGAAACTCTTCTGTGAAATAGCAATAATGTCCT ACTGCCCGGGCAGCCCCAGCCCAGCCCGCCGGGAGCAAGGATGGTGCTAGGTCATTCATGGCTGGCCTCCCAGCCCCCGGGTGGGGACCT GGCCTGTCATGCAGGGAGAGCTGTGCTCCTGGGTGCTGAAGCCTCGCTCCTGTCTGTCCCCCACCACCTGGCCCTCAGCTTCTGAGAGGC TTTCCCCTGCCCGACCTCCTCCCGTTTCCCTCTCCCACCCTGGCACCTCCCTCACCTAGTGACCACCCATGGCAAGTTGCCCTCTCCCAG CAGAGGGGGTGGGTGGGGTGGCATCTGCCCTCCCTGCTAGCACCAGGCTCCCCCTTCCTGAGAGGAGCCCCCAGGGACCAGAGGCCTGCC CTTCCCTCCTAGGCTTACCCAGCCCCTGCCCTGGGGGCTCCTTGGACCCCTTTCCCTCTGACCCTGCCTCCAGAGGGAAAGCAAGACAGA TGCAGGCCCCTGCAAAGCCCCAGGTAGAAGCATGCCCCCCAGGACAAGGCGCCTCCCACTAGTTAGGAGGAGGCCCGCTCTGCAGCCGCC GTCCTCACCCCAGGCCAGGCCTGCAGTACCAGACGGGATAGCTGGCCACTCCACCCCTGCACCCCAGGGTCTCCTCCCTCTACCTTTTGG GGCACCCTGGGAGCGTGGGAAGCAGGTCCGAGGGCCCCTGAGCTGGCAAGGGGAGGTGCCAGGCCAGCTGTGGTGCCAAGATACTGAGTG ACCTGGGCCCTGGCTCAGGGAGCATGTGGGGCCAGGCCCAGCGCCCCGTCTTCCTCCTTCTACCCCCGCTGGGCCTGGCCTGGGCAGCGC CCCCTGCAGAGGCCTTTGGGTCCTTGGTCCTGTAACAGGAAGGGGGAGGCTGGCTGGGGACGACCGACCACAGGCTGGGACACAGCTCCT GGTCTGGGGGCTCCAAGTGACAGCATGCAGGGGAGGGGGCTCCCAGTCAGTGCTGTGTTGGGAGCTTTCTGGAGGCTGTGGACTGAAGGC CTTGAGGGAAGCAGTGGCTGGAGGAGGGTGCTGGACCCATGACACGTTGCTTCCTCTGGCTTTTCCCTGCTGGGCCGCTTTCTCAGAGGC ACTTCCCCACCCCTAACACCCAGTGGGCCCCCCCAGGTTCTGTGCCACTCAGAGGGACCCTGGCAGGGGCCAGAACCACTTAAGGGTGGT GCTGGAGGGCCTTGTGCCCCAGTCCCATCCCAGGACGCCCTGAGGGATGGACGCAGCCATGCACCCCCCATCTGGGGCCTCTCCCTGCTC CCTCTCCCACCTGGCAGCTGGGAGTTCTGGCTTCTAGGCCTGCCCTGTCACCAGGCCTCTGAGTGGCCAGGCCCTTCCACCTCCCCATCT GTAAAACGAGGCAGCTGCCCGGACAGCCTTGGGGTCCTTAGTGGCCCTGCAGGTCCTCTGGCAGCTCTGCTGACCCCACCCTCTCCCGGA CTGCCCTTCTGTCCCAGAGGGGTCACCCTGACCCGGCCCACCTTGCCACTGGGCTTTGGACTCCAGCCCTGACAGGGCCCAGCCACACTG GCTCTGCCCCTCGAAGGGGCTATGAGCAAGGTAGGAGGGAGCTGGTCTCCTTTCTTCGGGCCCCACCCAGGCCCTGAGCACCCCCCACCC CTGTGAGGGCCCCAGGCCTTAAGTCCCTGGCGGGGTCATGGGTTTGCGACTTGAGCAGAGCGGAGGAACAGGGCACTGGAAGGCCGACGA GCTCAGCATGCGACTCGGTGACGGACCAGGCTCGGCAGGGCCGGTGTACTTTTTGTGGTTGTCATTGGTGTGTTGTTGCACATTCCAGGA CGTCAGTATTTTAACAGGTTCTAAGTGCCTTTCTATCGTAGCTTATGTTTTCCTCCTCTTGGCTCCATTGCTGTTAGCATAGAGTTTTAA >In-frame_PHF21A_ENST00000418153_chr11_45967391_-_GLIS2_ENST00000262366_chr16_4386726_+_4522nt CCTCCTCCTCCTGCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCT GAAGGAGAGCCAGTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGA GAAAGTGGAGAAGGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAA TGAAGCAGGATCCACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAG TAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAAC TACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTC CCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGA CCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGC AGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTC TGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGG TTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCG TCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCA TAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTA GCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTG CACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCC AAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAG TGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTA CCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTG TGTCCCTGCCCAGCCCCACCTCCACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGA CCGCTTTAAGCACACGCGCACCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTC ACTGCGCAAGCACATCAAGGCCCATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACT GCCCGCCCCCGACGGCGGCCCCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGG CTTACCCCTACCCCTGGCCCCCGGCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGG CCCTGGGCTGCCAGGCCCCGTCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCC TGTGGTCTCCCTCCTTGCTGGCGCAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGA GGGCCACAAGACGCCCCTTGAAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGA CCTGTCCACGGGCGTCAACTCAGCTGCCAGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAA ACCGGCTGTGGTGAACTGAGCCCATCCTGCGGACAGTTGTGGTGCCCCCCCGGCAGCTCCCGGCACTGCCCCCGACGAACGGAAACTCTT CTGTGAAATAGCAATAATGTCCTACTGCCCGGGCAGCCCCAGCCCAGCCCGCCGGGAGCAAGGATGGTGCTAGGTCATTCATGGCTGGCC TCCCAGCCCCCGGGTGGGGACCTGGCCTGTCATGCAGGGAGAGCTGTGCTCCTGGGTGCTGAAGCCTCGCTCCTGTCTGTCCCCCACCAC CTGGCCCTCAGCTTCTGAGAGGCTTTCCCCTGCCCGACCTCCTCCCGTTTCCCTCTCCCACCCTGGCACCTCCCTCACCTAGTGACCACC CATGGCAAGTTGCCCTCTCCCAGCAGAGGGGGTGGGTGGGGTGGCATCTGCCCTCCCTGCTAGCACCAGGCTCCCCCTTCCTGAGAGGAG CCCCCAGGGACCAGAGGCCTGCCCTTCCCTCCTAGGCTTACCCAGCCCCTGCCCTGGGGGCTCCTTGGACCCCTTTCCCTCTGACCCTGC CTCCAGAGGGAAAGCAAGACAGATGCAGGCCCCTGCAAAGCCCCAGGTAGAAGCATGCCCCCCAGGACAAGGCGCCTCCCACTAGTTAGG AGGAGGCCCGCTCTGCAGCCGCCGTCCTCACCCCAGGCCAGGCCTGCAGTACCAGACGGGATAGCTGGCCACTCCACCCCTGCACCCCAG GGTCTCCTCCCTCTACCTTTTGGGGCACCCTGGGAGCGTGGGAAGCAGGTCCGAGGGCCCCTGAGCTGGCAAGGGGAGGTGCCAGGCCAG CTGTGGTGCCAAGATACTGAGTGACCTGGGCCCTGGCTCAGGGAGCATGTGGGGCCAGGCCCAGCGCCCCGTCTTCCTCCTTCTACCCCC GCTGGGCCTGGCCTGGGCAGCGCCCCCTGCAGAGGCCTTTGGGTCCTTGGTCCTGTAACAGGAAGGGGGAGGCTGGCTGGGGACGACCGA CCACAGGCTGGGACACAGCTCCTGGTCTGGGGGCTCCAAGTGACAGCATGCAGGGGAGGGGGCTCCCAGTCAGTGCTGTGTTGGGAGCTT TCTGGAGGCTGTGGACTGAAGGCCTTGAGGGAAGCAGTGGCTGGAGGAGGGTGCTGGACCCATGACACGTTGCTTCCTCTGGCTTTTCCC TGCTGGGCCGCTTTCTCAGAGGCACTTCCCCACCCCTAACACCCAGTGGGCCCCCCCAGGTTCTGTGCCACTCAGAGGGACCCTGGCAGG GGCCAGAACCACTTAAGGGTGGTGCTGGAGGGCCTTGTGCCCCAGTCCCATCCCAGGACGCCCTGAGGGATGGACGCAGCCATGCACCCC CCATCTGGGGCCTCTCCCTGCTCCCTCTCCCACCTGGCAGCTGGGAGTTCTGGCTTCTAGGCCTGCCCTGTCACCAGGCCTCTGAGTGGC CAGGCCCTTCCACCTCCCCATCTGTAAAACGAGGCAGCTGCCCGGACAGCCTTGGGGTCCTTAGTGGCCCTGCAGGTCCTCTGGCAGCTC TGCTGACCCCACCCTCTCCCGGACTGCCCTTCTGTCCCAGAGGGGTCACCCTGACCCGGCCCACCTTGCCACTGGGCTTTGGACTCCAGC CCTGACAGGGCCCAGCCACACTGGCTCTGCCCCTCGAAGGGGCTATGAGCAAGGTAGGAGGGAGCTGGTCTCCTTTCTTCGGGCCCCACC CAGGCCCTGAGCACCCCCCACCCCTGTGAGGGCCCCAGGCCTTAAGTCCCTGGCGGGGTCATGGGTTTGCGACTTGAGCAGAGCGGAGGA ACAGGGCACTGGAAGGCCGACGAGCTCAGCATGCGACTCGGTGACGGACCAGGCTCGGCAGGGCCGGTGTACTTTTTGTGGTTGTCATTG GTGTGTTGTTGCACATTCCAGGACGTCAGTATTTTAACAGGTTCTAAGTGCCTTTCTATCGTAGCTTATGTTTTCCTCCTCTTGGCTCCA TTGCTGTTAGCATAGAGTTTTAAAAAAAGAGATAAGCTAATGACTATAACAATATATTCCTCCATGGGAGAGGAAGTTTATAAAGAAACA >In-frame_PHF21A_ENST00000418153_chr11_45967391_-_GLIS2_ENST00000433375_chr16_4386726_+_4522nt CCTCCTCCTCCTGCTTCTCCTGCTCAGAGTTCCTGCCTCCAGCTGCCAGGGGGGACAGCCAGCCAGCAGCAGGAGGGGGGCTAGAGAGCT GAAGGAGAGCCAGTTTCCCCAAAATTGCTGCAGTGAGAAGAGGAGTTTGTTACTTTAAACAGAGGCTGAAGAAACTATAGAATTAGCAGA GAAAGTGGAGAAGGTAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCTCAAA TGAAGCAGGATCCACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAGAAAAGAG TAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAAC TACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTC CCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGA CCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGC AGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTC TGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGG TTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCG TCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCA TAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTA GCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTG CACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCC AAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAG TGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTA CCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTG TGTCCCTGCCCAGCCCCACCTCCACAGACGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGTGA CCGCTTTAAGCACACGCGCACCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCCGGCTGCCACAAGCGCTACACGGACCCCAGCTC ACTGCGCAAGCACATCAAGGCCCATGGCCACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCACT GCCCGCCCCCGACGGCGGCCCCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCAGCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGG CTTACCCCTACCCCTGGCCCCCGGCCCCCTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATGGG CCCTGGGCTGCCAGGCCCCGTCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCCTCGCCCTTTGGGGCTGGCGGACTGGGCTTGCC TGTGGTCTCCCTCCTTGCTGGCGCAGCTGGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATGGA GGGCCACAAGACGCCCCTTGAAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGATGGACTCCCCCTGCTGCCAGGCACCGTGCTGGA CCTGTCCACGGGCGTCAACTCAGCTGCCAGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTCAA ACCGGCTGTGGTGAACTGAGCCCATCCTGCGGACAGTTGTGGTGCCCCCCCGGCAGCTCCCGGCACTGCCCCCGACGAACGGAAACTCTT CTGTGAAATAGCAATAATGTCCTACTGCCCGGGCAGCCCCAGCCCAGCCCGCCGGGAGCAAGGATGGTGCTAGGTCATTCATGGCTGGCC TCCCAGCCCCCGGGTGGGGACCTGGCCTGTCATGCAGGGAGAGCTGTGCTCCTGGGTGCTGAAGCCTCGCTCCTGTCTGTCCCCCACCAC CTGGCCCTCAGCTTCTGAGAGGCTTTCCCCTGCCCGACCTCCTCCCGTTTCCCTCTCCCACCCTGGCACCTCCCTCACCTAGTGACCACC CATGGCAAGTTGCCCTCTCCCAGCAGAGGGGGTGGGTGGGGTGGCATCTGCCCTCCCTGCTAGCACCAGGCTCCCCCTTCCTGAGAGGAG CCCCCAGGGACCAGAGGCCTGCCCTTCCCTCCTAGGCTTACCCAGCCCCTGCCCTGGGGGCTCCTTGGACCCCTTTCCCTCTGACCCTGC CTCCAGAGGGAAAGCAAGACAGATGCAGGCCCCTGCAAAGCCCCAGGTAGAAGCATGCCCCCCAGGACAAGGCGCCTCCCACTAGTTAGG AGGAGGCCCGCTCTGCAGCCGCCGTCCTCACCCCAGGCCAGGCCTGCAGTACCAGACGGGATAGCTGGCCACTCCACCCCTGCACCCCAG GGTCTCCTCCCTCTACCTTTTGGGGCACCCTGGGAGCGTGGGAAGCAGGTCCGAGGGCCCCTGAGCTGGCAAGGGGAGGTGCCAGGCCAG CTGTGGTGCCAAGATACTGAGTGACCTGGGCCCTGGCTCAGGGAGCATGTGGGGCCAGGCCCAGCGCCCCGTCTTCCTCCTTCTACCCCC GCTGGGCCTGGCCTGGGCAGCGCCCCCTGCAGAGGCCTTTGGGTCCTTGGTCCTGTAACAGGAAGGGGGAGGCTGGCTGGGGACGACCGA CCACAGGCTGGGACACAGCTCCTGGTCTGGGGGCTCCAAGTGACAGCATGCAGGGGAGGGGGCTCCCAGTCAGTGCTGTGTTGGGAGCTT TCTGGAGGCTGTGGACTGAAGGCCTTGAGGGAAGCAGTGGCTGGAGGAGGGTGCTGGACCCATGACACGTTGCTTCCTCTGGCTTTTCCC TGCTGGGCCGCTTTCTCAGAGGCACTTCCCCACCCCTAACACCCAGTGGGCCCCCCCAGGTTCTGTGCCACTCAGAGGGACCCTGGCAGG GGCCAGAACCACTTAAGGGTGGTGCTGGAGGGCCTTGTGCCCCAGTCCCATCCCAGGACGCCCTGAGGGATGGACGCAGCCATGCACCCC CCATCTGGGGCCTCTCCCTGCTCCCTCTCCCACCTGGCAGCTGGGAGTTCTGGCTTCTAGGCCTGCCCTGTCACCAGGCCTCTGAGTGGC CAGGCCCTTCCACCTCCCCATCTGTAAAACGAGGCAGCTGCCCGGACAGCCTTGGGGTCCTTAGTGGCCCTGCAGGTCCTCTGGCAGCTC TGCTGACCCCACCCTCTCCCGGACTGCCCTTCTGTCCCAGAGGGGTCACCCTGACCCGGCCCACCTTGCCACTGGGCTTTGGACTCCAGC CCTGACAGGGCCCAGCCACACTGGCTCTGCCCCTCGAAGGGGCTATGAGCAAGGTAGGAGGGAGCTGGTCTCCTTTCTTCGGGCCCCACC CAGGCCCTGAGCACCCCCCACCCCTGTGAGGGCCCCAGGCCTTAAGTCCCTGGCGGGGTCATGGGTTTGCGACTTGAGCAGAGCGGAGGA ACAGGGCACTGGAAGGCCGACGAGCTCAGCATGCGACTCGGTGACGGACCAGGCTCGGCAGGGCCGGTGTACTTTTTGTGGTTGTCATTG GTGTGTTGTTGCACATTCCAGGACGTCAGTATTTTAACAGGTTCTAAGTGCCTTTCTATCGTAGCTTATGTTTTCCTCCTCTTGGCTCCA TTGCTGTTAGCATAGAGTTTTAAAAAAAGAGATAAGCTAATGACTATAACAATATATTCCTCCATGGGAGAGGAAGTTTATAAAGAAACA |
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FusionGenePPI for PHF21A_GLIS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PHF21A | LPXN, HDAC1, KDM1A, HMG20B, RCOR1, HDAC2, GTF2I, TAF10, ESCO2, HIST2H3C, ELAVL1, HIST3H3, FHL3, TRAF1, ZYX, NUP62, BANP, KRT40, SCLT1, CD14, KIF22, LLGL2, SOD1, MYH13, NUPL1, HMG20A, NAF1, IP6K3, RBPJ, EXOC1, MAX, ARNTL, RPRD1A, HAUS6, PHLDB3, PTRF, OIP5, CCDC93, CCDC132, DZIP3, GRIPAP1, VPS53, PSMD9, CLOCK, RABGAP1L, GOLGA5, TUFT1, YEATS4, CCHCR1, TFPT, NCKAP5L, PKN3, GIT2, RABGEF1, NUF2, THAP11, VPS51, JUN, TSSC1 | GLIS2 | CTNNB1, RBFOX2, SPECC1L, CPSF1, GPSM2, U2AF2, WNK1, XAB2, BBS1, BBS2, TRIM32, PML, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000262366 | + | 6 | 8 | 35_174 | 258 | 525 | CTNND1 |
| Tgene | GLIS2 | chr11:45967391 | chr16:4386726 | ENST00000433375 | + | 4 | 6 | 35_174 | 258 | 525 | CTNND1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF21A_GLIS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF21A_GLIS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GLIS2 | C0022658 | Kidney Diseases | 1 | CTD_human |
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