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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26913

FusionGeneSummary for PHF17_LARP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF17_LARP1B
Fusion gene ID: 26913
HgeneTgene
Gene symbol

PHF17

LARP1B

Gene ID

79960

55132

Gene namejade family PHD finger 1La ribonucleoprotein domain family member 1B
SynonymsPHF17LARP2
Cytomap

4q28.2

4q28.2

Type of geneprotein-codingprotein-coding
Descriptionprotein Jade-1PHD finger protein 17PHD protein Jade-1gene for apoptosis and differentiation in epitheliajade family PHD finger protein 1la-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2
Modification date2018051920180519
UniProtAcc

Q659C4

Ensembl transtripts involved in fusion geneENST00000226319, ENST00000511647, 
ENST00000452328, ENST00000512960, 
ENST00000413543, 
ENST00000326639, 
ENST00000264584, ENST00000441387, 
ENST00000354456, ENST00000506199, 
ENST00000512292, ENST00000394288, 
ENST00000432347, ENST00000427266, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 4 X 2=24
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/24*10)=1.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHF17 [Title/Abstract] AND LARP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF17

GO:0043966

histone H3 acetylation

16387653

HgenePHF17

GO:0043981

histone H4-K5 acetylation

16387653

HgenePHF17

GO:0043982

histone H4-K8 acetylation

16387653

HgenePHF17

GO:0043983

histone H4-K12 acetylation

16387653

HgenePHF17

GO:0043984

histone H4-K16 acetylation

16387653

HgenePHF17

GO:0090090

negative regulation of canonical Wnt signaling pathway

22654112

HgenePHF17

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

23001567


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-KB-A6F7-01APHF17chr4

129752965

+LARP1Bchr4

129083349

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000226319ENST00000326639PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000226319ENST00000264584PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000226319ENST00000441387PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-5UTRENST00000226319ENST00000354456PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000226319ENST00000506199PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000226319ENST00000512292PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000226319ENST00000394288PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000226319ENST00000432347PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000226319ENST00000427266PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000511647ENST00000326639PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000511647ENST00000264584PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000511647ENST00000441387PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-5UTRENST00000511647ENST00000354456PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000511647ENST00000506199PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000511647ENST00000512292PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000511647ENST00000394288PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000511647ENST00000432347PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000511647ENST00000427266PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000452328ENST00000326639PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000452328ENST00000264584PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000452328ENST00000441387PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-5UTRENST00000452328ENST00000354456PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000452328ENST00000506199PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000452328ENST00000512292PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000452328ENST00000394288PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000452328ENST00000432347PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000452328ENST00000427266PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000512960ENST00000326639PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000512960ENST00000264584PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000512960ENST00000441387PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-5UTRENST00000512960ENST00000354456PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000512960ENST00000506199PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000512960ENST00000512292PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000512960ENST00000394288PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000512960ENST00000432347PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000512960ENST00000427266PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000413543ENST00000326639PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000413543ENST00000264584PHF17chr4

129752965

+LARP1Bchr4

129083349

+
Frame-shiftENST00000413543ENST00000441387PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-5UTRENST00000413543ENST00000354456PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000413543ENST00000506199PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000413543ENST00000512292PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000413543ENST00000394288PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000413543ENST00000432347PHF17chr4

129752965

+LARP1Bchr4

129083349

+
5CDS-intronENST00000413543ENST00000427266PHF17chr4

129752965

+LARP1Bchr4

129083349

+

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FusionProtFeatures for PHF17_LARP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHF17

LARP1B

Q659C4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHF17_LARP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHF17_LARP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHF17LARP1BELAVL1, CUL3, APP, UBC, POLR2J, KIF2A, TRIM69, CCNI2, TRA2A, NIFK, RPS2, ZC3H3, HNRNPA1, LUC7L2, CCNG1, POC1A, GSPT2, LARP1, ELAVL2, CDX1, DGCR8, H2AFX, APOBEC3D, WDR46, HIST1H1E, SNRNP70


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHF17_LARP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHF17_LARP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource