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Fusion gene ID: 26904 |
FusionGeneSummary for PHF12_RBMS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHF12_RBMS1 | Fusion gene ID: 26904 | Hgene | Tgene | Gene symbol | PHF12 | RBMS1 | Gene ID | 57649 | 5937 |
| Gene name | PHD finger protein 12 | RNA binding motif single stranded interacting protein 1 | |
| Synonyms | PF1 | C2orf12|HCC-4|MSSP|MSSP-1|MSSP-2|MSSP-3|SCR2|YC1 | |
| Cytomap | 17q11.2 | 2q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PHD finger protein 12PHD factor 1PHD zinc finger transcription factor | RNA-binding motif, single-stranded-interacting protein 1c-myc gene single strand binding protein 2cervical cancer oncogene 4single-stranded DNA-binding protein MSSP-1suppressor of CDC2 with RNA-binding motif 2suppressor of cdc 2 (cdc13) with RNA bind | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96QT6 | P29558 | |
| Ensembl transtripts involved in fusion gene | ENST00000332830, ENST00000577226, ENST00000268756, ENST00000582655, | ENST00000474820, ENST00000348849, ENST00000409075, ENST00000409289, ENST00000392753, ENST00000409972, | |
| Fusion gene scores | * DoF score | 11 X 7 X 6=462 | 4 X 8 X 5=160 |
| # samples | 11 | 9 | |
| ** MAII score | log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/160*10)=-0.830074998557688 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHF12 [Title/Abstract] AND RBMS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PHF12 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 22048773 |
| Hgene | PHF12 | GO:0045892 | negative regulation of transcription, DNA-templated | 11390640 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN399833 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000332830 | ENST00000474820 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000332830 | ENST00000348849 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000332830 | ENST00000409075 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000332830 | ENST00000409289 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000332830 | ENST00000392753 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000332830 | ENST00000409972 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-5UTR | ENST00000577226 | ENST00000474820 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000577226 | ENST00000348849 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000577226 | ENST00000409075 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000577226 | ENST00000409289 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000577226 | ENST00000392753 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000577226 | ENST00000409972 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-5UTR | ENST00000268756 | ENST00000474820 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000268756 | ENST00000348849 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000268756 | ENST00000409075 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000268756 | ENST00000409289 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000268756 | ENST00000392753 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000268756 | ENST00000409972 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-5UTR | ENST00000582655 | ENST00000474820 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000582655 | ENST00000348849 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000582655 | ENST00000409075 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000582655 | ENST00000409289 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000582655 | ENST00000392753 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
| intron-3UTR | ENST00000582655 | ENST00000409972 | PHF12 | chr17 | 27251420 | - | RBMS1 | chr2 | 161131242 | - |
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FusionProtFeatures for PHF12_RBMS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHF12 | RBMS1 |
| Acts as a transcriptional repressor. Involved inrecruitment of functional SIN3A complexes to DNA. Repressestranscription at least in part through the activity of anassociated histone deacetylase (HDAC). May also represstranscription in a SIN3A-independent manner through recruitment offunctional AES complexes to DNA. {ECO:0000269|PubMed:11390640,ECO:0000303|PubMed:11390640}. | Single-stranded DNA binding protein that interacts withthe region upstream of the MYC gene. Binds specifically to the DNAsequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNAreplication. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHF12_RBMS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHF12_RBMS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF12_RBMS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF12_RBMS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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