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Fusion gene ID: 26900 |
FusionGeneSummary for PHF12_LIG3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHF12_LIG3 | Fusion gene ID: 26900 | Hgene | Tgene | Gene symbol | PHF12 | LIG3 | Gene ID | 57649 | 121227 |
| Gene name | PHD finger protein 12 | leucine rich repeats and immunoglobulin like domains 3 | |
| Synonyms | PF1 | LIG3 | |
| Cytomap | 17q11.2 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PHD finger protein 12PHD factor 1PHD zinc finger transcription factor | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96QT6 | P49916 | |
| Ensembl transtripts involved in fusion gene | ENST00000332830, ENST00000577226, ENST00000268756, ENST00000582655, | ENST00000378526, ENST00000262327, ENST00000586407, | |
| Fusion gene scores | * DoF score | 11 X 7 X 6=462 | 5 X 5 X 4=100 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHF12 [Title/Abstract] AND LIG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PHF12 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 22048773 |
| Hgene | PHF12 | GO:0045892 | negative regulation of transcription, DNA-templated | 11390640 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-7509-01A | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000332830 | ENST00000378526 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| In-frame | ENST00000332830 | ENST00000262327 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| 5CDS-intron | ENST00000332830 | ENST00000586407 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| In-frame | ENST00000577226 | ENST00000378526 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| In-frame | ENST00000577226 | ENST00000262327 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| 5CDS-intron | ENST00000577226 | ENST00000586407 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| In-frame | ENST00000268756 | ENST00000378526 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| In-frame | ENST00000268756 | ENST00000262327 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| 5CDS-intron | ENST00000268756 | ENST00000586407 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| intron-3CDS | ENST00000582655 | ENST00000378526 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| intron-3CDS | ENST00000582655 | ENST00000262327 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
| intron-intron | ENST00000582655 | ENST00000586407 | PHF12 | chr17 | 27277083 | - | LIG3 | chr17 | 33324757 | + |
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FusionProtFeatures for PHF12_LIG3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHF12 | LIG3 |
| Acts as a transcriptional repressor. Involved inrecruitment of functional SIN3A complexes to DNA. Repressestranscription at least in part through the activity of anassociated histone deacetylase (HDAC). May also represstranscription in a SIN3A-independent manner through recruitment offunctional AES complexes to DNA. {ECO:0000269|PubMed:11390640,ECO:0000303|PubMed:11390640}. | Isoform 3 functions as heterodimer with DNA-repairprotein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatmentwith ionizing radiation and alkylating agents. Isoform 1 istargeted to mitochondria, where it functions as DNA ligase inmitochondrial base-excision DNA repair (PubMed:10207110,PubMed:24674627). {ECO:0000269|PubMed:10207110,ECO:0000269|PubMed:24674627}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 894_897 | 82 | 705 | Compositional bias | Poly-Arg |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 929_932 | 82 | 705 | Compositional bias | Poly-Ser |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 894_897 | 82 | 1005 | Compositional bias | Poly-Arg |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 929_932 | 82 | 1005 | Compositional bias | Poly-Ser |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 815_869 | 82 | 705 | Domain | FHA |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 815_869 | 82 | 1005 | Domain | FHA |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 105_128 | 82 | 705 | Region | Note=PBR |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 105_128 | 82 | 1005 | Region | Note=PBR |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 271_321 | 82 | 705 | Zinc finger | PHD-type 2%3B atypical |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 56_105 | 82 | 705 | Zinc finger | PHD-type 1 |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 271_321 | 82 | 1005 | Zinc finger | PHD-type 2%3B atypical |
| Hgene | >PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 56_105 | 82 | 1005 | Zinc finger | PHD-type 1 |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000262327 | + | 10 | 20 | 93_185 | 607 | 950 | Zinc finger | PARP-type |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000378526 | + | 10 | 20 | 93_185 | 607 | 1010 | Zinc finger | PARP-type |
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FusionGeneSequence for PHF12_LIG3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PHF12_ENST00000332830_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_485aa MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCXPLCERRK FLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAH TADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLS NSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSA >In-frame_PHF12_ENST00000332830_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_425aa MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCXPLCERRK FLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAH TADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLS >In-frame_PHF12_ENST00000577226_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_485aa MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCXPLCERRK FLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAH TADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLS NSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSA >In-frame_PHF12_ENST00000577226_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_425aa MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCXPLCERRK FLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAH TADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLS >In-frame_PHF12_ENST00000268756_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_485aa MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCXPLCERRK FLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAH TADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLS NSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSA >In-frame_PHF12_ENST00000268756_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_425aa MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCXPLCERRK FLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAH TADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PHF12_ENST00000332830_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_1455nt ATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCC CCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGAT AGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAG TTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATG ATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAA GTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGC GGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGAT GCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAG ATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCAT ACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTC AAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAA GAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGT AACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTG AAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTG CCACCCTCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCC ACGCACGTGCTGGGTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTG >In-frame_PHF12_ENST00000332830_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_1275nt ATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCC CCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGAT AGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAG TTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATG ATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAA GTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGC GGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGAT GCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAG ATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCAT ACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTC AAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAA GAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGT AACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTG AAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCA >In-frame_PHF12_ENST00000577226_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_1455nt ATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCC CCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGAT AGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAG TTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATG ATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAA GTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGC GGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGAT GCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAG ATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCAT ACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTC AAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAA GAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGT AACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTG AAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTG CCACCCTCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCC ACGCACGTGCTGGGTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTG >In-frame_PHF12_ENST00000577226_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_1275nt ATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCC CCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGAT AGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAG TTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATG ATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAA GTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGC GGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGAT GCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAG ATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCAT ACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTC AAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAA GAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGT AACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTG AAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCA >In-frame_PHF12_ENST00000268756_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_1455nt ATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCC CCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGAT AGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAG TTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATG ATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAA GTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGC GGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGAT GCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAG ATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCAT ACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTC AAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAA GAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGT AACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTG AAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTG CCACCCTCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCC ACGCACGTGCTGGGTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTG >In-frame_PHF12_ENST00000268756_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_1275nt ATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCC CCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGAT AGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAG TTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATG ATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAA GTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGC GGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGAT GCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAG ATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCAT ACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTC AAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAA GAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGT AACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTG AAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PHF12_ENST00000332830_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_2824nt CTTAGTTTGCACACAAACACCAATGGATGAACAGTCCCTAGCTTCCTGCGGCTGCGCCTTGACCCCTACAAGCTTTCTCAAGCGCCTGCG CGAGACCTCAGGTCCCGCCCTTTTGTCTCAGTGCGCTGGCGCAGGGCAGAAAGGTGGGGCTTCGGTCCTCCAGACGAATGCCAGCGCGGC TGCGCGCTGGGGGGTACTCCCTCACCGCGGCTGCGCGGGAGCCAGGCCGCCGGCTGTCACTGCGGTTGCGCGCGGCGAGCGCCGATCCCG GGGCGCCTGCGCGGGTGGCTTTGCGGGCGCTCGCGGTAAGTTTGCGCCAAGTGCGCGGCAGCCGGGACGCAGACGGCGGCGGCGGCGAGA GGCGGAGCCCGGGGACCACCCCCCATCACCCTCCCCCCAGTCACCTCACGTACCACAACCTCACGTAACCTCTCACCCCCCCTCCGATAC CCCCAGCCCCGGGATGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGC CGAGGCCTGACCCCCGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGA GGACGCTGTCGTCCCGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCC GGGGTCAGGAGCGCCCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATG AATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCC CCCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGA TAGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAA GTTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACAT GATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAA AGTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGG CGGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGA TGCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAA GATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCA TACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACT CAAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGA AGAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAG TAACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGT GAAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTT GCCACCCTCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGC CACGCACGTGCTGGGTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACT GGTAGCTCCCTGCTAGGTTTGCTGTCTTCCCTCTCCCTCAGGCCATACTCTCCTTTACCATACTACTGGACTGGACTCAGGCTGGAGGCA GATAGACACAGTATAGGGGGAATGGGCTTGCTTCTCCCAAACCCACCAGTTCTCCACTGTCTCTTCTGGACCAGGAATTAGTTGCTGTGG GTGCCACAGCTGAAGTCAGTTTGTCTTGCTGGTTTAAATAGATCTTTCAGAGCTGGGTGCTGGGTTTGCCATCTTTTTGTTTTCTTTGAA AAGCAGCTTAGTTACCCTTTTTATAAATAAAATATCTTGCAGTTATCTTTGTCCTTTCCCCACCTACACCCCCAATAATTTCCCTAGAGA TTAAGGAGTAAAGGCTGGGCTATGGCAGCTCTGTCCACAAAGCCTTCTCTCCCATCCTTGCCTGTTCCTTTGTACTTCCAGGCTCATTTT AAAGTTGTATTTAAAGGACTGCCCTCGGAAATGCTTCTGTTTAGCGGAACTTGTATTCAGCCTGACACGCTTTGCCAGGAACAAACCTCA >In-frame_PHF12_ENST00000332830_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_2210nt CTTAGTTTGCACACAAACACCAATGGATGAACAGTCCCTAGCTTCCTGCGGCTGCGCCTTGACCCCTACAAGCTTTCTCAAGCGCCTGCG CGAGACCTCAGGTCCCGCCCTTTTGTCTCAGTGCGCTGGCGCAGGGCAGAAAGGTGGGGCTTCGGTCCTCCAGACGAATGCCAGCGCGGC TGCGCGCTGGGGGGTACTCCCTCACCGCGGCTGCGCGGGAGCCAGGCCGCCGGCTGTCACTGCGGTTGCGCGCGGCGAGCGCCGATCCCG GGGCGCCTGCGCGGGTGGCTTTGCGGGCGCTCGCGGTAAGTTTGCGCCAAGTGCGCGGCAGCCGGGACGCAGACGGCGGCGGCGGCGAGA GGCGGAGCCCGGGGACCACCCCCCATCACCCTCCCCCCAGTCACCTCACGTACCACAACCTCACGTAACCTCTCACCCCCCCTCCGATAC CCCCAGCCCCGGGATGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGC CGAGGCCTGACCCCCGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGA GGACGCTGTCGTCCCGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCC GGGGTCAGGAGCGCCCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATG AATGTGGGAGAAAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCC CCCCAAGACGGACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGA TAGCTGCAAGGAAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAA GTTTCTTCATGACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACAT GATAACCCGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAA AGTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGG CGGCATGATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGA TGCCACGCTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAA GATCTACTATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCA TACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACT CAAGGAACTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGA AGAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAG TAACTCCAACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGT GAAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCC AGCAGGCAGGAGATAGAACAGCCCGGCCTAGCCAGGAGAGACTGCAGGGACTCACTCAGCTGCTGGCCCCAAGTCAAAATTTACATTAAA >In-frame_PHF12_ENST00000577226_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_2360nt TGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGCCGAGGCCTGACCCC CGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGAGGACGCTGTCGTCC CGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCCGGGGTCAGGAGCGC CCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATGAATGTGGGAGAAAA TGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCCCCCAAGACGGACG AGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGATAGCTGCAAGGAAG GTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAGTTTCTTCATGACA ACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATGATAACCCGGGTGA TCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAGACT ATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATGATGTCAA TCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACGCTTGCCC GCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTACTATCCTG ACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCTGACGGGA TCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAACTGTACC AGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAATAAGGGTC CCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCCAACAGCA AAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGGAGA AGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTGCCACCCTCCACAC CAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCCACGCACGTGCTGG GTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTGGTAGCTCCCTGCT AGGTTTGCTGTCTTCCCTCTCCCTCAGGCCATACTCTCCTTTACCATACTACTGGACTGGACTCAGGCTGGAGGCAGATAGACACAGTAT AGGGGGAATGGGCTTGCTTCTCCCAAACCCACCAGTTCTCCACTGTCTCTTCTGGACCAGGAATTAGTTGCTGTGGGTGCCACAGCTGAA GTCAGTTTGTCTTGCTGGTTTAAATAGATCTTTCAGAGCTGGGTGCTGGGTTTGCCATCTTTTTGTTTTCTTTGAAAAGCAGCTTAGTTA CCCTTTTTATAAATAAAATATCTTGCAGTTATCTTTGTCCTTTCCCCACCTACACCCCCAATAATTTCCCTAGAGATTAAGGAGTAAAGG CTGGGCTATGGCAGCTCTGTCCACAAAGCCTTCTCTCCCATCCTTGCCTGTTCCTTTGTACTTCCAGGCTCATTTTAAAGTTGTATTTAA AGGACTGCCCTCGGAAATGCTTCTGTTTAGCGGAACTTGTATTCAGCCTGACACGCTTTGCCAGGAACAAACCTCATGTGAAAGAAAACA >In-frame_PHF12_ENST00000577226_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_1746nt TGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGCCGAGGCCTGACCCC CGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGAGGACGCTGTCGTCC CGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCCGGGGTCAGGAGCGC CCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATGAATGTGGGAGAAAA TGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCCCCCAAGACGGACG AGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGATAGCTGCAAGGAAG GTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAGTTTCTTCATGACA ACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATGATAACCCGGGTGA TCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAGACT ATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATGATGTCAA TCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACGCTTGCCC GCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTACTATCCTG ACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCTGACGGGA TCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAACTGTACC AGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAATAAGGGTC CCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCCAACAGCA AAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGGAGA AGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCAGCAGGCAGGAGAT AGAACAGCCCGGCCTAGCCAGGAGAGACTGCAGGGACTCACTCAGCTGCTGGCCCCAAGTCAAAATTTACATTAAAGGGAAAAGACCAGT >In-frame_PHF12_ENST00000268756_chr17_27277083_-_LIG3_ENST00000378526_chr17_33324757_+_2543nt CGGGTGGCTTTGCGGGCGCTCGCGGTAAGTTTGCGCCAAGTGCGCGGCAGCCGGGACGCAGACGGCGGCGGCGGCGAGAGGCGGAGCCCG GGGACCACCCCCCATCACCCTCCCCCCAGTCACCTCACGTACCACAACCTCACGTAACCTCTCACCCCCCCTCCGATACCCCCAGCCCCG GGATGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGCCGAGGCCTGAC CCCCGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGAGGACGCTGTCG TCCCGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCCGGGGTCAGGAG CGCCCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATGAATGTGGGAGA AAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCCCCCAAGACGG ACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGATAGCTGCAAGG AAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAGTTTCTTCATG ACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATGATAACCCGGG TGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAG ACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATGATGT CAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACGCTTG CCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTACTATC CTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCTGACG GGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAACTGT ACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAATAAGG GTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCCAACA GCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGG AGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTGCCACCCTCCA CACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCCACGCACGTGC TGGGTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTGGTAGCTCCCT GCTAGGTTTGCTGTCTTCCCTCTCCCTCAGGCCATACTCTCCTTTACCATACTACTGGACTGGACTCAGGCTGGAGGCAGATAGACACAG TATAGGGGGAATGGGCTTGCTTCTCCCAAACCCACCAGTTCTCCACTGTCTCTTCTGGACCAGGAATTAGTTGCTGTGGGTGCCACAGCT GAAGTCAGTTTGTCTTGCTGGTTTAAATAGATCTTTCAGAGCTGGGTGCTGGGTTTGCCATCTTTTTGTTTTCTTTGAAAAGCAGCTTAG TTACCCTTTTTATAAATAAAATATCTTGCAGTTATCTTTGTCCTTTCCCCACCTACACCCCCAATAATTTCCCTAGAGATTAAGGAGTAA AGGCTGGGCTATGGCAGCTCTGTCCACAAAGCCTTCTCTCCCATCCTTGCCTGTTCCTTTGTACTTCCAGGCTCATTTTAAAGTTGTATT TAAAGGACTGCCCTCGGAAATGCTTCTGTTTAGCGGAACTTGTATTCAGCCTGACACGCTTTGCCAGGAACAAACCTCATGTGAAAGAAA >In-frame_PHF12_ENST00000268756_chr17_27277083_-_LIG3_ENST00000262327_chr17_33324757_+_1929nt CGGGTGGCTTTGCGGGCGCTCGCGGTAAGTTTGCGCCAAGTGCGCGGCAGCCGGGACGCAGACGGCGGCGGCGGCGAGAGGCGGAGCCCG GGGACCACCCCCCATCACCCTCCCCCCAGTCACCTCACGTACCACAACCTCACGTAACCTCTCACCCCCCCTCCGATACCCCCAGCCCCG GGATGGCAGCGCCCGCCAGCCTTCCCGGCCGGACCGGCTGTCGCCAGTGCCGGCTTTAGCCTGTGGGACTAGGCCCCGCCGAGGCCTGAC CCCCGGAGCCGGGACCCACTGTGCAGCCAGCAGCCGGGCCGGGACTGAGGGGCCGCTCCCCCCTCGCGGCCCGTCGGGAGGACGCTGTCG TCCCGGGGACTGGGGGCCGGGGGGTGGGGGGGAGCCAGGGCGAGGAAGTCGGGACCCGTATTGGGAAAAAAGCGGGGCCGGGGTCAGGAG CGCCCCCTCCCCTCACCTCCCCCCTCCCCCCGGGGTTGGGGGGGCCGGAGCAGAGAGCACCCAGCCCGGGAGGTGGATGAATGTGGGAGA AAATGGAGACCAAGACGATCGTGTACGACTTGGACACATCAGGGGGGCTGATGGAGCAAATCCAAGCTCTGCTGGCTCCCCCCAAGACGG ACGAGGCAGAAAAGCGCAGTCGGAAGCCTGAGAAGGAGCCCCGGAGAAGCGGCAGGGCCACCAACCACGACAGCTGCGATAGCTGCAAGG AAGGTGGAGATCTCCTGTGCTGCGACCACTGCCCGGCTGCCTTCCACCTCCAGTGCTGACCTCTGTGTGAGCGGCGGAAGTTTCTTCATG ACAACATGGTTGAAATTCCAAACCGGATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATGATAACCCGGG TGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAG ACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATGATGT CAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACGCTTG CCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTACTATC CTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCTGACG GGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAACTGT ACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAATAAGG GTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCCAACA GCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGG AGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCAGCAGGCAGGA GATAGAACAGCCCGGCCTAGCCAGGAGAGACTGCAGGGACTCACTCAGCTGCTGGCCCCAAGTCAAAATTTACATTAAAGGGAAAAGACC |
Top |
FusionGenePPI for PHF12_LIG3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PHF12 | SIN3A, HDAC1, SAP30, MORF4L1, MORF4L2, BRCA1, HIST3H3, GATAD1, RBBP7, HDAC2, KDM5A, S100A4, SIN3B, C11orf30, SPICE1, ZNF281, ZNF131, QSER1, CHD9, PHF12, TUBA4A, ZNF143, DPM1, ZNF335, RBFOX2, RBFOX1, H2AFY, BAG2, HSPB1, NFE2L1, TUBB8, DNAJA3, SENP1, ABCF2, GPATCH8, ABCG2 | LIG3 | XRCC1, PNKP, NEIL1, NCAPG, THRA, THRB, PARP1, XRCC5, XRCC6, NBN, APP, APTX, CBX8, RPA1, RPA2, RPA3, MOV10, NXF1, PYCARD, CCDC8, EED, TOP3A, PREPL, JMJD4, CLPX, RSAD1, C7orf55, PSME3, NDUFS6, RNF146, POLB, APLF, HIST1H2BA, KIF23, RACGAP1, NTRK1, HIST1H2BG, HIST1H3A, BAX, TMPO, EMC2, EXOSC4, MMGT1, SPC24, JUN, MAX, FOXB1, FOXD3, FOXE1, FOXK2, FOXP1, NF2, NFATC1, NFATC2, H2AFX, RNF166, WDR76, MACROD1, LARS2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 102_273 | 82 | 705 | SIN3A |
| Hgene | PHF12 | chr17:27277083 | chr17:33324757 | ENST00000268756 | - | 2 | 9 | 300_704 | 82 | 705 | SIN3A |
| Hgene | PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 102_273 | 82 | 1005 | SIN3A |
| Hgene | PHF12 | chr17:27277083 | chr17:33324757 | ENST00000332830 | - | 2 | 15 | 300_704 | 82 | 1005 | SIN3A |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000262327 | + | 10 | 20 | 277_280 | 607 | 950 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000262327 | + | 10 | 20 | 318_323 | 607 | 950 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000262327 | + | 10 | 20 | 388_391 | 607 | 950 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000262327 | + | 10 | 20 | 421_427 | 607 | 950 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000378526 | + | 10 | 20 | 277_280 | 607 | 1010 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000378526 | + | 10 | 20 | 318_323 | 607 | 1010 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000378526 | + | 10 | 20 | 388_391 | 607 | 1010 | DNA |
| Tgene | LIG3 | chr17:27277083 | chr17:33324757 | ENST00000378526 | + | 10 | 20 | 421_427 | 607 | 1010 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PHF12_LIG3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | LIG3 | P49916 | DB00290 | Bleomycin | DNA ligase 3 | small molecule | approved|investigational |
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RelatedDiseases for PHF12_LIG3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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