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Fusion gene ID: 26874 |
FusionGeneSummary for PHB2_SPINT1 |
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Fusion gene information | Fusion gene name: PHB2_SPINT1 | Fusion gene ID: 26874 | Hgene | Tgene | Gene symbol | PHB2 | SPINT1 | Gene ID | 11331 | 6692 |
Gene name | prohibitin 2 | serine peptidase inhibitor, Kunitz type 1 | |
Synonyms | BAP|BCAP37|Bap37|PNAS-141|REA|hBAP|p22 | HAI|HAI1|MANSC2 | |
Cytomap | 12p13.31 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | prohibitin-2B-cell associated proteinB-cell receptor-associated protein BAP37D-prohibitinrepressor of estrogen receptor activity | kunitz-type protease inhibitor 1HAI-1hepatocyte growth factor activator inhibitor type 1serine protease inhibitor, Kunitz type 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q99623 | O43278 | |
Ensembl transtripts involved in fusion gene | ENST00000546111, ENST00000535923, ENST00000542912, ENST00000440277, ENST00000399433, ENST00000544134, | ENST00000562057, ENST00000344051, ENST00000431806, | |
Fusion gene scores | * DoF score | 7 X 7 X 2=98 | 3 X 3 X 1=9 |
# samples | 7 | 5 | |
** MAII score | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PHB2 [Title/Abstract] AND SPINT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PHB2 | GO:0000060 | protein import into nucleus, translocation | 17008324|19116139 |
Hgene | PHB2 | GO:0007062 | sister chromatid cohesion | 23548868 |
Hgene | PHB2 | GO:0030449 | regulation of complement activation | 17070910 |
Hgene | PHB2 | GO:0045892 | negative regulation of transcription, DNA-templated | 10359819 |
Hgene | PHB2 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 18629613 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE281028 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000546111 | ENST00000562057 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000546111 | ENST00000344051 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000546111 | ENST00000431806 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000535923 | ENST00000562057 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000535923 | ENST00000344051 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000535923 | ENST00000431806 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000542912 | ENST00000562057 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000542912 | ENST00000344051 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000542912 | ENST00000431806 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000440277 | ENST00000562057 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000440277 | ENST00000344051 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000440277 | ENST00000431806 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000399433 | ENST00000562057 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000399433 | ENST00000344051 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
Frame-shift | ENST00000399433 | ENST00000431806 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
5UTR-3CDS | ENST00000544134 | ENST00000562057 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
5UTR-3CDS | ENST00000544134 | ENST00000344051 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
5UTR-3CDS | ENST00000544134 | ENST00000431806 | PHB2 | chr12 | 7079358 | - | SPINT1 | chr15 | 41148087 | + |
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FusionProtFeatures for PHB2_SPINT1 |
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Hgene | Tgene |
PHB2 | SPINT1 |
Acts as a mediator of transcriptional repression bynuclear hormone receptors via recruitment of histone deacetylases(By similarity). Functions as an estrogen receptor (ER)-selectivecoregulator that potentiates the inhibitory activities ofantiestrogens and represses the activity of estrogens. Competeswith NCOA1 for modulation of ER transcriptional activity. Probablyinvolved in regulating mitochondrial respiration activity and inaging. {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:10359819,ECO:0000303|PubMed:11302691}. | Inhibitor of HGF activator. Also acts as an inhibitor ofmatriptase (ST14). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHB2_SPINT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHB2_SPINT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHB2 | CTNNB1, TFE3, SIRT2, CDC25B, SERINC3, JUP, NUP205, USP15, MMS19, PDXDC1, RIPK2, DDX20, NUP93, NELFCD, RUNX3, TIMM50, EPPK1, COPG1, LGALS3BP, ESR1, PTMA, ATG2A, HDAC1, HDAC2, HDAC3, HDAC5, NR2F1, NR2F2, EZH2, PHB, RNF185, ICT1, AGO3, CDK2, RNF2, KIAA1244, ILF3, UQCRC1, TUFM, AKT1, MYOD1, MEF2A, FHL2, BRCA1, ECT2, MDC1, PAXIP1, FMNL1, EPAS1, FN1, VCAM1, C1QBP, ATF2, UBL4A, ITGA4, ADRB2, TEAD3, AFP, UPF2, ASB14, ASB17, STAU1, NCOR1, IGF1R, HUWE1, PPARG, SUZ12, EED, BLK, RIC3, XIAP, NMRAL1, HNRNPA1, UNK, NTRK1, ATP6V1C1, CCDC47, COX4I1, GOSR1, LGALS1, MRPL17, NDUFB8, AFG3L2, ATAD3A, ATAD3B, ATL3, ATP5L, CLTC, CYB5B, CYC1, HNRNPA3, IDH1, LDHB, LMAN1, MRPL2, MRPL40, MTCH2, NDUFA2, NDUFB7, NDUFS8, NDUFV1, PSMC3, RAB11B, STOML2, TOMM40, TUBB, TUBB4B, VAPA, VDAC1, VDAC2, VDAC3, PTBP1, SSR1, FAP, ANKRA2, RFXANK, MED20, PTPN1, RAB2A, RAB5C, TMPO, XRCC3, RAB7A, AKAP1, RAB11A, EMC2, MTX2, FGFR1OP2, GOLT1B, TMEM63B, YIPF5, MMGT1, TRIM29, MCM2, MCM5, GLI1, ESRRB, U2AF2, KPNA1, KPNA2, KPNA5, KPNA6, ARMC7, ZNF746, TPTE, STOM, ALDH2, TUBA1A, CYLD, LMNA, YAP1, MTF1, BRD1 | SPINT1 | ST14, UBQLN4, FAM46A, ZNF250, NLGN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHB2_SPINT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PHB2 | Q99623 | DB06774 | Capsaicin | Prohibitin-2 | small molecule | approved |
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RelatedDiseases for PHB2_SPINT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |