![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 26867 |
FusionGeneSummary for PHACTR4_SESN2 |
![]() |
Fusion gene information | Fusion gene name: PHACTR4_SESN2 | Fusion gene ID: 26867 | Hgene | Tgene | Gene symbol | PHACTR4 | SESN2 | Gene ID | 65979 | 83667 |
Gene name | phosphatase and actin regulator 4 | sestrin 2 | |
Synonyms | PPP1R124 | HI95|SES2|SEST2 | |
Cytomap | 1p35.3 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124 | sestrin-2hypoxia induced gene 95hypoxia-induced | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IZ21 | P58004 | |
Ensembl transtripts involved in fusion gene | ENST00000373839, ENST00000493669, ENST00000373836, | ENST00000253063, | |
Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 3 X 3 X 2=18 |
# samples | 7 | 4 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PHACTR4 [Title/Abstract] AND SESN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SESN2 | GO:0001932 | regulation of protein phosphorylation | 25040165 |
Tgene | SESN2 | GO:0098869 | cellular oxidant detoxification | 26612684 |
Tgene | SESN2 | GO:0098869 | cellular oxidant detoxification | 19113821 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-ZS-A9CF-01A | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
TCGA | RV | LIHC | TCGA-ZS-A9CF-02A | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000373839 | ENST00000253063 | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
3UTR-3CDS | ENST00000493669 | ENST00000253063 | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
intron-3CDS | ENST00000373836 | ENST00000253063 | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
Top |
FusionProtFeatures for PHACTR4_SESN2 |
![]() |
Hgene | Tgene |
PHACTR4 | SESN2 |
Functions as an intracellular leucine sensor thatnegatively regulates the TORC1 signaling pathway through the GATORcomplex. In absence of leucine, binds the GATOR subcomplex GATOR2and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562,PubMed:25457612, PubMed:26449471, PubMed:26612684,PubMed:26586190). Binding of leucine to SESN2 disrupts itsinteraction with GATOR2 thereby activating the TORC1 signalingpathway (PubMed:26449471, PubMed:26586190). This stress-induciblemetabolic regulator also plays a role in protection againstoxidative and genotoxic stresses. May negatively regulate proteintranslation in response to endoplasmic reticulum stress, via TORC1(PubMed:24947615). May positively regulate the transcription byNFE2L2 of genes involved in the response to oxidative stress byfacilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May also mediate TP53 inhibition of TORC1signaling upon genotoxic stress (PubMed:18692468). Has analkylhydroperoxide reductase activity born by the N-terminaldomain of the protein (PubMed:26612684). Was originally reportedto contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(PubMed:19113821). {ECO:0000269|PubMed:15105503,ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821,ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615,ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612,ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190,ECO:0000269|PubMed:26612684}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PHACTR4_SESN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PHACTR4_SESN2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHACTR4 | CALM1, RAD21, ELAVL1, SH3KBP1, APP, PPP1CC, GRB2, SNRPD3, PPP1CA, RAB9B, NPHP1, SCLT1, TMEM17, LLGL2, UBE2I, TOMM40, CDH1, IFIT2, BCL7A, IFIT3, BCL7C, IFIT1, GAPDHS, TRIM25 | SESN2 | PRDX1, SQSTM1, RBX1, KEAP1, VCP, MDM2, ULK1, RB1CC1, ATG13, SEC13, WDR5, WDR59, EGFR, DHX57 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PHACTR4_SESN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PHACTR4_SESN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |