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Fusion gene ID: 26866 |
FusionGeneSummary for PHACTR4_SCMH1 |
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Fusion gene information | Fusion gene name: PHACTR4_SCMH1 | Fusion gene ID: 26866 | Hgene | Tgene | Gene symbol | PHACTR4 | SCMH1 | Gene ID | 65979 | 22955 |
Gene name | phosphatase and actin regulator 4 | Scm polycomb group protein homolog 1 | |
Synonyms | PPP1R124 | Scml3 | |
Cytomap | 1p35.3 | 1p34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124 | polycomb protein SCMH1sex comb on midleg homolog 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8IZ21 | Q96GD3 | |
Ensembl transtripts involved in fusion gene | ENST00000373839, ENST00000493669, ENST00000373836, | ENST00000456518, ENST00000397174, ENST00000402904, ENST00000361191, ENST00000397171, ENST00000361705, ENST00000326197, ENST00000372595, ENST00000337495, ENST00000372596, ENST00000372597, ENST00000472037, | |
Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 6 X 4 X 5=120 |
# samples | 7 | 6 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PHACTR4 [Title/Abstract] AND SCMH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-09-1674-01A | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000373839 | ENST00000456518 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000397174 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000402904 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000361191 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000397171 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000361705 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000326197 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000372595 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000337495 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000372596 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-3CDS | ENST00000373839 | ENST00000372597 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
5UTR-intron | ENST00000373839 | ENST00000472037 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000456518 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000397174 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000402904 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000361191 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000397171 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000361705 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000326197 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000372595 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000337495 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000372596 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-3CDS | ENST00000493669 | ENST00000372597 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
3UTR-intron | ENST00000493669 | ENST00000472037 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000456518 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000397174 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000402904 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000361191 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000397171 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000361705 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000326197 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000372595 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000337495 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000372596 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-3CDS | ENST00000373836 | ENST00000372597 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
intron-intron | ENST00000373836 | ENST00000472037 | PHACTR4 | chr1 | 28696336 | + | SCMH1 | chr1 | 41541123 | - |
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FusionProtFeatures for PHACTR4_SCMH1 |
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Hgene | Tgene |
PHACTR4 | SCMH1 |
Associates with Polycomb group (PcG) multiproteincomplexes; the complex class is required to maintain thetranscriptionally repressive state of some genes. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHACTR4_SCMH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHACTR4_SCMH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHACTR4 | CALM1, RAD21, ELAVL1, SH3KBP1, APP, PPP1CC, GRB2, SNRPD3, PPP1CA, RAB9B, NPHP1, SCLT1, TMEM17, LLGL2, UBE2I, TOMM40, CDH1, IFIT2, BCL7A, IFIT3, BCL7C, IFIT1, GAPDHS, TRIM25 | SCMH1 | POLR2M, LYPLA2, SCMH1, TOB1, MOB4, PHC2, EWSR1, PCBD1, LZTR1, MAML3, PCGF2, BMI1, RNF2, PHC1, PHC3, CBX4, UBQLN4, MAGEA12, UBQLN1, CDC42, ZWINT, ACTBL2, ACTA2, PGK2, GNB2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHACTR4_SCMH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHACTR4_SCMH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |