FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26866

FusionGeneSummary for PHACTR4_SCMH1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHACTR4_SCMH1
Fusion gene ID: 26866
HgeneTgene
Gene symbol

PHACTR4

SCMH1

Gene ID

65979

22955

Gene namephosphatase and actin regulator 4Scm polycomb group protein homolog 1
SynonymsPPP1R124Scml3
Cytomap

1p35.3

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124polycomb protein SCMH1sex comb on midleg homolog 1
Modification date2018051920180519
UniProtAcc

Q8IZ21

Q96GD3

Ensembl transtripts involved in fusion geneENST00000373839, ENST00000493669, 
ENST00000373836, 		ENST00000456518, 
ENST00000397174, ENST00000402904, 
ENST00000361191, ENST00000397171, 
ENST00000361705, ENST00000326197, 
ENST00000372595, ENST00000337495, 
ENST00000372596, ENST00000372597, 
ENST00000472037, 
Fusion gene scores* DoF score6 X 3 X 5=906 X 4 X 5=120
# samples 76
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHACTR4 [Title/Abstract] AND SCMH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-1674-01APHACTR4chr1

28696336

+SCMH1chr1

41541123

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000373839ENST00000456518PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000397174PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000402904PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000361191PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000397171PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000361705PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000326197PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000372595PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000337495PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000372596PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-3CDSENST00000373839ENST00000372597PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
5UTR-intronENST00000373839ENST00000472037PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000456518PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000397174PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000402904PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000361191PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000397171PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000361705PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000326197PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000372595PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000337495PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000372596PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-3CDSENST00000493669ENST00000372597PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
3UTR-intronENST00000493669ENST00000472037PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000456518PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000397174PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000402904PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000361191PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000397171PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000361705PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000326197PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000372595PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000337495PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000372596PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-3CDSENST00000373836ENST00000372597PHACTR4chr1

28696336

+SCMH1chr1

41541123

-
intron-intronENST00000373836ENST00000472037PHACTR4chr1

28696336

+SCMH1chr1

41541123

-

Top

FusionProtFeatures for PHACTR4_SCMH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHACTR4

Q8IZ21

SCMH1

Q96GD3

Associates with Polycomb group (PcG) multiproteincomplexes; the complex class is required to maintain thetranscriptionally repressive state of some genes. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PHACTR4_SCMH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PHACTR4_SCMH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHACTR4CALM1, RAD21, ELAVL1, SH3KBP1, APP, PPP1CC, GRB2, SNRPD3, PPP1CA, RAB9B, NPHP1, SCLT1, TMEM17, LLGL2, UBE2I, TOMM40, CDH1, IFIT2, BCL7A, IFIT3, BCL7C, IFIT1, GAPDHS, TRIM25SCMH1POLR2M, LYPLA2, SCMH1, TOB1, MOB4, PHC2, EWSR1, PCBD1, LZTR1, MAML3, PCGF2, BMI1, RNF2, PHC1, PHC3, CBX4, UBQLN4, MAGEA12, UBQLN1, CDC42, ZWINT, ACTBL2, ACTA2, PGK2, GNB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PHACTR4_SCMH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PHACTR4_SCMH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource