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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26865

FusionGeneSummary for PHACTR4_MED18

check button Fusion gene summary
Fusion gene informationFusion gene name: PHACTR4_MED18
Fusion gene ID: 26865
HgeneTgene
Gene symbol

PHACTR4

MED18

Gene ID

65979

54797

Gene namephosphatase and actin regulator 4mediator complex subunit 18
SynonymsPPP1R124SRB5|p28b
Cytomap

1p35.3

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionphosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124mediator of RNA polymerase II transcription subunit 18TRAP/mediator complex subunit p28bmediator of RNA polymerase II transcription, subunit 18 homolog
Modification date2018051920180523
UniProtAcc

Q8IZ21

Q9BUE0

Ensembl transtripts involved in fusion geneENST00000373839, ENST00000493669, 
ENST00000373836, 
ENST00000479574, 
ENST00000373842, ENST00000398997, 
Fusion gene scores* DoF score6 X 3 X 5=902 X 1 X 2=4
# samples 72
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PHACTR4 [Title/Abstract] AND MED18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N8-A56S-01APHACTR4chr1

28733974

+MED18chr1

28657108

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000373839ENST00000479574PHACTR4chr1

28733974

+MED18chr1

28657108

+
5CDS-5UTRENST00000373839ENST00000373842PHACTR4chr1

28733974

+MED18chr1

28657108

+
5CDS-5UTRENST00000373839ENST00000398997PHACTR4chr1

28733974

+MED18chr1

28657108

+
3UTR-3UTRENST00000493669ENST00000479574PHACTR4chr1

28733974

+MED18chr1

28657108

+
3UTR-5UTRENST00000493669ENST00000373842PHACTR4chr1

28733974

+MED18chr1

28657108

+
3UTR-5UTRENST00000493669ENST00000398997PHACTR4chr1

28733974

+MED18chr1

28657108

+
intron-3UTRENST00000373836ENST00000479574PHACTR4chr1

28733974

+MED18chr1

28657108

+
intron-5UTRENST00000373836ENST00000373842PHACTR4chr1

28733974

+MED18chr1

28657108

+
intron-5UTRENST00000373836ENST00000398997PHACTR4chr1

28733974

+MED18chr1

28657108

+

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FusionProtFeatures for PHACTR4_MED18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHACTR4

Q8IZ21

MED18

Q9BUE0

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHACTR4_MED18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHACTR4_MED18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHACTR4CALM1, RAD21, ELAVL1, SH3KBP1, APP, PPP1CC, GRB2, SNRPD3, PPP1CA, RAB9B, NPHP1, SCLT1, TMEM17, LLGL2, UBE2I, TOMM40, CDH1, IFIT2, BCL7A, IFIT3, BCL7C, IFIT1, GAPDHS, TRIM25MED18MED10, MED9, MED29, MED19, MED28, MED26, MED20, MED1, MED13, MED12, MED17, MED21, MED4, CCNC, MED16, MED24, MED22, MED23, MED8, MED31, MED15, MED6, MED14, MED30, MED27, TADA2A, CDK19, MED11, PIP4K2B, EPAS1, CDK8, CAMK2B, TRIM39, HOMEZ, MED7, POLR2G, MED13L, MED12L, MED25, MTMR3, G6PD, BIRC5, MTMR4, RPAP2, GPN3, POLR2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHACTR4_MED18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHACTR4_MED18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource