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Fusion gene ID: 26864 |
FusionGeneSummary for PHACTR4_LRRC42 |
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Fusion gene information | Fusion gene name: PHACTR4_LRRC42 | Fusion gene ID: 26864 | Hgene | Tgene | Gene symbol | PHACTR4 | LRRC42 | Gene ID | 65979 | 115353 |
Gene name | phosphatase and actin regulator 4 | leucine rich repeat containing 42 | |
Synonyms | PPP1R124 | dJ167A19.4 | |
Cytomap | 1p35.3 | 1p32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124 | leucine-rich repeat-containing protein 42 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8IZ21 | Q9Y546 | |
Ensembl transtripts involved in fusion gene | ENST00000373839, ENST00000493669, ENST00000373836, | ENST00000371370, ENST00000319223, ENST00000477905, | |
Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 3 X 3 X 3=27 |
# samples | 7 | 3 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PHACTR4 [Title/Abstract] AND LRRC42 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-29-A5NZ-01A | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000373839 | ENST00000371370 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
Frame-shift | ENST00000373839 | ENST00000319223 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
5CDS-intron | ENST00000373839 | ENST00000477905 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
3UTR-3CDS | ENST00000493669 | ENST00000371370 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
3UTR-3CDS | ENST00000493669 | ENST00000319223 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
3UTR-intron | ENST00000493669 | ENST00000477905 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
intron-3CDS | ENST00000373836 | ENST00000371370 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
intron-3CDS | ENST00000373836 | ENST00000319223 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
intron-intron | ENST00000373836 | ENST00000477905 | PHACTR4 | chr1 | 28733974 | + | LRRC42 | chr1 | 54426029 | + |
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FusionProtFeatures for PHACTR4_LRRC42 |
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Hgene | Tgene |
PHACTR4 | LRRC42 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHACTR4_LRRC42 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHACTR4_LRRC42 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHACTR4 | CALM1, RAD21, ELAVL1, SH3KBP1, APP, PPP1CC, GRB2, SNRPD3, PPP1CA, RAB9B, NPHP1, SCLT1, TMEM17, LLGL2, UBE2I, TOMM40, CDH1, IFIT2, BCL7A, IFIT3, BCL7C, IFIT1, GAPDHS, TRIM25 | LRRC42 | CUL3, APP, NARS, ZC3H14, ENO1, SHMT2, MOV10, NXF1, SUGT1, PLXDC2, AMBRA1, KAT5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHACTR4_LRRC42 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHACTR4_LRRC42 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |