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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26858

FusionGeneSummary for PHACTR2_PLAGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHACTR2_PLAGL1
Fusion gene ID: 26858
HgeneTgene
Gene symbol

PHACTR2

PLAGL1

Gene ID

9749

5325

Gene namephosphatase and actin regulator 2PLAG1 like zinc finger 1
SynonymsC6orf56LOT1|ZAC|ZAC1
Cytomap

6q24.2

6q24.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatase and actin regulator 2zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC
Modification date2018051920180523
UniProtAcc

O75167

Q9UM63

Ensembl transtripts involved in fusion geneENST00000367584, ENST00000427704, 
ENST00000305766, ENST00000440869, 
ENST00000367582, ENST00000397980, 
ENST00000429150, ENST00000416623, 
ENST00000392309, ENST00000392307, 
ENST00000437412, ENST00000444202, 
ENST00000493898, ENST00000360537, 
ENST00000354765, ENST00000367572, 
ENST00000367571, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 4 X 4=96
# samples 86
** MAII scorelog2(8/125*10)=-0.643856189774725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHACTR2 [Title/Abstract] AND PLAGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAGL1

GO:0045944

positive regulation of transcription by RNA polymerase II

9671765|15888726


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BA-4076-01APHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000367584ENST00000429150PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000416623PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000392309PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000392307PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000437412PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000444202PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000493898PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000360537PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000367584ENST00000354765PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-intronENST00000367584ENST00000367572PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-intronENST00000367584ENST00000367571PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000429150PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000416623PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000392309PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000392307PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000437412PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000444202PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000493898PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000360537PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000427704ENST00000354765PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-intronENST00000427704ENST00000367572PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-intronENST00000427704ENST00000367571PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000429150PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000416623PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000392309PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000392307PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000437412PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000444202PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000493898PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000360537PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-5UTRENST00000305766ENST00000354765PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-intronENST00000305766ENST00000367572PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
intron-intronENST00000305766ENST00000367571PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000429150PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000416623PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000392309PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000392307PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000437412PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000444202PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000493898PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000360537PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000440869ENST00000354765PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-intronENST00000440869ENST00000367572PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-intronENST00000440869ENST00000367571PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000429150PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000416623PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000392309PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000392307PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000437412PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000444202PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000493898PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000360537PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000367582ENST00000354765PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-intronENST00000367582ENST00000367572PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-intronENST00000367582ENST00000367571PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000429150PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000416623PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000392309PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000392307PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000437412PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000444202PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000493898PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000360537PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-5UTRENST00000397980ENST00000354765PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-intronENST00000397980ENST00000367572PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-
5CDS-intronENST00000397980ENST00000367571PHACTR2chr6

143999346

+PLAGL1chr6

144290115

-

Top

FusionProtFeatures for PHACTR2_PLAGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHACTR2

O75167

PLAGL1

Q9UM63


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHACTR2_PLAGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHACTR2_PLAGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHACTR2ELAVL1, CDH1, BCL7C, POTEI, BCL7A, ACTA2, ACTBL2, ACTB, TMOD3, ACTC1, TRIM25PLAGL1TP53, DAXX, PML, EP300, CREBBP, HDAC1, UBE2I, PIAS2, SMAD3, TP73, KAT2B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PHACTR2_PLAGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHACTR2_PLAGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLAGL1C0038356Stomach Neoplasms1CTD_human