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Fusion gene ID: 26850 |
FusionGeneSummary for PGS1_TM9SF1 |
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Fusion gene information | Fusion gene name: PGS1_TM9SF1 | Fusion gene ID: 26850 | Hgene | Tgene | Gene symbol | PGS1 | TM9SF1 | Gene ID | 9489 | 10548 |
Gene name | phosphatidylglycerophosphate synthase 1 | transmembrane 9 superfamily member 1 | |
Synonyms | - | HMP70|MP70 | |
Cytomap | 17q25.3 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPGP synthase 1 | transmembrane 9 superfamily member 1MP70 protein family membermultispanning membrane protein (70kD)transmembrane protein 9 superfamily member 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q32NB8 | O15321 | |
Ensembl transtripts involved in fusion gene | ENST00000262764, ENST00000329897, ENST00000588281, | ENST00000261789, ENST00000528669, ENST00000556387, ENST00000530611, ENST00000524835, ENST00000396854, | |
Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 2 X 2 X 2=8 |
# samples | 9 | 2 | |
** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PGS1 [Title/Abstract] AND TM9SF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A08J-01A | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000262764 | ENST00000261789 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000262764 | ENST00000528669 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000262764 | ENST00000556387 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000262764 | ENST00000530611 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000262764 | ENST00000524835 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000262764 | ENST00000396854 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000329897 | ENST00000261789 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000329897 | ENST00000528669 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000329897 | ENST00000556387 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000329897 | ENST00000530611 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000329897 | ENST00000524835 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
Frame-shift | ENST00000329897 | ENST00000396854 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
3UTR-3CDS | ENST00000588281 | ENST00000261789 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
3UTR-3CDS | ENST00000588281 | ENST00000528669 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
3UTR-3CDS | ENST00000588281 | ENST00000556387 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
3UTR-3CDS | ENST00000588281 | ENST00000530611 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
3UTR-3CDS | ENST00000588281 | ENST00000524835 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
3UTR-3CDS | ENST00000588281 | ENST00000396854 | PGS1 | chr17 | 76396936 | + | TM9SF1 | chr14 | 24662475 | - |
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FusionProtFeatures for PGS1_TM9SF1 |
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Hgene | Tgene |
PGS1 | TM9SF1 |
Functions in the biosynthesis of the anionicphospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}. | Plays an essential role in autophagy.{ECO:0000269|PubMed:19029833}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PGS1_TM9SF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PGS1_TM9SF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PGS1 | TM9SF1 | MME, ATP6V1B1, P2RX7, TCOF1, RNASEH1, CHMP4B, CLEC2D, MTNR1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PGS1_TM9SF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PGS1_TM9SF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |