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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26850

FusionGeneSummary for PGS1_TM9SF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PGS1_TM9SF1
Fusion gene ID: 26850
HgeneTgene
Gene symbol

PGS1

TM9SF1

Gene ID

9489

10548

Gene namephosphatidylglycerophosphate synthase 1transmembrane 9 superfamily member 1
Synonyms-HMP70|MP70
Cytomap

17q25.3

14q12

Type of geneprotein-codingprotein-coding
DescriptionCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPGP synthase 1transmembrane 9 superfamily member 1MP70 protein family membermultispanning membrane protein (70kD)transmembrane protein 9 superfamily member 1
Modification date2018051920180523
UniProtAcc

Q32NB8

O15321

Ensembl transtripts involved in fusion geneENST00000262764, ENST00000329897, 
ENST00000588281, 
ENST00000261789, 
ENST00000528669, ENST00000556387, 
ENST00000530611, ENST00000524835, 
ENST00000396854, 
Fusion gene scores* DoF score9 X 7 X 6=3782 X 2 X 2=8
# samples 92
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PGS1 [Title/Abstract] AND TM9SF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08J-01APGS1chr17

76396936

+TM9SF1chr14

24662475

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262764ENST00000261789PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000262764ENST00000528669PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000262764ENST00000556387PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000262764ENST00000530611PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000262764ENST00000524835PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000262764ENST00000396854PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000329897ENST00000261789PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000329897ENST00000528669PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000329897ENST00000556387PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000329897ENST00000530611PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000329897ENST00000524835PGS1chr17

76396936

+TM9SF1chr14

24662475

-
Frame-shiftENST00000329897ENST00000396854PGS1chr17

76396936

+TM9SF1chr14

24662475

-
3UTR-3CDSENST00000588281ENST00000261789PGS1chr17

76396936

+TM9SF1chr14

24662475

-
3UTR-3CDSENST00000588281ENST00000528669PGS1chr17

76396936

+TM9SF1chr14

24662475

-
3UTR-3CDSENST00000588281ENST00000556387PGS1chr17

76396936

+TM9SF1chr14

24662475

-
3UTR-3CDSENST00000588281ENST00000530611PGS1chr17

76396936

+TM9SF1chr14

24662475

-
3UTR-3CDSENST00000588281ENST00000524835PGS1chr17

76396936

+TM9SF1chr14

24662475

-
3UTR-3CDSENST00000588281ENST00000396854PGS1chr17

76396936

+TM9SF1chr14

24662475

-

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FusionProtFeatures for PGS1_TM9SF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGS1

Q32NB8

TM9SF1

O15321

Functions in the biosynthesis of the anionicphospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}. Plays an essential role in autophagy.{ECO:0000269|PubMed:19029833}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PGS1_TM9SF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PGS1_TM9SF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PGS1TM9SF1MME, ATP6V1B1, P2RX7, TCOF1, RNASEH1, CHMP4B, CLEC2D, MTNR1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGS1_TM9SF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PGS1_TM9SF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource