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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26846

FusionGeneSummary for PGS1_KIF22

check button Fusion gene summary
Fusion gene informationFusion gene name: PGS1_KIF22
Fusion gene ID: 26846
HgeneTgene
Gene symbol

PGS1

KIF22

Gene ID

9489

3835

Gene namephosphatidylglycerophosphate synthase 1kinesin family member 22
Synonyms-A-328A3.2|KID|KNSL4|OBP|OBP-1|OBP-2|SEMDJL2
Cytomap

17q25.3

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPGP synthase 1kinesin-like protein KIF22kinesin-like DNA-binding protein pseudogenekinesin-like protein 4oriP binding proteinorigin of plasmid DNA replication-binding protein
Modification date2018051920180523
UniProtAcc

Q32NB8

Q14807

Ensembl transtripts involved in fusion geneENST00000262764, ENST00000329897, 
ENST00000588281, 
ENST00000561482, 
ENST00000160827, ENST00000400750, 
ENST00000400751, ENST00000569382, 
ENST00000563263, 
Fusion gene scores* DoF score9 X 7 X 6=3783 X 2 X 2=12
# samples 95
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PGS1 [Title/Abstract] AND KIF22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A18R-01APGS1chr17

76374889

+KIF22chr16

29808214

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262764ENST00000561482PGS1chr17

76374889

+KIF22chr16

29808214

+
5CDS-5UTRENST00000262764ENST00000160827PGS1chr17

76374889

+KIF22chr16

29808214

+
5CDS-5UTRENST00000262764ENST00000400750PGS1chr17

76374889

+KIF22chr16

29808214

+
5CDS-5UTRENST00000262764ENST00000400751PGS1chr17

76374889

+KIF22chr16

29808214

+
5CDS-5UTRENST00000262764ENST00000569382PGS1chr17

76374889

+KIF22chr16

29808214

+
5CDS-intronENST00000262764ENST00000563263PGS1chr17

76374889

+KIF22chr16

29808214

+
5UTR-5UTRENST00000329897ENST00000561482PGS1chr17

76374889

+KIF22chr16

29808214

+
5UTR-5UTRENST00000329897ENST00000160827PGS1chr17

76374889

+KIF22chr16

29808214

+
5UTR-5UTRENST00000329897ENST00000400750PGS1chr17

76374889

+KIF22chr16

29808214

+
5UTR-5UTRENST00000329897ENST00000400751PGS1chr17

76374889

+KIF22chr16

29808214

+
5UTR-5UTRENST00000329897ENST00000569382PGS1chr17

76374889

+KIF22chr16

29808214

+
5UTR-intronENST00000329897ENST00000563263PGS1chr17

76374889

+KIF22chr16

29808214

+
intron-5UTRENST00000588281ENST00000561482PGS1chr17

76374889

+KIF22chr16

29808214

+
intron-5UTRENST00000588281ENST00000160827PGS1chr17

76374889

+KIF22chr16

29808214

+
intron-5UTRENST00000588281ENST00000400750PGS1chr17

76374889

+KIF22chr16

29808214

+
intron-5UTRENST00000588281ENST00000400751PGS1chr17

76374889

+KIF22chr16

29808214

+
intron-5UTRENST00000588281ENST00000569382PGS1chr17

76374889

+KIF22chr16

29808214

+
intron-intronENST00000588281ENST00000563263PGS1chr17

76374889

+KIF22chr16

29808214

+

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FusionProtFeatures for PGS1_KIF22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGS1

Q32NB8

KIF22

Q14807

Functions in the biosynthesis of the anionicphospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}. Kinesin family member that is involved in spindleformation and the movements of chromosomes during mitosis andmeiosis. Binds to microtubules and to DNA (By similarity). Plays arole in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869,ECO:0000269|PubMed:25743205}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PGS1_KIF22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PGS1_KIF22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PGS1KIF22SIAH1, GDF9, IMMT, PJA1, SVIL, CHFR, ATXN1, MOV10, NXF1, BRCA1, OBSL1, MAPK14, HIST1H2BG, HIST1H3A, C4A, CCNB1, FUS, SP110, RPL10, RBM45, KPNA3, KPNA4, LIMS1, PSEN2, STAT6, TAF12, MPDZ, COX5A, CEP350, BCL2L11, HMGXB4, MARCH6, CEPT1, CD2BP2, CKAP2, PHF21A, SFMBT1, EPB41L4B, BIRC6, ZNF668, C2orf44, CCNL2, C18orf21, UTP23, PSRC1, CIRH1A, KNSTRN, PGM2L1, TEAD2, FOXE1, FOXL1, FOXM1, FOXQ1, CDC14B, TBC1D15, CNPY2, USP47, ZYG11B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGS1_KIF22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PGS1_KIF22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKIF22C1863732Spondyloepimetaphyseal dysplasia with multiple dislocations2ORPHANET;UNIPROT