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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26842

FusionGeneSummary for PGR_IGHG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PGR_IGHG1
Fusion gene ID: 26842
HgeneTgene
Gene symbol

PGR

IGHG1

Gene ID

5241

3500

Gene nameprogesterone receptorimmunoglobulin heavy constant gamma 1 (G1m marker)
SynonymsNR3C3|PR-
Cytomap

11q22.1

14q32.33

Type of geneprotein-codingother
Descriptionprogesterone receptornuclear receptor subfamily 3 group C member 3constant region of heavy chain of IgG1immunoglobulin gamma 1 (Gm marker)
Modification date2018052020180523
UniProtAcc

P06401

P01857

Ensembl transtripts involved in fusion geneENST00000325455, ENST00000534013, 
ENST00000263463, 
ENST00000390548, 
Fusion gene scores* DoF score1 X 1 X 1=132 X 42 X 3=4032
# samples 146
** MAII scorelog2(1/1*10)=3.32192809488736log2(46/4032*10)=-3.13178987255554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGR [Title/Abstract] AND IGHG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePGR

GO:0045944

positive regulation of transcription by RNA polymerase II

17785366


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF752574PGRchr11

101000351

+IGHG1chr14

107013113

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000325455ENST00000390548PGRchr11

101000351

+IGHG1chr14

107013113

-
intron-intronENST00000534013ENST00000390548PGRchr11

101000351

+IGHG1chr14

107013113

-
intron-intronENST00000263463ENST00000390548PGRchr11

101000351

+IGHG1chr14

107013113

-

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FusionProtFeatures for PGR_IGHG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGR

P06401

IGHG1

P01857

The steroid hormones and their receptors are involved inthe regulation of eukaryotic gene expression and affect cellularproliferation and differentiation in target tissues. Depending onthe isoform, progesterone receptor functions as transcriptionalactivator or repressor. {ECO:0000269|PubMed:10757795,ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:9407067,ECO:0000305}. Isoform A: Ligand-dependent transdominant repressor ofsteroid hormone receptor transcriptional activity includingrepression of its isoform B, MR and ER. Transrepressional activitymay involve recruitment of corepressor NCOR2.{ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103,ECO:0000269|PubMed:8264658, ECO:0000305,ECO:0000305|PubMed:10757795}. Isoform B: Transcriptional activator of severalprogesteron-dependent promoters in a variety of cell types.Involved in activation of SRC-dependent MAPK signaling on hormonestimulation. {ECO:0000269|PubMed:7969170}. Isoform 4: Increases mitochondrial membrane potentialand cellular respiration upon stimulation by progesterone. Constant region of immunoglobulin heavy chains.Immunoglobulins, also known as antibodies, are membrane-bound orsecreted glycoproteins produced by B lymphocytes. In therecognition phase of humoral immunity, the membrane-boundimmunoglobulins serve as receptors which, upon binding of aspecific antigen, trigger the clonal expansion and differentiationof B lymphocytes into immunoglobulins-secreting plasma cells.Secreted immunoglobulins mediate the effector phase of humoralimmunity, which results in the elimination of bound antigens(PubMed:22158414, PubMed:20176268). The antigen binding site isformed by the variable domain of one heavy chain, together withthat of its associated light chain. Thus, each immunoglobulin hastwo antigen binding sites with remarkable affinity for aparticular antigen. The variable domains are assembled by aprocess called V-(D)-J rearrangement and can then be subjected tosomatic hypermutations which, after exposure to antigen andselection, allow affinity maturation for a particular antigen(PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170,ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PGR_IGHG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PGR_IGHG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGR_IGHG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePGRP06401DB00304DesogestrelProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB00421SpironolactoneProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB00648MitotaneProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB00717NorethisteroneProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB01395DrospirenoneProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB01406DanazolProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB01431AllylestrenolProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB08867UlipristalProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB09123DienogestProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB09124MedrogestoneProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB09389NorgestrelProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB11619GestrinoneProgesterone receptorsmall moleculeapproved
HgenePGRP06401DB00294EtonogestrelProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB00367LevonorgestrelProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB00603Medroxyprogesterone acetateProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB00834MifepristoneProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB00957NorgestimateProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB06713NorelgestrominProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB06789Hydroxyprogesterone caproateProgesterone receptorsmall moleculeapproved|investigational
HgenePGRP06401DB00351Megestrol acetateProgesterone receptorsmall moleculeapproved|investigational|vet_approved
HgenePGRP06401DB00378DydrogesteroneProgesterone receptorsmall moleculeapproved|investigational|withdrawn
HgenePGRP06401DB00396ProgesteroneProgesterone receptorsmall moleculeapproved|vet_approved
HgenePGRP06401DB00764MometasoneProgesterone receptorsmall moleculeapproved|vet_approved
HgenePGRP06401DB00431LindaneProgesterone receptorsmall moleculeapproved|withdrawn

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RelatedDiseases for PGR_IGHG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGRC0025286Meningioma3CTD_human
HgenePGRC0014175Endometriosis2CTD_human
HgenePGRC1458155Mammary Neoplasms2CTD_human
HgenePGRC0001418Adenocarcinoma1CTD_human
HgenePGRC0014170Endometrial Neoplasms1CTD_human
HgenePGRC0024667Animal Mammary Neoplasms1CTD_human
HgenePGRC0024668Mammary Neoplasms, Experimental1CTD_human
HgenePGRC0025500Mesothelioma1CTD_human
TgeneIGHG1C0027121Myositis1CTD_human
TgeneIGHG1C0032460Polycystic Ovary Syndrome1CTD_human