FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26841

FusionGeneSummary for PGRMC2_IRF2BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: PGRMC2_IRF2BP2
Fusion gene ID: 26841
HgeneTgene
Gene symbol

PGRMC2

IRF2BP2

Gene ID

10424

359948

Gene nameprogesterone receptor membrane component 2interferon regulatory factor 2 binding protein 2
SynonymsDG6|PMBPCVID14
Cytomap

4q28.2

1q42.3

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated progesterone receptor component 2progesterone membrane binding proteinsteroid receptor protein DG6interferon regulatory factor 2-binding protein 2IRF-2-binding protein 2
Modification date2018052320180523
UniProtAcc

O15173

Q7Z5L9

Ensembl transtripts involved in fusion geneENST00000296425, ENST00000520121, 
ENST00000394276, ENST00000512483, 
ENST00000503872, ENST00000503588, 
ENST00000366610, ENST00000366609, 
ENST00000491430, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PGRMC2 [Title/Abstract] AND IRF2BP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC028143PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000296425ENST00000366610PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000296425ENST00000366609PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-intronENST00000296425ENST00000491430PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000520121ENST00000366610PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000520121ENST00000366609PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-intronENST00000520121ENST00000491430PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000394276ENST00000366610PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000394276ENST00000366609PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-intronENST00000394276ENST00000491430PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000512483ENST00000366610PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000512483ENST00000366609PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-intronENST00000512483ENST00000491430PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000503872ENST00000366610PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000503872ENST00000366609PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-intronENST00000503872ENST00000491430PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000503588ENST00000366610PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-3CDSENST00000503588ENST00000366609PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-
intron-intronENST00000503588ENST00000491430PGRMC2chr4

129208737

-IRF2BP2chr1

234744454

-

Top

FusionProtFeatures for PGRMC2_IRF2BP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGRMC2

O15173

IRF2BP2

Q7Z5L9

Receptor for steroids. {ECO:0000305}. Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histonedeacetylase activities. Represses the NFAT1-dependenttransactivation of NFAT-responsive promoters. Acts as acoactivator of VEGFA expression in cardiac and skeletal muscle.{ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774,ECO:0000269|PubMed:21576369}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PGRMC2_IRF2BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PGRMC2_IRF2BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PGRMC2_IRF2BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PGRMC2_IRF2BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIRF2BP2C0023487Acute Promyelocytic Leukemia1CTD_human