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Fusion gene ID: 26841 |
FusionGeneSummary for PGRMC2_IRF2BP2 |
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Fusion gene information | Fusion gene name: PGRMC2_IRF2BP2 | Fusion gene ID: 26841 | Hgene | Tgene | Gene symbol | PGRMC2 | IRF2BP2 | Gene ID | 10424 | 359948 |
Gene name | progesterone receptor membrane component 2 | interferon regulatory factor 2 binding protein 2 | |
Synonyms | DG6|PMBP | CVID14 | |
Cytomap | 4q28.2 | 1q42.3 | |
Type of gene | protein-coding | protein-coding | |
Description | membrane-associated progesterone receptor component 2progesterone membrane binding proteinsteroid receptor protein DG6 | interferon regulatory factor 2-binding protein 2IRF-2-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O15173 | Q7Z5L9 | |
Ensembl transtripts involved in fusion gene | ENST00000296425, ENST00000520121, ENST00000394276, ENST00000512483, ENST00000503872, ENST00000503588, | ENST00000366610, ENST00000366609, ENST00000491430, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PGRMC2 [Title/Abstract] AND IRF2BP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC028143 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000296425 | ENST00000366610 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000296425 | ENST00000366609 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-intron | ENST00000296425 | ENST00000491430 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000520121 | ENST00000366610 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000520121 | ENST00000366609 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-intron | ENST00000520121 | ENST00000491430 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000394276 | ENST00000366610 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000394276 | ENST00000366609 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-intron | ENST00000394276 | ENST00000491430 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000512483 | ENST00000366610 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000512483 | ENST00000366609 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-intron | ENST00000512483 | ENST00000491430 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000503872 | ENST00000366610 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000503872 | ENST00000366609 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-intron | ENST00000503872 | ENST00000491430 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000503588 | ENST00000366610 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-3CDS | ENST00000503588 | ENST00000366609 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
intron-intron | ENST00000503588 | ENST00000491430 | PGRMC2 | chr4 | 129208737 | - | IRF2BP2 | chr1 | 234744454 | - |
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FusionProtFeatures for PGRMC2_IRF2BP2 |
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Hgene | Tgene |
PGRMC2 | IRF2BP2 |
Receptor for steroids. {ECO:0000305}. | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histonedeacetylase activities. Represses the NFAT1-dependenttransactivation of NFAT-responsive promoters. Acts as acoactivator of VEGFA expression in cardiac and skeletal muscle.{ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774,ECO:0000269|PubMed:21576369}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PGRMC2_IRF2BP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PGRMC2_IRF2BP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PGRMC2_IRF2BP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PGRMC2_IRF2BP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IRF2BP2 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |