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Fusion gene ID: 26833 |
FusionGeneSummary for PGM5_CTSL |
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Fusion gene information | Fusion gene name: PGM5_CTSL | Fusion gene ID: 26833 | Hgene | Tgene | Gene symbol | PGM5 | CTSL | Gene ID | 5239 | 1514 |
Gene name | phosphoglucomutase 5 | cathepsin L | |
Synonyms | PGMRP | CATL|CTSL1|MEP | |
Cytomap | 9q21.11 | 9q21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphoglucomutase-like protein 5PGM-RPaciculinphosphoglucomutase-related protein | cathepsin L1major excreted protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15124 | P07711 | |
Ensembl transtripts involved in fusion gene | ENST00000396392, ENST00000396396, ENST00000604870, | ENST00000343150, ENST00000340342, ENST00000495822, ENST00000342020, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 5 X 1=15 |
# samples | 2 | 6 | |
** MAII score | log2(2/1*10)=4.32192809488736 | log2(6/15*10)=2 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PGM5 [Title/Abstract] AND CTSL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CTSL | GO:0006508 | proteolysis | 8811434|21326229 |
Tgene | CTSL | GO:0030574 | collagen catabolic process | 22952693 |
Tgene | CTSL | GO:0051603 | proteolysis involved in cellular protein catabolic process | 22952693 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE836772 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - | ||
ChiTaRS3.1 | BE836763 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000396392 | ENST00000343150 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-3CDS | ENST00000396392 | ENST00000340342 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-3UTR | ENST00000396392 | ENST00000495822 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-intron | ENST00000396392 | ENST00000342020 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
3UTR-3CDS | ENST00000396396 | ENST00000343150 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
3UTR-3CDS | ENST00000396396 | ENST00000340342 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
3UTR-3UTR | ENST00000396396 | ENST00000495822 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
3UTR-intron | ENST00000396396 | ENST00000342020 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-3CDS | ENST00000604870 | ENST00000343150 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-3CDS | ENST00000604870 | ENST00000340342 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-3UTR | ENST00000604870 | ENST00000495822 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
intron-intron | ENST00000604870 | ENST00000342020 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
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FusionProtFeatures for PGM5_CTSL |
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Hgene | Tgene |
PGM5 | CTSL |
Component of adherens-type cell-cell and cell-matrixjunctions. Lacks phosphoglucomutase activity. | Important for the overall degradation of proteins inlysosomes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PGM5_CTSL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PGM5_CTSL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PGM5_CTSL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PGM5_CTSL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PGM5 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | CTSL | C0025286 | Meningioma | 1 | CTD_human |
Tgene | CTSL | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | CTSL | C0038356 | Stomach Neoplasms | 1 | CTD_human |