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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26832

FusionGeneSummary for PGM2_PGM2

check button Fusion gene summary
Fusion gene informationFusion gene name: PGM2_PGM2
Fusion gene ID: 26832
HgeneTgene
Gene symbol

PGM2

PGM2

Gene ID

55276

55276

Gene namephosphoglucomutase 2phosphoglucomutase 2
SynonymsMSTP006MSTP006
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionphosphoglucomutase-2PGM 2glucose phosphomutase 2phosphodeoxyribomutasephosphoglucomutase-2PGM 2glucose phosphomutase 2phosphodeoxyribomutase
Modification date2018052320180523
UniProtAcc

Q96G03

Q96G03

Ensembl transtripts involved in fusion geneENST00000381967, ENST00000544359, 
ENST00000537241, 
ENST00000381967, 
ENST00000544359, ENST00000537241, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: PGM2 [Title/Abstract] AND PGM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA410910PGM2chr4

37841704

-PGM2chr4

37836313

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000381967ENST00000381967PGM2chr4

37841704

-PGM2chr4

37836313

+
5CDS-5UTRENST00000381967ENST00000544359PGM2chr4

37841704

-PGM2chr4

37836313

+
5CDS-intronENST00000381967ENST00000537241PGM2chr4

37841704

-PGM2chr4

37836313

+
Frame-shiftENST00000544359ENST00000381967PGM2chr4

37841704

-PGM2chr4

37836313

+
5CDS-5UTRENST00000544359ENST00000544359PGM2chr4

37841704

-PGM2chr4

37836313

+
5CDS-intronENST00000544359ENST00000537241PGM2chr4

37841704

-PGM2chr4

37836313

+
Frame-shiftENST00000537241ENST00000381967PGM2chr4

37841704

-PGM2chr4

37836313

+
5CDS-5UTRENST00000537241ENST00000544359PGM2chr4

37841704

-PGM2chr4

37836313

+
5CDS-intronENST00000537241ENST00000537241PGM2chr4

37841704

-PGM2chr4

37836313

+

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FusionProtFeatures for PGM2_PGM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGM2

Q96G03

PGM2

Q96G03

Catalyzes the conversion of the nucleoside breakdownproducts ribose-1-phosphate and deoxyribose-1-phosphate to thecorresponding 5-phosphopentoses. May also catalyze theinterconversion of glucose-1-phosphate and glucose-6-phosphate.Has low glucose 1,6-bisphosphate synthase activity.{ECO:0000269|PubMed:17804405}. Catalyzes the conversion of the nucleoside breakdownproducts ribose-1-phosphate and deoxyribose-1-phosphate to thecorresponding 5-phosphopentoses. May also catalyze theinterconversion of glucose-1-phosphate and glucose-6-phosphate.Has low glucose 1,6-bisphosphate synthase activity.{ECO:0000269|PubMed:17804405}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PGM2_PGM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PGM2_PGM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGM2_PGM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PGM2_PGM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource