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Fusion gene ID: 26808 |
FusionGeneSummary for PGD_NTSR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PGD_NTSR1 | Fusion gene ID: 26808 | Hgene | Tgene | Gene symbol | PGD | NTSR1 | Gene ID | 26227 | 4923 |
| Gene name | phosphoglycerate dehydrogenase | neurotensin receptor 1 | |
| Synonyms | 3-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERA | NTR | |
| Cytomap | 1p12 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenase | neurotensin receptor type 1NT-R-1NTR1NTRHhigh-affinity levocabastine-insensitive neurotensin receptorneurotensin receptor 1 (high affinity) | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P52209 | P30989 | |
| Ensembl transtripts involved in fusion gene | ENST00000541529, ENST00000270776, ENST00000538557, ENST00000498356, | ENST00000370501, ENST00000482259, | |
| Fusion gene scores | * DoF score | 9 X 6 X 6=324 | 3 X 1 X 3=9 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PGD [Title/Abstract] AND NTSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NTSR1 | GO:0007218 | neuropeptide signaling pathway | 21725197 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-58-A46K-01A | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000541529 | ENST00000370501 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| 5CDS-intron | ENST00000541529 | ENST00000482259 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| In-frame | ENST00000270776 | ENST00000370501 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| 5CDS-intron | ENST00000270776 | ENST00000482259 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| In-frame | ENST00000538557 | ENST00000370501 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| 5CDS-intron | ENST00000538557 | ENST00000482259 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| intron-3CDS | ENST00000498356 | ENST00000370501 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
| intron-intron | ENST00000498356 | ENST00000482259 | PGD | chr1 | 10459761 | + | NTSR1 | chr20 | 61386037 | + |
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FusionProtFeatures for PGD_NTSR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PGD | NTSR1 |
| Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), withconcomitant reduction of NADP to NADPH. {ECO:0000250}. | G-protein coupled receptor for the tridecapeptideneurotensin (NTS) (PubMed:8381365, PubMed:21725197,PubMed:23140271). Signaling is effected via G proteins thatactivate a phosphatidylinositol-calcium second messenger system.Signaling leads to the activation of downstream MAP kinases andprotects cells against apoptosis (PubMed:21725197).{ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271,ECO:0000269|PubMed:8381365}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PGD | chr1:10459761 | chr20:61386037 | ENST00000270776 | + | 2 | 13 | 10_15 | 28 | 484 | Nucleotide binding | NADP |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 321_344 | 238 | 419 | Region | Neurotensin binding |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 260_303 | 238 | 419 | Topological domain | Cytoplasmic |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 326_343 | 238 | 419 | Topological domain | Extracellular |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 365_418 | 238 | 419 | Topological domain | Cytoplasmic |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 235_259 | 238 | 419 | Transmembrane | Helical%3B Name%3D5 |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 304_325 | 238 | 419 | Transmembrane | Helical%3B Name%3D6 |
| Tgene | >NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 344_364 | 238 | 419 | Transmembrane | Helical%3B Name%3D7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PGD | chr1:10459761 | chr20:61386037 | ENST00000270776 | + | 2 | 13 | 33_35 | 28 | 484 | Nucleotide binding | NADP |
| Hgene | >PGD | chr1:10459761 | chr20:61386037 | ENST00000270776 | + | 2 | 13 | 478_481 | 28 | 484 | Nucleotide binding | NADP%3B shared with dimeric partner |
| Hgene | >PGD | chr1:10459761 | chr20:61386037 | ENST00000270776 | + | 2 | 13 | 75_77 | 28 | 484 | Nucleotide binding | NADP |
| Hgene | >PGD | chr1:10459761 | chr20:61386037 | ENST00000270776 | + | 2 | 13 | 129_131 | 28 | 484 | Region | Substrate binding |
| Hgene | >PGD | chr1:10459761 | chr20:61386037 | ENST00000270776 | + | 2 | 13 | 187_188 | 28 | 484 | Region | Substrate binding |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 123_142 | 238 | 419 | Topological domain | Extracellular |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 165_184 | 238 | 419 | Topological domain | Cytoplasmic |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 1_67 | 238 | 419 | Topological domain | Extracellular |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 206_234 | 238 | 419 | Topological domain | Extracellular |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 89_102 | 238 | 419 | Topological domain | Cytoplasmic |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 103_122 | 238 | 419 | Transmembrane | Helical%3B Name%3D2 |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 143_164 | 238 | 419 | Transmembrane | Helical%3B Name%3D3 |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 185_205 | 238 | 419 | Transmembrane | Helical%3B Name%3D4 |
| Tgene | NTSR1 | chr1:10459761 | chr20:61386037 | ENST00000370501 | + | 0 | 4 | 68_88 | 238 | 419 | Transmembrane | Helical%3B Name%3D1 |
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FusionGeneSequence for PGD_NTSR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PGD_ENST00000541529_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_209aa MAQADIALIGLAVMGQNLILNMNDHGFVVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRR >In-frame_PGD_ENST00000270776_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_209aa MAQADIALIGLAVMGQNLILNMNDHGFVVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRR >In-frame_PGD_ENST00000538557_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_196aa MGQNLILNMNDHGFVVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFV VCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PGD_ENST00000541529_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_627nt ATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCAAC ACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCG GCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCAC GGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCG GATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAAC CCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGG >In-frame_PGD_ENST00000270776_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_627nt ATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCAAC ACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCG GCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCAC GGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCG GATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAAC CCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGG >In-frame_PGD_ENST00000538557_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_588nt ATGGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCG GTCCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCAC AGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTG GTCTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCAC TACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCAC ATCTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PGD_ENST00000541529_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_3180nt ACTCGTCCTCCGCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCAT GGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGT CCTGAACACCATCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAG CACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGT CTGCTGGCTGCCCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTA CTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACAT CTTCCTGGCCACACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAG CAACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGT CCTTGCCCCCGACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGG ACCCCCCCCTCCCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCT TTGAAAGCCAGAACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTC TTTGTTCTCAGACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCAT GTCCACATCTCTGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGC AGACCCTGCCATGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGG CCCATCGCCGTGGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATG GGCTGGCCTGGAATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCAC ATGGGAGGGGGCTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTC CAGCACCTGCCCGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGC CCAGAGCTGGCTTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAG GAACTCAGGCTTCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTC TGGCGGCGGCAGCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATG ACTAGCCAGGCCCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGA GCCACAGGAAGCAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCT GCCTGCACCGGCCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGT CTGAGAAATGAGAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCT CTCCAACCACAGGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCAC AAGCCTGGTCATCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCC CACAGAGCCCCCATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTG CTCAGGAGTGGGCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGC CTCAGACCCTTCTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCC CTCTCAGCTGGATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGT GGATGCCCCACTGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATG TCTTGATGCTCCTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACT AGCTTGCGGCCAGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGC CCCTGGTGACGGCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCA >In-frame_PGD_ENST00000270776_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_3169nt GCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACT TAATTCTGAACATGAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCA TCATCGCCAACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCA TGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGC CCTACCACGTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGG TGACCAACGCACTCTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCA CACTGGCCTGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGCAACCACACCC TCTCCAGCAATGCCACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTCCTTGCCCCCG ACAGACAGAGCAGCCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGACCCCCCCCTC CCACCCCCTAACCCATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTTTGAAAGCCAG AACAAGAGAGCGCTCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCTTTGTTCTCAG ACTAATGGATGGTTCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATGTCCACATCTC TGAGGCCTGCACCCCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCAGACCCTGCCA TGCAGACCCATGCCCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGCCCATCGCCGT GGGGAGTCCCTCCCACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGGGCTGGCCTGG AATGGCCCAGACCCCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACATGGGAGGGGG CTCAGGCCTCAGCCTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCCAGCACCTGCC CGAGTGGCCGTGGCCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCCCAGAGCTGGC TTCAGGGTGGGGCCTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGGAACTCAGGCT TCAGGTGAGAAGGAGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCTGGCGGCGGCA GCCCTGGCCCCGGCCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGACTAGCCAGGC CCCTGGCTTAAGAAGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAGCCACAGGAAG CAAAAGTCAGCCTTTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTGCCTGCACCGG CCATGTCGACCCAGGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTCTGAGAAATGA GAGTCGAATGCTACAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTCTCCAACCACA GGACCCTTCGGCTCACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACAAGCCTGGTCA TCAGCCAGGCAGCCCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCCACAGAGCCCC CATGACATAGTCTGCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGCTCAGGAGTGG GCTCAGAGTCTAGCAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCCTCAGACCCTT CTCTGGGGCTCCTGGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCCTCTCAGCTGG ATGAGACTGTCCTGGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTGGATGCCCCAC TGCCCTAGACCCTCGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGTCTTGATGCTC CTATCTGTGCACTTACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTAGCTTGCGGCC AGGTCATGATGTGGCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCCCCTGGTGACG GCACAGCCCTCACAGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCAATAAAGGTGGC >In-frame_PGD_ENST00000538557_chr1_10459761_+_NTSR1_ENST00000370501_chr20_61386037_+_3336nt ATGGCCCAGTGAGTGACTCGCCAGGGGCAGCCCGGCTCGGCCTCAGCGGGCGGGGAACTCTTTGGGGGTCGAGATCTCCCTCGTTCTCTC CGACGCCTCCCACCCTGGGGGTCGCCTGAGCTCACTTGGGGCTCTGTGACCCTGGCCCTACGGCGTCTCGGGCCCAGAGCTCCTTCCCTG CGGGCCCGGCCCCCTGCCCTCTCGGCCGCGCAGAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACAT GAATGACCACGGCTTTGTGGTCAACACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCCAACAA GCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGGGGCGAGCACAGCACATTCAGCATGGCCATCGAGCC TGGCAGGGTCCAGGCCCTGCGGCACGGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCACGTGCG GCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGACTTCTACCACTACTTCTACATGGTGACCAACGCACT CTTCTACGTCAGCTCCACCATCAACCCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCCTGCCT CTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGACAGCGTGTCCAGCAACCACACCCTCTCCAGCAATGC CACCCGCGAGACGCTGTACTAGGCTGTGCGCCCCGGAACGTGTCCAGGAGGAGCCTGGCCATGGGTCCTTGCCCCCGACAGACAGAGCAG CCCCCACCCGGGAGCCTTGATGGGGGTCAGGCAGAGGCCAGCCTGCACTGGAGTCTGAGGCCTGGGACCCCCCCCTCCCACCCCCTAACC CATGTTTCTCATTAGTGTCTCCCGGGCCTGTCCCCAACTCCTCCCCACCCCTCCCCCATCTCCTCTTTGAAAGCCAGAACAAGAGAGCGC TCCTCTCCCAGATAGGAAAAGGGCCTCTAACAAGGAGAAATTAGTGTGCGGCAAAAGGCAGTTTTCTTTGTTCTCAGACTAATGGATGGT TCCAGAGAAGGAAATGAAAGGTGCTGGGTGGGGCCGGGCCTCCGGCGGCCCGGCTGCTGTTCCCATGTCCACATCTCTGAGGCCTGCACC CCCTCTGTCTAGCTCGGGGAGTCCAGCCCCAGTCCCGCAGGCTCCGTGGCTTTGGGCCTCACGTGCAGACCCTGCCATGCAGACCCATGC CCCCCTCCCCCAGGCAGCTCCAAGAAAGCTCCCTGACTCGCCCCTTCAGGCCTGGCAAGCTGGGGGCCCATCGCCGTGGGGAGTCCCTCC CACCACCCTCGCCGCAGGCAGCTGCAGCCCCCAGAGGGGACCACAAGCCCAAAAAGGACAAAAATGGGCTGGCCTGGAATGGCCCAGACC CCAGCCTCCCCTCCTCCCTCCCATCCTCACCCAGGCCAAGGCCCAGGGGCTCTGCCAGGACACCACATGGGAGGGGGCTCAGGCCTCAGC CTCAAGATCTTCAGCTGTGGCCTCTCGGGCTCGGCAGAAGGGACGCCGGATCAGGGGCCTGGTCTCCAGCACCTGCCCGAGTGGCCGTGG CCAGGATGGGGTGCGCATTCCGTGTGCTTTGCTTGTGGCTGTGCAGGCTGAGGTCTGGAGCCAGGCCCAGAGCTGGCTTCAGGGTGGGGC CTTGAGAAGGGGAATGTGGGACAGGGGCGATGGTGCCTGGTCTCTGAGTAAGATGCCAGGTCCCAGGAACTCAGGCTTCAGGTGAGAAGG AGCGGTGTGTCCAGGCACCGCTGGCCGGCAGCCCTGGGCTGAGGCACAGACTCATTTGTCACCTTCTGGCGGCGGCAGCCCTGGCCCCGG CCTCCAAGCAGTTGAAAAAGCTGGCGCCTCCTTGGTCTCTAGGATCCAGGCTCCACAGAGCACATGACTAGCCAGGCCCCTGGCTTAAGA AGGTCGCCTAAGCCTAAGAGAAGACAGTCCCAGGAGAAGCTGGCCGGGACCAGCCAGGAGCTGGGAGCCACAGGAAGCAAAAGTCAGCCT TTTCTTCAAGGGATTTCCCTGTCTCAGAGCAGCCTTTGCCCCAGGGAAATGGGCTCTGGGCTGGCTGCCTGCACCGGCCATGTCGACCCA GGACCCGGACACCTGGTCTTGGGCTGTGTTCAGCCACTTTGCCTTCTCTGGACTCAGTTTCCCCGTCTGAGAAATGAGAGTCGAATGCTA CAGTATCTGCAGTCGCTTGGATCTGGCTGTTGAGTTGACGGGTTCCTTGAACCCCACAAAATCCCTCTCCAACCACAGGACCCTTCGGCT CACCAAGAACAGGGCCCAGGGGAGTCAGGCCTATTCGCTGCACTTCCTGCCAAACTTTGCCCCCACAAGCCTGGTCATCAGCCAGGCAGC CCTCCCAGTGCCCAAGGGCCACCAACCCCAGGGAAACAGGGCCAGCACAGAGGGGCCTTCCTCCCCCACAGAGCCCCCATGACATAGTCT GCTCTGGGCGGAAGAGCTTTGCTGCCAGCCAGGGATGTCCAGAGGTCAGTGCAGCCCCTACCCCTGCTCAGGAGTGGGCTCAGAGTCTAG CAAATGCTAAGGCCCCTCAGGCTGGGCTCTGAACGAGGACCTGGACTCAGAGCCAGACAGGGCAGCCTCAGACCCTTCTCTGGGGCTCCT GGACCTTGGGCCATAATTTCTGAGCCTCGGTTTCCCCATCTAAGGAACAGATGTGGTCGTTCCGCCCTCTCAGCTGGATGAGACTGTCCT GGAGGATCCACCCCGGAACAGACAGAATGGTGTCTCTCAGGATGGTGCTCTGAGAGAGGGCAGAGTGGATGCCCCACTGCCCTAGACCCT CGGTAGACGTGGGGTCTCTGGGGCGGGGTCTGTGGCTGTGACTGAAGTCGGCTTTTCCCGTTGATGTCTTGATGCTCCTATCTGTGCACT TACCGTAGGTAGGGACACGTGTCCACGCACCACAGACACACCCACGACACCTGATCTCGTATCACTAGCTTGCGGCCAGGTCATGATGTG GCCCCGGAAGCTGGCCCTGCGTGCCATGAGTGCGTCGGTCATGGAGTCCGGAGCCCCTGAGCCGGCCCCTGGTGACGGCACAGCCCTCAC AGCTCAAACGCCCACCCCCACTCCCACCATCTGCAGGTGGTGAAAACAAACCCCGTGTATCTCTCAATAAAGGTGGCCGAAGGGCCTCGA |
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FusionGenePPI for PGD_NTSR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PGD | LSM8, USPL1, ISG15, TERF1, CDK2, IQCB1, CDK4, ALDH7A1, ALDH9A1, EEF2, GLA, GNAI3, HMGB2, AHSA1, C12orf10, CHORDC1, EIF4H, G6PD, LDHA, LDHB, NDRG1, PDIA3, SORD, TCEA1, TGM2, THOP1, YWHAB, YWHAG, YWHAQ, RPS6KA1, TXNDC5, WWOX, MOV10, NXF1, FABP5, GDI1, P4HB, ACAA2, CDV3, CTSL, EZR, ISYNA1, MSN, NCBP1, RDX, SUMO2, TAGLN, UCHL3, SUMO3, TALDO1, CEP290, OFD1, RBM8A, CDC73, BRCA1 | NTSR1 | NTS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PGD_NTSR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PGD | P52209 | DB00920 | Ketotifen | 6-phosphogluconate dehydrogenase, decarboxylating | small molecule | approved |
| Hgene | PGD | P52209 | DB00851 | Dacarbazine | 6-phosphogluconate dehydrogenase, decarboxylating | small molecule | approved|investigational |
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RelatedDiseases for PGD_NTSR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PGD | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | NTSR1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | NTSR1 | C0030193 | Pain | 1 | CTD_human |
| Tgene | NTSR1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | NTSR1 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | NTSR1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
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