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Fusion gene ID: 26714 |
FusionGeneSummary for PEX1_CDK6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PEX1_CDK6 | Fusion gene ID: 26714 | Hgene | Tgene | Gene symbol | PEX1 | CDK6 | Gene ID | 339324 | 1021 |
| Gene name | zinc finger protein 260 | cyclin dependent kinase 6 | |
| Synonyms | OZRF1|PEX1|ZFP260 | MCPH12|PLSTIRE | |
| Cytomap | 19q13.12 | 7q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 260zfp-260 | cyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIRE | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | O43933 | Q00534 | |
| Ensembl transtripts involved in fusion gene | ENST00000438045, ENST00000248633, ENST00000428214, ENST00000541751, | ENST00000265734, ENST00000424848, ENST00000491250, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 7 X 7 X 4=196 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/196*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PEX1 [Title/Abstract] AND CDK6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDK6 | GO:0001954 | positive regulation of cell-matrix adhesion | 10205165 |
| Tgene | CDK6 | GO:0003323 | type B pancreatic cell development | 20668294 |
| Tgene | CDK6 | GO:0006468 | protein phosphorylation | 8114739 |
| Tgene | CDK6 | GO:0010468 | regulation of gene expression | 15254224 |
| Tgene | CDK6 | GO:0045638 | negative regulation of myeloid cell differentiation | 17431401 |
| Tgene | CDK6 | GO:0045656 | negative regulation of monocyte differentiation | 26542173 |
| Tgene | CDK6 | GO:0045668 | negative regulation of osteoblast differentiation | 15254224 |
| Tgene | CDK6 | GO:0045786 | negative regulation of cell cycle | 14985467 |
| Tgene | CDK6 | GO:2000773 | negative regulation of cellular senescence | 17420273 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-AA-3697-01A | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000438045 | ENST00000265734 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| In-frame | ENST00000438045 | ENST00000424848 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| 5CDS-intron | ENST00000438045 | ENST00000491250 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| In-frame | ENST00000248633 | ENST00000265734 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| In-frame | ENST00000248633 | ENST00000424848 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| 5CDS-intron | ENST00000248633 | ENST00000491250 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| In-frame | ENST00000428214 | ENST00000265734 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| In-frame | ENST00000428214 | ENST00000424848 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| 5CDS-intron | ENST00000428214 | ENST00000491250 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| intron-3CDS | ENST00000541751 | ENST00000265734 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| intron-3CDS | ENST00000541751 | ENST00000424848 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
| intron-intron | ENST00000541751 | ENST00000491250 | PEX1 | chr7 | 92157621 | - | CDK6 | chr7 | 92355107 | - |
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FusionProtFeatures for PEX1_CDK6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PEX1 | CDK6 |
| Serine/threonine-protein kinase involved in the controlof the cell cycle and differentiation; promotes G1/S transition.Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclinsduring interphase at G1 to form a pRB/RB1 kinase and controls theentrance into the cell cycle. Involved in initiation andmaintenance of cell cycle exit during cell differentiation;prevents cell proliferation and regulates negatively celldifferentiation, but is required for the proliferation of specificcell types (e.g. erythroid and hematopoietic cells). Essential forcell proliferation within the dentate gyrus of the hippocampus andthe subventricular zone of the lateral ventricles. Required duringthymocyte development. Promotes the production of newborn neurons,probably by modulating G1 length. Promotes, at least inastrocytes, changes in patterns of gene expression, changes in theactin cytoskeleton including loss of stress fibers, and enhancedmotility during cell differentiation. Prevents myeloiddifferentiation by interfering with RUNX1 and reducing itstranscription transactivation activity, but promotes proliferationof normal myeloid progenitors. Delays senescence. Promotes theproliferation of beta-cells in pancreatic islets of Langerhans.May play a role in the centrosome organization during the cellcycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137,ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224,ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273,ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249,ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663,ECO:0000269|PubMed:8114739}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PEX1 | chr7:92157621 | chr7:92355107 | ENST00000248633 | - | 1 | 24 | 599_606 | 43 | 1284 | Nucleotide binding | ATP |
| Hgene | >PEX1 | chr7:92157621 | chr7:92355107 | ENST00000248633 | - | 1 | 24 | 881_888 | 43 | 1284 | Nucleotide binding | ATP |
| Hgene | >PEX1 | chr7:92157621 | chr7:92355107 | ENST00000428214 | - | 1 | 23 | 599_606 | 43 | 1227 | Nucleotide binding | ATP |
| Hgene | >PEX1 | chr7:92157621 | chr7:92355107 | ENST00000428214 | - | 1 | 23 | 881_888 | 43 | 1227 | Nucleotide binding | ATP |
| Tgene | CDK6 | chr7:92157621 | chr7:92355107 | ENST00000265734 | - | 2 | 8 | 13_300 | 123 | 327 | Domain | Protein kinase |
| Tgene | CDK6 | chr7:92157621 | chr7:92355107 | ENST00000424848 | - | 2 | 8 | 13_300 | 123 | 327 | Domain | Protein kinase |
| Tgene | CDK6 | chr7:92157621 | chr7:92355107 | ENST00000265734 | - | 2 | 8 | 19_27 | 123 | 327 | Nucleotide binding | ATP |
| Tgene | CDK6 | chr7:92157621 | chr7:92355107 | ENST00000424848 | - | 2 | 8 | 19_27 | 123 | 327 | Nucleotide binding | ATP |
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FusionGeneSequence for PEX1_CDK6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PEX1_ENST00000438045_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_247aa MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ >In-frame_PEX1_ENST00000438045_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_247aa MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ >In-frame_PEX1_ENST00000248633_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_247aa MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ >In-frame_PEX1_ENST00000248633_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_247aa MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ >In-frame_PEX1_ENST00000428214_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_247aa MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ >In-frame_PEX1_ENST00000428214_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_247aa MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PEX1_ENST00000438045_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC >In-frame_PEX1_ENST00000438045_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC >In-frame_PEX1_ENST00000248633_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC >In-frame_PEX1_ENST00000248633_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC >In-frame_PEX1_ENST00000428214_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC >In-frame_PEX1_ENST00000428214_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PEX1_ENST00000438045_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_10966nt GGGACGATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTC CTCCACCTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCA CACCGAGTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGC ATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACC CCCGTGGATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTA GGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCT GCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGA ATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAG AACACCTCGGAGCTGAATACAGCCTGAGGCCTCAGCAGCCGCCTTAAGCTGATCCTGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCC TCAGCAAGCCCTACAGAGCTGTGGAGGATTGCTATCTGGAGGCCTTCCAGCTGCTGTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACC GCCTAGTTTACTGTTTTGAAATCAATGCAAGAGTGATTGCAGCTTTATGTTCATTTGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTG GAAAAATTCCAGAAGAAGAGAAGCTGCTGACCAATTGTGCTGCCATTTGATTTTTCTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAAT CCAGGCACAGCTGAGTTATGATGTAATCTCTCTGCAGCTGCCGGGCCTGATTTGGTACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTATGTGAGAGATTCTGTGATCTTTTAAAGTGTTACTTTTTGTAAACGACAAGAATAATTCAATTTTAAAGA CTCAAGGTGGTCAGTAAATAACAGGCATTTGTTCACTGAAGGTGATTCACCAAAATAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCC TCAGCATTTCTTTTCTGGCCAAAAGCAGTAAATTTGCTAGCAGTAAAAGATGAAGTTTTATACACACAGCAAAAAGGAGAAAAAATTCTA GTATATTTTAAGAGATGTGCATGCATTCTATTTAGTCTTCAGAATGCTGAATTTACTTGTTGTAAGTCTATTTTAACCTTCTGTATGACA TCATGCTTTATCATTTCTTTTGGAAAATAGCCTGTAAGCTTTTTATTACTTGCTATAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAA AAAAAGAATAGAAAGCCTTTATTTCCTGGTTTGAAATTCCTTTCTTCCCTTTTTTTGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTG TTTTTGTTTTTAGGAATTTGTCAGAAACTCTTTCCTGTTTTGGTTTGGAGAGTAGTTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAAT TTTCCTCATCTATTACACTGTACTTTCTGCCACACACTGCCTTGTTGGCAAAGTATCCATCTTGTCTATCTCCCGGCACTTCTGAAATAT ATTGCTACCATTGTATAACTAATAACAGATTGCTTAAGCTGTTCCCATGCACCACCTGTTTGCTTGCTTTCAATGAACCTTTCATAAATT CGCAGTCTCAGCTTATGGTTTATGGCCTCGATTCTGCAAACCTAACAGGGTCACATATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTT ACTTTTGTTACCTAAATAATGAGTAGGATCTTGTTTTGTTTTATCACCAGCACACAGATTGCTATAAACTGTTACTTTGTGAATTACATT TTTATAGAAGATATTTTCAGTGTCTTTACCTGAGGGTATGTCTTTAGCTATGTTTTAGGGCCATACATTTACTCTATCAAATGATCTTTT CTCCATCCCCCAGGCTGTGCTTATTTCTAGTGCCTTGTGCTCACTCCTGCTCTCTACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCT TTTCCTTTTTCTCTTACTGTTTTCTCTACAGTCCTTTATATTTCATACCATCTCTGCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAG TAACCAGAGGACACAGAAAGTATCTTTTGGAAAGTTTAGCCACCTGTGCTTTCTGACTCAGAGTGCATGCAACAGTTAGATCATGCAACA GTTAGATTATGTTTAGGGTTAGGATTTTCAAAGAATGGAGGTTGCTGCACTCAGAAAATAATTCAGATCATGTTTATGCATTATTAAGTT GTACTGAATTCTTTGCAGCTTAATGTGATATATGACTATCTTGAACAAGAGAAAAAACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGG TTGGGAACTATTCTTTTTTAATTGCTGTACTACTTAACATTGTTCTAATTCAGTAGCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAG ATAATAAAGGAGATGGGCCATACAAATGTTTTCTACTTTCGTTGTGACAACATTGATTAGGTGTTGTCAGTACTATAAATGCTTGAGATA TAATGAATCCACAGCATTCAAGGTCAGGTCTACTCAAAGTCTCACATGGAAAAGTGAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATA CAAAGACATTTTTGCTAGGGCCTACAAATTGAATTTAAAAACTCACTGCACTGATTCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGA GTGAACATAGCTTTAGTTTTTGCTGTTGTAAAAGTGTTTTCATAAGTTCACTCAAGAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAG CATTCTTTAGAATTTTAAATGAGTAGAGAGCTCAACTTTTATTCCTAGCATCTGCTTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAA AATTAAAGCACAAACATTCTGGCATTCAATCGTTGGCAGATTATCTTCTGATGACACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTT TGTAAAAATCTGTCCCCAGTTCTTCCATCGGTGTAGTTGTTGCATTTGAGTGAATACTCTCTTGATTTATGTATTTTATGTCCAGATTCG CCATTTCTGAAATCCAGATCCAACACAAGCAGTCTTGCCGTTAGGGCATTTTGAAGCAGATAGTAGAGTAAGAACTTAGTGACTACAGCT TATTCTTCTGTAACATATGGTTTCAAACATCTTTGCCAAAAGCTAAGCAGTGGTGAACTGAAAAGGGCATATTGCCCCAAGGTTACACTG AAGCAGCTCATAGCAAGTTAAAATATTGTGACAGATTTGAAATCATGTTTGAATTTCATAGTAGGACCAGTACAAGAATGTCCCTGCTAG TTTCTGTTTGATGTTTGGTTCTGGCGGCTCAGGCATTTTGGGAACTGTTGCACAGGGTGGAGTCAAAACAACCTACATATAAAAAGAGAA AAAGAGAAACTTGTCCATTTAGCTTTCATAAGAAATCCCATGGCAAAGGGTAATAAAAAGGACCTAATCTTAAAAATACAATTTCTAAGC ACTTGTAAGAACCCAGTGGGTTGGAGCCTCCCACTTTGTCCCTCCTTTGAAGTGGATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAA GAAAGCTTGGGGCCATTTCAGCCCCCTGTATTCTCATGATTTTCTCTCAGGAAGCACACACTGTGAATGGCAGACTTTTCATTTAGCCCC AGGTGACTTACTAAAAATAGTTGAAAATTATTCACCTAAGAATAGAATCTCAGCATTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCAT GAGATGTTCCTATCTTAAATAAAGCATGTTTCTTTTCTATAGAGAAATGTATAGTTTGACTCTCCAGAATGTACTATCCATCTTGATGAG AAAACTCTTAAATAGTACCAAACATTTTGAACTTTAAATTATGTATTTAAAGTGAGTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGT GGTGCCTATTAAAGTCAGTAATGGCCATTATTGTTCCATTGTGGAAATTAAATTATGTAAGCTTCCTAATATCATAAACATATTAAAATT CTTCTAAAATATTGCTTTTCTTTTAAGTGACAATTTGACTATTCTTATGATAAGCACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCT TTAATTGCATAGTTGAGTCTAGGAAAAAATAATGTTAAAAGTGAATATGCCACCATAATTACTTAATTATGTTAGTATAGAAACTACAGA ATATTTACCCTGGAAAGAAAATATTGGAATGTTATTATAAACTCTTAGATATTTATATAATTCAAAAGAATGCATGTTTCACATTGTGAC AGATAAAGATGTATGATTTCTAAGGCTTTAAAAATTATTCATAAAACAGTGGGCAATAGATAAAGGAAATTCTGGAGAAAATGAAGGTAT TTAAAGGGTAGTTTCAAAGCTATATATATTTTGAAGGATATATTCTTTATGAACAAATATATTGTAAAAATTTATACTAAGGTCATCTGG TAACTGTGGGATTAATATGGTCGAAAACAAATGTTATGGAGAAGCTGTCCCAAGCAAACTAAATTACCTGTACTTTTTTCCCATTTCAAG GGAAGAGGCAACCACATGAAGCAATACTTCTTACACATGCCTAAGAACGTTCATTGAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTA TGCCACCAATACTTTTGAAAAATTGTGAACCTTACCCAAAACCATTTATCATGTCCATTAAGTATATTTGGGTATATAATTAGGAAGATA TTTACATGTTCCATCTCCACAGTGGAAAAACTTATTGAGGCTACCAAAGTGTGCCAAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCT GTTTTCCTCAAAAGCATGAGAAACTAGCATTTTCATTTCTTATTTACTCCCTTTCTATATCAATGCAATTCACAACCCAATTTTAATACA TCCCTATATCTCAAGCATTTCTATCTTGTACTTTTTCAGAAAATAAACCAAAAATAATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAA GCAACAGAAATGTAAAAACAGAAGGGGTCCAATTTTTACACGTTTTTTTCTCAAGTAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAG TGCCAATCAGCTTTTCAAAATGTTTTCTATTTCTCAGCATTTCCAGGAAGTGATAACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTC AACATATTGTTACCTTGTCTAGCCTTAGGAAGAAAACAAGAGCCACCTGAAAATAAATACAGGCTCTTTTCGAGCATCTGCTGAAATACT GTTACAGCAATTTGAAGTTGATGTGGTAGGAAAGGAAGGTGACTTTTCTTGCAAAAGTCTTTCTAAACATTCACACTGTCCTAAGAGATG AGCTTTCTTGTTTTATTCCGGTATATTCCACAAGGTGGCACTTTTAGAGAAAAACAAATCTGATGAAGACTAAAGAGGTACTTCTAAAAG AGATTTCATTCTAACTTTATTTTTCTGCGCATATTTAACTCTTTCCTAGCACTTGTTTTTTGGGATGATTAATAGTCTCTATAATGTTCT GTAACTTCAATATTTTACTTGTTACCTAGGTTCTGAACAATTGTCTGCAAATAAATTGTTCTTAAGGATGGATAATACACCCATTTTGAT CATTTAAGTAAAGAAAGCCTAGTCATTCATTCAGTCAAGAAAAAATTTTTGAAGTACCCAGTTACCTTACTTTTCTAGATTAAAACAGGC TTAGTTACTAAAAAGGCAGTCCTCATCTGTGAACAGGATAGTTTCGTTAGAAGTATAAAACTCCTTTAGTGGCCCCAGTTAAAACACACA TACCCTCTCTGCTGCTTTCAAATTCCCTAGCATGGTGGCCTTTCAACATTGATTAAATTTTAAAATCCTAATTTAAAGATCAGGTGAGCA AAATGAGTAGCACATCAGTAATTCAGTAGACAAAACTTTTGTCTGAAAAATTGCTGTATTGAAACAGAGCCCTAAAATACCAAAAGACCA GGTAATTTTAACATTTGTGGAATCACAAATGTAAATTCATAAGAAGCTCTAATTAAAAAAAAAAAGTCTGAAGTATATGAGCATAACAAC TTAGGAGTGTGTCTACATACTTAACTTTTGAAGTTTTTTGGCAACTTTATATACTTTTTTTAAATTTACAAGTCTACTTAAAGACTTCTT ATACCCCAAATGATTAAGTTAATTTTAGAGGTCACCTTTCTCACAGCAGTGTCACTTGAAATTTAGTAGGGAAGGATATTGCAGTATTTT TCAGTTTCCTTAGCACAGCACCACAGAAAGCAGCTTATTCCTTTTGAGTGGCAGACACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGT GGCAAGCAGATGAGTCTCAGTAATTCATACTGAACCAAAATGCCACATACACTAGGGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCT CATTCGCCCCTCTGCTCCCAGGAACTAGAGTCCAGTTAAAGCCCCTATGCGAAAGGCCGAATTCCACCCCAGGGTTTGTTATAACAGTGG CCAGTCTGAACCCCATTTGCTCGTGCTCAAAACTTGATTCCCACTTGAAAGCCTTCCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGC AGGAGAGAGGCAGTGGGCGAGGCCGGGCTGGGGCCCCGCCTCCCACTCACCTGCCGGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCT TTCCGAGGTCAGAGTGCCCTGCTGCTGTCTCAGAGGCATCTGTTCTGCAAATCTTAGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTC TTCTGTGCATAAATAAGTACAACACAATTCTCCGAAAGTTCGGGTAAAAAGAGATGCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCC CGCATCTCTCAGGCGCTAAGCTCAGTTTTTGTTTTTGTTTTTGTTTTTTTAAAGAAAAGATGTATAATTGCAGGAATTTTTTTTTATTTT TTTATTTTCCATCATTCTATATATGTGATGGTGAAAGATATGCCTGGAAAAGTTTTGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAG TTGGCAAAAGCTCTCAATTCTTTAGCTTCCAGTTTCTTTTCTCTCTTTTTCTTTGTTAGGTAATTAAAGGTATGTAAACAAATTATCTCA TGTAGCAGGGGATTTTCATGTTGAGAGGAATCTTCCGTGTGAGTTGTTTGGTCACACAAATAACCCTTTCTCAATTTTAGGAGTTTGGAT TGTCAAATGTAGGTTTTTCTCAAAGGGGGCATATAACTACATATTGACTGCCAAGAACTATGACTGTAGCACTAATCAGCACACATAGAG CCACACAATTATTTAATTTCTAACTCTCTGTGGTCCCTAGAAAAATTCCGTTGATGTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTA CCCTTACTTGAAAGTTTCTAATCTTAAGTTTTATGAAATGCAATAATATGTATCAGCTAGCAATATTTCTGTGATCACCAACAACTCTCA GTTTGATCTTAAAGTCTGAATAATAAAACAAATCCCAGCAGTAATACATTTCTTAAACCTCACAGTGCATGATATATCTTTTCATTCTGA TCCTGTGTTTGCAAAAATATACACATGTATATCATAGTTCCTCACTTTTTATTCATTTGTTTTCCTATTACCTGTAGTAAATATATTAGT TAGTACATGGAATTTATAGCATCAGCTACCCCCAGGAACAGCACCTGACAGGCGGGGGATTTTTTTTCAAGTTGTTCTACATTTGCATAA ATTATTTCTATTATTATTCATGTATGTTATTTATTTCTGAATCACACTAGTCCTGTGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATT TTGCATCTAATGTTCATTATCATGGTATTGATGGACCTAAGAAAATAAAAATTAGACTAAGCCCCCAAATAAGCTGCATGCATTTGTAAC ATGATTAGTAGATTTGAATATATAGATGTAGTATTTTGGGTATCTAGGTGTTTTATCATTATGTAAAGGAATTAAAGTAAAGGACTTTGT AGTTGTTTTTATTAAATATGCATATAGTAGAGTGCAAAAATATAGCAAAAATAAAAACTAAAGGTAGAAAAGCATTTTAGATATGCCTTA ATTTAGAAACTGTGCCAGGTGGCCCTCGGAATAGATGCCAGGCAGAGACCAGTGCCTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAG AAGCTTCCCTCACGTGATGTAGTGCCCTCGTAGGTGTCATGTGGAGTAGTGGGAACAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAG TTTTTCTGTAGAAGCAGAACTGTCAGCTTGTGCCTTGAGGCTTCCAGAACGTGTCAGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAA CTTAGCTGTGTACAGAAGCAATCCAGTGTGGTAATAAAAAGCAAGGATTGCCTGTATAATTTATTATAAAATAAAAGGGATTTTAACAAC CAACAATTCCCAACACCTCAAAAGCTTGTTGCATTTTTTGGTATTTGAGGTTTTTATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAA GAGCAGTATGTGTTAAGAAAAGAAAAATATTGGTTCACGTAGAGTGCAAATTAGAACTAGAAAGTTTTATACGATTATCATTTTGAGATG TGTTAAAGTAGGTTTTCACTGTAAAATGTATTAGTGTTTCTGCATTGCCATAGGGCCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGAC TGTCACATACAGTAAGCTTTTTTCCTTCTGACTTATAATAGAAAATGTTTTGAAAGTAAAAAAAAAAAATCTAATTTGGAAATTTGACTT GTTAGTTTCTGTGTTTGAAATCATGGTTCTAGAAATGTAGAAATTGTGTATATCAGATACTCATCTAGGCTGTGTGAACCAGCCCAAGAT GACCAACATCCCCACACCTCTACATCTCTGTCCCCTGTATCTCTTCCTTTCTACCACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCC ACATGGTGCTCTCCATCTTCCTCCACATCATGGACCACAGGTGTGCCTGTCTAGGCCTGGCCACCACTCCCAACTTGACCTAGCCACATT CATCTAGAGATGGTTCCTGATGCTGGGCACAGACTGTGCTCATGGCACCCATTAGAAATGCCTCTAGCATCTTTGTATGCATCTTGATTT TTAAACCAAGTCATTGTACAGAGCATTCAGTTTTGGCTGTGGTACCAAGAGAAAAACTAATCAAGAATATAAACCACATTCCAGGCTGCT GTTTTCTCTCCATCTACAGGCCACACTTTTACTGTATTTCTTCATACTTGAAATTCATTCTGCTATTTTCATATCAGGGTACAGACTTAT AAGGGTGCATGTTCCTTAAAGGTGCATAATTATTCTTATTCCGTTTGCTTATATTGCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCT GCAGACCCAAGAAGCAGTGTGGAAATTCACTGCCTGGGACACAGTCTTATAAGAATGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCT CTTTTCTCTGTACACAGATTGAGAGTTACCACAGTGGCCTGTCGGGTCCACCCTGTGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTT CCTACCTATTCTAACGTTTTTGCCCTCTAAGAAAAATGGCCTCAGGTATGGTATAGACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAG CAACCATCCCTCCATTACACACAGAAAGCCCTCTTGAAGCAAAAGAAGAAGAAAGAAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGA ATGCTCTGAGCTGAATGCTCTTGCTCCTTTCCCAAGAGGCAGATGAAAATATAGCCAGTTTATCTATACCCTTCCTATCTGAGGAGGAGA ATAGAAAAGTAGGGTAAATATGTAACGTAAAATATGTCATTCAAGGACCACCAAAACTTTAAGTACCCTATCATTAAAAATCTGGTTTTA AAAGTAGCTCAAGTAAGGGATGCTTTGTGACCCAGGGTTTCTGAAGTCAGATAGCCATTCTTACCTGCCCCTTACTCTGACTTATTGGGA AAGGGAGAACTGCAGTGGTGTTTCTGTTGCAGTGGCAAAGGTAACATGTCAGAAAATTCAGAGGGTTGCATACCAATAATCCTTTGGAAA CTGGATGTCTTACTGGGTGCTAGAATGAAAATGTAGGTATTTATTGTCAGATGATGAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAA TATCACTGTCCAATGTGTTCACTTATGTGAAAGCTAAATTGAATGAGGCAAAAAGAGCAAATAGTTTGTATATTTGTAATACCTTTTGTA TTTCTTACAATAAAAATATTGGTAGCAAATAAAAATAATAAAAACAATAACTTTAAACTGCTTTCTGGAGATGAATTACTCTCCTGGCTA >In-frame_PEX1_ENST00000438045_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_747nt GGGACGATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTC CTCCACCTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCA CACCGAGTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGC ATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACC CCCGTGGATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTA GGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCT GCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGA ATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAG >In-frame_PEX1_ENST00000248633_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_11056nt CGATCGATCTCCTCCGGCTCCGACGTCCTCGGCCTGCCGGGTCCCGGGTCCTTTGCGGCGCTAGGGTGGGCGAACCCAGAGCGACGCTCC GGGACGATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTC CTCCACCTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCA CACCGAGTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGC ATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACC CCCGTGGATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTA GGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCT GCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGA ATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAG AACACCTCGGAGCTGAATACAGCCTGAGGCCTCAGCAGCCGCCTTAAGCTGATCCTGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCC TCAGCAAGCCCTACAGAGCTGTGGAGGATTGCTATCTGGAGGCCTTCCAGCTGCTGTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACC GCCTAGTTTACTGTTTTGAAATCAATGCAAGAGTGATTGCAGCTTTATGTTCATTTGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTG GAAAAATTCCAGAAGAAGAGAAGCTGCTGACCAATTGTGCTGCCATTTGATTTTTCTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAAT CCAGGCACAGCTGAGTTATGATGTAATCTCTCTGCAGCTGCCGGGCCTGATTTGGTACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTATGTGAGAGATTCTGTGATCTTTTAAAGTGTTACTTTTTGTAAACGACAAGAATAATTCAATTTTAAAGA CTCAAGGTGGTCAGTAAATAACAGGCATTTGTTCACTGAAGGTGATTCACCAAAATAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCC TCAGCATTTCTTTTCTGGCCAAAAGCAGTAAATTTGCTAGCAGTAAAAGATGAAGTTTTATACACACAGCAAAAAGGAGAAAAAATTCTA GTATATTTTAAGAGATGTGCATGCATTCTATTTAGTCTTCAGAATGCTGAATTTACTTGTTGTAAGTCTATTTTAACCTTCTGTATGACA TCATGCTTTATCATTTCTTTTGGAAAATAGCCTGTAAGCTTTTTATTACTTGCTATAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAA AAAAAGAATAGAAAGCCTTTATTTCCTGGTTTGAAATTCCTTTCTTCCCTTTTTTTGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTG TTTTTGTTTTTAGGAATTTGTCAGAAACTCTTTCCTGTTTTGGTTTGGAGAGTAGTTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAAT TTTCCTCATCTATTACACTGTACTTTCTGCCACACACTGCCTTGTTGGCAAAGTATCCATCTTGTCTATCTCCCGGCACTTCTGAAATAT ATTGCTACCATTGTATAACTAATAACAGATTGCTTAAGCTGTTCCCATGCACCACCTGTTTGCTTGCTTTCAATGAACCTTTCATAAATT CGCAGTCTCAGCTTATGGTTTATGGCCTCGATTCTGCAAACCTAACAGGGTCACATATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTT ACTTTTGTTACCTAAATAATGAGTAGGATCTTGTTTTGTTTTATCACCAGCACACAGATTGCTATAAACTGTTACTTTGTGAATTACATT TTTATAGAAGATATTTTCAGTGTCTTTACCTGAGGGTATGTCTTTAGCTATGTTTTAGGGCCATACATTTACTCTATCAAATGATCTTTT CTCCATCCCCCAGGCTGTGCTTATTTCTAGTGCCTTGTGCTCACTCCTGCTCTCTACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCT TTTCCTTTTTCTCTTACTGTTTTCTCTACAGTCCTTTATATTTCATACCATCTCTGCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAG TAACCAGAGGACACAGAAAGTATCTTTTGGAAAGTTTAGCCACCTGTGCTTTCTGACTCAGAGTGCATGCAACAGTTAGATCATGCAACA GTTAGATTATGTTTAGGGTTAGGATTTTCAAAGAATGGAGGTTGCTGCACTCAGAAAATAATTCAGATCATGTTTATGCATTATTAAGTT GTACTGAATTCTTTGCAGCTTAATGTGATATATGACTATCTTGAACAAGAGAAAAAACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGG TTGGGAACTATTCTTTTTTAATTGCTGTACTACTTAACATTGTTCTAATTCAGTAGCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAG ATAATAAAGGAGATGGGCCATACAAATGTTTTCTACTTTCGTTGTGACAACATTGATTAGGTGTTGTCAGTACTATAAATGCTTGAGATA TAATGAATCCACAGCATTCAAGGTCAGGTCTACTCAAAGTCTCACATGGAAAAGTGAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATA CAAAGACATTTTTGCTAGGGCCTACAAATTGAATTTAAAAACTCACTGCACTGATTCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGA GTGAACATAGCTTTAGTTTTTGCTGTTGTAAAAGTGTTTTCATAAGTTCACTCAAGAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAG CATTCTTTAGAATTTTAAATGAGTAGAGAGCTCAACTTTTATTCCTAGCATCTGCTTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAA AATTAAAGCACAAACATTCTGGCATTCAATCGTTGGCAGATTATCTTCTGATGACACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTT TGTAAAAATCTGTCCCCAGTTCTTCCATCGGTGTAGTTGTTGCATTTGAGTGAATACTCTCTTGATTTATGTATTTTATGTCCAGATTCG CCATTTCTGAAATCCAGATCCAACACAAGCAGTCTTGCCGTTAGGGCATTTTGAAGCAGATAGTAGAGTAAGAACTTAGTGACTACAGCT TATTCTTCTGTAACATATGGTTTCAAACATCTTTGCCAAAAGCTAAGCAGTGGTGAACTGAAAAGGGCATATTGCCCCAAGGTTACACTG AAGCAGCTCATAGCAAGTTAAAATATTGTGACAGATTTGAAATCATGTTTGAATTTCATAGTAGGACCAGTACAAGAATGTCCCTGCTAG TTTCTGTTTGATGTTTGGTTCTGGCGGCTCAGGCATTTTGGGAACTGTTGCACAGGGTGGAGTCAAAACAACCTACATATAAAAAGAGAA AAAGAGAAACTTGTCCATTTAGCTTTCATAAGAAATCCCATGGCAAAGGGTAATAAAAAGGACCTAATCTTAAAAATACAATTTCTAAGC ACTTGTAAGAACCCAGTGGGTTGGAGCCTCCCACTTTGTCCCTCCTTTGAAGTGGATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAA GAAAGCTTGGGGCCATTTCAGCCCCCTGTATTCTCATGATTTTCTCTCAGGAAGCACACACTGTGAATGGCAGACTTTTCATTTAGCCCC AGGTGACTTACTAAAAATAGTTGAAAATTATTCACCTAAGAATAGAATCTCAGCATTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCAT GAGATGTTCCTATCTTAAATAAAGCATGTTTCTTTTCTATAGAGAAATGTATAGTTTGACTCTCCAGAATGTACTATCCATCTTGATGAG AAAACTCTTAAATAGTACCAAACATTTTGAACTTTAAATTATGTATTTAAAGTGAGTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGT GGTGCCTATTAAAGTCAGTAATGGCCATTATTGTTCCATTGTGGAAATTAAATTATGTAAGCTTCCTAATATCATAAACATATTAAAATT CTTCTAAAATATTGCTTTTCTTTTAAGTGACAATTTGACTATTCTTATGATAAGCACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCT TTAATTGCATAGTTGAGTCTAGGAAAAAATAATGTTAAAAGTGAATATGCCACCATAATTACTTAATTATGTTAGTATAGAAACTACAGA ATATTTACCCTGGAAAGAAAATATTGGAATGTTATTATAAACTCTTAGATATTTATATAATTCAAAAGAATGCATGTTTCACATTGTGAC AGATAAAGATGTATGATTTCTAAGGCTTTAAAAATTATTCATAAAACAGTGGGCAATAGATAAAGGAAATTCTGGAGAAAATGAAGGTAT TTAAAGGGTAGTTTCAAAGCTATATATATTTTGAAGGATATATTCTTTATGAACAAATATATTGTAAAAATTTATACTAAGGTCATCTGG TAACTGTGGGATTAATATGGTCGAAAACAAATGTTATGGAGAAGCTGTCCCAAGCAAACTAAATTACCTGTACTTTTTTCCCATTTCAAG GGAAGAGGCAACCACATGAAGCAATACTTCTTACACATGCCTAAGAACGTTCATTGAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTA TGCCACCAATACTTTTGAAAAATTGTGAACCTTACCCAAAACCATTTATCATGTCCATTAAGTATATTTGGGTATATAATTAGGAAGATA TTTACATGTTCCATCTCCACAGTGGAAAAACTTATTGAGGCTACCAAAGTGTGCCAAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCT GTTTTCCTCAAAAGCATGAGAAACTAGCATTTTCATTTCTTATTTACTCCCTTTCTATATCAATGCAATTCACAACCCAATTTTAATACA TCCCTATATCTCAAGCATTTCTATCTTGTACTTTTTCAGAAAATAAACCAAAAATAATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAA GCAACAGAAATGTAAAAACAGAAGGGGTCCAATTTTTACACGTTTTTTTCTCAAGTAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAG TGCCAATCAGCTTTTCAAAATGTTTTCTATTTCTCAGCATTTCCAGGAAGTGATAACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTC AACATATTGTTACCTTGTCTAGCCTTAGGAAGAAAACAAGAGCCACCTGAAAATAAATACAGGCTCTTTTCGAGCATCTGCTGAAATACT GTTACAGCAATTTGAAGTTGATGTGGTAGGAAAGGAAGGTGACTTTTCTTGCAAAAGTCTTTCTAAACATTCACACTGTCCTAAGAGATG AGCTTTCTTGTTTTATTCCGGTATATTCCACAAGGTGGCACTTTTAGAGAAAAACAAATCTGATGAAGACTAAAGAGGTACTTCTAAAAG AGATTTCATTCTAACTTTATTTTTCTGCGCATATTTAACTCTTTCCTAGCACTTGTTTTTTGGGATGATTAATAGTCTCTATAATGTTCT GTAACTTCAATATTTTACTTGTTACCTAGGTTCTGAACAATTGTCTGCAAATAAATTGTTCTTAAGGATGGATAATACACCCATTTTGAT CATTTAAGTAAAGAAAGCCTAGTCATTCATTCAGTCAAGAAAAAATTTTTGAAGTACCCAGTTACCTTACTTTTCTAGATTAAAACAGGC TTAGTTACTAAAAAGGCAGTCCTCATCTGTGAACAGGATAGTTTCGTTAGAAGTATAAAACTCCTTTAGTGGCCCCAGTTAAAACACACA TACCCTCTCTGCTGCTTTCAAATTCCCTAGCATGGTGGCCTTTCAACATTGATTAAATTTTAAAATCCTAATTTAAAGATCAGGTGAGCA AAATGAGTAGCACATCAGTAATTCAGTAGACAAAACTTTTGTCTGAAAAATTGCTGTATTGAAACAGAGCCCTAAAATACCAAAAGACCA GGTAATTTTAACATTTGTGGAATCACAAATGTAAATTCATAAGAAGCTCTAATTAAAAAAAAAAAGTCTGAAGTATATGAGCATAACAAC TTAGGAGTGTGTCTACATACTTAACTTTTGAAGTTTTTTGGCAACTTTATATACTTTTTTTAAATTTACAAGTCTACTTAAAGACTTCTT ATACCCCAAATGATTAAGTTAATTTTAGAGGTCACCTTTCTCACAGCAGTGTCACTTGAAATTTAGTAGGGAAGGATATTGCAGTATTTT TCAGTTTCCTTAGCACAGCACCACAGAAAGCAGCTTATTCCTTTTGAGTGGCAGACACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGT GGCAAGCAGATGAGTCTCAGTAATTCATACTGAACCAAAATGCCACATACACTAGGGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCT CATTCGCCCCTCTGCTCCCAGGAACTAGAGTCCAGTTAAAGCCCCTATGCGAAAGGCCGAATTCCACCCCAGGGTTTGTTATAACAGTGG CCAGTCTGAACCCCATTTGCTCGTGCTCAAAACTTGATTCCCACTTGAAAGCCTTCCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGC AGGAGAGAGGCAGTGGGCGAGGCCGGGCTGGGGCCCCGCCTCCCACTCACCTGCCGGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCT TTCCGAGGTCAGAGTGCCCTGCTGCTGTCTCAGAGGCATCTGTTCTGCAAATCTTAGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTC TTCTGTGCATAAATAAGTACAACACAATTCTCCGAAAGTTCGGGTAAAAAGAGATGCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCC CGCATCTCTCAGGCGCTAAGCTCAGTTTTTGTTTTTGTTTTTGTTTTTTTAAAGAAAAGATGTATAATTGCAGGAATTTTTTTTTATTTT TTTATTTTCCATCATTCTATATATGTGATGGTGAAAGATATGCCTGGAAAAGTTTTGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAG TTGGCAAAAGCTCTCAATTCTTTAGCTTCCAGTTTCTTTTCTCTCTTTTTCTTTGTTAGGTAATTAAAGGTATGTAAACAAATTATCTCA TGTAGCAGGGGATTTTCATGTTGAGAGGAATCTTCCGTGTGAGTTGTTTGGTCACACAAATAACCCTTTCTCAATTTTAGGAGTTTGGAT TGTCAAATGTAGGTTTTTCTCAAAGGGGGCATATAACTACATATTGACTGCCAAGAACTATGACTGTAGCACTAATCAGCACACATAGAG CCACACAATTATTTAATTTCTAACTCTCTGTGGTCCCTAGAAAAATTCCGTTGATGTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTA CCCTTACTTGAAAGTTTCTAATCTTAAGTTTTATGAAATGCAATAATATGTATCAGCTAGCAATATTTCTGTGATCACCAACAACTCTCA GTTTGATCTTAAAGTCTGAATAATAAAACAAATCCCAGCAGTAATACATTTCTTAAACCTCACAGTGCATGATATATCTTTTCATTCTGA TCCTGTGTTTGCAAAAATATACACATGTATATCATAGTTCCTCACTTTTTATTCATTTGTTTTCCTATTACCTGTAGTAAATATATTAGT TAGTACATGGAATTTATAGCATCAGCTACCCCCAGGAACAGCACCTGACAGGCGGGGGATTTTTTTTCAAGTTGTTCTACATTTGCATAA ATTATTTCTATTATTATTCATGTATGTTATTTATTTCTGAATCACACTAGTCCTGTGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATT TTGCATCTAATGTTCATTATCATGGTATTGATGGACCTAAGAAAATAAAAATTAGACTAAGCCCCCAAATAAGCTGCATGCATTTGTAAC ATGATTAGTAGATTTGAATATATAGATGTAGTATTTTGGGTATCTAGGTGTTTTATCATTATGTAAAGGAATTAAAGTAAAGGACTTTGT AGTTGTTTTTATTAAATATGCATATAGTAGAGTGCAAAAATATAGCAAAAATAAAAACTAAAGGTAGAAAAGCATTTTAGATATGCCTTA ATTTAGAAACTGTGCCAGGTGGCCCTCGGAATAGATGCCAGGCAGAGACCAGTGCCTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAG AAGCTTCCCTCACGTGATGTAGTGCCCTCGTAGGTGTCATGTGGAGTAGTGGGAACAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAG TTTTTCTGTAGAAGCAGAACTGTCAGCTTGTGCCTTGAGGCTTCCAGAACGTGTCAGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAA CTTAGCTGTGTACAGAAGCAATCCAGTGTGGTAATAAAAAGCAAGGATTGCCTGTATAATTTATTATAAAATAAAAGGGATTTTAACAAC CAACAATTCCCAACACCTCAAAAGCTTGTTGCATTTTTTGGTATTTGAGGTTTTTATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAA GAGCAGTATGTGTTAAGAAAAGAAAAATATTGGTTCACGTAGAGTGCAAATTAGAACTAGAAAGTTTTATACGATTATCATTTTGAGATG TGTTAAAGTAGGTTTTCACTGTAAAATGTATTAGTGTTTCTGCATTGCCATAGGGCCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGAC TGTCACATACAGTAAGCTTTTTTCCTTCTGACTTATAATAGAAAATGTTTTGAAAGTAAAAAAAAAAAATCTAATTTGGAAATTTGACTT GTTAGTTTCTGTGTTTGAAATCATGGTTCTAGAAATGTAGAAATTGTGTATATCAGATACTCATCTAGGCTGTGTGAACCAGCCCAAGAT GACCAACATCCCCACACCTCTACATCTCTGTCCCCTGTATCTCTTCCTTTCTACCACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCC ACATGGTGCTCTCCATCTTCCTCCACATCATGGACCACAGGTGTGCCTGTCTAGGCCTGGCCACCACTCCCAACTTGACCTAGCCACATT CATCTAGAGATGGTTCCTGATGCTGGGCACAGACTGTGCTCATGGCACCCATTAGAAATGCCTCTAGCATCTTTGTATGCATCTTGATTT TTAAACCAAGTCATTGTACAGAGCATTCAGTTTTGGCTGTGGTACCAAGAGAAAAACTAATCAAGAATATAAACCACATTCCAGGCTGCT GTTTTCTCTCCATCTACAGGCCACACTTTTACTGTATTTCTTCATACTTGAAATTCATTCTGCTATTTTCATATCAGGGTACAGACTTAT AAGGGTGCATGTTCCTTAAAGGTGCATAATTATTCTTATTCCGTTTGCTTATATTGCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCT GCAGACCCAAGAAGCAGTGTGGAAATTCACTGCCTGGGACACAGTCTTATAAGAATGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCT CTTTTCTCTGTACACAGATTGAGAGTTACCACAGTGGCCTGTCGGGTCCACCCTGTGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTT CCTACCTATTCTAACGTTTTTGCCCTCTAAGAAAAATGGCCTCAGGTATGGTATAGACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAG CAACCATCCCTCCATTACACACAGAAAGCCCTCTTGAAGCAAAAGAAGAAGAAAGAAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGA ATGCTCTGAGCTGAATGCTCTTGCTCCTTTCCCAAGAGGCAGATGAAAATATAGCCAGTTTATCTATACCCTTCCTATCTGAGGAGGAGA ATAGAAAAGTAGGGTAAATATGTAACGTAAAATATGTCATTCAAGGACCACCAAAACTTTAAGTACCCTATCATTAAAAATCTGGTTTTA AAAGTAGCTCAAGTAAGGGATGCTTTGTGACCCAGGGTTTCTGAAGTCAGATAGCCATTCTTACCTGCCCCTTACTCTGACTTATTGGGA AAGGGAGAACTGCAGTGGTGTTTCTGTTGCAGTGGCAAAGGTAACATGTCAGAAAATTCAGAGGGTTGCATACCAATAATCCTTTGGAAA CTGGATGTCTTACTGGGTGCTAGAATGAAAATGTAGGTATTTATTGTCAGATGATGAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAA TATCACTGTCCAATGTGTTCACTTATGTGAAAGCTAAATTGAATGAGGCAAAAAGAGCAAATAGTTTGTATATTTGTAATACCTTTTGTA TTTCTTACAATAAAAATATTGGTAGCAAATAAAAATAATAAAAACAATAACTTTAAACTGCTTTCTGGAGATGAATTACTCTCCTGGCTA >In-frame_PEX1_ENST00000248633_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_837nt CGATCGATCTCCTCCGGCTCCGACGTCCTCGGCCTGCCGGGTCCCGGGTCCTTTGCGGCGCTAGGGTGGGCGAACCCAGAGCGACGCTCC GGGACGATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTC CTCCACCTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCA CACCGAGTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGC ATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACC CCCGTGGATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTA GGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCT GCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGA ATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAG >In-frame_PEX1_ENST00000428214_chr7_92157621_-_CDK6_ENST00000265734_chr7_92355107_-_10960nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC TCGGAGCTGAATACAGCCTGAGGCCTCAGCAGCCGCCTTAAGCTGATCCTGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCA AGCCCTACAGAGCTGTGGAGGATTGCTATCTGGAGGCCTTCCAGCTGCTGTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAG TTTACTGTTTTGAAATCAATGCAAGAGTGATTGCAGCTTTATGTTCATTTGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAA TTCCAGAAGAAGAGAAGCTGCTGACCAATTGTGCTGCCATTTGATTTTTCTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGC ACAGCTGAGTTATGATGTAATCTCTCTGCAGCTGCCGGGCCTGATTTGGTACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTATGTGAGAGATTCTGTGATCTTTTAAAGTGTTACTTTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAG GTGGTCAGTAAATAACAGGCATTTGTTCACTGAAGGTGATTCACCAAAATAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCA TTTCTTTTCTGGCCAAAAGCAGTAAATTTGCTAGCAGTAAAAGATGAAGTTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATAT TTTAAGAGATGTGCATGCATTCTATTTAGTCTTCAGAATGCTGAATTTACTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGC TTTATCATTTCTTTTGGAAAATAGCCTGTAAGCTTTTTATTACTTGCTATAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAG AATAGAAAGCCTTTATTTCCTGGTTTGAAATTCCTTTCTTCCCTTTTTTTGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTG TTTTTAGGAATTTGTCAGAAACTCTTTCCTGTTTTGGTTTGGAGAGTAGTTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCT CATCTATTACACTGTACTTTCTGCCACACACTGCCTTGTTGGCAAAGTATCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCT ACCATTGTATAACTAATAACAGATTGCTTAAGCTGTTCCCATGCACCACCTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGT CTCAGCTTATGGTTTATGGCCTCGATTCTGCAAACCTAACAGGGTCACATATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTT GTTACCTAAATAATGAGTAGGATCTTGTTTTGTTTTATCACCAGCACACAGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATA GAAGATATTTTCAGTGTCTTTACCTGAGGGTATGTCTTTAGCTATGTTTTAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCAT CCCCCAGGCTGTGCTTATTTCTAGTGCCTTGTGCTCACTCCTGCTCTCTACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCT TTTTCTCTTACTGTTTTCTCTACAGTCCTTTATATTTCATACCATCTCTGCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCA GAGGACACAGAAAGTATCTTTTGGAAAGTTTAGCCACCTGTGCTTTCTGACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGA TTATGTTTAGGGTTAGGATTTTCAAAGAATGGAGGTTGCTGCACTCAGAAAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTG AATTCTTTGCAGCTTAATGTGATATATGACTATCTTGAACAAGAGAAAAAACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGA ACTATTCTTTTTTAATTGCTGTACTACTTAACATTGTTCTAATTCAGTAGCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATA AAGGAGATGGGCCATACAAATGTTTTCTACTTTCGTTGTGACAACATTGATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGA ATCCACAGCATTCAAGGTCAGGTCTACTCAAAGTCTCACATGGAAAAGTGAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGA CATTTTTGCTAGGGCCTACAAATTGAATTTAAAAACTCACTGCACTGATTCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAAC ATAGCTTTAGTTTTTGCTGTTGTAAAAGTGTTTTCATAAGTTCACTCAAGAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCT TTAGAATTTTAAATGAGTAGAGAGCTCAACTTTTATTCCTAGCATCTGCTTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAA AGCACAAACATTCTGGCATTCAATCGTTGGCAGATTATCTTCTGATGACACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAA AATCTGTCCCCAGTTCTTCCATCGGTGTAGTTGTTGCATTTGAGTGAATACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTT CTGAAATCCAGATCCAACACAAGCAGTCTTGCCGTTAGGGCATTTTGAAGCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCT TCTGTAACATATGGTTTCAAACATCTTTGCCAAAAGCTAAGCAGTGGTGAACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAG CTCATAGCAAGTTAAAATATTGTGACAGATTTGAAATCATGTTTGAATTTCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTG TTTGATGTTTGGTTCTGGCGGCTCAGGCATTTTGGGAACTGTTGCACAGGGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAG AAACTTGTCCATTTAGCTTTCATAAGAAATCCCATGGCAAAGGGTAATAAAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGT AAGAACCCAGTGGGTTGGAGCCTCCCACTTTGTCCCTCCTTTGAAGTGGATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGC TTGGGGCCATTTCAGCCCCCTGTATTCTCATGATTTTCTCTCAGGAAGCACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGA CTTACTAAAAATAGTTGAAAATTATTCACCTAAGAATAGAATCTCAGCATTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATG TTCCTATCTTAAATAAAGCATGTTTCTTTTCTATAGAGAAATGTATAGTTTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACT CTTAAATAGTACCAAACATTTTGAACTTTAAATTATGTATTTAAAGTGAGTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCC TATTAAAGTCAGTAATGGCCATTATTGTTCCATTGTGGAAATTAAATTATGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTA AAATATTGCTTTTCTTTTAAGTGACAATTTGACTATTCTTATGATAAGCACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATT GCATAGTTGAGTCTAGGAAAAAATAATGTTAAAAGTGAATATGCCACCATAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTT ACCCTGGAAAGAAAATATTGGAATGTTATTATAAACTCTTAGATATTTATATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAA AGATGTATGATTTCTAAGGCTTTAAAAATTATTCATAAAACAGTGGGCAATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAG GGTAGTTTCAAAGCTATATATATTTTGAAGGATATATTCTTTATGAACAAATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTG TGGGATTAATATGGTCGAAAACAAATGTTATGGAGAAGCTGTCCCAAGCAAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGA GGCAACCACATGAAGCAATACTTCTTACACATGCCTAAGAACGTTCATTGAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCAC CAATACTTTTGAAAAATTGTGAACCTTACCCAAAACCATTTATCATGTCCATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACA TGTTCCATCTCCACAGTGGAAAAACTTATTGAGGCTACCAAAGTGTGCCAAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTC CTCAAAAGCATGAGAAACTAGCATTTTCATTTCTTATTTACTCCCTTTCTATATCAATGCAATTCACAACCCAATTTTAATACATCCCTA TATCTCAAGCATTTCTATCTTGTACTTTTTCAGAAAATAAACCAAAAATAATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACA GAAATGTAAAAACAGAAGGGGTCCAATTTTTACACGTTTTTTTCTCAAGTAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAA TCAGCTTTTCAAAATGTTTTCTATTTCTCAGCATTTCCAGGAAGTGATAACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATA TTGTTACCTTGTCTAGCCTTAGGAAGAAAACAAGAGCCACCTGAAAATAAATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACA GCAATTTGAAGTTGATGTGGTAGGAAAGGAAGGTGACTTTTCTTGCAAAAGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTT CTTGTTTTATTCCGGTATATTCCACAAGGTGGCACTTTTAGAGAAAAACAAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTT CATTCTAACTTTATTTTTCTGCGCATATTTAACTCTTTCCTAGCACTTGTTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACT TCAATATTTTACTTGTTACCTAGGTTCTGAACAATTGTCTGCAAATAAATTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTA AGTAAAGAAAGCCTAGTCATTCATTCAGTCAAGAAAAAATTTTTGAAGTACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTT ACTAAAAAGGCAGTCCTCATCTGTGAACAGGATAGTTTCGTTAGAAGTATAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCT CTCTGCTGCTTTCAAATTCCCTAGCATGGTGGCCTTTCAACATTGATTAAATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGA GTAGCACATCAGTAATTCAGTAGACAAAACTTTTGTCTGAAAAATTGCTGTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAAT TTTAACATTTGTGGAATCACAAATGTAAATTCATAAGAAGCTCTAATTAAAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGA GTGTGTCTACATACTTAACTTTTGAAGTTTTTTGGCAACTTTATATACTTTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCC CAAATGATTAAGTTAATTTTAGAGGTCACCTTTCTCACAGCAGTGTCACTTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTT TCCTTAGCACAGCACCACAGAAAGCAGCTTATTCCTTTTGAGTGGCAGACACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAG CAGATGAGTCTCAGTAATTCATACTGAACCAAAATGCCACATACACTAGGGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCG CCCCTCTGCTCCCAGGAACTAGAGTCCAGTTAAAGCCCCTATGCGAAAGGCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTC TGAACCCCATTTGCTCGTGCTCAAAACTTGATTCCCACTTGAAAGCCTTCCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGA GAGGCAGTGGGCGAGGCCGGGCTGGGGCCCCGCCTCCCACTCACCTGCCGGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGA GGTCAGAGTGCCCTGCTGCTGTCTCAGAGGCATCTGTTCTGCAAATCTTAGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGT GCATAAATAAGTACAACACAATTCTCCGAAAGTTCGGGTAAAAAGAGATGCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATC TCTCAGGCGCTAAGCTCAGTTTTTGTTTTTGTTTTTGTTTTTTTAAAGAAAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATT TTCCATCATTCTATATATGTGATGGTGAAAGATATGCCTGGAAAAGTTTTGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCA AAAGCTCTCAATTCTTTAGCTTCCAGTTTCTTTTCTCTCTTTTTCTTTGTTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGC AGGGGATTTTCATGTTGAGAGGAATCTTCCGTGTGAGTTGTTTGGTCACACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAA ATGTAGGTTTTTCTCAAAGGGGGCATATAACTACATATTGACTGCCAAGAACTATGACTGTAGCACTAATCAGCACACATAGAGCCACAC AATTATTTAATTTCTAACTCTCTGTGGTCCCTAGAAAAATTCCGTTGATGTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTA CTTGAAAGTTTCTAATCTTAAGTTTTATGAAATGCAATAATATGTATCAGCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGA TCTTAAAGTCTGAATAATAAAACAAATCCCAGCAGTAATACATTTCTTAAACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGT GTTTGCAAAAATATACACATGTATATCATAGTTCCTCACTTTTTATTCATTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTAC ATGGAATTTATAGCATCAGCTACCCCCAGGAACAGCACCTGACAGGCGGGGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATT TCTATTATTATTCATGTATGTTATTTATTTCTGAATCACACTAGTCCTGTGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCAT CTAATGTTCATTATCATGGTATTGATGGACCTAAGAAAATAAAAATTAGACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATT AGTAGATTTGAATATATAGATGTAGTATTTTGGGTATCTAGGTGTTTTATCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGT TTTTATTAAATATGCATATAGTAGAGTGCAAAAATATAGCAAAAATAAAAACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAG AAACTGTGCCAGGTGGCCCTCGGAATAGATGCCAGGCAGAGACCAGTGCCTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTT CCCTCACGTGATGTAGTGCCCTCGTAGGTGTCATGTGGAGTAGTGGGAACAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTC TGTAGAAGCAGAACTGTCAGCTTGTGCCTTGAGGCTTCCAGAACGTGTCAGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGC TGTGTACAGAAGCAATCCAGTGTGGTAATAAAAAGCAAGGATTGCCTGTATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAA TTCCCAACACCTCAAAAGCTTGTTGCATTTTTTGGTATTTGAGGTTTTTATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAG TATGTGTTAAGAAAAGAAAAATATTGGTTCACGTAGAGTGCAAATTAGAACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAA AGTAGGTTTTCACTGTAAAATGTATTAGTGTTTCTGCATTGCCATAGGGCCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCAC ATACAGTAAGCTTTTTTCCTTCTGACTTATAATAGAAAATGTTTTGAAAGTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGT TTCTGTGTTTGAAATCATGGTTCTAGAAATGTAGAAATTGTGTATATCAGATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAA CATCCCCACACCTCTACATCTCTGTCCCCTGTATCTCTTCCTTTCTACCACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGG TGCTCTCCATCTTCCTCCACATCATGGACCACAGGTGTGCCTGTCTAGGCCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTA GAGATGGTTCCTGATGCTGGGCACAGACTGTGCTCATGGCACCCATTAGAAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAAC CAAGTCATTGTACAGAGCATTCAGTTTTGGCTGTGGTACCAAGAGAAAAACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTC TCTCCATCTACAGGCCACACTTTTACTGTATTTCTTCATACTTGAAATTCATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGT GCATGTTCCTTAAAGGTGCATAATTATTCTTATTCCGTTTGCTTATATTGCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGAC CCAAGAAGCAGTGTGGAAATTCACTGCCTGGGACACAGTCTTATAAGAATGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTC TCTGTACACAGATTGAGAGTTACCACAGTGGCCTGTCGGGTCCACCCTGTGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACC TATTCTAACGTTTTTGCCCTCTAAGAAAAATGGCCTCAGGTATGGTATAGACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCA TCCCTCCATTACACACAGAAAGCCCTCTTGAAGCAAAAGAAGAAGAAAGAAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTC TGAGCTGAATGCTCTTGCTCCTTTCCCAAGAGGCAGATGAAAATATAGCCAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAA AAGTAGGGTAAATATGTAACGTAAAATATGTCATTCAAGGACCACCAAAACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTA GCTCAAGTAAGGGATGCTTTGTGACCCAGGGTTTCTGAAGTCAGATAGCCATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGA GAACTGCAGTGGTGTTTCTGTTGCAGTGGCAAAGGTAACATGTCAGAAAATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGAT GTCTTACTGGGTGCTAGAATGAAAATGTAGGTATTTATTGTCAGATGATGAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCAC TGTCCAATGTGTTCACTTATGTGAAAGCTAAATTGAATGAGGCAAAAAGAGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTT ACAATAAAAATATTGGTAGCAAATAAAAATAATAAAAACAATAACTTTAAACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCT >In-frame_PEX1_ENST00000428214_chr7_92157621_-_CDK6_ENST00000424848_chr7_92355107_-_741nt ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCCTTCACCAACGCTCGCGACTGCTTCCTCCAC CTGCCGCGGCGTCTCGTGGCCCAGCTGCATCTGCTGCAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTAT AGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAA ATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCT GCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC |
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FusionGenePPI for PEX1_CDK6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PEX1 | PEX26, PEX6, PPP2R1A, RELA, DTWD2, FAS, THBS3, FBXW11, HERC2, SMC1A, EXOSC2, DKKL1, FAM174A, ICAM1 | CDK6 | CDKN2C, CDKN2A, CCND1, CDKN2D, PPP2CA, PPM1B, CDK2, CCND2, CCND3, CDKN1B, CDC37, FBXO7, CDKN1A, UHRF2, CDK5R1, ELAVL1, CCNE1, CCNA2, KIF26B, RB1, CDK7, ATXN1, HIST1H1A, PML, HSP90AA1, FOXM1, ZSCAN1, SYNPO2, DEDD2, SRSF12, ZNF101, SNIP1, ZNF335, PRX, EBF4, EIF4ENIF1, RBM23, BCL11A, TCEB3B, PPHLN1, TRA2A, SENP3, NIPBL, CBY1, SSBP2, SIRT1, POGZ, LPIN1, ANKRD12, TPX2, TRAK1, CASC3, CLASRP, PPARGC1A, MSL3, SORBS1, ABI2, N4BP1, VGLL4, TJP2, SRSF11, ZMYM3, ZNF174, SLBP, ZFP36, MZF1, KLF10, TFDP1, ZEB1, SOX5, SOX10, SRSF1, SRSF2, SRSF7, TRA2B, RBL1, RBL2, NUMA1, NFATC3, MYC, MEF2D, MLLT3, ISL1, HSF1, EZH2, FOXO3, ELK1, ATF6B, DDIT3, CDC6, MCM2, MCM10, UCHL1, CDKN2B, WDR33, CDKL3, CDK6, DMBT1, AMY2A, PIGR, CDK4, DAB1, PSMA3, RTFDC1, HSP90AA5P, UBE2W, CCNT2, CCNT1, RCHY1, EIF2AK1, CDKN1C, NTRK1, RUNX1, CTNNB1, AR, VHL, FGFR3, USP17L2, MCF2L2, PAK4, FKBP5, FAM26E, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PEX1_CDK6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CDK6 | Q00534 | DB09073 | Palbociclib | Cyclin-dependent kinase 6 | small molecule | approved|investigational |
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RelatedDiseases for PEX1_CDK6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PEX1 | C0043459 | Zellweger Syndrome | 7 | CTD_human;ORPHANET;UNIPROT |
| Hgene | PEX1 | C0282527 | Infantile Refsum Disease (disorder) | 7 | ORPHANET;UNIPROT |
| Hgene | PEX1 | C1832200 | Peroxisome biogenesis disorders | 3 | CTD_human |
| Hgene | PEX1 | C1856186 | Deafness enamel hypoplasia nail defects | 1 | ORPHANET;UNIPROT |
| Tgene | CDK6 | C0025149 | Medulloblastoma | 2 | CTD_human |
| Tgene | CDK6 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | CDK6 | C0008625 | Chromosome Aberrations | 1 | CTD_human |
| Tgene | CDK6 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | CDK6 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | CDK6 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | CDK6 | C0263454 | Chloracne | 1 | CTD_human |
| Tgene | CDK6 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | CDK6 | C0677866 | Brain Stem Neoplasms | 1 | CTD_human |
| Tgene | CDK6 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Tgene | CDK6 | C4015156 | MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE | 1 | UNIPROT |
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