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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26662

FusionGeneSummary for PEMT_NEU3

check button Fusion gene summary
Fusion gene informationFusion gene name: PEMT_NEU3
Fusion gene ID: 26662
HgeneTgene
Gene symbol

PEMT

NEU3

Gene ID

10400

10825

Gene namephosphatidylethanolamine N-methyltransferaseneuraminidase 3
SynonymsPEAMT|PEMPT|PEMT2|PLMT|PNMTSIAL3
Cytomap

17p11.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylethanolamine N-methyltransferasephospholipid methyltransferasesialidase-3N-acetyl-alpha-neuraminidase 3ganglioside sialidasemembrane sialidasesialidase 3 (membrane sialidase)
Modification date2018052320180523
UniProtAcc

Q9UBM1

Q9UQ49

Ensembl transtripts involved in fusion geneENST00000395782, ENST00000395783, 
ENST00000435340, ENST00000255389, 
ENST00000395781, ENST00000484838, 
ENST00000294064, ENST00000531509, 
ENST00000544263, ENST00000529024, 
ENST00000532963, ENST00000531619, 
ENST00000545272, ENST00000526068, 
ENST00000534628, 
Fusion gene scores* DoF score9 X 4 X 6=2163 X 1 X 3=9
# samples 83
** MAII scorelog2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PEMT [Title/Abstract] AND NEU3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEU3

GO:0005975

carbohydrate metabolic process

12730204

TgeneNEU3

GO:0006689

ganglioside catabolic process

10861246

TgeneNEU3

GO:0009313

oligosaccharide catabolic process

10861246


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A0TZ-01APEMTchr17

17494845

-NEU3chr11

74705554

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000395782ENST00000294064PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000395782ENST00000531509PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-5UTRENST00000395782ENST00000544263PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395782ENST00000529024PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395782ENST00000532963PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395782ENST00000531619PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395782ENST00000545272PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395782ENST00000526068PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395782ENST00000534628PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000395783ENST00000294064PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000395783ENST00000531509PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-5UTRENST00000395783ENST00000544263PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395783ENST00000529024PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395783ENST00000532963PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395783ENST00000531619PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395783ENST00000545272PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395783ENST00000526068PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000395783ENST00000534628PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000435340ENST00000294064PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000435340ENST00000531509PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-5UTRENST00000435340ENST00000544263PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000435340ENST00000529024PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000435340ENST00000532963PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000435340ENST00000531619PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000435340ENST00000545272PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000435340ENST00000526068PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000435340ENST00000534628PEMTchr17

17494845

-NEU3chr11

74705554

+
Frame-shiftENST00000255389ENST00000294064PEMTchr17

17494845

-NEU3chr11

74705554

+
Frame-shiftENST00000255389ENST00000531509PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-5UTRENST00000255389ENST00000544263PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000255389ENST00000529024PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000255389ENST00000532963PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000255389ENST00000531619PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000255389ENST00000545272PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000255389ENST00000526068PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000255389ENST00000534628PEMTchr17

17494845

-NEU3chr11

74705554

+
Frame-shiftENST00000395781ENST00000294064PEMTchr17

17494845

-NEU3chr11

74705554

+
Frame-shiftENST00000395781ENST00000531509PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-5UTRENST00000395781ENST00000544263PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000395781ENST00000529024PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000395781ENST00000532963PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000395781ENST00000531619PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000395781ENST00000545272PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000395781ENST00000526068PEMTchr17

17494845

-NEU3chr11

74705554

+
5CDS-intronENST00000395781ENST00000534628PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000484838ENST00000294064PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-3CDSENST00000484838ENST00000531509PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-5UTRENST00000484838ENST00000544263PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000484838ENST00000529024PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000484838ENST00000532963PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000484838ENST00000531619PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000484838ENST00000545272PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000484838ENST00000526068PEMTchr17

17494845

-NEU3chr11

74705554

+
intron-intronENST00000484838ENST00000534628PEMTchr17

17494845

-NEU3chr11

74705554

+

Top

FusionProtFeatures for PEMT_NEU3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PEMT

Q9UBM1

NEU3

Q9UQ49

Plays a role in modulating the ganglioside content ofthe lipid bilayer at the level of membrane-bound sialylglycoconjugates. {ECO:0000269|PubMed:10861246,ECO:0000269|PubMed:20511247}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PEMT_NEU3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PEMT_NEU3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PEMTSPP1NEU3GRB2, CAV1, KLK11, KLK5, PLA2G10, ALOX5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PEMT_NEU3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PEMT_NEU3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePEMTC0036341Schizophrenia2PSYGENET