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Fusion gene ID: 26653 |
FusionGeneSummary for PELI2_GPHN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PELI2_GPHN | Fusion gene ID: 26653 | Hgene | Tgene | Gene symbol | PELI2 | GPHN | Gene ID | 57161 | 10243 |
| Gene name | pellino E3 ubiquitin protein ligase family member 2 | gephyrin | |
| Synonyms | - | GEPH|GPH|GPHRYN|HKPX1|MOCODC | |
| Cytomap | 14q22.3 | 14q23.3-q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase pellino homolog 2RING-type E3 ubiquitin transferase pellino homolog 2pellino homolog 2pellino-2protein pellino homolog 2 | gephyrin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HAT8 | Q9NQX3 | |
| Ensembl transtripts involved in fusion gene | ENST00000267460, | ENST00000315266, ENST00000478722, ENST00000459628, ENST00000543237, ENST00000305960, ENST00000544752, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 9 X 13 X 12=1404 |
| # samples | 5 | 20 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1404*10)=-2.81147103052984 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PELI2 [Title/Abstract] AND GPHN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PELI2 | GO:0001934 | positive regulation of protein phosphorylation | 12804775 |
| Hgene | PELI2 | GO:0043410 | positive regulation of MAPK cascade | 12804775 |
| Tgene | GPHN | GO:0032324 | molybdopterin cofactor biosynthetic process | 26613940 |
| Tgene | GPHN | GO:0097112 | gamma-aminobutyric acid receptor clustering | 26613940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-W3-AA1R-06A | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000267460 | ENST00000315266 | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
| In-frame | ENST00000267460 | ENST00000478722 | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
| In-frame | ENST00000267460 | ENST00000459628 | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
| In-frame | ENST00000267460 | ENST00000543237 | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
| In-frame | ENST00000267460 | ENST00000305960 | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
| 5CDS-3UTR | ENST00000267460 | ENST00000544752 | PELI2 | chr14 | 56645182 | + | GPHN | chr14 | 67490350 | + |
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FusionProtFeatures for PELI2_GPHN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PELI2 | GPHN |
| E3 ubiquitin ligase catalyzing the covalent attachmentof ubiquitin moieties onto substrate proteins. Involved in the TLRand IL-1 signaling pathways via interaction with the complexcontaining IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linkedubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Canactivate the MAP (mitogen activated protein) kinase pathwayleading to activation of ELK1. {ECO:0000269|PubMed:12804775,ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:17675297,ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:22669975}. | Microtubule-associated protein involved in membraneprotein-cytoskeleton interactions. It is thought to anchor theinhibitory glycine receptor (GLYR) to subsynaptic microtubules.Catalyzes two steps in the biosynthesis of the molybdenumcofactor. In the first step, molybdopterin is adenylated.Subsequently, molybdate is inserted into adenylated molybdopterinand AMP is released. {ECO:0000269|PubMed:26613940}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GPHN | chr14:56645182 | chr14:67490350 | ENST00000315266 | + | 7 | 22 | 326_736 | 288 | 737 | Region | Note=MPT adenylyltransferase |
| Tgene | >GPHN | chr14:56645182 | chr14:67490350 | ENST00000478722 | + | 8 | 23 | 326_736 | 321 | 770 | Region | Note=MPT adenylyltransferase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PELI2 | chr14:56645182 | chr14:67490350 | ENST00000267460 | + | 2 | 6 | 15_202 | 69 | 421 | Domain | Note=FHA%3B atypical |
| Tgene | GPHN | chr14:56645182 | chr14:67490350 | ENST00000315266 | + | 7 | 22 | 14_166 | 288 | 737 | Region | Note=MPT Mo-transferase |
| Tgene | GPHN | chr14:56645182 | chr14:67490350 | ENST00000478722 | + | 8 | 23 | 14_166 | 321 | 770 | Region | Note=MPT Mo-transferase |
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FusionGeneSequence for PELI2_GPHN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000315266_chr14_67490350_+_518aa MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKVQSRCSSKENILRASHSAVDI TKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQP TQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVG VTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEK DYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDP >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000478722_chr14_67490350_+_518aa MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKVQSRCSSKENILRASHSAVDI TKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQP TQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVG VTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEK DYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDP >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000459628_chr14_67490350_+_147aa MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKVQSRCSSKENILRASHSAVDI >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000543237_chr14_67490350_+_518aa MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKVQSRCSSKENILRASHSAVDI TKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQP TQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVG VTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEK DYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDP >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000305960_chr14_67490350_+_518aa MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKVQSRCSSKENILRASHSAVDI TKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQP TQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVG VTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEK DYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000315266_chr14_67490350_+_1554nt ATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCTCGGGTACAATGGTGCT TTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAAACCCAGCACCGTCCAT GTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCACAGTGCTGTCGATATC ACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTG CTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCA GCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCA ACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGAT ACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCC ATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGT GTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCA GGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGAC AACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAG GACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTT GCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTT GTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCT CGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGT CTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGAT >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000478722_chr14_67490350_+_1554nt ATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCTCGGGTACAATGGTGCT TTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAAACCCAGCACCGTCCAT GTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCACAGTGCTGTCGATATC ACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTG CTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCA GCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCA ACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGAT ACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCC ATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGT GTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCA GGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGAC AACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAG GACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTT GCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTT GTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCT CGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGT CTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGAT >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000459628_chr14_67490350_+_441nt ATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCTCGGGTACAATGGTGCT TTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAAACCCAGCACCGTCCAT GTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCACAGTGCTGTCGATATC ACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTG >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000543237_chr14_67490350_+_1554nt ATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCTCGGGTACAATGGTGCT TTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAAACCCAGCACCGTCCAT GTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCACAGTGCTGTCGATATC ACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTG CTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCA GCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCA ACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGAT ACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCC ATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGT GTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCA GGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGAC AACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAG GACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTT GCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTT GTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCT CGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGT CTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGAT >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000305960_chr14_67490350_+_1554nt ATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCTCGGGTACAATGGTGCT TTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAAACCCAGCACCGTCCAT GTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCACAGTGCTGTCGATATC ACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTG CTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCA GCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCA ACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGAT ACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCC ATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGT GTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCA GGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGAC AACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAG GACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTT GCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTT GTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCT CGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGT CTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000315266_chr14_67490350_+_2701nt GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT CGGGTACAATGGTGCTTTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAA ACCCAGCACCGTCCATGTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCA CAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCT GGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAA TTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCA AGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGT AGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGG CCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCT TCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGA AGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTT GGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGT ATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGG CTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCAC CTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGA TGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAA TCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAA AGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACATATCATTGACTG TATCCTGTAATATGCAACGGCACAGCTAGTTTTCCCGATTTGGATAAAAGTTGATCTGTATAGTCAACATCTTGAACTATATTTCAAATG AATTTAAATATCTTTTAAAGAAAAAAACACCTAAAAATAAATCTTAACAGAAAATTCTGTTCTGATTATATCAAGGCAAATTTTTCCTTT CTTGCAAATTGCTTTGTGTGTTCAATGCTAGGTCTGATAGCGATAGCTTTTAGTAGACAGCGGTAGGTGCCTGCAGAACTTGTGTTTTTC TCATCTTTAAAATACAACTACTTATGCTCTTAAATCAAGGCTGTCTGCTTATTTATACTAGCGTAGGCAACACTTGGATTTCCCTTCTTA GTATGCTTCATAACTGCTTTACAGAGAGCTTTTGCTTGTTCTTTCTCATGTATCTCGTGTTTATGTGCACAGTGCCAAAAGAAGACTGAC TGGGTGGAGGCTCTGCCTTGCCTCAAGAACCATCCCCTGCAGAGCATCCAGGGAGGTTTCTCGCCCCAATAGCCTCACGGCACAGTACTC TTGGGCAGTAACTGGACACCTTTTATTTGAAGAAACAAACTGAAGAAAAAATGCTTCCTTAAGTGCTGACAGCCTTTTTAACCAATACAT TTAAAATTGTACAGAACAAAAAAATAAAATCAAAGACTGATCTTGTACAGATATTAGTGTTACCAGCATTCATGTGGAAATCAAGAGCAA AGACAAAATAATGTTAAACAATTCTGTACCATAACATTTTCTGTAATGATACTGAAACTTAATGAATAAAAAAATTCCTTGATCATTATT >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000478722_chr14_67490350_+_2706nt GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT CGGGTACAATGGTGCTTTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAA ACCCAGCACCGTCCATGTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCA CAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCT GGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAA TTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCA AGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGT AGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGG CCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCT TCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGA AGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTT GGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGT ATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGG CTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCAC CTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGA TGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAA TCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAA AGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACATATCATTGACTG TATCCTGTAATATGCAACGGCACAGCTAGTTTTCCCGATTTGGATAAAAGTTGATCTGTATAGTCAACATCTTGAACTATATTTCAAATG AATTTAAATATCTTTTAAAGAAAAAAACACCTAAAAATAAATCTTAACAGAAAATTCTGTTCTGATTATATCAAGGCAAATTTTTCCTTT CTTGCAAATTGCTTTGTGTGTTCAATGCTAGGTCTGATAGCGATAGCTTTTAGTAGACAGCGGTAGGTGCCTGCAGAACTTGTGTTTTTC TCATCTTTAAAATACAACTACTTATGCTCTTAAATCAAGGCTGTCTGCTTATTTATACTAGCGTAGGCAACACTTGGATTTCCCTTCTTA GTATGCTTCATAACTGCTTTACAGAGAGCTTTTGCTTGTTCTTTCTCATGTATCTCGTGTTTATGTGCACAGTGCCAAAAGAAGACTGAC TGGGTGGAGGCTCTGCCTTGCCTCAAGAACCATCCCCTGCAGAGCATCCAGGGAGGTTTCTCGCCCCAATAGCCTCACGGCACAGTACTC TTGGGCAGTAACTGGACACCTTTTATTTGAAGAAACAAACTGAAGAAAAAATGCTTCCTTAAGTGCTGACAGCCTTTTTAACCAATACAT TTAAAATTGTACAGAACAAAAAAATAAAATCAAAGACTGATCTTGTACAGATATTAGTGTTACCAGCATTCATGTGGAAATCAAGAGCAA AGACAAAATAATGTTAAACAATTCTGTACCATAACATTTTCTGTAATGATACTGAAACTTAATGAATAAAAAAATTCCTTGATCATTATT >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000459628_chr14_67490350_+_917nt GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT CGGGTACAATGGTGCTTTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAA ACCCAGCACCGTCCATGTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCA CAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCT GGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGGTACTATTATATTTGACCATTGCCCTTTCTTTTCTTCATTTTTTTC CAAATAAGATTCATGTAACATTAATGCACAGTTTTCCTGAAAAAGAAAGATTATTAACCATTATTACAGTTATCATCATTCTTTTTTTTT CTTATTTCTACTCAATAAGAAAAAGGCTAAGGGTTCAGCCTTAACAGTATACAGAGTAAAATCCATGAAACTGCCTTTTCATTAAAAAAA >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000543237_chr14_67490350_+_1926nt GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT CGGGTACAATGGTGCTTTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAA ACCCAGCACCGTCCATGTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCA CAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCT GGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAA TTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCA AGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGT AGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGG CCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCT TCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGA AGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTT GGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGT ATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGG CTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCAC CTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGA TGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAA TCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAA AGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACATATCATTGACTG >In-frame_PELI2_ENST00000267460_chr14_56645182_+_GPHN_ENST00000305960_chr14_67490350_+_2100nt GGCGCTCAGCGCAGGCAGGTCCCCCTGCTGCCGGGTCCCATTTGTTGCCGGCTCTGACTCGGGGCGGCCGCGGCGCGCGGAGCTCCGGGG AGTCAGGCGGAGCAGCCGCGCAGCCACGACGGAGCAGCAGCGGGACTGGCCGCCCCGCGCCCCCTTCGCCGCCGTGCCCTTCCCCGGCGC GCTCACCCCGTTCTCGGGATGGGATTGTAGCGGCGGCGCGGACTCGGCGGGGATCGCGGCGGAGGCGGCGGCGTCGGCGGCGGCGTCGGC GGCCGAGCGGGGCTCCATGTTTTCCCCTGGCCAGGAGGAACACTGCGCCCCCAATAAGGAGCCAGTGAAATACGGGGAGCTGGTGGTGCT CGGGTACAATGGTGCTTTACCCAATGGAGATAGAGGACGGAGGAAAAGTAGATTTGCCCTCTACAAGCGGCCCAAGGCAAATGGTGTCAA ACCCAGCACCGTCCATGTGATATCCACGCCCCAGGCATCCAAGGTCCAGTCCAGGTGCAGCAGCAAGGAGAACATTCTCAGAGCCAGTCA CAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCT GGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAA TTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCA AGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGT AGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGG CCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCT TCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGA AGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTT GGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGT ATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGG CTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCAC CTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGA TGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAA TCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAA AGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACATATCATTGACTG TATCCTGTAATATGCAACGGCACAGCTAGTTTTCCCGATTTGGATAAAAGTTGATCTGTATAGTCAACATCTTGAACTATATTTCAAATG AATTTAAATATCTTTTAAAGAAAAAAACACCTAAAAATAAATCTTAACAGAAAATTCTGTTCTGATTATATCAAGGCAAATTTTTCCTTT |
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FusionGenePPI for PELI2_GPHN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PELI2 | IRAK1, IRAK4, IRAK2, UBQLN4, TRAF6, NR2C2, ERO1L, HNRNPK, LAMC3, CREB3L3, FN1, LTBP3, PICALM, DEAF1, THAP7, FRYL, SRPK1, UQCRFS1 | GPHN | ARHGEF9, GLRB, MTOR, PFN1, OTUD4, PRPF4, PCK1, SPATS1, GPHN, KHDRBS1, ACADVL, BRCC3, MTA2, PAAF1, PPP4R1, ROCK2, SPTAN1, TSSK1B, ODF3L2, NTRK1, DYNLL1, CDCA5, TCF4, SENP3, VASP, ENAH, KLKB1, KMO, LGALS3BP, STS, DYNLL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | GPHN | chr14:56645182 | chr14:67490350 | ENST00000315266 | + | 7 | 22 | 140_316 | 288 | 737 | GABARAP |
| Tgene | GPHN | chr14:56645182 | chr14:67490350 | ENST00000478722 | + | 8 | 23 | 140_316 | 321 | 770 | GABARAP |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PELI2_GPHN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PELI2_GPHN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GPHN | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
| Tgene | GPHN | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | GPHN | C1854990 | Molybdenum Cofactor Deficiency, Complementation Group C | 1 | ORPHANET;UNIPROT |
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