![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 26650 |
FusionGeneSummary for PELI1_APLF |
![]() |
Fusion gene information | Fusion gene name: PELI1_APLF | Fusion gene ID: 26650 | Hgene | Tgene | Gene symbol | PELI1 | APLF | Gene ID | 57162 | 200558 |
Gene name | pellino E3 ubiquitin protein ligase 1 | aprataxin and PNKP like factor | |
Synonyms | - | APFL|C2orf13|PALF|Xip1|ZCCHH1 | |
Cytomap | 2p14 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase pellino homolog 1RING-type E3 ubiquitin transferase pellino homolog 1pellino homolog 1pellino-1pellino-related intracellular-signaling moleculeprotein pellino homolog 1 | aprataxin and PNK-like factorPNK and APTX-like FHA domain-containing proteinPNK and APTX-like FHA proteinXRCC1-interacting protein 1aprataxin- and PNK-like factorapurinic-apyrimidinic endonuclease APLFzinc finger, CX5CX6HX5H motif containing 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96FA3 | Q8IW19 | |
Ensembl transtripts involved in fusion gene | ENST00000358912, ENST00000466177, | ENST00000471727, ENST00000303795, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PELI1 [Title/Abstract] AND APLF [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | APLF | GO:0006974 | cellular response to DNA damage stimulus | 17396150 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A1F6-01A | PELI1 | chr2 | 64371215 | - | APLF | chr2 | 68794473 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000358912 | ENST00000471727 | PELI1 | chr2 | 64371215 | - | APLF | chr2 | 68794473 | + |
5UTR-3UTR | ENST00000358912 | ENST00000303795 | PELI1 | chr2 | 64371215 | - | APLF | chr2 | 68794473 | + |
5UTR-3UTR | ENST00000466177 | ENST00000471727 | PELI1 | chr2 | 64371215 | - | APLF | chr2 | 68794473 | + |
5UTR-3UTR | ENST00000466177 | ENST00000303795 | PELI1 | chr2 | 64371215 | - | APLF | chr2 | 68794473 | + |
Top |
FusionProtFeatures for PELI1_APLF |
![]() |
Hgene | Tgene |
PELI1 | APLF |
E3 ubiquitin ligase catalyzing the covalent attachmentof ubiquitin moieties onto substrate proteins. Involved in the TLRand IL-1 signaling pathways via interaction with the complexcontaining IRAK kinases and TRAF6. Mediates 'Lys-63'-linkedpolyubiquitination of IRAK1 allowing subsequent NF-kappa-Bactivation. {ECO:0000269|PubMed:12496252,ECO:0000269|PubMed:17675297}. | Nuclease involved in single-strand and double-strand DNAbreak repair. Recruited to sites of DNA damage through interactionwith poly(ADP-ribose), a polymeric post-translational modificationsynthesized transiently at sites of chromosomal damage toaccelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities invitro. Also able to introduce nicks at hydroxyuracil and othertypes of pyrimidine base damage. {ECO:0000269|PubMed:17353262,ECO:0000269|PubMed:17396150}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PELI1_APLF |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PELI1_APLF |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PELI1 | IRAK1, IRAK4, IRAK2, RIPK1, UBE2I, UBC, TBK1, IKBKB, TRAF6, IL1R1, SMAD6, MYD88, NR2C2, UBE2N, UBE2V1, UBE2D1, UBE2D2, DEAF1, SRPK2, SRPK1, BCL6, TRIP13, VAC14, IRS1, BIRC3, MDM4 | APLF | CHD1L, HIST3H3, PARP1, LIG4, XRCC5, APP, FBXO25, GMCL1, POLB, H2AFY2, H2AFY, SUPT16H, XRCC1, LIG3, PARP2, XRCC6, HLTF, HIST1H2BJ, HIST1H2AG, HIST2H2AB, XRCC4, XPC, CETN2, TDP1, TOP1, SSRP1, ZG16B, HIST2H3PS2, CST4, HIST1H2BA, HIST2H2AC, MSH3, CST1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PELI1_APLF |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PELI1_APLF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PELI1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | PELI1 | C0311375 | Arsenic Poisoning | 1 | CTD_human |