FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26650

FusionGeneSummary for PELI1_APLF

check button Fusion gene summary
Fusion gene informationFusion gene name: PELI1_APLF
Fusion gene ID: 26650
HgeneTgene
Gene symbol

PELI1

APLF

Gene ID

57162

200558

Gene namepellino E3 ubiquitin protein ligase 1aprataxin and PNKP like factor
Synonyms-APFL|C2orf13|PALF|Xip1|ZCCHH1
Cytomap

2p14

2p13.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase pellino homolog 1RING-type E3 ubiquitin transferase pellino homolog 1pellino homolog 1pellino-1pellino-related intracellular-signaling moleculeprotein pellino homolog 1aprataxin and PNK-like factorPNK and APTX-like FHA domain-containing proteinPNK and APTX-like FHA proteinXRCC1-interacting protein 1aprataxin- and PNK-like factorapurinic-apyrimidinic endonuclease APLFzinc finger, CX5CX6HX5H motif containing 1
Modification date2018052320180523
UniProtAcc

Q96FA3

Q8IW19

Ensembl transtripts involved in fusion geneENST00000358912, ENST00000466177, 
ENST00000471727, ENST00000303795, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 3=27
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PELI1 [Title/Abstract] AND APLF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPLF

GO:0006974

cellular response to DNA damage stimulus

17396150


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A1F6-01APELI1chr2

64371215

-APLFchr2

68794473

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000358912ENST00000471727PELI1chr2

64371215

-APLFchr2

68794473

+
5UTR-3UTRENST00000358912ENST00000303795PELI1chr2

64371215

-APLFchr2

68794473

+
5UTR-3UTRENST00000466177ENST00000471727PELI1chr2

64371215

-APLFchr2

68794473

+
5UTR-3UTRENST00000466177ENST00000303795PELI1chr2

64371215

-APLFchr2

68794473

+

Top

FusionProtFeatures for PELI1_APLF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PELI1

Q96FA3

APLF

Q8IW19

E3 ubiquitin ligase catalyzing the covalent attachmentof ubiquitin moieties onto substrate proteins. Involved in the TLRand IL-1 signaling pathways via interaction with the complexcontaining IRAK kinases and TRAF6. Mediates 'Lys-63'-linkedpolyubiquitination of IRAK1 allowing subsequent NF-kappa-Bactivation. {ECO:0000269|PubMed:12496252,ECO:0000269|PubMed:17675297}. Nuclease involved in single-strand and double-strand DNAbreak repair. Recruited to sites of DNA damage through interactionwith poly(ADP-ribose), a polymeric post-translational modificationsynthesized transiently at sites of chromosomal damage toaccelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities invitro. Also able to introduce nicks at hydroxyuracil and othertypes of pyrimidine base damage. {ECO:0000269|PubMed:17353262,ECO:0000269|PubMed:17396150}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PELI1_APLF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PELI1_APLF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PELI1IRAK1, IRAK4, IRAK2, RIPK1, UBE2I, UBC, TBK1, IKBKB, TRAF6, IL1R1, SMAD6, MYD88, NR2C2, UBE2N, UBE2V1, UBE2D1, UBE2D2, DEAF1, SRPK2, SRPK1, BCL6, TRIP13, VAC14, IRS1, BIRC3, MDM4APLFCHD1L, HIST3H3, PARP1, LIG4, XRCC5, APP, FBXO25, GMCL1, POLB, H2AFY2, H2AFY, SUPT16H, XRCC1, LIG3, PARP2, XRCC6, HLTF, HIST1H2BJ, HIST1H2AG, HIST2H2AB, XRCC4, XPC, CETN2, TDP1, TOP1, SSRP1, ZG16B, HIST2H3PS2, CST4, HIST1H2BA, HIST2H2AC, MSH3, CST1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PELI1_APLF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PELI1_APLF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePELI1C0037274Dermatologic disorders1CTD_human
HgenePELI1C0311375Arsenic Poisoning1CTD_human