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Fusion gene ID: 26592 |
FusionGeneSummary for PDXK_EYS |
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Fusion gene information | Fusion gene name: PDXK_EYS | Fusion gene ID: 26592 | Hgene | Tgene | Gene symbol | PDXK | EYS | Gene ID | 8566 | 346007 |
Gene name | pyridoxal kinase | eyes shut homolog (Drosophila) | |
Synonyms | C21orf124|C21orf97|HEL-S-1a|PKH|PNK|PRED79 | C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1 | |
Cytomap | 21q22.3 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | pyridoxal kinaseepididymis secretory sperm binding protein Li 1apyridoxal (pyridoxine, vitamin B6) kinasepyridoxamine kinasepyridoxine kinasevitamin B6 kinase | protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O00764 | Q5T1H1 | |
Ensembl transtripts involved in fusion gene | ENST00000398081, ENST00000468090, ENST00000291565, ENST00000327574, ENST00000476313, ENST00000467908, | ENST00000503581, ENST00000370621, ENST00000370616, ENST00000393380, ENST00000342421, ENST00000370618, ENST00000486069, | |
Fusion gene scores | * DoF score | 7 X 7 X 8=392 | 26 X 15 X 12=4680 |
# samples | 8 | 27 | |
** MAII score | log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/4680*10)=-4.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDXK [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDXK | GO:0008283 | cell proliferation | 10930737 |
Hgene | PDXK | GO:0042823 | pyridoxal phosphate biosynthetic process | 9099727|10987144|17766369 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-85-8582-01A | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000398081 | ENST00000503581 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000398081 | ENST00000370621 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000398081 | ENST00000370616 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000398081 | ENST00000393380 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000398081 | ENST00000342421 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000398081 | ENST00000370618 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000398081 | ENST00000486069 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000468090 | ENST00000503581 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000468090 | ENST00000370621 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000468090 | ENST00000370616 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000468090 | ENST00000393380 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000468090 | ENST00000342421 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000468090 | ENST00000370618 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000468090 | ENST00000486069 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000291565 | ENST00000503581 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000291565 | ENST00000370621 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000291565 | ENST00000370616 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000291565 | ENST00000393380 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000291565 | ENST00000342421 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000291565 | ENST00000370618 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000291565 | ENST00000486069 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000327574 | ENST00000503581 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000327574 | ENST00000370621 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000327574 | ENST00000370616 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000327574 | ENST00000393380 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000327574 | ENST00000342421 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000327574 | ENST00000370618 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000327574 | ENST00000486069 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000476313 | ENST00000503581 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000476313 | ENST00000370621 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-3CDS | ENST00000476313 | ENST00000370616 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000476313 | ENST00000393380 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000476313 | ENST00000342421 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000476313 | ENST00000370618 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
intron-intron | ENST00000476313 | ENST00000486069 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000467908 | ENST00000503581 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000467908 | ENST00000370621 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
Frame-shift | ENST00000467908 | ENST00000370616 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000467908 | ENST00000393380 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000467908 | ENST00000342421 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000467908 | ENST00000370618 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
5CDS-intron | ENST00000467908 | ENST00000486069 | PDXK | chr21 | 45175935 | + | EYS | chr6 | 65016975 | - |
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FusionProtFeatures for PDXK_EYS |
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Hgene | Tgene |
PDXK | EYS |
Required for synthesis of pyridoxal-5-phosphate fromvitamin B6. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDXK_EYS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDXK_EYS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDXK | ELAVL1, CUL3, CUL1, COPS5, CAND1, BARD1, YWHAQ, MOV10, NXF1, ABAT, OGT, EIF4E, EZR, G6PD, HIBADH, HYI, ITPA, MDH1, OAT, SNX2, SOD1, RABIF, TPI1, ATOH1 | EYS | EGFR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDXK_EYS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDXK | O00764 | DB00165 | Pyridoxine | Pyridoxal kinase | small molecule | approved|investigational|nutraceutical|vet_approved |
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RelatedDiseases for PDXK_EYS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDXK | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | EYS | C1864446 | Retinitis Pigmentosa 25 | 2 | CTD_human;UNIPROT |
Tgene | EYS | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;ORPHANET |