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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 26591

FusionGeneSummary for PDXK_ABCG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDXK_ABCG1
Fusion gene ID: 26591
HgeneTgene
Gene symbol

PDXK

ABCG1

Gene ID

8566

9619

Gene namepyridoxal kinaseATP binding cassette subfamily G member 1
SynonymsC21orf124|C21orf97|HEL-S-1a|PKH|PNK|PRED79ABC8|WHITE1
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionpyridoxal kinaseepididymis secretory sperm binding protein Li 1apyridoxal (pyridoxine, vitamin B6) kinasepyridoxamine kinasepyridoxine kinasevitamin B6 kinaseATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2018052320180523
UniProtAcc

O00764

P45844

Ensembl transtripts involved in fusion geneENST00000398081, ENST00000468090, 
ENST00000291565, ENST00000327574, 
ENST00000476313, ENST00000467908, 
ENST00000398457, ENST00000462050, 
ENST00000347800, ENST00000398449, 
ENST00000361802, ENST00000343687, 
ENST00000398437, ENST00000340588, 
Fusion gene scores* DoF score7 X 7 X 8=3928 X 3 X 7=168
# samples 88
** MAII scorelog2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDXK [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDXK

GO:0008283

cell proliferation

10930737

HgenePDXK

GO:0042823

pyridoxal phosphate biosynthetic process

9099727|10987144|17766369

TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0010033

response to organic substance

11500512

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BL-A0C8-01APDXKchr21

45139262

+ABCG1chr21

43645781

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398081ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000398081ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000398081ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000398081ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
In-frameENST00000468090ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000468090ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000468090ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000468090ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
In-frameENST00000291565ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-3UTRENST00000291565ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000291565ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
5CDS-intronENST00000291565ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3CDSENST00000327574ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000327574ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000327574ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000327574ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3CDSENST00000476313ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000476313ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000476313ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000476313ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3CDSENST00000467908ENST00000398457PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000462050PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000347800PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000398449PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000361802PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-3UTRENST00000467908ENST00000343687PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000467908ENST00000398437PDXKchr21

45139262

+ABCG1chr21

43645781

+
intron-intronENST00000467908ENST00000340588PDXKchr21

45139262

+ABCG1chr21

43645781

+

Top

FusionProtFeatures for PDXK_ABCG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDXK

O00764

ABCG1

P45844

Required for synthesis of pyridoxal-5-phosphate fromvitamin B6.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015415_67325678DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+01577_31725678DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015415_67311664DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+01577_31711664DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015415_67314679DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+01577_31714679DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015415_67314667DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+01577_31714667DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116415_67316669DomainNote=ABC transmembrane type-2
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+11677_31716669DomainABC transporter
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015118_12525678Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015118_12511664Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015118_12514679Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015118_12514667Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116118_12516669Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015446_45625678Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015478_50625678Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015526_53325678Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015556_56725678Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015587_64925678Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015670_67825678Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015446_45611664Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015478_50611664Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015526_53311664Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015556_56711664Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015587_64911664Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015670_67811664Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015446_45614679Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015478_50614679Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015526_53314679Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015556_56714679Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015587_64914679Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015670_67814679Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015446_45614667Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015478_50614667Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015526_53314667Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015556_56714667Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015587_64914667Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015670_67814667Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116446_45616669Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116478_50616669Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116526_53316669Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116556_56716669Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116587_64916669Topological domainExtracellular
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116670_67816669Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015427_44525678TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015457_47725678TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015507_52525678TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015534_55525678TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015568_58625678TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+015650_66925678TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015427_44511664TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015457_47711664TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015507_52511664TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015534_55511664TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015568_58611664TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+015650_66911664TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015427_44514679TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015457_47714679TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015507_52514679TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015534_55514679TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015568_58614679TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+015650_66914679TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015427_44514667TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015457_47714667TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015507_52514667TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015534_55514667TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015568_58614667TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+015650_66914667TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116427_44516669TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116457_47716669TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116507_52516669TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116534_55516669TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116568_58616669TransmembraneHelical
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+116650_66916669TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDXKchr21:45139262chr21:43645781ENST00000291565+111186_18729313Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000291565+111223_23429313Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000468090+110186_18729285Nucleotide bindingATP
HgenePDXKchr21:45139262chr21:43645781ENST00000468090+110223_23429285Nucleotide bindingATP
TgeneABCG1chr21:45139262chr21:43645781ENST00000343687+0151_42625678Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000347800+0151_42611664Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000361802+0151_42614679Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398449+0151_42614667Topological domainCytoplasmic
TgeneABCG1chr21:45139262chr21:43645781ENST00000398457+1161_42616669Topological domainCytoplasmic


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FusionGeneSequence for PDXK_ABCG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDXK_ENST00000398081_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_682aa
MEEECRVLSIQSHVIRGYVGNRAATFPLQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAV
NIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQD
DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQV
VSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVR
EGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNE
AKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLF
AALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDE

>In-frame_PDXK_ENST00000468090_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_682aa
MEEECRVLSIQSHVIRGYVGNRAATFPLQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAV
NIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQD
DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQV
VSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVR
EGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNE
AKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLF
AALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDE

>In-frame_PDXK_ENST00000291565_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_682aa
MEEECRVLSIQSHVIRGYVGNRAATFPLQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAV
NIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQD
DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQV
VSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVR
EGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNE
AKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLF
AALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDXK_ENST00000398081_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_2046nt
ATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCCACGTTCCCGCTGCAGAAT
GCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACTGAG
ACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTG
AACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATTTCC
GGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGG
GAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGAT
GACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAA
ATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTG
GCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTG
GTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGAC
CAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGC
CCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGG
GAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGAC
TCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATG
AGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAA
GCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTT
CCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTG
CCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTT
GCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTC
GTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCC
TACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAG
ACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATT

>In-frame_PDXK_ENST00000468090_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_2046nt
ATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCCACGTTCCCGCTGCAGAAT
GCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACTGAG
ACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTG
AACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATTTCC
GGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGG
GAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGAT
GACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAA
ATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTG
GCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTG
GTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGAC
CAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGC
CCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGG
GAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGAC
TCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATG
AGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAA
GCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTT
CCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTG
CCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTT
GCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTC
GTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCC
TACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAG
ACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATT

>In-frame_PDXK_ENST00000291565_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_2046nt
ATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCCACGTTCCCGCTGCAGAAT
GCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACTGAG
ACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTG
AACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATTTCC
GGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGG
GAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGAT
GACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAA
ATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTG
GCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTG
GTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGAC
CAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGC
CCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGG
GAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGAC
TCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATG
AGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAA
GCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTT
CCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTG
CCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTT
GCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTC
GTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCC
TACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAG
ACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDXK_ENST00000398081_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_3099nt
GCGCGGAACTCGCGGGTTCGGAGCCGCCCGCTGAGGTCAGAAGGAGGCGTCTGCGCTGATCGGGTCCGCCGCGCGCCAGAGCCAGAGTCG
CAGCCGAGGGGAGCCGGGGCCGGAGCCCGAGCCCGAGCCGAGCCGGAGCCCGAGCGAGCGGCGGAGACCGTGCCCCCGCCTCGGCCCCGC
GCCGCCGCGGCCAGGCCCGGCATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCG
GCCACGTTCCCGCTGCAGAATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCC
AGCAACATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCC
TTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAG
ACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATG
AACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTG
TCCTGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAG
AAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCA
GGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGAC
AGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCC
AAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTG
AGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGT
CGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGG
CACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAG
AGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTG
TACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTC
ATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTG
GCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGAC
GCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACG
TCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCC
ACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGAT
CTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTG
GACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAAC
ACCTGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACAC
AGAGACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTC
TCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACT
GGGGCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGAT
GGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGA
CTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATT
CATTTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACC
GAGTCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCA
CTGAGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCT

>In-frame_PDXK_ENST00000468090_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_3096nt
CGGAACTCGCGGGTTCGGAGCCGCCCGCTGAGGTCAGAAGGAGGCGTCTGCGCTGATCGGGTCCGCCGCGCGCCAGAGCCAGAGTCGCAG
CCGAGGGGAGCCGGGGCCGGAGCCCGAGCCCGAGCCGAGCCGGAGCCCGAGCGAGCGGCGGAGACCGTGCCCCCGCCTCGGCCCCGCGCC
GCCGCGGCCAGGCCCGGCATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCC
ACGTTCCCGCTGCAGAATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGC
AACATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTG
CCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACC
CTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAAC
ATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCC
TGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAG
GATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGT
GGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGC
GCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAA
CTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGG
GATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGG
CTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCAC
CGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGG
ACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTAC
TTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATG
CCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCC
AAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCC
GTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCC
CTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACG
TACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTG
CACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGAC
TTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACC
TGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGA
GACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCC
ATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGG
GCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGG
GAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTG
TTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCAT
TTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAG
TCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTG
AGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCT

>In-frame_PDXK_ENST00000291565_chr21_45139262_+_ABCG1_ENST00000398457_chr21_43645781_+_3081nt
CGGAGCCGCCCGCTGAGGTCAGAAGGAGGCGTCTGCGCTGATCGGGTCCGCCGCGCGCCAGAGCCAGAGTCGCAGCCGAGGGGAGCCGGG
GCCGGAGCCCGAGCCCGAGCCGAGCCGGAGCCCGAGCGAGCGGCGGAGACCGTGCCCCCGCCTCGGCCCCGCGCCGCCGCGGCCAGGCCC
GGCATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGCAACCGGGCGGCCACGTTCCCGCTGCAG
AATGCCAGCAGTTACTCTGCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACT
GAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCT
GTGAACATTGAATTCAGGGACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATT
TCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATAC
AGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAG
GATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGG
GAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGC
CTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAG
GTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTC
GACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAAC
TGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTT
CGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAG
GACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATC
ATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAAC
GAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACA
TTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGAC
GTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTG
TTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACT
TTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATG
TCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGAC
GAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGG
ATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAATGCCAGGAAAC
AGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTCTTCTGATCCA
ACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCCCCTTTCTAGC
TTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACCACAACTGGGGCAGAATTTAAAGCT
GCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACTGCAAGCAGCC
TCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTTTTTCACATTT
TCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAAGAAATTATAC
CTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACCCAGCTGGTCT
CATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCATGCAGACATT
TTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCACGTGCTTCTTATTTTAAGCGAAAT


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FusionGenePPI for PDXK_ABCG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDXKELAVL1, CUL3, CUL1, COPS5, CAND1, BARD1, YWHAQ, MOV10, NXF1, ABAT, OGT, EIF4E, EZR, G6PD, HIBADH, HYI, ITPA, MDH1, OAT, SNX2, SOD1, RABIF, TPI1, ATOH1ABCG1ELAVL1, ACSL4, AP1S2, NEDD4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDXK_ABCG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDXKO00764DB00165PyridoxinePyridoxal kinasesmall moleculeapproved|investigational|nutraceutical|vet_approved

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RelatedDiseases for PDXK_ABCG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDXKC0038220Status Epilepticus1CTD_human
TgeneABCG1C0009404Colorectal Neoplasms1CTD_human
TgeneABCG1C0022661Kidney Failure, Chronic1CTD_human
TgeneABCG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCG1C0043094Weight Gain1CTD_human
TgeneABCG1C0525045Mood Disorders1PSYGENET