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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26569

FusionGeneSummary for PDS5B_UBR2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDS5B_UBR2
Fusion gene ID: 26569
HgeneTgene
Gene symbol

PDS5B

UBR2

Gene ID

23047

23304

Gene namePDS5 cohesin associated factor Bubiquitin protein ligase E3 component n-recognin 2
SynonymsAPRIN|AS3|CG008C6orf133|bA49A4.1|dJ242G1.1|dJ392M17.3
Cytomap

13q13.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionsister chromatid cohesion protein PDS5 homolog Bandrogen induced inhibitor of proliferationandrogen-induced proliferation inhibitorandrogen-induced prostate proliferative shutoff-associated protein AS3androgen-induced shutoff 3E3 ubiquitin-protein ligase UBR2RING-type E3 ubiquitin transferase UBR2ubiquitin-protein ligase E3-alpha-2ubiquitin-protein ligase E3-alpha-II
Modification date2018052320180529
UniProtAcc

Q9NTI5

Q8IWV8

Ensembl transtripts involved in fusion geneENST00000315596, ENST00000372899, 
ENST00000372901, ENST00000372883, 
ENST00000372903, 
Fusion gene scores* DoF score9 X 3 X 6=1629 X 9 X 8=648
# samples 1111
** MAII scorelog2(11/162*10)=-0.558490289359965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/648*10)=-2.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDS5B [Title/Abstract] AND UBR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDS5B

GO:0008285

negative regulation of cell proliferation

10963680

HgenePDS5B

GO:0042127

regulation of cell proliferation

10963680

TgeneUBR2

GO:0071233

cellular response to leucine

20298436


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A209-01APDS5Bchr13

33160730

+UBR2chr6

42658770

+
TCGALDBRCATCGA-AR-A24R-01APDS5Bchr13

33160730

+UBR2chr6

42658770

+
TCGALDBRCATCGA-AR-A24X-01APDS5Bchr13

33160730

+UBR2chr6

42658770

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000315596ENST00000372899PDS5Bchr13

33160730

+UBR2chr6

42658770

+
5UTR-3CDSENST00000315596ENST00000372901PDS5Bchr13

33160730

+UBR2chr6

42658770

+
5UTR-3UTRENST00000315596ENST00000372883PDS5Bchr13

33160730

+UBR2chr6

42658770

+
5UTR-intronENST00000315596ENST00000372903PDS5Bchr13

33160730

+UBR2chr6

42658770

+

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FusionProtFeatures for PDS5B_UBR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDS5B

Q9NTI5

UBR2

Q8IWV8

Regulator of sister chromatid cohesion in mitosis whichmay stabilize cohesin complex association with chromatin. Maycouple sister chromatid cohesion during mitosis to DNAreplication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. Plays a role in androgen-induced proliferativearrest in prostate cells. {ECO:0000269|PubMed:10963680,ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. E3 ubiquitin-protein ligase which is a component of theN-end rule pathway. Recognizes and binds to proteins bearingspecific N-terminal residues that are destabilizing according tothe N-end rule, leading to their ubiquitination and subsequentdegradation. Plays a critical role in chromatin inactivation andchromosome-wide transcriptional silencing during meiosis viaubiquitination of histone H2A. Binds leucine and is a negativeregulator of the leucine-mTOR signaling pathway, therebycontrolling cell growth. Required for spermatogenesis, promotes,with Tex19.1, SPO11-dependent recombination foci to accumulate anddrive robust homologous chromosome synapsis (By similarity).Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, whichinduces degradation, inhibiting LINE-1 retranstoposon mobilization(By similarity). {ECO:0000250|UniProtKB:Q6WKZ8,ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436,ECO:0000269|PubMed:20835242}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDS5B_UBR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDS5B_UBR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDS5BCDCA5, STAG1, STAG2, SMC3, SMC1A, WFDC5, PDS5A, RAD21, WAPAL, SIRT7, NSMCE2, APP, LAMP2, OBSL1, EED, RNF2, BSG, CD274, SEPT12, LYPD3, SLC30A4, TGOLN2, SCN2B, BRCA2, RAD51, PALB2, CDC45, PCNA, NTRK1, CEP164, GYPB, VIPR2, CHRM4, APLNR, ANK1, SLC15A1, CD70, KIAA1467, SCN3B, HTR2C, MAS1, P2RX5, LPAR4, TRIM25, G3BP1UBR2UBE2B, HNRNPA1, UBC, HIST2H2AC, MYC, UBXN7, FAF2, FAF1, UBXN1, UBE2Z, TIRAP, HIST1H2BG, RECQL4, UBE2H, GCFC2, NXPH2, NUDT6, MRM1, POLR2M, SOD2, PLEKHO2, PAM, PLXDC2, TEX33, PON2, UBE2A, CLCC1, METTL15, ALDH18A1, EPPK1, PDP2, EPHA7, SNX18, NDUFS3, PSMC2, NES, MRPL50, PARD6B, SGOL1, FOXJ3, UBXN2B, BAG6, DUSP26, NRP1, SPINK2, HS3ST2, INSL5, SMOC1, HYAL1, GFAP, SIL1, RGS8, CROCC, PAK7, ASB6, CRHBP, HEPACAM2, CCDC130, PNLIPRP1, METTL2A, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDS5B_UBR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDS5B_UBR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource