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Fusion gene ID: 26564 |
FusionGeneSummary for PDS5B_CIDEC |
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Fusion gene information | Fusion gene name: PDS5B_CIDEC | Fusion gene ID: 26564 | Hgene | Tgene | Gene symbol | PDS5B | CIDEC | Gene ID | 23047 | 63924 |
Gene name | PDS5 cohesin associated factor B | cell death inducing DFFA like effector c | |
Synonyms | APRIN|AS3|CG008 | CIDE-3|CIDE3|FPLD5|FSP27 | |
Cytomap | 13q13.1 | 3p25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | sister chromatid cohesion protein PDS5 homolog Bandrogen induced inhibitor of proliferationandrogen-induced proliferation inhibitorandrogen-induced prostate proliferative shutoff-associated protein AS3androgen-induced shutoff 3 | cell death activator CIDE-3fat specific protein 27 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NTI5 | Q96AQ7 | |
Ensembl transtripts involved in fusion gene | ENST00000315596, | ENST00000455015, ENST00000336832, ENST00000423850, ENST00000383817, ENST00000430427, ENST00000443115, | |
Fusion gene scores | * DoF score | 9 X 3 X 6=162 | 7 X 6 X 3=126 |
# samples | 11 | 7 | |
** MAII score | log2(11/162*10)=-0.558490289359965 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDS5B [Title/Abstract] AND CIDEC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDS5B | GO:0008285 | negative regulation of cell proliferation | 10963680 |
Hgene | PDS5B | GO:0042127 | regulation of cell proliferation | 10963680 |
Tgene | CIDEC | GO:0006915 | apoptotic process | 12429024 |
Tgene | CIDEC | GO:0097194 | execution phase of apoptosis | 12429024 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF924179 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000315596 | ENST00000455015 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
intron-intron | ENST00000315596 | ENST00000336832 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
intron-intron | ENST00000315596 | ENST00000423850 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
intron-intron | ENST00000315596 | ENST00000383817 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
intron-intron | ENST00000315596 | ENST00000430427 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
intron-intron | ENST00000315596 | ENST00000443115 | PDS5B | chr13 | 33346384 | - | CIDEC | chr3 | 9986696 | - |
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FusionProtFeatures for PDS5B_CIDEC |
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Hgene | Tgene |
PDS5B | CIDEC |
Regulator of sister chromatid cohesion in mitosis whichmay stabilize cohesin complex association with chromatin. Maycouple sister chromatid cohesion during mitosis to DNAreplication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. Plays a role in androgen-induced proliferativearrest in prostate cells. {ECO:0000269|PubMed:10963680,ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. | Binds to lipid droplets and regulates their enlargement,thereby restricting lipolysis and favoring storage. At focalcontact sites between lipid droplets, promotes directional netneutral lipid transfer from the smaller to larger lipid droplets.The transfer direction may be driven by the internal pressuredifference between the contacting lipid droplet pair. Its role inneutral lipid transfer and lipid droplet enlargement is activatedby the interaction with PLIN1. May act as a CEBPB coactivator inthe white adipose tissue to control the expression of a subset ofCEBPB downstream target genes, including SOCS1, SOCS3, TGFB1,TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, inducesapoptosis or increases cell susceptibility to apoptosis induced byserum deprivation or TGFB treatment. As mature adipocytes, thatexpress high CIDEC levels, are quite resistant to apoptoticstimuli, the physiological significance of its role in apoptosisis unclear. May play a role in the modulation of the response toosmotic stress by preventing NFAT5 to translocate into the nucleusand activate its target genes expression.{ECO:0000269|PubMed:12429024, ECO:0000269|PubMed:18334488,ECO:0000269|PubMed:19843876, ECO:0000269|PubMed:20049731,ECO:0000269|PubMed:23399566}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDS5B_CIDEC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDS5B_CIDEC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDS5B_CIDEC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDS5B_CIDEC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CIDEC | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |