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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26562

FusionGeneSummary for PDS5B_CBLB

check button Fusion gene summary
Fusion gene informationFusion gene name: PDS5B_CBLB
Fusion gene ID: 26562
HgeneTgene
Gene symbol

PDS5B

CBLB

Gene ID

23047

868

Gene namePDS5 cohesin associated factor BCbl proto-oncogene B
SynonymsAPRIN|AS3|CG008Cbl-b|Nbla00127|RNF56
Cytomap

13q13.1

3q13.11

Type of geneprotein-codingprotein-coding
Descriptionsister chromatid cohesion protein PDS5 homolog Bandrogen induced inhibitor of proliferationandrogen-induced proliferation inhibitorandrogen-induced prostate proliferative shutoff-associated protein AS3androgen-induced shutoff 3E3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase
Modification date2018052320180523
UniProtAcc

Q9NTI5

Q13191

Ensembl transtripts involved in fusion geneENST00000315596, ENST00000264122, 
ENST00000407712, ENST00000394027, 
ENST00000403724, ENST00000405772, 
ENST00000545639, 
Fusion gene scores* DoF score9 X 3 X 6=1626 X 8 X 4=192
# samples 118
** MAII scorelog2(11/162*10)=-0.558490289359965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDS5B [Title/Abstract] AND CBLB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDS5B

GO:0008285

negative regulation of cell proliferation

10963680

HgenePDS5B

GO:0042127

regulation of cell proliferation

10963680


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA510891PDS5Bchr13

33160763

+CBLBchr3

105422905

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000315596ENST00000264122PDS5Bchr13

33160763

+CBLBchr3

105422905

-
intron-intronENST00000315596ENST00000407712PDS5Bchr13

33160763

+CBLBchr3

105422905

-
intron-intronENST00000315596ENST00000394027PDS5Bchr13

33160763

+CBLBchr3

105422905

-
intron-intronENST00000315596ENST00000403724PDS5Bchr13

33160763

+CBLBchr3

105422905

-
intron-intronENST00000315596ENST00000405772PDS5Bchr13

33160763

+CBLBchr3

105422905

-
intron-intronENST00000315596ENST00000545639PDS5Bchr13

33160763

+CBLBchr3

105422905

-

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FusionProtFeatures for PDS5B_CBLB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDS5B

Q9NTI5

CBLB

Q13191

Regulator of sister chromatid cohesion in mitosis whichmay stabilize cohesin complex association with chromatin. Maycouple sister chromatid cohesion during mitosis to DNAreplication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. Plays a role in androgen-induced proliferativearrest in prostate cells. {ECO:0000269|PubMed:10963680,ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. E3 ubiquitin-protein ligase which accepts ubiquitin fromspecific E2 ubiquitin-conjugating enzymes, and transfers it tosubstrates, generally promoting their degradation by theproteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilonreceptor) signal transduction pathways. In naive T-cells, inhibitsVAV1 activation upon TCR engagement and imposes a requirement forCD28 costimulation for proliferation and IL-2 production. Alsoacts by promoting PIK3R1/p85 ubiquitination, which impairs itsrecruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization uponrestimulation and promotes anergy. In B-cells, acts byubiquitinating SYK and promoting its proteasomal degradation.Slightly promotes SRC ubiquitination. May be involved in EGFRubiquitination and internalization. May be functionally coupledwith the E2 ubiquitin-protein ligase UB2D3.{ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340,ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404,ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDS5B_CBLB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDS5B_CBLB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDS5B_CBLB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDS5B_CBLB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCBLBC0014072Experimental Autoimmune Encephalomyelitis1CTD_human
TgeneCBLBC0026769Multiple Sclerosis1CTD_human